#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N4G2 uniprotkb:Q16820 intact:EBI-3921493|uniprotkb:Q9H655|ensembl:ENSP00000323847 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:arl14_human(display_long)|uniprotkb:ARL14(gene name)|psi-mi:ARL14(display_short)|uniprotkb:ARF7(gene name synonym)|uniprotkb:ADP-ribosylation factor 7(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20765925|imex:IM-26523-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079323.1|ensembl:ENSG00000179674(gene)|ensembl:ENST00000320767(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:7Fi1v32EgjFh3EcGN46Tb16wF9Q9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:IdHfhQmgxQEeXUXEtRqp/ipV9Xs false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NVV5 uniprotkb:Q16820 intact:EBI-3942989|uniprotkb:Q9Y5B4|uniprotkb:Q9Y3A9|uniprotkb:Q6N047|uniprotkb:Q8TB14|uniprotkb:Q7Z378|uniprotkb:Q5T2H2|ensembl:ENSP00000350509|uniprotkb:B4DPX2|uniprotkb:C9J569 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:aig1_human(display_long)|uniprotkb:Fatty acid esters of hydroxy fatty acids hydrolase AIG1(gene name synonym)|uniprotkb:CGI-103(orf name)|uniprotkb:AIG1(gene name)|psi-mi:AIG1(display_short) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20765934|imex:IM-26523-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273516.1|refseq:NP_001273517.1|refseq:NP_001273518.1|ensembl:ENSG00000146416(gene)|ensembl:ENST00000357847(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042758"(long-chain fatty acid catabolic process)|interpro:IPR006838(FAR-17a/AIG1-like protein)|mint:Q9NVV5|refseq:NP_057192.2 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2020/10/21 rogid:BzP4VaY7yZZE8oxNSw9V9i8APtc9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:N1hwUeMKQuAiyo9ibsOq86zn4uw false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02656 uniprotkb:Q16820 intact:EBI-1220113|uniprotkb:Q08E83|uniprotkb:Q6Q786|ensembl:ENSP00000227667 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:apoc3_human(display_long)|uniprotkb:APOC3(gene name)|psi-mi:APOC3(display_short)|uniprotkb:Apolipoprotein C3(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20765942|imex:IM-26523-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000031.1|ensembl:ENSG00000110245(gene)|ensembl:ENST00000227667(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0010987"(negative regulation of high-density lipoprotein particle clearance)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0015485"(cholesterol binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060621"(negative regulation of cholesterol import)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|interpro:IPR008403(Apolipoprotein CIII)|interpro:IPR038195|mint:P02656|rcsb pdb:2JQ3|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964058|reactome:R-HSA-975634 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:DDj33pQWDh0i5+mwMy16Dmg6JPg9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:h9ND6BSuG8Jz++8pEWUjNipq+Ts false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14520 uniprotkb:Q16820 intact:EBI-20765950|ensembl:ENSP00000297988|uniprotkb:Q08E94|uniprotkb:Q5T5L9|uniprotkb:Q8NHM3 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:aqp7_human(display_long)|uniprotkb:AQP7(gene name)|psi-mi:AQP7(display_short)|uniprotkb:AQP7L(gene name synonym)|uniprotkb:AQP9(gene name synonym)|uniprotkb:Aquaglyceroporin-7(gene name synonym)|uniprotkb:Aquaporin adipose(gene name synonym)|uniprotkb:Aquaporin-7-like(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20765984|imex:IM-26523-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165269(gene)|ensembl:ENST00000297988(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006833"(water transport)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015254"(glycerol channel activity)|go:"GO:0015793"(glycerol transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR023271|rcsb pdb:6KXW|rcsb pdb:6N1G|rcsb pdb:6QZI|rcsb pdb:6QZJ|reactome:R-HSA-432030|reactome:R-HSA-432047|refseq:NP_001161.1|refseq:NP_001305086.1|refseq:NP_001305087.1|refseq:XP_005251510.1|refseq:XP_011516168.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:y1EZcnNFc+FmXrtwlxRc0ImJbvA9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:KRiCzMKaZ7sw4ahzklOHLI+DRlM false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P48201 uniprotkb:Q16820 intact:EBI-347797|uniprotkb:Q4ZFX7|uniprotkb:B2R4Z0|uniprotkb:D3DPF0|ensembl:ENSP00000284727|ensembl:ENSP00000376324|ensembl:ENSP00000387317 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:at5g3_human(display_long)|uniprotkb:ATP5MC3(gene name)|psi-mi:ATP5MC3(display_short)|uniprotkb:ATP synthase lipid-binding protein(gene name synonym)|uniprotkb:ATP synthase membrane subunit c locus 3(gene name synonym)|uniprotkb:ATP synthase proteolipid P3(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit C3"(gene name synonym)|uniprotkb:ATP5G3(gene name synonym)|uniprotkb:ATPase protein 9(gene name synonym)|uniprotkb:ATPase subunit c(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20765992|imex:IM-26523-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001002258.1|refseq:NP_001680.1|ensembl:ENSG00000154518(gene)|ensembl:ENST00000284727(transcript)|ensembl:ENST00000392541(transcript)|ensembl:ENST00000409194(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|interpro:IPR000454(ATPase, F0 complex, subunit C)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR020537|interpro:IPR035921|interpro:IPR038662|reactome:R-HSA-163210|reactome:R-HSA-8949613 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:09JFHVdOi1FEXzpqyLx0aDVhvTk9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:8BkNlwWxJ8Z2L2Kwo6L/34Tu/Xo false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8WUD6 uniprotkb:Q16820 intact:EBI-11337856|uniprotkb:Q7Z7H1|uniprotkb:Q8WYI4|uniprotkb:Q8IWQ5|uniprotkb:Q7Z7H0|uniprotkb:Q9NRQ6|uniprotkb:B3KQM2|uniprotkb:Q9Y6M6|uniprotkb:Q9NRQ7|uniprotkb:Q7Z7H2|uniprotkb:Q8IWQ4|ensembl:ENSP00000229266 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:chpt1_human(display_long)|uniprotkb:CHPT1(gene name)|psi-mi:CHPT1(display_short)|uniprotkb:AAPT1-like protein(gene name synonym)|uniprotkb:CPT1(gene name synonym)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:MSTP022(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766000|imex:IM-26523-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064629.2|ensembl:ENSG00000111666(gene)|ensembl:ENST00000229266(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|mint:Q8WUD6|reactome:R-HSA-1483191 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:4RFBPd6zmk0NFjCdHC01wIXZd989606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:HWNxhEf5AYa6sRhXQ4/rK4cDw/Y false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75131 uniprotkb:Q16820 intact:EBI-718988|uniprotkb:Q8IYA1|uniprotkb:A8KA47|ensembl:ENSP00000477590 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:cpne3_human(display_long)|uniprotkb:Copine III(gene name synonym)|uniprotkb:CPNE3(gene name)|psi-mi:CPNE3(display_short)|uniprotkb:CPN3(gene name synonym)|uniprotkb:KIAA0636(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766008|imex:IM-26523-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003900.1|refseq:XP_005251150.1|ensembl:ENSG00000085719(gene)|ensembl:ENST00000517490(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:O75131|reactome:R-HSA-1483206|reactome:R-HSA-6798695|refseq:XP_016869434.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:75lb/sKHpJYCwCLIq973pzNMfzw9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:OqXWmHI/mHxqegR+vN1EM3GfMCE false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14607 uniprotkb:Q16820 intact:EBI-3934106|uniprotkb:O14608|uniprotkb:A8K9Z3|intact:EBI-28988456|ensembl:ENSP00000328939|uniprotkb:E1U199|uniprotkb:E1U1A0|uniprotkb:F5H4V7|uniprotkb:F8W8R7 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:uty_human(display_long)|uniprotkb:UTY(gene name)|psi-mi:UTY(display_short)|uniprotkb:KDM6C(gene name synonym)|uniprotkb:Ubiquitously-transcribed TPR protein on the Y chromosome(gene name synonym)|uniprotkb:Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase UTY"(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766016|imex:IM-26523-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183878(gene)|ensembl:ENST00000331397(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O14607|rcsb pdb:3ZLI|rcsb pdb:3ZPO|rcsb pdb:4UF0|rcsb pdb:5A1L|rcsb pdb:5FXV|rcsb pdb:5FXW|rcsb pdb:5FXX|rcsb pdb:5FXZ|rcsb pdb:5FY0|rcsb pdb:5FY1|rcsb pdb:5FY7|rcsb pdb:5FYM|reactome:R-HSA-3214842|go:"GO:0007507"(heart development)|refseq:NP_009056.3|refseq:NP_872600.1|refseq:NP_872601.1|refseq:NP_001245181.1|refseq:NP_001245183.1|ensembl:ENST00000329134|ensembl:ENSP00000330446|ensembl:ENSP00000328939|ensembl:ENST00000362096|ensembl:ENSP00000355420|ensembl:ENST00000624098|ensembl:ENSP00000485539|ensembl:ENST00000682913|ensembl:ENSP00000507736|dip:DIP-48650N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:CwoStszULfVOM9pEVWdSRcUXWhY9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:Y+s3Uc4Rc8b1pnAi1KtN7tn6WGc false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10316 uniprotkb:Q16820 intact:EBI-11337951|uniprotkb:B1PKZ3 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:1a69_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:Aw-69(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-28 alpha chain(gene name synonym)|uniprotkb:HLAA(gene name synonym)|uniprotkb:MHC class I antigen A*69(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766024|imex:IM-26523-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0055038"(recycling endosome membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENST00000457879|interpro:IPR036179|interpro:IPR037055 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - no-uniprot-update:This interactor won't be updated using Uniprot. - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:7OTCPtpzsA6j+fK+MoF+0EDFVZ49606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:g/Kfd4oPWxzkXHwFC+kUHlQvR5c false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P28067 uniprotkb:Q16820 intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766032|imex:IM-26523-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:S7y1u8fnAg5AvxRXpFZEuP6j+iM false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P13164 uniprotkb:Q16820 intact:EBI-348505|uniprotkb:Q15322|ensembl:ENSP00000330825|ensembl:ENSP00000386187|ensembl:ENSP00000437057|ensembl:ENSP00000505380|uniprotkb:Q53XZ0 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:ifm1_human(display_long)|uniprotkb:IFITM1(gene name)|psi-mi:IFITM1(display_short)|uniprotkb:IFI17(gene name synonym)|uniprotkb:Interferon-inducible protein 9-27(gene name synonym)|uniprotkb:Interferon-induced protein 17(gene name synonym)|uniprotkb:Leu-13 antigen(gene name synonym)|uniprotkb:CD225(gene name synonym)|uniprotkb:Dispanin subfamily A member 2a(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766040|imex:IM-26523-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003632.3|ensembl:ENSG00000185885(gene)|ensembl:ENST00000328221(transcript)|ensembl:ENST00000408968(transcript)|ensembl:ENST00000528780(transcript)|ensembl:ENST00000680588(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007593(Interferon-induced transmembrane protein)|mint:P13164|reactome:R-HSA-198933|reactome:R-HSA-909733|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|dip:DIP-32672N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:+WojFAUu4AZAydvg1PBePvxrBWs9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:MJI7AKo6eF/7BcbyjY79/kdVZX0 false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P24001 uniprotkb:Q16820 intact:EBI-2866752|uniprotkb:Q5VFH7|uniprotkb:Q5VFH8|uniprotkb:Q96GK9|uniprotkb:Q8WV38|uniprotkb:D3DUB0|uniprotkb:D3DUB2|uniprotkb:A8MPX0|uniprotkb:B4DJM1|uniprotkb:A6NNM0|uniprotkb:B8Q191|ensembl:ENSP00000380099|ensembl:ENSP00000431775|ensembl:ENSP00000449483 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:il32_human(display_long)|uniprotkb:IL32(gene name)|psi-mi:IL32(display_short)|uniprotkb:NK4(gene name synonym)|uniprotkb:TAIF(gene name synonym)|uniprotkb:Natural killer cells protein 4(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-inducing factor(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766048|imex:IM-26523-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295007.1|refseq:NP_001012649.1|refseq:NP_001012650.1|refseq:NP_001012651.1|refseq:NP_001012736.1|refseq:NP_004212.4|refseq:NP_001012652.1|refseq:NP_001012653.1|refseq:NP_001012654.1|dip:DIP-61119N|ensembl:ENSG00000008517(gene)|ensembl:ENST00000396890(transcript)|ensembl:ENST00000534507(transcript)|ensembl:ENST00000548476(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR028067|reactome:R-HSA-449836|reactome:R-HSA-9013423 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:nqJAdeihv1nYJsMpG+RklQbUqXM9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:JIf/c4L4gkGufbIOpN0mkaYyzdQ false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O43291 uniprotkb:Q16820 intact:EBI-7810230|ensembl:ENSP00000301244|intact:MINT-1366946|uniprotkb:Q5TZQ3|uniprotkb:O14895|uniprotkb:B4DLU1|uniprotkb:Q969E0|uniprotkb:O00271|uniprotkb:A8K667 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:spit2_human(display_long)|uniprotkb:SPINT2(gene name)|psi-mi:SPINT2(display_short)|uniprotkb:HAI2(gene name synonym)|uniprotkb:KOP(gene name synonym)|uniprotkb:Placental bikunin(gene name synonym)|uniprotkb:Hepatocyte growth factor activator inhibitor type 2(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766056|imex:IM-26523-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000167642(gene)|ensembl:ENST00000301244(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0060672"(epithelial cell morphogenesis involved in placental branching)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:4U32|reactome:R-HSA-6806942|reactome:R-HSA-8852405|refseq:NP_001159575.1|refseq:NP_066925.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - comment:mint|function:Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:LC/m9zTMejqOhCn30qBZFKSKBws9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:J2eQ2F1nY7ZF8FptLUZGh3Ye7sI false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O15243 uniprotkb:Q16820 intact:EBI-15672507|ensembl:ENSP00000360104|uniprotkb:Q6FHL5 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:obrg_human(display_long)|uniprotkb:LEPROT(gene name)|psi-mi:LEPROT(display_short)|uniprotkb:LEPR(gene name synonym)|uniprotkb:OBR(gene name synonym)|uniprotkb:Endospanin-1(gene name synonym)|uniprotkb:Leptin receptor overlapping transcript protein(gene name synonym)|uniprotkb:OB-R gene-related protein(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766064|imex:IM-26523-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000213625(gene)|ensembl:ENST00000371065(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032511"(late endosome to vacuole transport via multivesicular body sorting pathway)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0060400"(negative regulation of growth hormone receptor signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR007262(Vacuolar protein sorting 55)|refseq:NP_001185612.1|refseq:NP_059996.1|dip:DIP-29969N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:zVXPHZKK3zKoNCPtdE1//DCJoj49606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:elbsb8tRvyLuroyHjQKDNMvEtA8 false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13113 uniprotkb:Q16820 intact:EBI-716063|uniprotkb:Q96EI1|uniprotkb:Q6ICT9|ensembl:ENSP00000294338|ensembl:ENSP00000360952 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:pdz1i_human(display_long)|uniprotkb:MAP17(gene name synonym)|uniprotkb:PDZK1IP1(gene name)|psi-mi:PDZK1IP1(display_short)|uniprotkb:17 kDa membrane-associated protein(gene name synonym)|uniprotkb:Protein DD96(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766072|imex:IM-26523-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005755.1|ensembl:ENSG00000162366(gene)|ensembl:ENST00000294338(transcript)|ensembl:ENST00000371885(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026628|interpro:IPR031627 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:YgaXhe5D8C2g1h5RNDA0PNSxTG89606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:mWFo8PRmfTglAU2gwTLHRYLDLpQ false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96NZ9 uniprotkb:Q16820 intact:EBI-2116102|uniprotkb:Q5VWY4|uniprotkb:Q7Z4X5|uniprotkb:Q8IWR3|uniprotkb:Q8NCS2|uniprotkb:B7ZL57|uniprotkb:B7ZL58|uniprotkb:E9KL31|ensembl:ENSP00000416126 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:prap1_human(display_long)|uniprotkb:PRAP1(gene name)|psi-mi:PRAP1(display_short)|uniprotkb:UPA(gene name synonym)|uniprotkb:Uterine-specific proline-rich acidic protein(gene name synonym)|uniprotkb:UNQ608/PRO1195(orf name)|uniprotkb:Epididymis tissue protein Li 178(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766080|imex:IM-26523-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138673.1|refseq:NP_660203.3|ensembl:ENSG00000165828(gene)|ensembl:ENST00000433452(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0017129"(triglyceride binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|go:"GO:1904731"(positive regulation of intestinal lipid absorption)|go:"GO:1905885"(positive regulation of triglyceride transport)|go:"GO:2001140"(positive regulation of phospholipid transport)|interpro:IPR027922 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:EmyXJsFqna4zZ/31AFeqkcq5q4E9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:LK1oR3P0h6ufq1pTyOp8wIGrrJs false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P58499 uniprotkb:Q16820 intact:EBI-12955347|ensembl:ENSP00000350673 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:fam3b_human(display_long)|uniprotkb:FAM3B(gene name)|psi-mi:FAM3B(display_short)|uniprotkb:C21orf11(gene name synonym)|uniprotkb:C21orf76(gene name synonym)|uniprotkb:Cytokine-like protein 2-21(gene name synonym)|uniprotkb:Pancreatic-derived factor(gene name synonym)|uniprotkb:PRED44(orf name)|uniprotkb:UNQ320/PRO365(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766088|imex:IM-26523-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183844(gene)|ensembl:ENST00000357985(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0030073"(insulin secretion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR039214|interpro:IPR039220|interpro:IPR039477|refseq:NP_478066.3|refseq:NP_996847.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:0fkWV8Kjaq8afuZMheiL8RgImhQ9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:KaMW+KDXJ0Y70oy9DkHai69mA7Y false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q16617 uniprotkb:Q16820 intact:EBI-3919611|ensembl:ENSP00000221978 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:nkg7_human(display_long)|uniprotkb:NKG7(gene name)|psi-mi:NKG7(display_short)|uniprotkb:GIG1(gene name synonym)|uniprotkb:G-CSF-induced gene 1 protein(gene name synonym)|uniprotkb:Granule membrane protein of 17 kDa(gene name synonym)|uniprotkb:Natural killer cell protein 7(gene name synonym)|uniprotkb:p15-TIA-1(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766097|imex:IM-26523-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000105374(gene)|ensembl:ENST00000221978(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR004032(PMP-22/EMP/MP20)|go:"GO:0005886"(plasma membrane)|refseq:NP_005592.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:YvYHU8QjKClAq07AGY/BIopvpBo9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:HLV0kX2mkDrfPeSoxvSZSFLWeCQ false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96CB5 uniprotkb:Q16820 intact:EBI-20766108|uniprotkb:Q9NUM6 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:ch044_human(display_long)|uniprotkb:C8orf44(gene name)|psi-mi:C8orf44(display_short) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766120|imex:IM-26523-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|refseq:NP_062553.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:G0u9W1sQNrXheYik/6i721fdys49606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:aWCeoPBeyvqS4HUIC4YdP/caFBA false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q00765 uniprotkb:Q16820 intact:EBI-1549827|uniprotkb:Q04198|uniprotkb:Q5QGT0|uniprotkb:Q9BWH9|uniprotkb:D3DT04|uniprotkb:B7Z681|ensembl:ENSP00000368959 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:reep5_human(display_long)|uniprotkb:REEP5(gene name)|psi-mi:REEP5(display_short)|uniprotkb:C5orf18(gene name synonym)|uniprotkb:DP1(gene name synonym)|uniprotkb:TB2(gene name synonym)|uniprotkb:Polyposis locus protein 1(gene name synonym)|uniprotkb:Protein TB2(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766132|imex:IM-26523-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005660.4|ensembl:ENSG00000129625(gene)|ensembl:ENST00000379638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0071782"(endoplasmic reticulum tubular network)|interpro:IPR004345(TB2/DP1 and HVA22 related protein)|reactome:R-HSA-381753 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:Z6Lzi37F0AfHZBnHri7k4EUpSRQ9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:a6ertmZAy17MU8lw2AXkQYR1vw0 false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NQC3 uniprotkb:Q16820 intact:EBI-715945|intact:EBI-1753019|uniprotkb:O94962|uniprotkb:Q9BXG5|uniprotkb:Q9H212|uniprotkb:Q9H3I3|uniprotkb:Q9UQ42|uniprotkb:Q9Y293|uniprotkb:Q9Y2Y7|uniprotkb:Q9Y5U6|intact:EBI-1958210|intact:EBI-1056082|uniprotkb:Q7L7Q8|uniprotkb:Q96B16|intact:EBI-28967519|ensembl:ENSP00000337838|uniprotkb:Q7L7Q5|uniprotkb:Q7L7Q6|uniprotkb:Q8IUA4 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:rtn4_human(display_long)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766140|imex:IM-26523-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000317610|ensembl:ENSP00000322147|ensembl:ENSP00000337838|ensembl:ENST00000357376|ensembl:ENSP00000349944|ensembl:ENST00000357732|ensembl:ENSP00000350365|ensembl:ENST00000394609|ensembl:ENSP00000378107|ensembl:ENST00000394611|ensembl:ENSP00000378109|ensembl:ENST00000404909|ensembl:ENSP00000385650|ensembl:ENST00000405240|ensembl:ENSP00000384471|refseq:NP_008939.1|refseq:NP_065393.1|refseq:NP_722550.1|refseq:NP_997403.1|refseq:NP_997404.1|ensembl:ENSG00000115310(gene)|ensembl:ENST00000337526(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q9NQC3|rcsb pdb:2G31|rcsb pdb:2JV5|reactome:R-HSA-193634|refseq:XP_005264491.1|refseq:NP_001308788.1|refseq:NP_001308789.1|refseq:NP_001308790.1|refseq:NP_001308791.1|refseq:NP_001308792.1|refseq:NP_001308833.1|refseq:XP_016860007.1|refseq:XP_016860008.1|dip:DIP-42003N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:uhivTNOPdC7+q81CliY0Ozu0EwA9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:Qpty+zwWXo8D0IrfXI/mp56gDRs false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6P5S7 uniprotkb:Q16820 intact:EBI-18397230|uniprotkb:G3V1Z9|uniprotkb:Q502Z2|ensembl:ENSP00000449500 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:rnk_human(display_long)|uniprotkb:RNASEK(gene name)|psi-mi:RNASEK(display_short) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766148|imex:IM-26523-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001004333.2|ensembl:ENSG00000219200(gene)|ensembl:ENST00000548577(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026770|mint:Q6P5S7|rcsb pdb:6WLW|rcsb pdb:6WM3|rcsb pdb:6WM4|rcsb pdb:6WM2 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:OyTvnVyt5VtLS9pT+nV85G4jAE09606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:LG+pt2P2zShq7ovR/M+ZG30Iesw false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y6D0 uniprotkb:Q16820 intact:EBI-9679163|uniprotkb:Q8IZQ3|uniprotkb:Q9P085|ensembl:ENSP00000418813 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:selk_human(display_long)|uniprotkb:SELENOK(gene name)|psi-mi:SELENOK(display_short)|uniprotkb:SELK(gene name synonym)|uniprotkb:HSPC030(orf name)|uniprotkb:HSPC297(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766156|imex:IM-26523-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067060.2|ensembl:ENSG00000113811(gene)|ensembl:ENST00000495461(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR024491|rcsb pdb:6DO3 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:e0SoDHprfiTOiInNeRHt0mWfPWU9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:4cw+6YIn0zhwyi/ojEWexhZyAqA false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P19075 uniprotkb:Q16820 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766164|imex:IM-26523-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1, Fig. 1A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:AncxiJd2JURYCYjEI4NazSO3CFw false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UNL2 uniprotkb:Q16820 intact:EBI-1043938|uniprotkb:Q549M4|ensembl:ENSP00000265044|uniprotkb:B2R7D0|uniprotkb:D3DNK5|uniprotkb:B4E2P2 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:ssrg_human(display_long)|uniprotkb:Signal sequence receptor subunit gamma(gene name synonym)|uniprotkb:SSR3(gene name)|psi-mi:SSR3(display_short)|uniprotkb:TRAPG(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766172|imex:IM-26523-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009038.1|ensembl:ENSG00000114850(gene)|ensembl:ENST00000265044(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009779(Translocon-associated, gamma subunit)|mint:Q9UNL2|reactome:R-HSA-1799339|refseq:NP_001295126.1|refseq:NP_001295133.1|refseq:NP_001295134.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:Fb918T41oaTpc+kzNIygp1h1tlo9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:djImTyJexp0uSbYhjcaCoU2f0sU false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q53R12 uniprotkb:Q16820 intact:EBI-1805798|uniprotkb:Q5U609|uniprotkb:Q6UWS1|uniprotkb:Q9H5X9|uniprotkb:B2RP42|ensembl:ENSP00000303028 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:t4s20_human(display_long)|uniprotkb:TM4SF20(gene name)|psi-mi:TM4SF20(display_short)|uniprotkb:UNQ518/PRO994(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766180|imex:IM-26523-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079071.2|ensembl:ENSG00000168955(gene)|ensembl:ENST00000304568(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045861"(negative regulation of proteolysis)|interpro:IPR008661(L6 membrane) ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:vkMFBdxQ0o/6WzxwA1HoYxNP08E9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:zjBVHVBGMBAaZRXaM54Y2g+jMOI false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P48230 uniprotkb:Q16820 intact:EBI-8650934|ensembl:ENSP00000305852|uniprotkb:B2RDA4|intact:MINT-8163900 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:t4s4_human(display_long)|uniprotkb:TM4SF4(gene name)|psi-mi:TM4SF4(display_short)|uniprotkb:ILTMP(gene name synonym)|uniprotkb:Intestine and liver tetraspan membrane protein(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766188|imex:IM-26523-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169903(gene)|ensembl:ENST00000305354(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042246"(tissue regeneration)|interpro:IPR008661(L6 membrane)|mint:P48230|refseq:NP_004608.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - comment:mint - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:01ZTlx/QaFa5cXn0bDU4DQ1uu+s9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:EFnTcPM7IFG2zbVLxl7wtjRRM+o false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14894 uniprotkb:Q16820 intact:EBI-19125949|uniprotkb:Q17RW9|uniprotkb:Q6IB79|ensembl:ENSP00000270560 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:t4s5_human(display_long)|uniprotkb:TM4SF5(gene name)|psi-mi:TM4SF5(display_short)|uniprotkb:Tetraspan transmembrane protein L6H(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766196|imex:IM-26523-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003954.2|go:"GO:0007049"(cell cycle)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034618"(arginine binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR008661(L6 membrane)|ensembl:ENSG00000142484(gene)|ensembl:ENST00000270560(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane) ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:xSjzc/ijPB9yE1jifXCXbT+98sc9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:AnektcZCIPPO/6q2ZWNWMHkUdbY false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9P0B6 uniprotkb:Q16820 intact:EBI-9083477|uniprotkb:Q5T7F7|uniprotkb:Q9BTQ9|ensembl:ENSP00000362507 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:cc167_human(display_long)|uniprotkb:CCDC167(gene name)|psi-mi:CCDC167(display_short)|uniprotkb:C6orf129(gene name synonym)|uniprotkb:HSPC265(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766204|imex:IM-26523-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_612502.1|ensembl:ENSG00000198937(gene)|ensembl:ENST00000373408(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR028194 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:el6K1I4AQwH3OgjfL0EgIJmQjVc9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:/hvptrXN9DsHPHbwhped2cWQfsM false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P17152 uniprotkb:Q16820 intact:EBI-723946|ensembl:ENSP00000319992|intact:EBI-749474|uniprotkb:Q53YB2 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tmm11_human(display_long)|uniprotkb:TMEM11(gene name)|psi-mi:TMEM11(display_short)|uniprotkb:C17orf35(gene name synonym)|uniprotkb:PM1(gene name synonym)|uniprotkb:Protein PM1(gene name synonym)|uniprotkb:Protein PMI(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766212|imex:IM-26523-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003867.1|ensembl:ENSG00000178307(gene)|ensembl:ENST00000317635(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR026120|mint:P17152|reactome:R-HSA-8949613 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:tQM/J4n5m5/8PH2niEtjBQY2xoY9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:zvdHO7zgKPB7f09tqf8L5ylkEVM false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75264 uniprotkb:Q16820 intact:EBI-20766220|ensembl:ENSP00000215531|uniprotkb:B9EJF4|uniprotkb:Q9P059 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:sim24_human(display_long)|uniprotkb:C19orf77(gene name synonym)|uniprotkb:HSPC323(orf name)|uniprotkb:SMIM24(gene name)|psi-mi:SMIM24(display_short) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766234|imex:IM-26523-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000095932(gene)|ensembl:ENST00000215531(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR031627|refseq:NP_001129975.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:h3Io02RJee/eJsb7poZ4eHcn41I9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:/uLKLGnmLdywr5mPR1qUb4dTmwo false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y2D2 uniprotkb:Q16820 intact:EBI-3917581|uniprotkb:A8K3F8|uniprotkb:Q68CR2|uniprotkb:D3DT54|uniprotkb:Q9BSB7|ensembl:ENSP00000414947|ensembl:ENSP00000418527|ensembl:ENSP00000433849 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:s35a3_human(display_long)|uniprotkb:SLC35A3(gene name)|psi-mi:SLC35A3(display_short)|uniprotkb:Golgi UDP-GlcNAc transporter(gene name synonym)|uniprotkb:Solute carrier family 35 member A3(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766242|imex:IM-26523-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011539438.1|refseq:NP_036375.1|refseq:NP_001258614.1|refseq:NP_001258613.1|refseq:XP_005270748.1|ensembl:ENSG00000117620(gene)|ensembl:ENST00000427993(transcript)|ensembl:ENST00000465289(transcript)|ensembl:ENST00000533028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005459"(UDP-galactose transmembrane transporter activity)|go:"GO:0005462"(UDP-N-acetylglucosamine transmembrane transporter activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006047"(UDP-N-acetylglucosamine metabolic process)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:1990569"(UDP-N-acetylglucosamine transmembrane transport)|interpro:IPR007271(Nucleotide-sugar transporter)|reactome:R-HSA-5619083|reactome:R-HSA-727802 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:tLJ/B/e0RdQwW8uO8ukRaAubUqY9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:vZnHWYYIoodplEz6IHzblaWzjuw false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96F05 uniprotkb:Q16820 intact:EBI-2836238|uniprotkb:Q9H2K4|ensembl:ENSP00000307264 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:ck024_human(display_long)|uniprotkb:C11orf24(gene name)|psi-mi:C11orf24(display_short)|uniprotkb:Protein DM4E3(gene name synonym)|uniprotkb:FP2568(orf name)|uniprotkb:UNQ1872/PRO4315(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766250|imex:IM-26523-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287842.1|ensembl:ENSG00000171067(gene)|ensembl:ENST00000304271(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR041056|refseq:NP_071733.1|refseq:XP_005274110.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:54d686EJB+TX8dPhBwsYCxXUP0k9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:FkSDSV0yRTUexmqLIxVbdco1voQ false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8N2U0 uniprotkb:Q16820 intact:EBI-720908|ensembl:ENSP00000301939|ensembl:ENSP00000491711 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tm256_human(display_long)|uniprotkb:TMEM256(gene name)|psi-mi:TMEM256(display_short)|uniprotkb:C17orf61(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766258|imex:IM-26523-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205544(gene)|ensembl:ENSG00000283771(gene)|ensembl:ENST00000302422(transcript)|ensembl:ENST00000639136(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006696(Protein of unknown function DUF423)|refseq:NP_689979.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/09/25 rogid:hWPs9w/2EeAK5Ltq1RnGhTQOoP89606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:hf3XtxPNvM4AX1TRDo4Zpo5vdHo false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H1C7 uniprotkb:Q16820 intact:EBI-12867082|ensembl:ENSP00000261811|uniprotkb:Q8TBA5 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:cytm1_human(display_long)|uniprotkb:CYSTM1(gene name)|psi-mi:CYSTM1(display_short)|uniprotkb:C5orf32(gene name synonym)|uniprotkb:ORF1-FL49(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-21002674|imex:IM-26523-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120306(gene)|ensembl:ENST00000261811(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR028144|interpro:IPR043240|reactome:R-HSA-6798695|refseq:NP_115788.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/12/05 rogid:SAW2ElJWSsU0K72GioLW5k93r5M9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:lGMATb2Pmhzl5ftgQpoxVBUBhOk false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O95562 uniprotkb:Q16820 intact:EBI-4402330|uniprotkb:A8K2R0|uniprotkb:Q6UWR8|ensembl:ENSP00000271375 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:sft2b_human(display_long)|uniprotkb:SFT2D2(gene name)|psi-mi:SFT2D2(display_short)|uniprotkb:SFT2 domain-containing protein 2(gene name synonym)|uniprotkb:UNQ512/PRO1027(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-21002683|imex:IM-26523-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_955376.1|ensembl:ENSG00000213064(gene)|ensembl:ENST00000271375(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007305(Got1-like protein)|interpro:IPR011691(SFT2-like) ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/12/05 rogid:4FBz4OBGxi03A+390vB3171DoYo9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:zmdsvhy1IV2As3qMfuxYgAEh1oc false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9BQB6 uniprotkb:Q16820 intact:EBI-6256462|ensembl:ENSP00000378426|uniprotkb:A6NIQ6|uniprotkb:B2R4Z6|uniprotkb:Q6UX90|uniprotkb:Q7Z2R4 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:vkor1_human(display_long)|uniprotkb:VKORC1(gene name)|psi-mi:VKORC1(display_short)|uniprotkb:VKOR(gene name synonym)|uniprotkb:Vitamin K1 2,3-epoxide reductase subunit 1(gene name synonym)|uniprotkb:MSTP134(orf name)|uniprotkb:MSTP576(orf name)|uniprotkb:UNQ308/PRO351(orf name) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0112"(ubiquitin reconstruction) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-21002692|imex:IM-26523-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000167397(gene)|ensembl:ENST00000394975(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017144"|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0060348"(bone development)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q9BQB6|rcsb pdb:6WV3|rcsb pdb:6WV4|rcsb pdb:6WV5|rcsb pdb:6WV6|rcsb pdb:6WV7|rcsb pdb:6WVH|reactome:R-HSA-6806664|refseq:NP_001298240.1|refseq:NP_076869.1|refseq:NP_996560.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/25 2018/12/05 rogid:C3RrQ+y7Huai7PExa9LOvfqni+U9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:0OrK/IR7InlIUHxHr8X3vA73Vck false nubg:n-n cub:c-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P19075 uniprotkb:Q16820 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:1203"(split luciferase complementation) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766279|imex:IM-26523-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/25 2018/09/25 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:AncxiJd2JURYCYjEI4NazSO3CFw false luciferase-n:c-c luciferase-c:c-c - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:Q16820 uniprotkb:Q16820 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:1203"(split luciferase complementation) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766422|imex:IM-26523-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/25 2018/09/26 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:LATRFt7pV0wp06C4dzY5F9zn8ss false luciferase-n:c-c luciferase-c:c-c - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:P19075 uniprotkb:P19075 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:"MI:1203"(split luciferase complementation) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766433|imex:IM-26523-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 - - - figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/25 2018/09/26 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rigid:5j81q8qiuWk2/GFxZl60xH0CIXc false luciferase-n:c-c luciferase-c:c-c - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:P19075 uniprotkb:Q16820 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:1203"(split luciferase complementation) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-21003460|imex:IM-26523-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N - - - figure legend:Fig. 1B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/25 2018/12/06 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:AncxiJd2JURYCYjEI4NazSO3CFw false luciferase-c:c-c luciferase-n:c-c - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay) uniprotkb:P19075 uniprotkb:Q16820 intact:EBI-4289938|uniprotkb:Q9BS78|uniprotkb:B2R7T7|ensembl:ENSP00000247829|ensembl:ENSP00000377003|ensembl:ENSP00000447160 intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6 psi-mi:tsn8_human(display_long)|uniprotkb:TSPAN8(gene name)|psi-mi:TSPAN8(display_short)|uniprotkb:TM4SF3(gene name synonym)|uniprotkb:Transmembrane 4 superfamily member 3(gene name synonym)|uniprotkb:Tumor-associated antigen CO-029(gene name synonym) psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym) psi-mi:"MI:0090"(protein complementation assay) Schmidt et al. (2016) imex:IM-26523|pubmed:27180358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20766453|imex:IM-26523-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000127324(gene)|ensembl:ENST00000247829(transcript)|ensembl:ENST00000393330(transcript)|ensembl:ENST00000546561(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|refseq:NP_004607.1|refseq:XP_006719646.1|refseq:XP_016875402.1 ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N go:"GO:0005886"(plasma membrane) - - figure legend:Fig. 1C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/25 2018/09/26 rogid:EDpjBumhSubvDFXID4wdvXDIcE09606 rogid:nDkbvnrqRM45H231bQ8XUntenNM9606 rigid:AncxiJd2JURYCYjEI4NazSO3CFw false red fluorescent protein tag:c-c red fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)