#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86U44	uniprotkb:Q9HCE5	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719450|imex:IM-26294-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	figure legend:Figure 1B/C,  Supp. figure 1A/C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rigid:uC9+mYi7Kaiy3nHOIXKZhXiq7zA	false	sufficient binding region:357-580(IPR029063)	sufficient binding region:111-456	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719555|wwpdb:5k7w|imex:IM-26294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Table 1|3d-resolution:1.65A|3d-r-factors:R Work= 0.16  R Free= 0.179|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:111-456	sufficient binding region:357-580(IPR029063)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16680"	uniprotkb:Q9HCE5	intact:EBI-1180228	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	psi-mi:s-adenosyl-l-homocysteine(display_short)|psi-mi:"CHEBI:16680"(display_long)	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719555|wwpdb:5k7w|imex:IM-26294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	figure legend:Table 1|3d-resolution:1.65A|3d-r-factors:R Work= 0.16  R Free= 0.179|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	-	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	false	-	sufficient binding region:111-456	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719567|wwpdb:5k7u|imex:IM-26294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Table 1i|3d-resolution:1.7A|3d-r-factors:R Work= 0.163  R Free= 0.187|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:111-456	sufficient binding region:357-580(IPR029063)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15414"	uniprotkb:Q9HCE5	intact:EBI-980183	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	psi-mi:s-adenosyl-l-methionine(display_short)|psi-mi:"CHEBI:15414"(display_long)	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719567|wwpdb:5k7u|imex:IM-26294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	figure legend:Table 1i|3d-resolution:1.7A|3d-r-factors:R Work= 0.163  R Free= 0.187|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	-	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	false	-	sufficient binding region:111-456	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719583|wwpdb:5k7m|imex:IM-26294-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Table 1ii|3d-resolution:1.65A|3d-r-factors:R Work= 0.16  R Free= 0.184|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	rigid:uC9+mYi7Kaiy3nHOIXKZhXiq7zA	false	sufficient binding region:111-456	sufficient binding region:357-580(IPR029063)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719622|imex:IM-26294-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 2D, 4H, 5A/D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:1-456	mutation disrupting interaction rate:395-395|mutation disrupting interaction rate:475-475|mutation disrupting interaction rate:294-294|mutation disrupting interaction strength:406-406|sufficient binding region:1-580(IPR029063)|mutation disrupting interaction rate:477-477|mutation disrupting interaction rate:326-326	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719622|imex:IM-26294-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 2D, 4H, 5A/D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	sufficient binding region:1-456	mutation decreasing interaction rate:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719656|imex:IM-26294-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 2E, 4G/I|comment:Mettl3 is the catalytically active subunit, its activity is negligible without forming stoichiometric complexes with Mettl14.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	mutation decreasing interaction rate:312-312|mutation with no effect:192-192|sufficient binding region:1-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719656|imex:IM-26294-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 2E, 4G/I|comment:Mettl3 is the catalytically active subunit, its activity is negligible without forming stoichiometric complexes with Mettl14.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	mutation decreasing interaction rate:312-312|mutation with no effect:192-192|sufficient binding region:1-456	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719672|imex:IM-26294-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 2D-2, 4H, 5A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	mutation decreasing interaction rate:312-312|mutation decreasing interaction rate:192-192|sufficient binding region:1-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719672|imex:IM-26294-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 2D-2, 4H, 5A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	mutation decreasing interaction rate:312-312|mutation decreasing interaction rate:192-192|sufficient binding region:1-456	mutation decreasing interaction rate:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719709|imex:IM-26294-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 4H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:111-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16719709|imex:IM-26294-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 4H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	sufficient binding region:111-456	mutation decreasing interaction rate:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720056|imex:IM-26294-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 2E-2, 4G/I,5B/E|comment:Mettl3 is the catalytically active subunit, its activity is negligible without forming stoichiometric complexes with Mettl14.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:1-456	mutation disrupting interaction rate:406-406|mutation disrupting interaction rate:395-395|sufficient binding region:1-580(IPR029063)|mutation decreasing interaction rate:475-475|mutation decreasing interaction rate:294-294|mutation disrupting interaction rate:326-326|mutation disrupting interaction rate:477-477	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720056|imex:IM-26294-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 2E-2, 4G/I,5B/E|comment:Mettl3 is the catalytically active subunit, its activity is negligible without forming stoichiometric complexes with Mettl14.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	sufficient binding region:1-456	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720154|imex:IM-26294-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:"Figure 5A (Supp fig 6A)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:111-456	necessary binding region:276..276-357..357|sufficient binding region:276-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720154|imex:IM-26294-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:"Figure 5A (Supp fig 6A)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	sufficient binding region:111-456	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720177|imex:IM-26294-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:"Figure 5D, (Supp 3A)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	mutation decreasing interaction rate:298-298|sufficient binding region:1-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720177|imex:IM-26294-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:"Figure 5D, (Supp 3A)"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/10	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	mutation decreasing interaction rate:298-298|sufficient binding region:1-456	mutation with no effect:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720263|imex:IM-26294-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Figure 5E, Supp 3A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/11	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	mutation decreasing interaction rate:298-298|sufficient binding region:1-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720263|imex:IM-26294-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Figure 5E, Supp 3A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/11	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	mutation decreasing interaction rate:298-298|sufficient binding region:1-456	mutation with no effect:16-16	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	uniprotkb:Q86U44	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	intact:EBI-11105430|uniprotkb:Q9HB32|uniprotkb:Q86V05|uniprotkb:O14736|ensembl:ENSP00000298717	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:mta70_human(display_long)|uniprotkb:N6-adenosine-methyltransferase 70 kDa subunit(gene name synonym)|uniprotkb:METTL3(gene name)|psi-mi:METTL3(display_short)|uniprotkb:MTA70(gene name synonym)|uniprotkb:Methyltransferase-like protein 3(gene name synonym)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720340|imex:IM-26294-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	refseq:NP_062826.2|ensembl:ENSG00000165819(gene)|ensembl:ENST00000298717(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001734"("mRNA (N6-adenosine)-methyltransferase activity")|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045087"(innate immune response)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048477"(oogenesis)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|go:"GO:1990744"(primary miRNA methylation)|interpro:IPR007757(MT-A70)|interpro:IPR025848|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:5YZ9|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|dip:DIP-60727N	-	-	-	figure legend:Supp 3A/C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/11	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	rogid:B7ORoNVaQb6/OA77jPsn558+k409606	-	false	sufficient binding region:1-456	sufficient binding region:1-580(IPR029063)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE5	intact:EBI-16719633	intact:EBI-6661081|ensembl:ENSP00000373474|uniprotkb:A6NIG1|uniprotkb:Q969V2	-	psi-mi:met14_human(display_long)|uniprotkb:Methyltransferase-like protein 14(gene name synonym)|uniprotkb:METTL14(gene name)|psi-mi:METTL14(display_short)|uniprotkb:KIAA1627(gene name synonym)	psi-mi:“ggacu”(display_short)|psi-mi:EBI-16719633(display_long)	psi-mi:"MI:0516"(methyltransferase radiometric assay)	Wang et al. (2016)	imex:IM-26294|pubmed:27373337	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:32630(synthetic construct)|taxid:32630(synthetic construct)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16720340|imex:IM-26294-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensembl:ENSG00000145388(gene)|ensembl:ENST00000388822(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0042063"(gliogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0080009"(mRNA methylation)|go:"GO:1901533"(negative regulation of hematopoietic progenitor cell differentiation)|interpro:IPR007757(MT-A70)|interpro:IPR029063|rcsb pdb:5IL0|rcsb pdb:5IL1|rcsb pdb:5IL2|rcsb pdb:5K7M|go:"GO:0016422"("mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity")|rcsb pdb:5K7U|rcsb pdb:5K7W|rcsb pdb:5L6D|rcsb pdb:5L6E|rcsb pdb:5TEY|rcsb pdb:6TTP|rcsb pdb:6TTT|rcsb pdb:6TTV|rcsb pdb:6TTW|rcsb pdb:6TTX|rcsb pdb:6TU1|rcsb pdb:6Y4G|rcsb pdb:7ACD|rcsb pdb:7O2I|rcsb pdb:7O2X|reactome:R-HSA-72203|refseq:NP_066012.1|dip:DIP-60726N	-	-	-	-	figure legend:Supp 3A/C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/10	2018/01/11	rogid:HrwI6DDJQW3GAzFuLRmpzbqfz7A9606	-	-	false	sufficient binding region:1-456	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)