#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21005963|imex:IM-27764-1|emdb:EMD-8247|emdb:EMD-8246|rcsb pdb:5KGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Figure 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21005963|imex:IM-27764-1|emdb:EMD-8247|emdb:EMD-8246|rcsb pdb:5KGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Figure 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21005963|imex:IM-27764-1|emdb:EMD-8247|emdb:EMD-8246|rcsb pdb:5KGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Figure 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21005963|imex:IM-27764-1|emdb:EMD-8247|emdb:EMD-8246|rcsb pdb:5KGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Figure 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:1484-1631	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21005963|imex:IM-27764-1|emdb:EMD-8247|emdb:EMD-8246|rcsb pdb:5KGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Figure 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21012274|imex:IM-27764-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Figure 1a, Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0067"(light scattering)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21012274|imex:IM-27764-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Figure 1a, Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0067"(light scattering)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21012274|imex:IM-27764-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	comment:further modified as in Cryo-Em structure	figure legend:Figure 1a, Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0067"(light scattering)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21012274|imex:IM-27764-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Figure 1a, Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0067"(light scattering)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21012274|imex:IM-27764-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Figure 1a, Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21014956|imex:IM-27764-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c|mutation disrupting interaction:1619-1619	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21014956|imex:IM-27764-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c|mutation disrupting interaction:1619-1619	mutation with no effect:37-37|mutation with no effect:14-14	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016298|imex:IM-27764-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 5h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016298|imex:IM-27764-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 5h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c	mutation with no effect:14-14|mutation with no effect:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P62807	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016298|imex:IM-27764-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 5h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P62807	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016314|imex:IM-27764-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 5c and 5f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	mutation disrupting interaction:120-120|mutation disrupting interaction:120-120	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016314|imex:IM-27764-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 5c and 5f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21016314|imex:IM-27764-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 5c and 5f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:4cN/nTtLoL/BL/IhHiqt6kq1K6w	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	mutation with no effect:14-14|mutation with no effect:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21133116|imex:IM-27764-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 8a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1616-1616|mutation decreasing interaction:1620-1620|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1617-1617|mutation decreasing interaction:1619-1619	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21133116|imex:IM-27764-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 8a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1616-1616|mutation decreasing interaction:1620-1620|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1617-1617|mutation decreasing interaction:1619-1619	mutation with no effect:14-14|mutation with no effect:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0CG47	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21133183|imex:IM-27764-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 8c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:fOAC0rCNCxiKpuyeIhSBSkg5ndQ	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	mutation disrupting interaction:68-68,6-6|mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21133183|imex:IM-27764-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 8c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:fOAC0rCNCxiKpuyeIhSBSkg5ndQ	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21133183|imex:IM-27764-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 8c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:fOAC0rCNCxiKpuyeIhSBSkg5ndQ	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	mutation with no effect:14-14|mutation with no effect:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21146538|imex:IM-27764-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 9c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21146538|imex:IM-27764-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 9c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	mutation with no effect:14-14|mutation with no effect:37-37|mutation disrupting interaction:61-62,92-93	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P84233	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21146639|imex:IM-27764-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 5c and 5f, Extended Data Figure 9e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation disrupting interaction:1627-1627	-	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:P0C0S8	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21146639|imex:IM-27764-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	-	-	-	figure legend:Extended Data Figure 5c and 5f, Extended Data Figure 9e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rigid:MQjZvBJ5jn+scR9su/8Wo6TP1F8	false	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation disrupting interaction:1627-1627	mutation decreasing interaction:14-14|mutation decreasing interaction:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21017362|imex:IM-27764-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 2g, Figure 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0071"(molecular sieving)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21017362|imex:IM-27764-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 2g, Figure 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0071"(molecular sieving)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21017362|imex:IM-27764-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	comment:further modified as in Cryo-Em structure	figure legend:Extended Data Figure 2g, Figure 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21017362|imex:IM-27764-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 2g, Figure 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0071"(molecular sieving)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21017362|imex:IM-27764-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 2g, Figure 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62807	uniprotkb:Q12888	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21132132|imex:IM-27764-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2019/01/24	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:ALYoZ9hRD+2u/6H6BxPopd/H0sM	false	mutation with no effect:106-106	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c|mutation decreasing interaction:1628-1628	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62807	uniprotkb:Q12888	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21132169|imex:IM-27764-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2019/01/24	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:ALYoZ9hRD+2u/6H6BxPopd/H0sM	false	mutation with no effect:85-85	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c|mutation with no effect:1609-1609	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P62807	uniprotkb:Q12888	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21132193|imex:IM-27764-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2019/01/24	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:ALYoZ9hRD+2u/6H6BxPopd/H0sM	false	mutation:85-85	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c|mutation:1628-1628	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12888	uniprotkb:P62807	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21132209|imex:IM-27764-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2019/01/24	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:ALYoZ9hRD+2u/6H6BxPopd/H0sM	false	binding-associated region:1484-1631|glutathione s tranferase tag:n-n|his tag:c-c	mutation with no effect:85-85	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0113"(western blot)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470195|imex:IM-27764-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470195|imex:IM-27764-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470195|imex:IM-27764-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Extended Data Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470195|imex:IM-27764-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:1484-1631	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470195|imex:IM-27764-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/15	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470296|imex:IM-27764-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470296|imex:IM-27764-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470296|imex:IM-27764-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470296|imex:IM-27764-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1617-1617|mutation decreasing interaction:1619-1619	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470296|imex:IM-27764-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470325|imex:IM-27764-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470325|imex:IM-27764-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470325|imex:IM-27764-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Extended Data Figure 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470325|imex:IM-27764-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	his tag:c-c|glutathione s tranferase tag:n-n|necessary binding region:1484-1631|sufficient binding region:1220-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25470325|imex:IM-27764-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494134|imex:IM-27764-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Figure 3d, Figure 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation decreasing interaction:109-109|mutation decreasing interaction:110-110|mutation decreasing interaction:106-106	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494134|imex:IM-27764-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Figure 3d, Figure 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494134|imex:IM-27764-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Figure 3d, Figure 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494134|imex:IM-27764-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Figure 3d, Figure 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1616-1616,1620-1620|mutation decreasing interaction:1617-1617|mutation decreasing interaction:1619-1619	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494134|imex:IM-27764-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Figure 3d, Figure 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494176|imex:IM-27764-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494176|imex:IM-27764-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494176|imex:IM-27764-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494176|imex:IM-27764-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631|mutation decreasing interaction:1626-1626|mutation decreasing interaction:1629-1629|mutation decreasing interaction:1627-1627|mutation decreasing interaction:1628-1628	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494176|imex:IM-27764-49	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Figure 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494406|imex:IM-27764-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	mutation decreasing interaction:120-120|mutation decreasing interaction:120-120	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494406|imex:IM-27764-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494406|imex:IM-27764-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Extended Data Figure 5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	mutation:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494406|imex:IM-27764-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:1484-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494406|imex:IM-27764-51	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 5e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494433|imex:IM-27764-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:Extended Data Figure 8d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494433|imex:IM-27764-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:Extended Data Figure 8d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494433|imex:IM-27764-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Extended Data Figure 8d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	mutation:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494433|imex:IM-27764-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:Extended Data Figure 8d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	his tag:c-c|glutathione s tranferase tag:n-n|binding-associated region:1484-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494433|imex:IM-27764-53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Extended Data Figure 8d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation:14-14|mutation:37-37	mutation decreasing interaction:44-44|mutation decreasing interaction:68-68,6-6	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494463|imex:IM-27764-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation decreasing interaction:106-106	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494463|imex:IM-27764-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494463|imex:IM-27764-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:"Extended Data Figure 10d (Upper Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494463|imex:IM-27764-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	glutathione s tranferase tag:n-n|his tag:c-c|binding-associated region:1484-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494463|imex:IM-27764-55	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:"Extended Data Figure 10d (Upper Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494507|imex:IM-27764-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation decreasing interaction:106-106	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494507|imex:IM-27764-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494507|imex:IM-27764-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:"Extended Data Figure 10d (Upper Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494507|imex:IM-27764-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:"Extended Data Figure 10d (Upper Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	his tag:c-c|sufficient binding region:1220-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494507|imex:IM-27764-57	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:"Extended Data Figure 10d (Upper Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37|mutation decreasing interaction:62-62|mutation decreasing interaction:92-92|mutation decreasing interaction:93-93	mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494537|imex:IM-27764-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation decreasing interaction:120-120	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494537|imex:IM-27764-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494537|imex:IM-27764-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:"Extended Data Figure 10d (Lower Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494537|imex:IM-27764-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	his tag:c-c|sufficient binding region:1220-1631	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494537|imex:IM-27764-59	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:"Extended Data Figure 10d (Lower Left Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62807	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-354552|uniprotkb:Q4VB69|uniprotkb:P02278|uniprotkb:Q3B872|uniprotkb:Q93078|uniprotkb:Q93080|ensembl:ENSP00000321744|ensembl:ENSP00000348924|ensembl:ENSP00000366962|ensembl:ENSP00000380180|ensembl:ENSP00000445633|ensembl:ENSP00000483237|ensembl:ENSP00000489317	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h2b1c_human(display_long)|uniprotkb:HIST1H2BG(gene name synonym)|uniprotkb:HIST1H2BI(gene name synonym)|uniprotkb:Histone H2B.1 A(gene name synonym)|uniprotkb:Histone H2B.a(gene name synonym)|uniprotkb:Histone H2B.g(gene name synonym)|uniprotkb:Histone H2B.h(gene name synonym)|uniprotkb:Histone H2B.k(gene name synonym)|uniprotkb:Histone H2B.l(gene name synonym)|uniprotkb:H2BC10(gene name)|psi-mi:H2BC10(display_short)|uniprotkb:H2BC4(gene name)|psi-mi:H2BC4(display_short)|uniprotkb:H2BC6(gene name)|psi-mi:H2BC6(display_short)|uniprotkb:H2BC7(gene name)|psi-mi:H2BC7(display_short)|uniprotkb:H2BC8(gene name)|psi-mi:H2BC8(display_short)|uniprotkb:H2BFA(gene name synonym)|uniprotkb:H2BFG(gene name synonym)|uniprotkb:H2BFH(gene name synonym)|uniprotkb:H2BFK(gene name synonym)|uniprotkb:H2BFL(gene name synonym)|uniprotkb:HIST1H2BC(gene name synonym)|uniprotkb:HIST1H2BE(gene name synonym)|uniprotkb:HIST1H2BF(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494565|imex:IM-27764-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_003509.1|refseq:NP_003513.1|refseq:NP_003514.2|refseq:NP_003516.1|refseq:NP_003517.2|refseq:NP_066407.1|rcsb pdb:7A08|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|rcsb pdb:6XJD|ensembl:ENSG00000180596(gene)|ensembl:ENSG00000273802(gene)|ensembl:ENSG00000274290(gene)|ensembl:ENSG00000277224(gene)|ensembl:ENSG00000278588(gene)|ensembl:ENST00000314332(transcript)|ensembl:ENST00000356530(transcript)|ensembl:ENST00000377733(transcript)|ensembl:ENST00000396984(transcript)|ensembl:ENST00000541790(transcript)|ensembl:ENST00000614097(transcript)|ensembl:ENST00000634910(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P62807|rcsb pdb:5GT0|rcsb pdb:5KGF|rcsb pdb:6ACO|rcsb pdb:6C0W|rcsb pdb:6FML|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6X59|rcsb pdb:6X5A|dip:DIP-32890N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:00sapwbWn8dtUr7qoPsRPUlL35A9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation decreasing interaction:120-120	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P84233	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-350041|uniprotkb:P02295|uniprotkb:P02297|uniprotkb:P16105|uniprotkb:P17269|uniprotkb:A4FVE2|uniprotkb:P17320	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h32_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494565|imex:IM-27764-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001091428.1|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XBK|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7K6P|rcsb pdb:7K6Q|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2L11|rcsb pdb:2L12|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3GV6|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:4ZUX|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:5BS7|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:5BSA|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:5CP6|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4QEO|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|refseq:XP_018079657.1|refseq:XP_018096294.1|refseq:XP_018096295.1|refseq:XP_018096296.1|refseq:XP_018098036.1|refseq:XP_018118226.1|refseq:XP_018118227.1|dip:DIP-37430N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P62799	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494565|imex:IM-27764-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:"Extended Data Figure 10d (Lower Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	mutation with no effect:21-21	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:Q12888	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494565|imex:IM-27764-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:"Extended Data Figure 10d (Lower Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	his tag:c-c|binding-associated region:1484-1631|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0S8	uniprotkb:P0CG47	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Wilson et al. (2016)	pubmed:27462807|imex:IM-27764	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25494565|imex:IM-27764-61	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:"Extended Data Figure 10d (Lower Right Picture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/16	2020/03/29	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rigid:OYkRscdQYdjrfJHrccMMP3iDVZQ	false	mutation with no effect:14-14|mutation with no effect:37-37	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)