#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13861	uniprotkb:P38484	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	intact:EBI-3905457|uniprotkb:Q9BTL5|ensembl:ENSP00000290219|ensembl:ENSP00000458487	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:ingr2_human(display_long)|uniprotkb:Interferon gamma receptor beta-chain(gene name synonym)|uniprotkb:IFNGR2(gene name)|psi-mi:IFNGR2(display_short)|uniprotkb:IFNGT1(gene name synonym)|uniprotkb:Interferon gamma receptor accessory factor 1(gene name synonym)|uniprotkb:Interferon gamma transducer 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kong et al. (2016)	imex:IM-26518|pubmed:27621415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20638806|imex:IM-26518-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	refseq:NP_005525.2|ensembl:ENSG00000159128(gene)|ensembl:ENSG00000262795(gene)|ensembl:ENST00000290219(transcript)|ensembl:ENST00000576463(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004906"(interferon-gamma receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030659"(cytoplasmic vesicle membrane)|reactome:R-HSA-877312|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-9679191|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:5EH1|rcsb pdb:6E3K|rcsb pdb:6E3L|reactome:R-HSA-877300	-	-	-	figure legend:Fig. 7P, Fig. 7Q|comment:DP1 activation increased the membrane mobilization of free PRKAR2A in macrophages, as well as its colocalization with IFN-γR2, whereas this was markedly decreased in Mac-DP1 KO macrophages|agonist:"CHEBI:131496 - BW 245C"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2018/07/20	2018/07/20	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	rogid:nevMpRU4Pz2jNKhOTagi4bhNkok9606	rigid:BQfD9J/S1YFiAAbUUhMDDnljYTE	false	-	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P13861	uniprotkb:P38484	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	intact:EBI-3905457|uniprotkb:Q9BTL5|ensembl:ENSP00000290219|ensembl:ENSP00000458487	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:ingr2_human(display_long)|uniprotkb:Interferon gamma receptor beta-chain(gene name synonym)|uniprotkb:IFNGR2(gene name)|psi-mi:IFNGR2(display_short)|uniprotkb:IFNGT1(gene name synonym)|uniprotkb:Interferon gamma receptor accessory factor 1(gene name synonym)|uniprotkb:Interferon gamma transducer 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kong et al. (2016)	imex:IM-26518|pubmed:27621415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20638797|imex:IM-26518-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	refseq:NP_005525.2|ensembl:ENSG00000159128(gene)|ensembl:ENSG00000262795(gene)|ensembl:ENST00000290219(transcript)|ensembl:ENST00000576463(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004906"(interferon-gamma receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030659"(cytoplasmic vesicle membrane)|reactome:R-HSA-877312|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-9679191|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:5EH1|rcsb pdb:6E3K|rcsb pdb:6E3L|reactome:R-HSA-877300	-	-	-	figure legend:Fig. 7R, Fig. 7S|agonist:"CHEBI:131496 - BW 245C"|comment:"Consistent with these observations, BW augmented the PRKAR2A–IFN-γR2 interaction (Fig. 7 R), which was blunted by Rp-cAMP in a dose-dependent manner (Fig. 7 S)."|antagonist:"CHEBI:84622 - (Rp)-cAMPS"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2018/07/20	2018/07/20	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	rogid:nevMpRU4Pz2jNKhOTagi4bhNkok9606	rigid:BQfD9J/S1YFiAAbUUhMDDnljYTE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)