#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46013	uniprotkb:Q9P2D1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-3951683|uniprotkb:D0VBA5|uniprotkb:E9PNZ2|uniprotkb:Q05DI5|uniprotkb:Q2TAN4|uniprotkb:Q66K35|uniprotkb:Q7Z6C0|uniprotkb:Q7Z7Q2|uniprotkb:Q9NXA0|uniprotkb:Q9NXA3|intact:EBI-28967545|ensembl:ENSP00000392028	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:chd7_human(display_long)|uniprotkb:CHD7(gene name)|psi-mi:CHD7(display_short)|uniprotkb:KIAA1416(gene name synonym)|uniprotkb:ATP-dependent helicase CHD7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000392028|ensembl:ENST00000524602|ensembl:ENSP00000437061|ensembl:ENST00000525508|ensembl:ENSP00000436027|refseq:NP_001303619.1|refseq:NP_060250.2|dip:DIP-48685N|ensembl:ENSG00000171316(gene)|ensembl:ENST00000423902(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003226"(right ventricular compact myocardium morphogenesis)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006364"(rRNA processing)|go:"GO:0007417"(central nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021545"(cranial nerve development)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030540"(female genitalia development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043584"(nose development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048806"(genitalia development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060123"(regulation of growth hormone secretion)|go:"GO:0060324"(face development)|go:"GO:0060384"(innervation)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060429"(epithelium development)|go:"GO:0062009"(secondary palate development)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR037259|go:"GO:0060173"(limb development)|interpro:IPR038718|mint:Q9P2D1|rcsb pdb:2CKC|rcsb pdb:2V0E|rcsb pdb:2V0F	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:TwKt9rt8nB0sdxPgchCTyxEfq/k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6P2Q9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:I0ot8b3pvieXRI66omFm145sGVA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UQ16	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43264	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1001217|ensembl:ENSP00000200135|uniprotkb:A1A528	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zw10_human(display_long)|uniprotkb:ZW10(gene name)|psi-mi:ZW10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004715.1|ensembl:ENSG00000086827(gene)|ensembl:ENST00000200135(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070939"(Dsl1/NZR complex)|go:"GO:1990423"(RZZ complex)|interpro:IPR009361(Centromerekinetochore Zw10)|mint:O43264|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-36471N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:yqOV+ZYOLEPClJbYtPp9Jvlhyvc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P16104	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P51531	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DmQot4h4SmtqmUGBgF5ictTah289606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:A1A4S6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1390944|uniprotkb:Q2VPC4|uniprotkb:Q2VPC5|uniprotkb:Q96EV3|uniprotkb:Q96S75|uniprotkb:A1L0S5|ensembl:ENSP00000336923	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rhg10_human(display_long)|uniprotkb:ARHGAP10(gene name)|psi-mi:ARHGAP10(display_short)|uniprotkb:GRAF2(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 10(gene name synonym)|uniprotkb:GTPase regulator associated with focal adhesion kinase 2(gene name synonym)|uniprotkb:Graf-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_078881.3|ensembl:ENSG00000071205(gene)|ensembl:ENST00000336498(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR035485|interpro:IPR035486|interpro:IPR036028|rcsb pdb:2MIO|reactome:R-HSA-211728|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:gbHj2b+qPHC9tKs3Y3eRicrt8mk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60566	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1001438|uniprotkb:B2R6U0|uniprotkb:B4DL09|uniprotkb:B4DLG3|uniprotkb:Q59HH6|uniprotkb:Q8WV50|intact:EBI-2551047|uniprotkb:O60501|uniprotkb:O60627|uniprotkb:O60758|uniprotkb:O75389|uniprotkb:Q96KM4|ensembl:ENSP00000287598	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bub1b_human(display_long)|uniprotkb:MAD3/BUB1-related protein kinase(gene name synonym)|uniprotkb:Mitotic checkpoint kinase MAD3L(gene name synonym)|uniprotkb:SSK1(gene name synonym)|uniprotkb:BUB1B(gene name)|psi-mi:BUB1B(display_short)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:MAD3L(gene name synonym)|uniprotkb:Protein SSK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001202.4|dip:DIP-24203N|ensembl:ENSG00000156970(gene)|ensembl:ENST00000287598(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|mint:O60566|rcsb pdb:2WVI|rcsb pdb:3SI5|rcsb pdb:4GGD|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:5SWF|rcsb pdb:6TLJ|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:EgsQ2ZywEJ+r8hd95vcNEyikMBA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H9A7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-621339|ensembl:ENSP00000317039|ensembl:ENSP00000402433|uniprotkb:Q5SQG8|uniprotkb:Q5SQG9|uniprotkb:Q6P1Q4|uniprotkb:Q6PI89|uniprotkb:Q7Z6L6|uniprotkb:Q05BX1|uniprotkb:Q05CW3|intact:EBI-2555508	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rmi1_human(display_long)|uniprotkb:BLM-associated protein of 75 kDa(gene name synonym)|uniprotkb:FAAP75(gene name synonym)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:C9orf76(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000178966(gene)|ensembl:ENST00000325875(transcript)|ensembl:ENST00000445877(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR013894(Region of unknown function DUF1767)|interpro:IPR032199|interpro:IPR033472|interpro:IPR042470|rcsb pdb:3MXN|rcsb pdb:3NBH|rcsb pdb:3NBI|rcsb pdb:4CGY|rcsb pdb:4CHT|rcsb pdb:4DAY|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:XP_011517336.1|refseq:NP_079221.2|refseq:XP_005252268.1|refseq:XP_005252270.1|refseq:XP_016870629.1|dip:DIP-33324N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:yB9i9QLqh7s19GI2ZG6WJpWXwOo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UIV1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WUK0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7199479|uniprotkb:Q7Z557|uniprotkb:Q9BXV8|uniprotkb:E9PAT8|intact:MINT-8162697|intact:MINT-8247525|uniprotkb:Q96CR2|ensembl:ENSP00000325958|ensembl:ENSP00000496417	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ptpm1_human(display_long)|uniprotkb:PTPMT1(gene name)|psi-mi:PTPMT1(display_short)|uniprotkb:MOSP(gene name synonym)|uniprotkb:PLIP(gene name synonym)|uniprotkb:PTEN-like phosphatase(gene name synonym)|uniprotkb:Phosphoinositide lipid phosphatase(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase mitochondrial 1(gene name synonym)|uniprotkb:PNAS-129(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001137456.1|refseq:NP_783859.1|ensembl:ENSG00000110536(gene)|ensembl:ENSG00000285206(gene)|ensembl:ENST00000326674(transcript)|ensembl:ENST00000647378(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008962"(phosphatidylglycerophosphatase activity)|go:"GO:0032049"(cardiolipin biosynthetic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR042165|interpro:IPR044596|mint:Q8WUK0|reactome:R-HSA-1483148	go:"GO:0005634"(nucleus)	-	comment:mint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:h7MaeKx6Cx3G2KpRm201THlTJqs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86XX4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7967766|uniprotkb:Q8NAU7|intact:UNK-5504239|uniprotkb:Q86UZ4|uniprotkb:Q9H6N9|uniprotkb:Q8N3U9|uniprotkb:Q9P228|uniprotkb:Q96JW7|uniprotkb:A2RRR8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fras1_human(display_long)|uniprotkb:Fraser syndrome 1 protein(gene name synonym)|uniprotkb:FRAS1(gene name)|psi-mi:FRAS1(display_short)|uniprotkb:KIAA1500(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR038081|interpro:IPR039005|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR006212(Furin-like repeat)|refseq:NP_001159605.1|refseq:NP_079350.5|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0043588"(skin development)|go:"GO:0046872"(metal ion binding)|go:"GO:0060021"(roof of mouth development)	go:"GO:0005634"(nucleus)	-	comment:mint|function:"Defects in FRAS1 are a cause of Fraser syndrome [MIM:219000]. It is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects"	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nJ/4j001Lihre1n+/qvt3K6k1rg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y3A4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7223720|uniprotkb:B2RBG4|uniprotkb:Q8NEY6|uniprotkb:Q8IVY0|intact:MINT-2823375|intact:UNK-5358198|uniprotkb:Q5JZ94|uniprotkb:Q6P4B5|uniprotkb:Q0VAD0|uniprotkb:Q8N5Q3|uniprotkb:Q9Y3H5|uniprotkb:A4FTX2|intact:UNK-5480409|uniprotkb:Q8IVR9|ensembl:ENSP00000321449	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rrp7a_human(display_long)|uniprotkb:CGI-96(orf name)|uniprotkb:RRP7A(gene name)|psi-mi:RRP7A(display_short)|uniprotkb:Gastric cancer antigen Zg14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056518.2|ensembl:ENSG00000189306(gene)|ensembl:ENST00000323013(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0032545"(CURI complex)|go:"GO:0034456"(UTP-C complex)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024326|interpro:IPR034890|interpro:IPR035979|interpro:IPR040446|interpro:IPR040447|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	comment:mint|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:8ydFaLpL9ttv+9iZyvaQf3GPWXg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6P161	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7825248|intact:EBI-28980137|ensembl:ENSP00000331849|intact:UNK-5479824	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rm54_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein mL54(gene name synonym)|uniprotkb:MRPL54(gene name)|psi-mi:MRPL54(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000331849|ensembl:ENSG00000183617(gene)|ensembl:ENST00000330133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR013870(Ribosomal protein L37, mitochondrial)|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:6I9R|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF2|rcsb pdb:7OF4|rcsb pdb:7OF6|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_758455.1	go:"GO:0005634"(nucleus)	-	comment:mint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4rkJDCtIKQnpiL2Zh/ri/NFSAms9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NRX2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7825154|ensembl:ENSP00000288937|uniprotkb:Q6IAH8|uniprotkb:Q9C066|uniprotkb:Q96Q53|uniprotkb:D3DQU3|intact:MINT-3064942	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rm17_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein bL17m(gene name synonym)|uniprotkb:MRPL17(gene name)|psi-mi:MRPL17(display_short)|uniprotkb:LIP2(gene name synonym)|uniprotkb:LYST-interacting protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000158042(gene)|ensembl:ENST00000288937(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR000456(Ribosomal protein L17)|interpro:IPR036373|mint:Q9NRX2|rcsb pdb:2CQM|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF7|refseq:NP_071344.1	go:"GO:0005634"(nucleus)	-	comment:mint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:9IL43XtZbhcbaI7Gkq3X6O1M3XE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WY36	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6425236|uniprotkb:A2RRM7|uniprotkb:Q8WY35|uniprotkb:Q8NDB0|uniprotkb:Q7LBY8|uniprotkb:Q2TAJ1|uniprotkb:Q9H0J6|uniprotkb:Q7L3J8|ensembl:ENSP00000319974	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bbx_human(display_long)|uniprotkb:BBX(gene name)|psi-mi:BBX(display_short)|uniprotkb:Bobby sox homolog(gene name synonym)|uniprotkb:HBP2(gene name synonym)|uniprotkb:HMG box-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001263215.1|refseq:XP_011511302.1|refseq:XP_011511303.1|refseq:XP_011511306.1|refseq:NP_001136040.1|refseq:NP_064620.2|refseq:XP_005247699.1|refseq:XP_005247700.1|refseq:XP_005247701.1|refseq:XP_016862370.1|refseq:XP_016862371.1|ensembl:ENSG00000114439(gene)|ensembl:ENST00000325805(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0060348"(bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR019102|interpro:IPR036910	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:IjEKkdmyIKspTlZ+C3wCXKIfbn09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15361	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7239664|uniprotkb:A1L160|uniprotkb:Q6P5T5|intact:MINT-1181965|uniprotkb:Q4VXF3|uniprotkb:Q58EY2|intact:EBI-28980067|ensembl:ENSP00000333920	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ttf1_human(display_long)|uniprotkb:TTF1(gene name)|psi-mi:TTF1(display_short)|uniprotkb:Transcription termination factor I(gene name synonym)|uniprotkb:RNA polymerase I termination factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000333920|refseq:XP_006717336.2|refseq:NP_031370.2|refseq:NP_001192225.1|ensembl:ENSG00000125482(gene)|ensembl:ENST00000334270(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0008156"(negative regulation of DNA replication)|interpro:IPR001005(SANT, DNA-binding)|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5683826|reactome:R-HSA-73762|reactome:R-HSA-73863	go:"GO:0005634"(nucleus)	-	comment:mint|function:Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with TIP5 recovers DNA-binding activity|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:GQtuk19E/MVU9LXgLsG+UT6ksqA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75564	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-8607681|intact:MINT-8176614|uniprotkb:O75565|intact:EBI-12040229|uniprotkb:D3DWI5|uniprotkb:Q86XJ5|ensembl:ENSP00000461610|ensembl:ENSP00000483808	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:jerky_human(display_long)|uniprotkb:JRK(gene name)|psi-mi:JRK(display_short)|uniprotkb:JH8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001070995.2|refseq:NP_001266281.1|refseq:NP_003715.3|refseq:XP_006716740.1|refseq:XP_006716741.1|refseq:XP_011515656.1|ensembl:ENSG00000234616(gene)|ensembl:ENST00000571961(transcript)|ensembl:ENST00000615982(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)	go:"GO:0005634"(nucleus)	-	comment:mint|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:UOnRaBYBfmixB5Ir7x9GOCL+Lss9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8IVF7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7242231|intact:MINT-1182764|uniprotkb:Q6ZRJ1|uniprotkb:B0JZA7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fmnl3_human(display_long)|uniprotkb:FHOD3(gene name synonym)|uniprotkb:KIAA2014(gene name synonym)|uniprotkb:FMNL3(gene name)|psi-mi:FMNL3(display_short)|uniprotkb:WBP3(gene name synonym)|uniprotkb:Formin homology 2 domain-containing protein 3(gene name synonym)|uniprotkb:WW domain-binding protein 3(gene name synonym)|uniprotkb:FRL2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	reactome:R-HSA-5663220|interpro:IPR043592|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR010473(Diaphanous GTPase-binding)|refseq:NP_783863.4|refseq:NP_944489.2|interpro:IPR015425(Actin-binding FH2)|refseq:XP_005269275.1|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051015"(actin filament binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR011989(Armadillo-like helical)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013409|interpro:IPR027655|interpro:IPR042201	go:"GO:0005634"(nucleus)	-	comment:mint|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sm2tPWzh9H/+mwiMT73nHTzGx0E9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86XZ4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NV06	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7402939|uniprotkb:Q3MII9|uniprotkb:Q96JY7|uniprotkb:Q9NZX3|intact:MINT-4994304|uniprotkb:Q8NCH8|uniprotkb:Q8TC51|ensembl:ENSP00000484962	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dca13_human(display_long)|uniprotkb:HSPC064(orf name)|uniprotkb:DCAF13(gene name)|psi-mi:DCAF13(display_short)|uniprotkb:WDSOF1(gene name synonym)|uniprotkb:WD repeat and SOF domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056235.4|ensembl:ENSG00000164934(gene)|ensembl:ENST00000612750(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030054"(cell junction)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR007287(Sof1-like protein)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9NV06|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-8951664	go:"GO:0005634"(nucleus)	-	comment:mint|comment:homomint|function:Possible role in ribosomal RNA processing	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Ep2z6/V6/US0sXDqjqjpVqmf/zM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NWT1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7641942|ensembl:ENSP00000368887|ensembl:ENSP00000496482|uniprotkb:Q5T4J2|uniprotkb:Q96T87|intact:MINT-3057412|uniprotkb:Q96QJ8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pk1ip_human(display_long)|uniprotkb:PAK1IP1(gene name)|psi-mi:PAK1IP1(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:WDR84(gene name synonym)|uniprotkb:PAK1-interacting protein 1(gene name synonym)|uniprotkb:PAK/PLC-interacting protein 1(gene name synonym)|uniprotkb:WD repeat-containing protein 84(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000111845(gene)|ensembl:ENSG00000285226(gene)|ensembl:ENST00000379568(transcript)|ensembl:ENST00000644756(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9NWT1|refseq:NP_060376.2	go:"GO:0005634"(nucleus)	-	comment:mint|function:Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nAGXksSPZ1aDBtcWOP59JX/lQGA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8N3Z6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7265024|uniprotkb:Q9P0F0|uniprotkb:Q8TBK8|uniprotkb:Q8N2M1|uniprotkb:Q5T0Q9|uniprotkb:D3DRQ0|uniprotkb:Q9H648|uniprotkb:Q8N4J2|uniprotkb:Q5T0Q8|intact:MINT-1182798|uniprotkb:B2RCI4|uniprotkb:Q5T0R0|ensembl:ENSP00000337839|ensembl:ENSP00000443113	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zchc7_human(display_long)|uniprotkb:ZCCHC7(gene name)|psi-mi:ZCCHC7(display_short)|uniprotkb:TRAMP-like complex RNA-binding factor ZCCHC7(gene name synonym)|uniprotkb:HSPC086(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_115602.2|refseq:XP_005251665.1|refseq:XP_005251669.1|ensembl:ENSG00000147905(gene)|ensembl:ENST00000336755(transcript)|ensembl:ENST00000534928(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|refseq:NP_001276048.1|refseq:NP_001276049.1|refseq:NP_001276050.1	go:"GO:0005634"(nucleus)	-	comment:mint|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:zm8NMOhdnKspXWuNvY/gjLTMQcI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6P9B9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-7600112|intact:MINT-4539005|uniprotkb:Q9C0G5|uniprotkb:Q8N6W5|ensembl:ENSP00000327889	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:int5_human(display_long)|uniprotkb:INTS5(gene name)|psi-mi:INTS5(display_short)|uniprotkb:KIAA1698(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_085131.1|ensembl:ENSG00000185085(gene)|ensembl:ENST00000330574(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016180"(snRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032039"(integrator complex)|go:"GO:0034472"(snRNA 3'-end processing)|interpro:IPR029444|interpro:IPR029445|interpro:IPR040316|rcsb pdb:7CUN|reactome:R-HSA-6807505	go:"GO:0005634"(nucleus)	-	function:"Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes"|comment:mint|comment:homomint	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:2pirjs+e6eyNQayJnDp3NCjUhCk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5VIR6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2850511|uniprotkb:Q9BY02|uniprotkb:A8K2S8|uniprotkb:Q9BRR2|uniprotkb:Q9NV25|uniprotkb:Q8WYW3|uniprotkb:B3FH42|ensembl:ENSP00000401435|ensembl:ENSP00000492761|ensembl:ENSP00000505997	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vps53_human(display_long)|uniprotkb:PP13624(orf name)|uniprotkb:VPS53(gene name)|psi-mi:VPS53(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001121631.1|refseq:NP_060759.2|dip:DIP-59352N|ensembl:ENSG00000141252(gene)|ensembl:ENSG00000283883(gene)|ensembl:ENST00000437048(transcript)|ensembl:ENST00000639801(transcript)|ensembl:ENST00000680465(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007234(Vps53-like, N-terminal)|interpro:IPR038260|interpro:IPR039766|reactome:R-HSA-6811440	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:gnrMqPquSOGNPQYESYuA7ztMI0Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UHA3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-749321|uniprotkb:Q561V8|uniprotkb:Q8N6S8|uniprotkb:Q96B04|uniprotkb:Q96C76|uniprotkb:Q96HJ1|uniprotkb:B2RD72|ensembl:ENSP00000260443	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rlp24_human(display_long)|uniprotkb:Ribosomal protein L24-like(gene name synonym)|uniprotkb:RSL24D1(gene name)|psi-mi:RSL24D1(display_short)|uniprotkb:RPL24L(gene name synonym)|uniprotkb:My024(orf name)|uniprotkb:C15orf15(gene name synonym)|uniprotkb:Ribosomal L24 domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057388.1|ensembl:ENSG00000137876(gene)|ensembl:ENST00000260443(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006412"(translation)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023438|interpro:IPR023442|interpro:IPR038630|mint:Q9UHA3|rcsb pdb:6LSS|rcsb pdb:6LU8|go:"GO:0022625"(cytosolic large ribosomal subunit)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dP0x5J6G4bPc/7sbV1LIxLNLDn09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8NEM2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-744700|uniprotkb:Q96N60|uniprotkb:Q9BVS0|uniprotkb:Q9H6P6|ensembl:ENSP00000306473	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:shcbp_human(display_long)|uniprotkb:SHCBP1(gene name)|psi-mi:SHCBP1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_079021.3|ensembl:ENSG00000171241(gene)|ensembl:ENST00000303383(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448|mint:Q8NEM2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:VkqhT9kcant5+JwTeubTotVcLfo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P84103	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372557|uniprotkb:P23152|uniprotkb:O08831|uniprotkb:B4E241|intact:EBI-11020748|uniprotkb:Q5R3K0|ensembl:ENSP00000362820|ensembl:ENSP00000482833	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srsf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)|uniprotkb:SRP20(gene name synonym)|uniprotkb:SFRS3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003008.1|ensembl:ENSG00000112081(gene)|ensembl:ENST00000373715(transcript)|ensembl:ENST00000620941(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84103|rcsb pdb:2I2Y|rcsb pdb:2I38|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-32961N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BcfyCj2cNNTH1igANKpvh4IHDVU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86Y07	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1207615|uniprotkb:Q49AK9|uniprotkb:Q53EU9|uniprotkb:Q86Y08|uniprotkb:Q86Y09|uniprotkb:Q86Y10|uniprotkb:Q86Y11|uniprotkb:Q86Y12|uniprotkb:Q8IXI5|uniprotkb:Q99987|uniprotkb:Q53S39|uniprotkb:Q53S77|uniprotkb:Q53TU1|uniprotkb:B4DKL0|uniprotkb:D6W5D4|uniprotkb:D6W5D6|ensembl:ENSP00000342381|ensembl:ENSP00000408002	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vrk2_human(display_long)|uniprotkb:VRK2(gene name)|psi-mi:VRK2(display_short)|uniprotkb:Vaccinia-related kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_011531394.1|refseq:XP_006712153.1|refseq:XP_006712154.1|refseq:XP_006712155.1|refseq:XP_006712156.1|refseq:NP_001123952.1|refseq:NP_001123953.1|refseq:NP_001123954.1|refseq:NP_001123955.1|refseq:NP_006287.2|refseq:NP_001275765.1|refseq:NP_001275766.1|refseq:NP_001275767.1|refseq:NP_001275768.1|refseq:XP_005264597.1|refseq:XP_016860347.1|refseq:XP_016860348.1|refseq:XP_016860349.1|refseq:XP_016860350.1|refseq:XP_016860351.1|refseq:XP_016860352.1|ensembl:ENSG00000028116(gene)|ensembl:ENST00000340157(transcript)|ensembl:ENST00000435505(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000659"(regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q86Y07|rcsb pdb:2V62|rcsb pdb:5UU1|rcsb pdb:6NCG|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sDftNP5rKcTUJgpJAcbJsNzag0I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96Q89	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055300|uniprotkb:O43277|uniprotkb:Q09471|uniprotkb:Q2KQ73|uniprotkb:Q32NE1|uniprotkb:Q561V3|uniprotkb:Q58EX8|uniprotkb:Q5T9M8|uniprotkb:Q5T9M9|uniprotkb:Q5T9N0|uniprotkb:Q5T9N1|uniprotkb:Q7KZ68|uniprotkb:Q7Z5E0|uniprotkb:Q7Z5E1|uniprotkb:Q7Z6M9|uniprotkb:Q86X82|uniprotkb:Q9H3R8|uniprotkb:Q9H6Q9|uniprotkb:Q9H755|uniprotkb:Q9NTC1|uniprotkb:Q9UFR5|uniprotkb:A8MXM7|ensembl:ENSP00000360793	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ki20b_human(display_long)|uniprotkb:MPHOSPH1(gene name synonym)|uniprotkb:M-phase phosphoprotein 1(gene name synonym)|uniprotkb:Kinesin-related motor interacting with PIN1(gene name synonym)|uniprotkb:Cancer/testis antigen 90(gene name synonym)|uniprotkb:KIF20B(gene name)|psi-mi:KIF20B(display_short)|uniprotkb:KRMP1(gene name synonym)|uniprotkb:Kinesin family member 20B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001271188.1|refseq:NP_057279.2|ensembl:ENSG00000138182(gene)|ensembl:ENST00000371728(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070938"(contractile ring)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR028828|reactome:R-HSA-983189|reactome:R-HSA-6811434|dip:DIP-103N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:QOOmPez8aHnIrd5XFB0jrSWtwn89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BYG3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2561019|ensembl:ENSP00000285814|uniprotkb:Q8TB66|uniprotkb:A8K788|uniprotkb:Q96ED4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mk67i_human(display_long)|uniprotkb:NIFK(gene name)|psi-mi:NIFK(display_short)|uniprotkb:MKI67IP(gene name synonym)|uniprotkb:NOPP34(gene name synonym)|uniprotkb:Nucleolar phosphoprotein Nopp34(gene name synonym)|uniprotkb:Nucleolar protein interacting with the FHA domain of pKI-67(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021043|interpro:IPR035979|mint:Q9BYG3|rcsb pdb:2AFF|ensembl:ENSG00000155438(gene)|ensembl:ENST00000285814(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000794"(condensed nuclear chromosome)|refseq:NP_115766.3|dip:DIP-28134N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DUc8AnzFxJjbK+cTW5H83GQcf6o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BYJ9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1051237|uniprotkb:Q8N3G5|uniprotkb:Q8TBT1|uniprotkb:Q96AN4|uniprotkb:Q96S57|uniprotkb:Q9BTI7|uniprotkb:Q9NX79|ensembl:ENSP00000359364	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ythd1_human(display_long)|uniprotkb:Dermatomyositis associated with cancer putative autoantigen 1(gene name synonym)|uniprotkb:YTHDF1(gene name)|psi-mi:YTHDF1(display_short)|uniprotkb:C20orf21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060268.2|ensembl:ENSG00000149658(gene)|ensembl:ENST00000370339(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002376"(immune system process)|go:"GO:0002577"(regulation of antigen processing and presentation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q9BYJ9|rcsb pdb:4RCI|rcsb pdb:4RCJ	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:uzNKPfwF7I+6hLk6l8iiDOhuBcQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96SB4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-539478|uniprotkb:Q12890|uniprotkb:Q5R364|uniprotkb:Q5R365|uniprotkb:Q8IY12|uniprotkb:B4DS61|ensembl:ENSP00000362931	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srpk1_human(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 1(gene name synonym)|uniprotkb:SFRS protein kinase 1(gene name synonym)|uniprotkb:SRPK1(gene name)|psi-mi:SRPK1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003128.3|ensembl:ENSG00000096063(gene)|ensembl:ENST00000373825(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q96SB4|rcsb pdb:1WAK|rcsb pdb:1WBP|rcsb pdb:3BEG|rcsb pdb:4WUA|rcsb pdb:5MXX|rcsb pdb:5MY8|rcsb pdb:5NNG|rcsb pdb:5XV7|rcsb pdb:6FAD|rcsb pdb:7DD1|dip:DIP-33888N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:e335v+Im7IjFP1CdFzPefvU8iQo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UBB9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1105213|uniprotkb:O95908|uniprotkb:Q5H8V8|uniprotkb:Q9UGV7|uniprotkb:Q9Y2Q8|ensembl:ENSP00000383892|ensembl:ENSP00000384297|ensembl:ENSP00000384421|ensembl:ENSP00000480171|ensembl:ENSP00000385861|uniprotkb:Q20WL0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tfp11_human(display_long)|uniprotkb:TFIP11(gene name)|psi-mi:TFIP11(display_short)|uniprotkb:HSPC006(orf name)|uniprotkb:STIP(gene name synonym)|uniprotkb:Septin and tuftelin-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000100109(gene)|refseq:NP_001008697.1|refseq:NP_036275.1|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000405938(transcript)|ensembl:ENST00000407148(transcript)|ensembl:ENST00000407431(transcript)|ensembl:ENST00000407690(transcript)|ensembl:ENST00000619735(transcript)|go:"GO:0000390"(spliceosomal complex disassembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0071008"(U2-type post-mRNA release spliceosomal complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1904876"(negative regulation of DNA ligase activity)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000467(D111/G-patch)|interpro:IPR022159|interpro:IPR022783|interpro:IPR024933|mint:Q9UBB9|reactome:R-HSA-72163|refseq:XP_011528381.1|refseq:XP_016884224.1|refseq:NP_001333786.1|refseq:NP_001333787.1|refseq:NP_001333788.1|refseq:NP_001333790.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Brk0v9dAoy5ntoJVHFsvt+FFE3g9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NX58	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-713507|uniprotkb:Q6FI78|uniprotkb:Q9NYS1|ensembl:ENSP00000345917|ensembl:ENSP00000397367|uniprotkb:D3DVS4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lyar_human(display_long)|uniprotkb:LYAR(gene name)|psi-mi:LYAR(display_short)|uniprotkb:PNAS-5(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000145220(gene)|ensembl:ENST00000343470(transcript)|ensembl:ENST00000452476(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR014898(Zinc finger, C2H2, LYAR-type)|interpro:IPR036236|interpro:IPR039999|interpro:IPR041010|mint:Q9NX58|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZVH|refseq:NP_001139197.1|refseq:NP_060286.1|refseq:XP_011511807.1|refseq:XP_011511808.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:AJ+5B1LahcUlSWQehJ2vxY+8pwY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13283	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5JTZ9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-308736|uniprotkb:Q8N198|uniprotkb:Q96D02|uniprotkb:Q9ULF0|uniprotkb:A2RRN5|ensembl:ENSP00000244571	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:syam_human(display_long)|uniprotkb:KIAA1270(gene name synonym)|uniprotkb:AARS2(gene name)|psi-mi:AARS2(display_short)|uniprotkb:AARSL(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_065796.1|ensembl:ENSG00000124608(gene)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018162|interpro:IPR018163|interpro:IPR018164|interpro:IPR018165|interpro:IPR023033|mint:Q5JTZ9|rcsb pdb:6NLQ|rcsb pdb:6NLY|rcsb pdb:6NOW|reactome:R-HSA-379726|ensembl:ENST00000244571(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006400"(tRNA modification)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016597"(amino acid binding)|go:"GO:0070143"(mitochondrial alanyl-tRNA aminoacylation)|interpro:IPR002318(Alanyl-tRNA synthetase, class IIc)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RzNZMsaNjWpD4eB5AdgpjhC3vP09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P55084	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q68D10	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11035441|uniprotkb:Q8N8I3|uniprotkb:Q8N3E7|uniprotkb:Q6MZI5|uniprotkb:Q86VG8|uniprotkb:Q7Z390|uniprotkb:Q6AWA5|uniprotkb:Q8N417|uniprotkb:Q7Z470|ensembl:ENSP00000337991	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spt2_human(display_long)|uniprotkb:SPTY2D1(gene name)|psi-mi:SPTY2D1(display_short)|uniprotkb:Protein KU002155(gene name synonym)|uniprotkb:SPT2 domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_919261.2|ensembl:ENSG00000179119(gene)|ensembl:ENST00000336349(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010847"(regulation of chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|interpro:IPR013256(Chromatin SPT2)|rcsb pdb:5BS7|rcsb pdb:5BSA	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:HCyEUXPH2GeH6wURfB8Hq72F2+w9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15226	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-766011|uniprotkb:Q4VC41|uniprotkb:Q9UJ91|uniprotkb:G3V1N1|ensembl:ENSP00000304803	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nkrf_human(display_long)|uniprotkb:Transcription factor NRF(gene name synonym)|uniprotkb:Protein ITBA4(gene name synonym)|uniprotkb:NKRF(gene name)|psi-mi:NKRF(display_short)|uniprotkb:ITBA4(gene name synonym)|uniprotkb:NRF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001166958.1|refseq:NP_001166959.1|refseq:NP_060014.2|refseq:XP_011529667.1|dip:DIP-34570N|ensembl:ENSG00000186416(gene)|ensembl:ENST00000304449(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000467(D111/G-patch)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036867|mint:O15226|rcsb pdb:6SH6|rcsb pdb:6SH7|interpro:IPR034071	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jH7qlOvuAHKsjuOyzDpBonpgtF09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P51610	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TDN6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1052326|uniprotkb:Q3ZTT4|uniprotkb:Q8N453|uniprotkb:Q96DH1|uniprotkb:A8K0P5|ensembl:ENSP00000338862	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:brx1_human(display_long)|uniprotkb:BRIX1(gene name)|psi-mi:BRIX1(display_short)|uniprotkb:BXDC2(gene name synonym)|uniprotkb:BRIX(gene name synonym)|uniprotkb:Brix domain-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060791.3|ensembl:ENSG00000113460(gene)|ensembl:ENST00000336767(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|interpro:IPR007109(Brix)|interpro:IPR026532|mint:Q8TDN6	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Xa2UDOXgdmWyJ7qBZsdInDt9Vaw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BQ39	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-395850|intact:EBI-2826089|uniprotkb:Q8WV76|uniprotkb:Q9BWI8|uniprotkb:Q5VX37|ensembl:ENSP00000362687	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx50_human(display_long)|uniprotkb:DEAD box protein 50(gene name synonym)|uniprotkb:Nucleolar protein Gu2(gene name synonym)|uniprotkb:Gu-beta(gene name synonym)|uniprotkb:DDX50(gene name)|psi-mi:DDX50(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_076950.1|ensembl:ENSG00000107625(gene)|ensembl:ENST00000373585(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9BQ39|rcsb pdb:2E29|refseq:XP_016872115.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:a8/VHQw5HVQh6L/rbsKonz0R34c9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5T5X7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1211496|uniprotkb:A2RRH2|uniprotkb:Q9HCL9|ensembl:ENSP00000358038|ensembl:ENSP00000411268	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bend3_human(display_long)|uniprotkb:BEND3(gene name)|psi-mi:BEND3(display_short)|uniprotkb:KIAA1553(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_005267136.1|refseq:XP_005267137.1|refseq:NP_001073919.1|refseq:XP_011534307.1|refseq:XP_016866627.1|ensembl:ENSG00000178409(gene)|ensembl:ENST00000369042(transcript)|ensembl:ENST00000429433(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000792"(heterochromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1903580"(positive regulation of ATP metabolic process)|interpro:IPR018379|interpro:IPR033583|rcsb pdb:5JNO	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:W+UmsinDpvnD5wV9MZI5YWywK6U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9HCE1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055820|uniprotkb:Q5JR03|uniprotkb:Q8TEF0|uniprotkb:Q9BSY3|uniprotkb:Q9BUJ9|ensembl:ENSP00000350028|ensembl:ENSP00000358659|ensembl:ENSP00000399797	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mov10_human(display_long)|uniprotkb:Moloney leukemia virus 10 protein(gene name synonym)|uniprotkb:MOV10(gene name)|psi-mi:MOV10(display_short)|uniprotkb:KIAA1631(gene name synonym)|uniprotkb:Armitage homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001273001.1|refseq:NP_001123551.1|refseq:NP_066014.1|refseq:NP_001308253.1|ensembl:ENSG00000155363(gene)|ensembl:ENST00000357443(transcript)|ensembl:ENST00000369645(transcript)|ensembl:ENST00000413052(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043186"(P granule)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|interpro:IPR026122|interpro:IPR027417|interpro:IPR041679|mint:Q9HCE1|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-8936459|dip:DIP-44158N|refseq:XP_005270926.1|refseq:XP_005270927.1|refseq:XP_016856807.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:symbA7qOGiAY2NuQXO+5gv/It3k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O00541	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1053271|uniprotkb:Q6IC29|ensembl:ENSP00000346725	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pesc_human(display_long)|uniprotkb:PES1(gene name)|psi-mi:PES1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001230154.1|refseq:NP_055118.1|ensembl:ENSG00000100029(gene)|ensembl:ENST00000354694(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|interpro:IPR001357(BRCT)|interpro:IPR010613(Pescadillo, N-terminal)|interpro:IPR036420|rcsb pdb:2EP8|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Nq1SJ37kJfe+vF9zmNASz1gnbfY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13573	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q12788	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-715766|uniprotkb:Q59GD6|uniprotkb:Q8IVB7|intact:EBI-749106|uniprotkb:Q96A78|ensembl:ENSP00000454836	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tbl3_human(display_long)|uniprotkb:WD repeat-containing protein SAZD(gene name synonym)|uniprotkb:TBL3(gene name)|psi-mi:TBL3(display_short)|uniprotkb:SAZD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006444.2|ensembl:ENSG00000183751(gene)|ensembl:ENST00000568546(transcript)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034511"(U3 snoRNA binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR013934(Small-subunit processome, Utp13)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q12788|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XFWYZxef3kNBYeTaoSBWEXQoF/M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q3KQU3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-713229|uniprotkb:Q9HBQ2|uniprotkb:Q8N905|uniprotkb:Q9ULN3|uniprotkb:Q7L8J5|uniprotkb:Q8TAK0|intact:EBI-2511981|intact:EBI-1056140|ensembl:ENSP00000362244|uniprotkb:Q9NW29|uniprotkb:D3DPS4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ma7d1_human(display_long)|uniprotkb:MAP7D1(gene name)|psi-mi:MAP7D1(display_short)|uniprotkb:KIAA1187(gene name synonym)|uniprotkb:PARCC1(gene name synonym)|uniprotkb:RPRC1(gene name synonym)|uniprotkb:Proline/arginine-rich coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:Arginine/proline-rich coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:PP2464(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001273294.1|refseq:NP_001273295.1|ensembl:ENSG00000116871(gene)|ensembl:ENST00000373151(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR008604(E-MAP-115)|mint:Q3KQU3|refseq:NP_060537.3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:AEal3/uaJsdRBdmijI8nuthBD9k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H6W3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2513645|ensembl:ENSP00000477507|uniprotkb:B4DT02	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:riox1_human(display_long)|uniprotkb:RIOX1(gene name)|psi-mi:RIOX1(display_short)|uniprotkb:60S ribosomal protein L8 histidine hydroxylase(gene name synonym)|uniprotkb:Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66(gene name synonym)|uniprotkb:C14orf169(gene name synonym)|uniprotkb:Histone lysine demethylase NO66(gene name synonym)|uniprotkb:MAPJD(gene name synonym)|uniprotkb:Myc-associated protein with JmjC domain(gene name synonym)|uniprotkb:NO66(gene name synonym)|uniprotkb:Nucleolar protein 66(gene name synonym)|uniprotkb:Ribosomal oxygenase NO66(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000304061(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0070544"(histone H3-K36 demethylation)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR013109(Cupin 4)|interpro:IPR039994|mint:Q9H6W3|rcsb pdb:4CCJ|rcsb pdb:4CCK|rcsb pdb:4CCM|rcsb pdb:4CCN|ensembl:ENSG00000170468(gene)|rcsb pdb:4CCO|rcsb pdb:4DIQ|rcsb pdb:4E4H|rcsb pdb:4Y33|rcsb pdb:4Y4R|rcsb pdb:4Y3O|refseq:NP_078920.2|dip:DIP-53768N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RsTFUH3upRu11eleWymp6N7cEpM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UKD2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1046493|ensembl:ENSP00000364320|uniprotkb:Q9BPV9|uniprotkb:Q5TG55|uniprotkb:Q96SS6|uniprotkb:B3KNB3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mrt4_human(display_long)|uniprotkb:MRTO4(gene name)|psi-mi:MRTO4(display_short)|uniprotkb:C1orf33(gene name synonym)|uniprotkb:MRT4(gene name synonym)|uniprotkb:Ribosome assembly factor MRTO4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000053372(gene)|ensembl:ENST00000330263(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:Q9UKD2|interpro:IPR033867|refseq:NP_057267.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:LpvX3By1Cp6MxlAx3d5qoDM3FNY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H0D6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372110|uniprotkb:Q3L8N4|uniprotkb:Q6KGZ9|uniprotkb:Q9BQL1|uniprotkb:Q9NTW0|uniprotkb:Q9NXS6|uniprotkb:Q9UL53|ensembl:ENSP00000366396	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:xrn2_human(display_long)|uniprotkb:XRN2(gene name)|psi-mi:XRN2(display_short)|uniprotkb:DHM1-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_036387.2|refseq:NP_001304889.1|ensembl:ENSG00000088930(gene)|ensembl:ENST00000377191(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000738"(DNA catabolic process, exonucleolytic)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001147"(transcription termination site sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016020"(membrane)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR017151(5'-3' exoribonuclease 2)|interpro:IPR027073|interpro:IPR041412|mint:Q9H0D6|reactome:R-HSA-390471|reactome:R-HSA-6791226|dip:DIP-31166N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Ui0NiU+fGe68hK5CYTolkhioQbQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8NI36	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WUM4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-310624|uniprotkb:Q9BX86|uniprotkb:Q9NUN0|uniprotkb:Q9P2H2|uniprotkb:Q9UKL5|uniprotkb:C5MQH7|intact:EBI-10971645|uniprotkb:E9PFU1|uniprotkb:Q6NUS1|ensembl:ENSP00000307387|intact:EBI-28983290	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pdc6i_human(display_long)|uniprotkb:PDCD6IP(gene name)|psi-mi:PDCD6IP(display_short)|uniprotkb:AIP1(gene name synonym)|uniprotkb:KIAA1375(gene name synonym)|uniprotkb:ALIX(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:Hp95(gene name synonym)|uniprotkb:ALG-2-interacting protein X(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_037506.2|ensembl:ENSP00000307387|ensembl:ENST00000457054|ensembl:ENSP00000411825|refseq:NP_001155901.1|ensembl:ENSG00000170248(gene)|ensembl:ENST00000307296(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q8WUM4|rcsb pdb:2OEV|rcsb pdb:2OEW|rcsb pdb:2OEX|rcsb pdb:2OJQ|rcsb pdb:2R02|rcsb pdb:2R03|rcsb pdb:2R05|rcsb pdb:2XS1|rcsb pdb:2XS8|rcsb pdb:2ZNE|rcsb pdb:3C3O|rcsb pdb:3C3Q|rcsb pdb:3C3R|rcsb pdb:3E1R|rcsb pdb:3WUV|rcsb pdb:4JJY|rcsb pdb:5V3R|rcsb pdb:5WA1|rcsb pdb:6KP3|reactome:R-HSA-162588|reactome:R-HSA-5210891|reactome:R-HSA-5213460|reactome:R-HSA-5675482|refseq:NP_001243121.1|dip:DIP-29327N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:FYD19EyMBAGl204Xlgr4MlE8GMs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H307	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-681904|uniprotkb:Q9UQR9|uniprotkb:O60899|uniprotkb:Q53EM7|uniprotkb:Q6P5X4|uniprotkb:Q7KYL1|uniprotkb:Q99738|uniprotkb:Q9UHZ9|uniprotkb:B4DZX8|ensembl:ENSP00000216832	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pinin_human(display_long)|uniprotkb:140 kDa nuclear and cell adhesion-related phosphoprotein(gene name synonym)|uniprotkb:Domain-rich serine protein(gene name synonym)|uniprotkb:Melanoma metastasis clone A protein(gene name synonym)|uniprotkb:Desmosome-associated protein(gene name synonym)|uniprotkb:SR-like protein(gene name synonym)|uniprotkb:Nuclear protein SDK3(gene name synonym)|uniprotkb:PNN(gene name)|psi-mi:PNN(display_short)|uniprotkb:DRS(gene name synonym)|uniprotkb:MEMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002678.2|dip:DIP-32950N|ensembl:ENSG00000100941(gene)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030057"(desmosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR006786(Pinin/SDK/memA protein)|interpro:IPR006787(Pinin/SDK)|interpro:IPR039853|mint:Q9H307|ensembl:ENST00000216832(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1pAhD0z8tks+HkWaYWkdMmSjk3s9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UNX3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2949703|ensembl:ENSP00000265100|ensembl:ENSP00000428177|ensembl:ENSP00000428223|ensembl:ENSP00000430147|uniprotkb:B3KY82|uniprotkb:D3DQM0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl26l_human(display_long)|uniprotkb:RPL26L1(gene name)|psi-mi:RPL26L1(display_short)|uniprotkb:RPL26P1(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL24-like 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000037241(gene)|ensembl:ENST00000265100(transcript)|ensembl:ENST00000519239(transcript)|ensembl:ENST00000519974(transcript)|ensembl:ENST00000521476(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:Q9UNX3|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-2408557|refseq:NP_057177.1|refseq:XP_011532867.1|refseq:NP_001304909.1|refseq:NP_001304910.1|refseq:NP_001304911.1|refseq:XP_016865008.1|refseq:XP_016865009.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dny/DWK4MvWD3FUJvW5+KGI3iJI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H0H5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13823	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1043365|uniprotkb:Q9BWN7|ensembl:ENSP00000362153	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nog2_human(display_long)|uniprotkb:Autoantigen NGP-1(gene name synonym)|uniprotkb:GNL2(gene name)|psi-mi:GNL2(display_short)|uniprotkb:NGP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000134697(gene)|ensembl:ENST00000373062(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012971(NGP1, N-terminal)|interpro:IPR023179|interpro:IPR024929|interpro:IPR027417|interpro:IPR030378|mint:Q13823|rcsb pdb:6LSS|rcsb pdb:6LU8|refseq:NP_037417.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CgIg/QNhk71SHIhV4iLvIuC/HUo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NYH9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-749211|uniprotkb:Q8IX96|uniprotkb:Q96BL2|uniprotkb:Q9NQ91|ensembl:ENSP00000261708	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:utp6_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated antigen 66(gene name synonym)|uniprotkb:Multiple hat domains protein(gene name synonym)|uniprotkb:UTP6(gene name)|psi-mi:UTP6(display_short)|uniprotkb:C17orf40(gene name synonym)|uniprotkb:HCA66(gene name synonym)|uniprotkb:MHAT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060898.2|ensembl:ENSG00000108651(gene)|ensembl:ENST00000261708(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0030515"(snoRNA binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013949(U3 small nucleolar RNA-associated protein 6)|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hMKHMRXUFqGjWKsyi9MedHMilhc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96GQ7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722051|uniprotkb:A0AVB6|uniprotkb:Q5VXM7|uniprotkb:Q8WYG4|uniprotkb:Q969N7|uniprotkb:Q96F57|uniprotkb:Q96L97|uniprotkb:Q9BWY9|uniprotkb:Q9BXF0|uniprotkb:Q9H990|uniprotkb:Q9NWU3|uniprotkb:Q9P0C2|uniprotkb:Q9UGD6|uniprotkb:B7ZLY1	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx27_human(display_long)|uniprotkb:DEAD box protein 27(gene name synonym)|uniprotkb:DDX27(gene name)|psi-mi:DDX27(display_short)|uniprotkb:RHLP(gene name synonym)|uniprotkb:cPERP-F(gene name synonym)|uniprotkb:HSPC259(orf name)|uniprotkb:PP3241(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR027417|refseq:NP_060365.7|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|mint:Q96GQ7|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Z4Dm6lxXyqB18+uPxROJszLWYdE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UNX4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-727436|ensembl:ENSP00000308179	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr3_human(display_long)|uniprotkb:WDR3(gene name)|psi-mi:WDR3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006775.1|ensembl:ENSG00000065183(gene)|ensembl:ENST00000349139(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR007148(Small-subunit processome, Utp12)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q9UNX4|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:aslkTiEP+9ytaN6cc+SC+TzOxUg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96BY6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-748520|uniprotkb:O75178|uniprotkb:Q9NW06|uniprotkb:Q9NXI8|uniprotkb:Q68DA4|uniprotkb:B3FL70|ensembl:ENSP00000258390	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:doc10_human(display_long)|uniprotkb:ZIZ3(gene name synonym)|uniprotkb:Zizimin-3(gene name synonym)|uniprotkb:DOCK10(gene name)|psi-mi:DOCK10(display_short)|uniprotkb:KIAA0694(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001277192.1|refseq:NP_055504.2|ensembl:ENSG00000135905(gene)|ensembl:ENST00000258390(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037809|interpro:IPR043162|rcsb pdb:6TKY|rcsb pdb:6TKZ|rcsb pdb:6TM1|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-983231|reactome:R-HSA-9013423	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:LdcK8sd7bCFtI/ZLYe4PNsEro8Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BVP2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-641642|uniprotkb:Q96SV6|uniprotkb:Q96SV7|uniprotkb:Q9UJY0|intact:EBI-2559594|intact:EBI-718302|uniprotkb:B2RDC1|uniprotkb:Q5PU80|intact:EBI-28973725|ensembl:ENSP00000395772	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:gnl3_human(display_long)|uniprotkb:Nucleolar GTP-binding protein 3(gene name synonym)|uniprotkb:Nucleostemin(gene name synonym)|uniprotkb:E2-induced gene 3 protein(gene name synonym)|uniprotkb:Novel nucleolar protein 47(gene name synonym)|uniprotkb:GNL3(gene name)|psi-mi:GNL3(display_short)|uniprotkb:E2IG3(gene name synonym)|uniprotkb:NS(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000394799|ensembl:ENSP00000378278|ensembl:ENSP00000395772|refseq:NP_055181.3|refseq:NP_996561.1|refseq:NP_996562.1|ensembl:ENSG00000163938(gene)|ensembl:ENST00000418458(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030496"(midbody)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|interpro:IPR006073(GTP1/OBG)|interpro:IPR014813(GNL3L/Grn1 putative GTPase)|interpro:IPR027417|interpro:IPR030378|mint:Q9BVP2|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:c1DgvQoZ51edxvnCa6GFhfNRR7M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9GZR7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-713081|ensembl:ENSP00000481495|ensembl:ENSP00000482106|uniprotkb:E7EMJ4|uniprotkb:Q4V9L5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx24_human(display_long)|uniprotkb:DEAD box protein 24(gene name synonym)|uniprotkb:DDX24(gene name)|psi-mi:DDX24(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000089737(gene)|ensembl:ENSG00000273761(gene)|ensembl:ENST00000613280(transcript)|ensembl:ENST00000621632(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR027417|mint:Q9GZR7|refseq:NP_065147.1|dip:DIP-47301N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:n9gQabTC50Y/LtGMAMFNVgj12as9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O76021	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358028|uniprotkb:Q2M1T7|uniprotkb:Q6PL22|uniprotkb:Q8IWS7|uniprotkb:Q8WUZ1|uniprotkb:Q9HDA9|uniprotkb:Q9Y3Z9|uniprotkb:B4DJ58|uniprotkb:D3DUG7|ensembl:ENSP00000460871	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl1d1_human(display_long)|uniprotkb:RSL1D1(gene name)|psi-mi:RSL1D1(display_short)|uniprotkb:CSIG(gene name synonym)|uniprotkb:PBK1(gene name synonym)|uniprotkb:CATX11(gene name synonym)|uniprotkb:L12(orf name)|uniprotkb:Cellular senescence-inhibited gene protein(gene name synonym)|uniprotkb:Protein PBK1(gene name synonym)|uniprotkb:CATX-11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056474.2|ensembl:ENSG00000171490(gene)|ensembl:ENST00000571133(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030686"(90S preribosome)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023674|interpro:IPR028364|mint:O76021	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/mAkpodrvvZA6mz3M8VwHDEJzKo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96L91	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-399163|uniprotkb:O15411|uniprotkb:Q6P2F5|uniprotkb:Q8N8Q7|uniprotkb:Q8NE05|uniprotkb:Q96JK7|uniprotkb:Q9P230	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ep400_human(display_long)|uniprotkb:p400 kDa SWI2/SNF2-related protein(gene name synonym)|uniprotkb:Domino homolog(gene name synonym)|uniprotkb:CAG repeat protein 32(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 12 protein(gene name synonym)|uniprotkb:CAGH32(gene name synonym)|uniprotkb:KIAA1498(gene name synonym)|uniprotkb:KIAA1818(gene name synonym)|uniprotkb:TNRC12(gene name synonym)|uniprotkb:EP400(gene name)|psi-mi:EP400(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056224.3|ensembl:ENST00000389561|ensembl:ENSP00000374212|ensembl:ENSG00000183495|go:"GO:0000812"(Swr1 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070615"|go:"GO:1990405"(protein antigen binding)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR027417|interpro:IPR031575|interpro:IPR038718|reactome:R-HSA-2559584|reactome:R-HSA-2559586|reactome:R-HSA-3214847|mint:Q96L91|dip:DIP-29915N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DrQFsyaSlUxjJBloZPFrjXooDpU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y2X3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-395469|uniprotkb:Q53SA4|uniprotkb:Q6PK08|uniprotkb:Q9P036|uniprotkb:Q9UFN3|ensembl:ENSP00000264279	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nop58_human(display_long)|uniprotkb:NOP58(gene name)|psi-mi:NOP58(display_short)|uniprotkb:NOL5(gene name synonym)|uniprotkb:Nucleolar protein 5(gene name synonym)|uniprotkb:NOP5(gene name synonym)|uniprotkb:HSPC120(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057018.1|ensembl:ENSG00000055044(gene)|ensembl:ENST00000264279(transcript)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0015030"(Cajal body)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|go:"GO:0016020"(membrane)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:Q9Y2X3|reactome:R-HSA-4570464|reactome:R-HSA-6790901|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|reactome:R-HSA-6791226|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070761"(pre-snoRNP complex)|dip:DIP-32926N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:L7mE30ZNpQbKsQElFrrDMBQwG+w9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q03001	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-310758|uniprotkb:Q5TBT0|uniprotkb:Q8N1T8|uniprotkb:Q8N8J3|uniprotkb:Q8WXK9|uniprotkb:Q96AK9|uniprotkb:Q96DQ5|uniprotkb:B7Z3H1|uniprotkb:Q9UN10|uniprotkb:Q9H555|uniprotkb:Q5TBT2|uniprotkb:Q8WXK8|uniprotkb:O94833|uniprotkb:Q12825|uniprotkb:Q13266|uniprotkb:Q13267|uniprotkb:Q13775|uniprotkb:Q5TF23|uniprotkb:Q96J76|uniprotkb:Q96QT5|uniprotkb:Q9UGD7|uniprotkb:Q9UGD8|intact:EBI-350219|uniprotkb:E7ERU0|intact:EBI-350252|uniprotkb:Q5TF24|intact:EBI-310783	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dyst_human(display_long)|uniprotkb:DST(gene name)|psi-mi:DST(display_short)|uniprotkb:BPAG1(gene name synonym)|uniprotkb:DMH(gene name synonym)|uniprotkb:DT(gene name synonym)|uniprotkb:KIAA0728(gene name synonym)|uniprotkb:230 kDa bullous pemphigoid antigen(gene name synonym)|uniprotkb:Hemidesmosomal plaque protein(gene name synonym)|uniprotkb:Dystonia musculorum protein(gene name synonym)|uniprotkb:BP230(gene name synonym)|uniprotkb:BP240(gene name synonym)|uniprotkb:230/240 kDa bullous pemphigoid antigen(gene name synonym)|uniprotkb:Bullous pemphigoid antigen 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_016866713.1|refseq:NP_001714.1|refseq:NP_056363.2|mint:Q03001|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031673"(H zone)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0042060"(wound healing)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|rcsb pdb:3GJO|reactome:R-HSA-2022090|reactome:R-HSA-446107|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR011992(EF-Hand type)|ensembl:ENST00000244364|ensembl:ENSP00000244364|ensembl:ENSG00000151914|ensembl:ENST00000370765|ensembl:ENSP00000359801|ensembl:ENST00000370788|ensembl:ENSP00000359824|ensembl:ENST00000439203|ensembl:ENSP00000404924|refseq:NP_001138241.1|refseq:NP_001138242.1|refseq:NP_899236.1|dip:DIP-33131N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:5jynCc9AQYiyXSw6P4v3wzlVNU49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P46821	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-764611|uniprotkb:A2BDK5|ensembl:ENSP00000296755	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:map1b_human(display_long)|uniprotkb:MAP1B(gene name)|psi-mi:MAP1B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005900.2|dip:DIP-33474N|ensembl:ENSG00000131711(gene)|ensembl:ENST00000296755(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009987"(cellular process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0021700"(developmental maturation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0033189"(response to vitamin A)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043196"(varicosity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0017085"(response to insecticide)|go:"GO:0045202"(synapse)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0051915"(induction of synaptic plasticity by chemical substance)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097457"(hippocampal mossy fiber)|interpro:IPR000102(Neuraxin/MAP1B repeat)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR027321|mint:P46821|interpro:IPR026074	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:uSRzrWaYU/dmkItUkCK4zex+/TM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q12789	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-357956|uniprotkb:B2RP21|uniprotkb:Q12838|uniprotkb:Q6DKN9|uniprotkb:Q9Y4W9|ensembl:ENSP00000348510	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tf3c1_human(display_long)|uniprotkb:GTF3C1(gene name)|psi-mi:GTF3C1(display_short)|uniprotkb:Transcription factor IIIC subunit alpha(gene name synonym)|uniprotkb:TF3C-alpha(gene name synonym)|uniprotkb:Transcription factor IIIC 220 kDa subunit(gene name synonym)|uniprotkb:TFIIIC box B-binding subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001511.2|refseq:NP_001273171.1|dip:DIP-38212N|ensembl:ENSG00000077235(gene)|ensembl:ENST00000356183(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009304"(tRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007309(B-block binding subunit of TFIIIC)|interpro:IPR035625|interpro:IPR044210|mint:Q12789|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1celgxr5g9oKbPr0x1SvI6S7hNE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75643	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y4A5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P69905	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-714680|uniprotkb:P01922|ensembl:ENSP00000251595|ensembl:ENSP00000322421|uniprotkb:Q3MIF5|uniprotkb:Q96KF1|uniprotkb:Q9NYR7|uniprotkb:Q1HDT5|uniprotkb:Q53F97|uniprotkb:Q9UCM0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hba_human(display_long)|uniprotkb:Hemoglobin alpha chain(gene name synonym)|uniprotkb:Alpha-globin(gene name synonym)|uniprotkb:HBA1(gene name)|psi-mi:HBA1(display_short)|uniprotkb:HBA2(gene name)|psi-mi:HBA2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000188536(gene)|ensembl:ENSG00000206172(gene)|ensembl:ENST00000251595(transcript)|ensembl:ENST00000320868(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0016020"(membrane)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0098869"(cellular oxidant detoxification)|interpro:IPR000971(Globin, subset)|interpro:IPR002338(Haemoglobin, alpha)|interpro:IPR002339(Haemoglobin, pi)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P69905|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|rcsb pdb:1A3O|rcsb pdb:1A9W|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FDH|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1YVQ|rcsb pdb:1YVT|rcsb pdb:1YZI|rcsb pdb:1Z8U|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3HXN|rcsb pdb:3IA3|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3OVU|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S48|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4MQJ|rcsb pdb:4MQK|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6HAL|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:4N7N|rcsb pdb:6KAU|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:6KAV|rcsb pdb:4N8T|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:4NI0|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4ROM|rcsb pdb:4WJG|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|rcsb pdb:7JY3|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:7AEU|refseq:NP_000508.1|refseq:NP_000549.1|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J3Z|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1SHR|rcsb pdb:1SI4|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|rcsb pdb:1XZ2|rcsb pdb:1XZ4|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y01|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|dip:DIP-35199N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:M4o0FF1DIrouBdyFXr4UtAlcjZw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5QJE6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5666736|ensembl:ENSP00000411010|uniprotkb:Q53H59|uniprotkb:Q86WX9|uniprotkb:Q76MJ8|uniprotkb:Q12987|uniprotkb:Q6TLI0|uniprotkb:Q5TFJ4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tdif2_human(display_long)|uniprotkb:ERBP(gene name synonym)|uniprotkb:Estrogen receptor-binding protein(gene name synonym)|uniprotkb:LPTS-interacting protein 2(gene name synonym)|uniprotkb:TDIF2(gene name synonym)|uniprotkb:Terminal deoxynucleotidyltransferase-interacting factor 2(gene name synonym)|uniprotkb:DNTTIP2(gene name)|psi-mi:DNTTIP2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000067334(gene)|ensembl:ENST00000436063(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|interpro:IPR014810(Fcf2 pre-rRNA processing)|interpro:IPR039883|refseq:NP_055412.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:GSN2/hZ+HZb29LuBvv2RVMawmNA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BV38	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-727429|uniprotkb:O60390|uniprotkb:Q9BWR2|intact:EBI-28969560|ensembl:ENSP00000476117	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr18_human(display_long)|uniprotkb:WDR18(gene name)|psi-mi:WDR18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_077005.2|ensembl:ENSP00000476117|go:"GO:0097344"(Rix1 complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026987|interpro:IPR036322|mint:Q9BV38|reactome:R-HSA-6791226|ensembl:ENSG00000065268(gene)|ensembl:ENST00000585809(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:03RKz4c6MKJvOePaNrKeInnS6Lg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P01857	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49116	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2652582|uniprotkb:A8K3H5|uniprotkb:P55092|uniprotkb:B6ZGT8|ensembl:ENSP00000376814|ensembl:ENSP00000384463|ensembl:ENSP00000388387	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nr2c2_human(display_long)|uniprotkb:NR2C2(gene name)|psi-mi:NR2C2(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:TR4(gene name synonym)|uniprotkb:Orphan nuclear receptor TR4(gene name synonym)|uniprotkb:Testicular receptor 4(gene name synonym)|uniprotkb:Orphan nuclear receptor TAK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003289.2|refseq:NP_001278623.1|ensembl:ENSG00000177463(gene)|ensembl:ENST00000393102(transcript)|ensembl:ENST00000406272(transcript)|ensembl:ENST00000425241(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P49116|rcsb pdb:3P0U|reactome:R-HSA-383280|refseq:XP_016862609.1|dip:DIP-5999N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:FQqhbuxItvCQ2iu5nydvHZaNog89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UQ13	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-993879|uniprotkb:O76063|uniprotkb:A8K9W8|uniprotkb:B3KR23|uniprotkb:Q5VZS8|uniprotkb:Q5VZS9|ensembl:ENSP00000358464	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:shoc2_human(display_long)|uniprotkb:Protein soc-2 homolog(gene name synonym)|uniprotkb:SHOC2(gene name)|psi-mi:SHOC2(display_short)|uniprotkb:KIAA0862(gene name synonym)|uniprotkb:Protein sur-8 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_031399.2|refseq:NP_001311265.1|refseq:NP_001311266.1|refseq:NP_001255968.1|refseq:XP_016872191.1|refseq:XP_016872192.1|refseq:XP_016872193.1|ensembl:ENSG00000108061(gene)|ensembl:ENST00000369452(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027036|interpro:IPR032675|mint:Q9UQ13|reactome:R-HSA-5673000|reactome:R-HSA-9660537	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:0RkCETF3NG59IZjnJevXVYkzBJU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P68871	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-715554|ensembl:ENSP00000333994|ensembl:ENSP00000494175|uniprotkb:P02023|uniprotkb:Q13852|uniprotkb:Q14481|uniprotkb:Q14510|uniprotkb:Q45KT0|uniprotkb:Q6FI08|uniprotkb:Q8IZI1|uniprotkb:Q9BX96|uniprotkb:Q9UCP8|uniprotkb:Q9UCP9|uniprotkb:A4GX73|uniprotkb:B2ZUE0|uniprotkb:Q549N7|uniprotkb:Q6R7N2|uniprotkb:Q9UCD6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hbb_human(display_long)|uniprotkb:Hemoglobin beta chain(gene name synonym)|uniprotkb:Beta-globin(gene name synonym)|uniprotkb:HBB(gene name)|psi-mi:HBB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000244734(gene)|ensembl:ENST00000335295(transcript)|ensembl:ENST00000647020(transcript)|refseq:NP_000509.1|rcsb pdb:1XZ4|rcsb pdb:1XZ2|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|rcsb pdb:1YVQ|rcsb pdb:1YZI|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:1YVT|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3HXN|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P68871|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|go:"GO:0072562"(blood microparticle)|rcsb pdb:1A3O|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CBL|rcsb pdb:1CBM|rcsb pdb:1CH4|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1J3Z|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-6798695|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-983231|rcsb pdb:7JY3|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4N7N|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:4N8T|rcsb pdb:4NI0|rcsb pdb:3W4U|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4WJG|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6FQF|rcsb pdb:6HAL|rcsb pdb:4ROM|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:6KAU|rcsb pdb:6KAV|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEU|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|dip:DIP-35526N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Y5tl4dXE3PBfaK/0lROD6QJ4U+c9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P46782	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-350569|uniprotkb:Q96BN0|uniprotkb:B2R4T2|ensembl:ENSP00000196551|ensembl:ENSP00000470114|ensembl:ENSP00000472985	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rs5_human(display_long)|uniprotkb:RPS5(gene name)|psi-mi:RPS5(display_short)|uniprotkb:Small ribosomal subunit protein uS7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001000.2|rcsb pdb:6OLZ|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6Z6M|rcsb pdb:6XA1|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6Y0G|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:5FLX|rcsb pdb:6OLG|rcsb pdb:6OLI|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72706|ensembl:ENSG00000083845(gene)|ensembl:ENST00000196551(transcript)|ensembl:ENST00000596046(transcript)|ensembl:ENST00000601521(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823|mint:P46782|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:5AJ0|reactome:R-HSA-72702	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:SoCJdf2InngZZtlz5qD1k5CEfEo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UBB4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NPQ8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-717509|uniprotkb:Q0P508|uniprotkb:Q2T9J1|uniprotkb:Q7Z352|uniprotkb:Q96EZ1|uniprotkb:Q96SZ2|uniprotkb:Q9H064|uniprotkb:Q9H5H3|uniprotkb:Q9H9E7|ensembl:ENSP00000432008	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ric8a_human(display_long)|uniprotkb:Protein Ric-8A(gene name synonym)|uniprotkb:RIC8A(gene name)|psi-mi:RIC8A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001273063.1|refseq:NP_068751.4|refseq:XP_016873596.1|ensembl:ENSG00000177963(gene)|ensembl:ENST00000526104(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0070586"(cell-cell adhesion involved in gastrulation)|go:"GO:0071711"(basement membrane organization)|interpro:IPR008376(Synembryn)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019318|mint:Q9NPQ8|go:"GO:0001965"(G-protein alpha-subunit binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jNCxRLnDY2aSw6SMtE82Tny1IE89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43166	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-310678|uniprotkb:O95321|uniprotkb:Q9UDU4|uniprotkb:Q9UNU4|intact:EBI-11025469|intact:EBI-28973250|uniprotkb:J3KP19|ensembl:ENSP00000450832	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:si1l1_human(display_long)|uniprotkb:SIPA1L1(gene name)|psi-mi:SIPA1L1(display_short)|uniprotkb:E6TP1(gene name synonym)|uniprotkb:KIAA0440(gene name synonym)|uniprotkb:High-risk human papilloma viruses E6 oncoproteins targeted protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000358550|ensembl:ENSP00000351352|ensembl:ENST00000381232|ensembl:ENSP00000370630|ensembl:ENSP00000450832|refseq:NP_001271174.1|refseq:NP_001271175.1|refseq:NP_056371.1|refseq:XP_005267573.1|refseq:XP_011534932.1|refseq:XP_011534933.1|refseq:XP_011534934.1|refseq:XP_011534937.1|refseq:XP_016876648.1|refseq:XP_016876649.1|refseq:XP_016876650.1|refseq:XP_016876651.1|refseq:XP_016876652.1|refseq:XP_016876653.1|refseq:XP_016876654.1|refseq:XP_016876655.1|refseq:XP_016876656.1|refseq:XP_016876657.1|refseq:XP_016876658.1|refseq:XP_016876659.1|refseq:XP_016876660.1|refseq:XP_016876661.1|refseq:XP_016876662.1|refseq:XP_016876663.1|refseq:XP_016876664.1|refseq:XP_016876665.1|refseq:XP_016876666.1|refseq:XP_016876667.1|refseq:XP_016876668.1|refseq:XP_016876669.1|refseq:XP_016876675.1|refseq:XP_016876676.1|refseq:XP_016876677.1|refseq:XP_016876678.1|refseq:XP_016876679.1|refseq:XP_016876680.1|refseq:XP_016876681.1|refseq:XP_016876682.1|ensembl:ENSG00000197555(gene)|ensembl:ENST00000555818(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021818|interpro:IPR030770|interpro:IPR035974|interpro:IPR036034|mint:O43166|reactome:R-HSA-6794361	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:whpEjAhxfeYqeZ1IbjNl6romgXk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60508	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2557812|uniprotkb:O75471|uniprotkb:Q9UPG1|uniprotkb:Q5SRN0|uniprotkb:B2RBC5|intact:EBI-28966772|ensembl:ENSP00000304370|ensembl:ENSP00000357928	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:prp17_human(display_long)|uniprotkb:CDC40(gene name)|psi-mi:CDC40(display_short)|uniprotkb:EHB3(gene name synonym)|uniprotkb:PRP17(gene name synonym)|uniprotkb:PRPF17(gene name synonym)|uniprotkb:PRP17 homolog(gene name synonym)|uniprotkb:Cell division cycle 40 homolog(gene name synonym)|uniprotkb:EH-binding protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000304370|ensembl:ENSP00000357928|refseq:NP_056975.1|ensembl:ENSG00000168438(gene)|ensembl:ENST00000307731(transcript)|ensembl:ENST00000368932(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR032847|interpro:IPR036322|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABI|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:NrgBBc3KK6rgtZpApcYyPZQzC0I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BRG1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-741945|uniprotkb:B2R581|ensembl:ENSP00000253794	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vps25_human(display_long)|uniprotkb:ELL-associated protein of 20 kDa(gene name synonym)|uniprotkb:Dermal papilla-derived protein 9(gene name synonym)|uniprotkb:VPS25(gene name)|psi-mi:VPS25(display_short)|uniprotkb:DERP9(gene name synonym)|uniprotkb:EAP20(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS25(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000253794(transcript)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000131475(gene)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008570(ESCRT-II complex, vps25 subunit)|interpro:IPR014041(ESCRT-II complex, vps25 subunit, N-terminal winged helix)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2ZME|rcsb pdb:3CUQ|rcsb pdb:3HTU|reactome:R-HSA-917729|reactome:R-HSA-9610379|refseq:NP_115729.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:fAf3o5rwpM1xz53oIyMwohQfbEg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NVN8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-746682|ensembl:ENSP00000338573|ensembl:ENSP00000354091|ensembl:ENSP00000501411|ensembl:ENSP00000501441|ensembl:ENSP00000501452	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:gnl3l_human(display_long)|uniprotkb:GNL3L(gene name)|psi-mi:GNL3L(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001171748.1|refseq:NP_061940.1|ensembl:ENSG00000130119(gene)|ensembl:ENST00000336470(transcript)|ensembl:ENST00000360845(transcript)|ensembl:ENST00000674225(transcript)|ensembl:ENST00000674311(transcript)|ensembl:ENST00000674498(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|interpro:IPR006073(GTP1/OBG)|interpro:IPR023179|interpro:IPR027417|interpro:IPR030378	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:EIfOgdBUzXC0ujJVM3TnMkiUWNI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6AI08	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-359123|uniprotkb:Q6MZX1|uniprotkb:Q6MZY2|uniprotkb:Q9H6B3|uniprotkb:Q9H6M7|uniprotkb:Q8TDM9|uniprotkb:B3KXP3|ensembl:ENSP00000184956	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:heat6_human(display_long)|uniprotkb:HEATR6(gene name)|psi-mi:HEATR6(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:Amplified in breast cancer protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071353.4|ensembl:ENSG00000068097(gene)|ensembl:ENST00000184956(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025283|mint:Q6AI08	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:NGkhkRsJprf1B6Bnm6OUInkcpv49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96T76	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1044169|uniprotkb:Q9BYS9|uniprotkb:Q17RZ8|uniprotkb:Q5T455|uniprotkb:Q66K82|uniprotkb:Q7L4W8|uniprotkb:Q969Z1|uniprotkb:Q96DF1|uniprotkb:Q96MR1|uniprotkb:Q96RK5|uniprotkb:Q96SK1|uniprotkb:Q9BUE2|ensembl:ENSP00000359818|ensembl:ENSP00000412698|uniprotkb:D3DR55|uniprotkb:B0QZ75|uniprotkb:B3KPE5|uniprotkb:B4DQX2|uniprotkb:B4E2I3|uniprotkb:F8W9Y2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mms19_human(display_long)|uniprotkb:MMS19(gene name)|psi-mi:MMS19(display_short)|uniprotkb:MMS19L(gene name synonym)|uniprotkb:MMS19-like protein(gene name synonym)|uniprotkb:MET18 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000155229(gene)|ensembl:ENST00000370782(transcript)|ensembl:ENST00000438925(transcript)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024687|interpro:IPR029240|interpro:IPR039920|mint:Q96T76|reactome:R-HSA-2564830|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009725"(response to hormone)|go:"GO:0016020"(membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0019899"(enzyme binding)|refseq:NP_071757.4|refseq:NP_001276332.1|refseq:NP_001276333.1|refseq:NP_001276334.1|refseq:NP_001317057.1|refseq:XP_016872013.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sujw9MQiwau6A0dumVM7gXVMGjE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q93034	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96BN2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2512236|ensembl:ENSP00000356848|uniprotkb:A8K4J9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tada1_human(display_long)|uniprotkb:TADA1(gene name)|psi-mi:TADA1(display_short)|uniprotkb:TADA1L(gene name synonym)|uniprotkb:Transcriptional adapter 1-like protein(gene name synonym)|uniprotkb:SPT3-associated factor 42(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000152382(gene)|ensembl:ENST00000367874(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030914"|go:"GO:0043966"(histone H3 acetylation)|interpro:IPR024738|mint:Q96BN2|reactome:R-HSA-3214847|refseq:NP_444281.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:07aGEsEjtD884LVJ6Jlj12+TdK49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92945	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hlybJllTqSgPgtwwz3kc12zDYh49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NY65	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356246|ensembl:ENSP00000333326|uniprotkb:B3KPW9|uniprotkb:Q2M3N4|uniprotkb:B2RCX2|uniprotkb:B4DWG3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tba8_human(display_long)|uniprotkb:TUBA8(gene name)|psi-mi:TUBA8(display_short)|uniprotkb:TUBAL2(gene name synonym)|uniprotkb:Alpha-tubulin 8(gene name synonym)|uniprotkb:Tubulin alpha chain-like 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001180343.1|refseq:NP_061816.1|ensembl:ENSG00000183785(gene)|ensembl:ENST00000330423(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|dip:DIP-40751N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:OGRoBAwLchNlK3LtAWkbSbCcxPQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P08651	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-741360|uniprotkb:B7Z4U5|uniprotkb:K7EMU1|uniprotkb:P08652|uniprotkb:Q14932|ensembl:ENSP00000396843|uniprotkb:Q9UPJ3|uniprotkb:Q9UPJ9|uniprotkb:Q9UPK0|uniprotkb:Q9UPK1|uniprotkb:A8K1H0|uniprotkb:B7Z9C3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nfic_human(display_long)|uniprotkb:Nuclear factor I/C(gene name synonym)|uniprotkb:CCAAT-box-binding transcription factor(gene name synonym)|uniprotkb:TGGCA-binding protein(gene name synonym)|uniprotkb:NFIC(gene name)|psi-mi:NFIC(display_short)|uniprotkb:NFI(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005588.2|refseq:NP_995315.1|ensembl:ENSG00000141905(gene)|ensembl:ENST00000443272(transcript)|interpro:IPR020604|mint:P08651|reactome:R-HSA-73980|reactome:R-HSA-749476|interpro:IPR019739|go:"GO:0000785"(chromatin)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000647(CTF/NF-I)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR019548|refseq:NP_001231931.1|refseq:NP_001231934.1|refseq:NP_001231933.1|refseq:XP_016882324.1|dip:DIP-44692N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ibeytu/0IDaaVQOeXbjqyepE9Ck9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75635	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-20562343|ensembl:ENSP00000337212|ensembl:ENSP00000381101|ensembl:ENSP00000444861|uniprotkb:B4DUW8|uniprotkb:F5GZC0|uniprotkb:Q1ED45|uniprotkb:Q3KPG4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spb7_human(display_long)|uniprotkb:Megsin(gene name synonym)|uniprotkb:TP55(gene name synonym)|uniprotkb:SERPINB7(gene name)|psi-mi:SERPINB7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000166396(gene)|ensembl:ENST00000336429(transcript)|ensembl:ENST00000398019(transcript)|ensembl:ENST00000546027(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|refseq:NP_001035237.1|refseq:NP_001248759.1|refseq:NP_001248760.1|refseq:NP_003775.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Myy50yZwBNokri1Ogt6FW/HOjF09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14004	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P12236	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q12962	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-708376|uniprotkb:O00703|uniprotkb:Q13175|uniprotkb:Q6FH13|ensembl:ENSP00000299424	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:taf10_human(display_long)|uniprotkb:Transcription initiation factor TFIID 30 kDa subunit(gene name synonym)|uniprotkb:STAF28(gene name synonym)|uniprotkb:TAF10(gene name)|psi-mi:TAF10(display_short)|uniprotkb:TAF2H(gene name synonym)|uniprotkb:TAFII30(gene name synonym)|uniprotkb:TAF2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006275.1|dip:DIP-297N|ensembl:ENSG00000166337(gene)|ensembl:ENST00000299424(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000125"|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0034622"|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR003923(Transcription initiation factor TFIID, 23-30 kDa subunit)|mint:Q12962|rcsb pdb:2F69|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4WV4|rcsb pdb:5EG2|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-3214847|reactome:R-HSA-5689880|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:8HFLtF8faq1WlDk5+r4B/+4Ldeg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P16615	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O94927	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2558224|uniprotkb:B2RXK1|uniprotkb:Q6P2P7|uniprotkb:Q96CT8|uniprotkb:Q7L3D5|ensembl:ENSP00000439056	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:haus5_human(display_long)|uniprotkb:HAUS5(gene name)|psi-mi:HAUS5(display_short)|uniprotkb:KIAA0841(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056117.1|ensembl:ENSG00000249115(gene)|ensembl:ENST00000203166(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026215|interpro:IPR029131|mint:O94927|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|dip:DIP-48831N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ChAZl+X89FxK08LHh2+lYDqQZn09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P51608	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1189067|uniprotkb:O15233|uniprotkb:Q6QHH9|uniprotkb:Q7Z384|ensembl:ENSP00000301948	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mecp2_human(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001104262.1|refseq:NP_004983.1|refseq:NP_001303266.1|ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0042551"(neuron maturation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:P51608|rcsb pdb:1QK9|rcsb pdb:3C2I|rcsb pdb:5BT2|rcsb pdb:6C1Y|rcsb pdb:6OGJ|rcsb pdb:6OGK|reactome:R-HSA-8986944|reactome:R-HSA-9022534|reactome:R-HSA-9022535|reactome:R-HSA-9022537|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9022927|dip:DIP-39983N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P21359	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WYA6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-748128|uniprotkb:Q0VAL9|uniprotkb:Q53HI8|uniprotkb:Q5JWZ2|uniprotkb:Q5JWZ3|uniprotkb:Q5JWZ7|uniprotkb:Q5JWZ8|uniprotkb:Q8N454|uniprotkb:Q8NCL2|uniprotkb:Q8TBD6|uniprotkb:Q96KD2|uniprotkb:Q9H7A5|uniprotkb:Q9NQF9|uniprotkb:Q9NTX0|uniprotkb:B4DE16|uniprotkb:Q0VAM0|uniprotkb:Q9Y3M7|intact:EBI-11161095|ensembl:ENSP00000355050	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ctbl1_human(display_long)|uniprotkb:Nuclear-associated protein(gene name synonym)|uniprotkb:Testis development protein NYD-SP19(gene name synonym)|uniprotkb:PP8304(orf name)|uniprotkb:CTNNBL1(gene name)|psi-mi:CTNNBL1(display_short)|uniprotkb:C20orf33(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_110517.2|refseq:XP_011527219.1|refseq:NP_001268424.1|ensembl:ENSG00000132792(gene)|ensembl:ENST00000361383(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016445"(somatic diversification of immunoglobulins)|go:"GO:0019899"(enzyme binding)|go:"GO:0043065"(positive regulation of apoptotic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013180(Protein of unknown function DUF1716, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039678|mint:Q8WYA6|rcsb pdb:4CB8|rcsb pdb:4CB9|rcsb pdb:4CBA|rcsb pdb:4HM9|rcsb pdb:4HNM|rcsb pdb:4MFU|rcsb pdb:4MFV|rcsb pdb:7ABI|reactome:R-HSA-72163	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:P9jJGHEpem4pEqr5O0mAosbiWZI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P48444	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P78362	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-593303|uniprotkb:A8MVX2|uniprotkb:O75220|uniprotkb:O75221|uniprotkb:Q6NUL0|uniprotkb:Q6V1X2|uniprotkb:Q8IYQ3|ensembl:ENSP00000349863|ensembl:ENSP00000419791	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srpk2_human(display_long)|uniprotkb:Serine/arginine-rich protein-specific kinase 2(gene name synonym)|uniprotkb:SFRS protein kinase 2(gene name synonym)|uniprotkb:SRPK2(gene name)|psi-mi:SRPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_872633.1|refseq:NP_872634.1|refseq:NP_001265202.1|refseq:XP_016868055.1|ensembl:ENSG00000135250(gene)|ensembl:ENST00000357311(transcript)|ensembl:ENST00000489828(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2X7G|rcsb pdb:5MYV	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dwIEunDCbmP7D/TZsXuoywX6o8U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60942	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1237132|uniprotkb:O43483|uniprotkb:O60257|uniprotkb:O60351|uniprotkb:Q5TCW8|uniprotkb:Q8WUM8|uniprotkb:E1P513|uniprotkb:E1P514|ensembl:ENSP00000358497	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mce1_human(display_long)|uniprotkb:RNGTT(gene name)|psi-mi:RNGTT(display_short)|uniprotkb:CAP1A(gene name synonym)|uniprotkb:HCE(gene name synonym)|uniprotkb:HCAP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001273355.1|refseq:NP_001273357.1|refseq:NP_003791.3|dip:DIP-61014N|ensembl:ENSG00000111880(gene)|ensembl:ENST00000369485(transcript)|go:"GO:0004484"(mRNA guanylyltransferase activity)|go:"GO:0004651"(polynucleotide 5'-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006396"(RNA processing)|go:"GO:0008192"(RNA guanylyltransferase activity)|go:"GO:0050355"(triphosphatase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001339(mRNA capping enzyme)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013846(mRNA capping enzyme, C-terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017074(mRNA capping enzyme, bifunctional)|interpro:IPR020422|interpro:IPR029021|mint:O60942|rcsb pdb:2C46|rcsb pdb:3S24|reactome:R-HSA-167160|reactome:R-HSA-72086|reactome:R-HSA-77075	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:xiqdXQd75dIqosHNWDCIs1ORyJQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P14625	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8NI77	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-355426|uniprotkb:Q4VPE3|uniprotkb:Q86VS5|uniprotkb:Q9H0F3|ensembl:ENSP00000263181	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ki18a_human(display_long)|uniprotkb:KIF18A(gene name)|psi-mi:KIF18A(display_short)|uniprotkb:OK/SW-cl.108(orf name)|uniprotkb:Marrow stromal KIF18A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_112494.3|go:"GO:0000776"(kinetochore)|go:"GO:0001726"(ruffle)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000121621(gene)|ensembl:ENST00000263181(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005901"(caveola)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0061673"(mitotic spindle astral microtubule)|go:"GO:0070463"(tubulin-dependent ATPase activity)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR036961|rcsb pdb:3LRE|rcsb pdb:5OAM|rcsb pdb:5OCU|rcsb pdb:5OGC|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189|interpro:IPR027640|interpro:IPR019821|interpro:IPR027417|refseq:XP_016873868.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nd3cA914DqYJStfSOLCnOSmVKhE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86Y46	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2830994|uniprotkb:Q32MB2|ensembl:ENSP00000307014	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:k2c73_human(display_long)|uniprotkb:KRT73(gene name)|psi-mi:KRT73(display_short)|uniprotkb:K6IRS3(gene name synonym)|uniprotkb:KB36(gene name synonym)|uniprotkb:KRT6IRS3(gene name synonym)|uniprotkb:Cytokeratin-73(gene name synonym)|uniprotkb:Keratin-73(gene name synonym)|uniprotkb:Type II inner root sheath-specific keratin-K6irs3(gene name synonym)|uniprotkb:Type-II keratin Kb36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0005829"(cytosol)|ensembl:ENSG00000186049(gene)|ensembl:ENST00000305748(transcript)|go:"GO:0005634"(nucleus)|refseq:NP_778238.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6kG8MsN4Kkiajs527gKWDg1zRpY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P42696	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2954772|ensembl:ENSP00000386226|uniprotkb:Q8N2Z8|uniprotkb:Q9H5A1|uniprotkb:A8K8J7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rbm34_human(display_long)|uniprotkb:RBM34(gene name)|psi-mi:RBM34(display_short)|uniprotkb:KIAA0117(gene name synonym)|uniprotkb:RNA-binding motif protein 34(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000188739(gene)|ensembl:ENST00000408888(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|interpro:IPR034220|interpro:IPR034221|interpro:IPR035979|mint:P42696|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_055829.2|refseq:NP_001333667.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:YrlnOTpyzg9F+4ZaZpLMfq4T4ts9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96E39	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2211204|ensembl:ENSP00000318415|ensembl:ENSP00000446099|ensembl:ENSP00000498248	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rmxl1_human(display_long)|uniprotkb:RBMXL1(gene name)|psi-mi:RBMXL1(display_short)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G-like 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001156008.1|refseq:NP_062556.2|ensembl:ENSG00000213516(gene)|ensembl:ENST00000321792(transcript)|ensembl:ENST00000399794(transcript)|ensembl:ENST00000652648(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:J2BrUHGcladV+yTecfJVfljlFz89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:A1L4K1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5661036|uniprotkb:B3KVG1|uniprotkb:B7ZM02|ensembl:ENSP00000335651	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fsd2_human(display_long)|uniprotkb:SPRY domain-containing protein 1(gene name synonym)|uniprotkb:SPRYD1(gene name synonym)|uniprotkb:FSD2(gene name)|psi-mi:FSD2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001007123.1|refseq:XP_005272482.1|refseq:NP_001268734.1|refseq:NP_001268735.1|ensembl:ENSG00000186628(gene)|ensembl:ENST00000334574(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR043136	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XD3MwGtfyGillIn2aNaHaiAwEls9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P55039	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-750565|uniprotkb:Q9BWB2|uniprotkb:B2R8G5|uniprotkb:Q53Y50|ensembl:ENSP00000225729	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:drg2_human(display_long)|uniprotkb:DRG2(gene name)|psi-mi:DRG2(display_short)|uniprotkb:Translation factor GTPase DRG2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001379.1|ensembl:ENSG00000108591(gene)|ensembl:ENST00000225729(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|interpro:IPR012676(TGS-like)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:9bgX8C0kJmO5KdaYHU+vAmDCTPo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NPF5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-399105|uniprotkb:Q0JSM4|uniprotkb:Q5TG41|uniprotkb:Q7Z3H7|uniprotkb:Q9H0S8|uniprotkb:Q9P2C2|uniprotkb:A8K001|uniprotkb:D3DPY8|ensembl:ENSP00000312697|ensembl:ENSP00000354697|ensembl:ENSP00000361363	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dmap1_human(display_long)|uniprotkb:DMAP1(gene name)|psi-mi:DMAP1(display_short)|uniprotkb:KIAA1425(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001029195.1|refseq:NP_001029196.1|refseq:NP_061973.1|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR008468(DNA methyltransferase 1-associated 1)|interpro:IPR027109|interpro:IPR032563|mint:Q9NPF5|rcsb pdb:3HM5|rcsb pdb:4IEJ|reactome:R-HSA-3214847|ensembl:ENSG00000178028(gene)|ensembl:ENST00000315913(transcript)|ensembl:ENST00000361745(transcript)|ensembl:ENST00000372289(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006306"(DNA methylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043486"(histone exchange)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:XP_016857297.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ujgZ1NbKKo/pw//CZvIGWfY2ob49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y333	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-347416|uniprotkb:Q6FGG1|ensembl:ENSP00000414006|ensembl:ENSP00000414634|ensembl:ENSP00000406280|ensembl:ENSP00000364813|ensembl:ENSP00000372883|ensembl:ENSP00000403345	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lsm2_human(display_long)|uniprotkb:LSM2(gene name)|psi-mi:LSM2(display_short)|uniprotkb:C6orf28(gene name synonym)|uniprotkb:G7B(gene name synonym)|uniprotkb:snRNP core Sm-like protein Sm-x5(gene name synonym)|uniprotkb:Small nuclear ribonuclear protein D homolog(gene name synonym)|uniprotkb:Protein G7b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_067000.1|ensembl:ENST00000375661(transcript)|ensembl:ENST00000383391(transcript)|ensembl:ENST00000424975(transcript)|ensembl:ENST00000432122(transcript)|ensembl:ENST00000434125(transcript)|ensembl:ENST00000455705(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016654(U6 snRNA-associated Sm-like protein LSm2)|mint:Q9Y333|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000172850(gene)|ensembl:ENSG00000204392(gene)|ensembl:ENSG00000224979(gene)|ensembl:ENSG00000225998(gene)|ensembl:ENSG00000231502(gene)|ensembl:ENSG00000236826(gene)|dip:DIP-31139N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lReyYTJxC/WlYg/ekKaqZiNNdVM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P52739	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2849346|uniprotkb:B4DRL3|uniprotkb:Q6PIF0|ensembl:ENSP00000426504|ensembl:ENSP00000507111	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zn131_human(display_long)|uniprotkb:ZNF131(gene name)|psi-mi:ZNF131(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001284477.1|refseq:XP_005248420.1|refseq:NP_001317636.1|refseq:NP_001317637.1|refseq:NP_001317641.1|refseq:NP_001317643.1|refseq:NP_001317646.1|refseq:XP_016865319.1|ensembl:ENSG00000172262(gene)|ensembl:ENST00000509156(transcript)|ensembl:ENST00000682664(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027758|interpro:IPR036236|reactome:R-HSA-3899300|refseq:XP_016865327.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lOpLfe/zMQVEvjp6wFCITqy3zms9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9P275	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96N11	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-718667|uniprotkb:Q9BQ43|ensembl:ENSP00000340220	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cg026_human(display_long)|uniprotkb:C7orf26(gene name)|psi-mi:C7orf26(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_076972.2|refseq:NP_001289968.1|ensembl:ENSG00000146576(gene)|ensembl:ENST00000344417(transcript)|interpro:IPR027844	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BURe1wh7SN0dkYBaMmJ51w/W+qA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P60953	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H7E9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-715389|uniprotkb:A6NGC0|uniprotkb:Q96BT8|ensembl:ENSP00000330361	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ch033_human(display_long)|uniprotkb:C8orf33(gene name)|psi-mi:C8orf33(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_075568.1|ensembl:ENSG00000182307(gene)|ensembl:ENST00000331434(transcript)|interpro:IPR029274|mint:Q9H7E9	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:R2UNBJ/dYewCXrmuO3E9apROd+Q9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P43897	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1049298|uniprotkb:Q561V7|uniprotkb:Q8TBC2|uniprotkb:Q9UQK0|uniprotkb:B4E391|uniprotkb:F5H2T7|ensembl:ENSP00000499171	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:efts_human(display_long)|uniprotkb:TSFM(gene name)|psi-mi:TSFM(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001166167.1|refseq:NP_005717.3|refseq:NP_001166166.1|refseq:NP_001166168.1|ensembl:ENSG00000123297(gene)|ensembl:ENST00000652027(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006414"(translational elongation)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0070125"(mitochondrial translational elongation)|go:"GO:0070129"(regulation of mitochondrial translation)|interpro:IPR001816(Translation elongation factor EFTs/EF1B)|interpro:IPR009060(UBA-like)|interpro:IPR014039(Translation elongation factor EFTs/EF1B, dimerisation)|interpro:IPR018101|interpro:IPR036402|mint:P43897|rcsb pdb:2CP9|reactome:R-HSA-5389840	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:fdTdlcMKmL+EWT1bJxwfmfUuLWM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q7Z406	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-355595|uniprotkb:Q5CZ75|uniprotkb:Q6XYE4|uniprotkb:Q76B62|uniprotkb:Q8WV23|uniprotkb:Q96I22|uniprotkb:Q9BT27|uniprotkb:Q9BW35|uniprotkb:Q9H882|uniprotkb:B0I1S2|ensembl:ENSP00000366169|ensembl:ENSP00000472819|uniprotkb:C3TTN4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:myh14_human(display_long)|uniprotkb:MYH14(gene name)|psi-mi:MYH14(display_short)|uniprotkb:KIAA2034(gene name synonym)|uniprotkb:FP17425(orf name)|uniprotkb:Myosin heavy chain 14(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIc(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001070654.1|refseq:NP_001139281.1|refseq:NP_079005.3|refseq:XP_011525625.1|ensembl:ENSG00000105357(gene)|ensembl:ENST00000376970(transcript)|ensembl:ENST00000596571(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030426"(growth cone)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0097513"(myosin II filament)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q7Z406|rcsb pdb:5I4E|rcsb pdb:5JLH|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|interpro:IPR002928(Myosin tail)|refseq:XP_006723449.1|dip:DIP-33170N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6aY3HPa5DIY5UadiOTTh/uSPi/M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H967	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1176089|uniprotkb:A0MNP5|uniprotkb:Q05CI4|ensembl:ENSP00000263795	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr76_human(display_long)|uniprotkb:WDR76(gene name)|psi-mi:WDR76(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001161413.1|refseq:NP_079184.2|ensembl:ENSG00000092470(gene)|ensembl:ENST00000263795(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0090734"(site of DNA damage)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR033052|interpro:IPR036322|refseq:XP_005254737.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:w8vcsTpVbxVcThbcxsCbv4kbsqo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q06787	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366305|ensembl:ENSP00000359506|uniprotkb:Q5PQZ6|uniprotkb:Q16578|uniprotkb:Q99054|uniprotkb:A6NNH4|uniprotkb:D3DWT0|uniprotkb:D3DWT1|uniprotkb:D3DWT2|uniprotkb:G8JL90	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fmr1_human(display_long)|uniprotkb:FMR1(gene name)|psi-mi:FMR1(display_short)|uniprotkb:Fragile X mental retardation protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000102081(gene)|ensembl:ENST00000370475(transcript)|refseq:NP_001172004.1|refseq:NP_001172005.1|refseq:NP_001172010.1|refseq:NP_001172011.1|refseq:NP_002015.1|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q06787|rcsb pdb:2BKD|rcsb pdb:2FMR|rcsb pdb:2LA5|rcsb pdb:2QND|rcsb pdb:4OVA|rcsb pdb:4QVZ|rcsb pdb:4QW2|rcsb pdb:5DE5|rcsb pdb:5DE8|rcsb pdb:5DEA|rcsb pdb:5UWJ|rcsb pdb:5UWO|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032196|interpro:IPR036612|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|dip:DIP-29509N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:+iN/J/MbxTcRwgDezYseEDwLep49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O95365	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2795384|uniprotkb:O00456|uniprotkb:Q14D41|uniprotkb:Q5XG86|uniprotkb:D6W619|ensembl:ENSP00000323670|ensembl:ENSP00000471865	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zbt7a_human(display_long)|uniprotkb:ZNF857A(gene name synonym)|uniprotkb:Zinc finger protein 857A(gene name synonym)|uniprotkb:ZBTB7A(gene name)|psi-mi:ZBTB7A(display_short)|uniprotkb:FBI1(gene name synonym)|uniprotkb:LRF(gene name synonym)|uniprotkb:ZBTB7(gene name synonym)|uniprotkb:Leukemia/lymphoma-related factor(gene name synonym)|uniprotkb:Factor that binds to inducer of short transcripts protein 1(gene name synonym)|uniprotkb:Factor binding IST protein 1(gene name synonym)|uniprotkb:HIV-1 1st-binding protein 1(gene name synonym)|uniprotkb:TTF-I-interacting peptide 21(gene name synonym)|uniprotkb:POZ and Krueppel erythroid myeloid ontogenic factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056982.1|refseq:NP_001304919.1|refseq:XP_005259628.1|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:2000677"(regulation of transcription regulatory region DNA binding)|interpro:IPR000210(BTB/POZ-like)|go:"GO:0070418"(DNA-dependent protein kinase complex)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:O95365|rcsb pdb:2IF5|rcsb pdb:2NN2|ensembl:ENSG00000178951(gene)|ensembl:ENST00000322357(transcript)|ensembl:ENST00000601588(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0006110"(regulation of glycolytic process)|dip:DIP-56307N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:2GA3qEU1lhU9iSlCbJ5ier7PYo89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q71UM5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-355126|uniprotkb:Q9BTJ1|ensembl:ENSP00000331019	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rs27l_human(display_long)|uniprotkb:RPS27L(gene name)|psi-mi:RPS27L(display_short)|uniprotkb:Small ribosomal subunit protein eS27-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057004.1|ensembl:ENSG00000185088(gene)|ensembl:ENST00000330964(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0006412"(translation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008494"(translation activator activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|mint:Q71UM5|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:OVIAlDF6dN3DxLZgQFrFl8r0Z0I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BRL6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6380719|ensembl:ENSP00000480140|uniprotkb:B2R6B8|uniprotkb:Q6PF01|uniprotkb:Q96TA3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srsf8_human(display_long)|uniprotkb:SRSF8(gene name)|psi-mi:SRSF8(display_short)|uniprotkb:SFRS2B(gene name synonym)|uniprotkb:SRP46(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRP46(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_016872631.1|ensembl:ENSG00000263465(gene)|ensembl:ENST00000587424(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|rcsb pdb:2DNM|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_115285.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Il/jCgENzEpp+AVMgkImR2iW3Cw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15126	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055562|uniprotkb:Q5TZW9|ensembl:ENSP00000357452	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pmvk_human(display_long)|uniprotkb:PMVK(gene name)|psi-mi:PMVK(display_short)|uniprotkb:PMKI(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006547.1|ensembl:ENSG00000163344(gene)|ensembl:ENST00000368467(transcript)|go:"GO:0004631"(phosphomevalonate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0019287"(isopentenyl diphosphate biosynthetic process, mevalonate pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070723"(response to cholesterol)|interpro:IPR005919(Higher eukaryotic phosphomevalonate kinase)|interpro:IPR027417|mint:Q15126|rcsb pdb:3CH4|reactome:R-HSA-191273|reactome:R-HSA-2426168	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:bDsF+xduPQB+HVXbNikncal5foo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H0X9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1753005|uniprotkb:A6NJS8|uniprotkb:Q54A90|uniprotkb:Q9BZB0|uniprotkb:Q9P1Z4|uniprotkb:A6NDP0|uniprotkb:Q8N596|uniprotkb:B4DVB0|intact:EBI-10976435|ensembl:ENSP00000263650	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:osbl5_human(display_long)|uniprotkb:OSBPL5(gene name)|psi-mi:OSBPL5(display_short)|uniprotkb:KIAA1534(gene name synonym)|uniprotkb:OBPH1(gene name synonym)|uniprotkb:ORP5(gene name synonym)|uniprotkb:Oxysterol-binding protein homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_011518175.1|refseq:NP_001137535.1|refseq:NP_065947.1|refseq:NP_663613.1|refseq:XP_016872652.1|dip:DIP-52332N|ensembl:ENSG00000021762(gene)|ensembl:ENST00000263650(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0008142"(oxysterol binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030301"(cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9H0X9|reactome:R-HSA-1482801	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:W1w0OJd5Po42/NYnTXeGbp1iQq09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96EY7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-721110|uniprotkb:A6NHD2|uniprotkb:Q597H0|uniprotkb:Q658Y9|uniprotkb:Q9BUZ8|uniprotkb:Q9NWL0|intact:EBI-2560120|uniprotkb:D6W5M1|ensembl:ENSP00000254630	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ptcd3_human(display_long)|uniprotkb:Transformation-related gene 15 protein(gene name synonym)|uniprotkb:TRG15(orf name)|uniprotkb:28S ribosomal protein S39, mitochondrial(gene name synonym)|uniprotkb:MRPS39(gene name synonym)|uniprotkb:PTCD3(gene name)|psi-mi:PTCD3(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS39(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060422.4|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR037387|mint:Q96EY7|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|go:"GO:0019843"(rRNA binding)|rcsb pdb:6ZSC|ensembl:ENSG00000132300(gene)|ensembl:ENST00000254630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006417"(regulation of translation)|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSD	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:k9hyBtBrNbiBMJ5gtOQ9R6Grl9U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5PR19	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-20562340|intact:EBI-28970489	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:yi024_human(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0048306"(calcium-dependent protein binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6dx30DpWt7HyNe4mbgZgvJRrUGg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BYV8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11331358|uniprotkb:Q9NPV3|uniprotkb:A4D1M0|uniprotkb:Q8NFU8|uniprotkb:F5H0V6|uniprotkb:Q86TM1|uniprotkb:Q7Z496|uniprotkb:B4DQ35|uniprotkb:Q9H6A3|ensembl:ENSP00000223208	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cep41_human(display_long)|uniprotkb:CEP41(gene name)|psi-mi:CEP41(display_short)|uniprotkb:TSGA14(gene name synonym)|uniprotkb:Testis-specific gene A14 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001244087.1|refseq:NP_001244088.1|refseq:NP_001244089.1|refseq:NP_061188.1|ensembl:ENSG00000106477(gene)|ensembl:ENST00000223208(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0018095"(protein polyglutamylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RRINByA+bt24Sjr1qtrxmKM+v2M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NSP4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11051095|uniprotkb:B1AHQ9|uniprotkb:Q6I9W3|uniprotkb:A7LM22|ensembl:ENSP00000215980	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cenpm_human(display_long)|uniprotkb:CENPM(gene name)|psi-mi:CENPM(display_short)|uniprotkb:C22orf18(gene name synonym)|uniprotkb:ICEN39(gene name synonym)|uniprotkb:Interphase centromere complex protein 39(gene name synonym)|uniprotkb:PANE1(gene name synonym)|uniprotkb:Proliferation-associated nuclear element protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001002876.1|refseq:NP_001103685.1|refseq:NP_001291299.1|refseq:NP_001291300.1|refseq:NP_001291301.1|refseq:NP_001291302.1|refseq:NP_076958.1|ensembl:ENSG00000100162(gene)|ensembl:ENST00000215980(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020987|interpro:IPR027417|mint:Q9NSP4|rcsb pdb:4P0T|rcsb pdb:4WAU|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Ei3FrYFSQRwyweYc/yqcenf5aXg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q08170	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722621|uniprotkb:Q5VXP1|uniprotkb:Q9BUA4|ensembl:ENSP00000362900|uniprotkb:Q9UEB5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srsf4_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP75(gene name synonym)|uniprotkb:SRP001LB(gene name synonym)|uniprotkb:SFRS4(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 4(gene name synonym)|uniprotkb:SRSF4(gene name)|psi-mi:SRSF4(display_short)|uniprotkb:SRP75(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005617.2|ensembl:ENSG00000116350(gene)|ensembl:ENST00000373795(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979|mint:Q08170|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:LVIhOlsJ8rUYB68fWFDsovUGTeU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q7Z2Z1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11097738|uniprotkb:Q8N4X8|uniprotkb:Q8NCH6|uniprotkb:B2RE07|uniprotkb:B3KVV9|uniprotkb:D3IUT4|uniprotkb:Q9BU55|ensembl:ENSP00000268138	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ticrr_human(display_long)|uniprotkb:TICRR(gene name)|psi-mi:TICRR(display_short)|uniprotkb:C15orf42(gene name synonym)|uniprotkb:TopBP1-interacting checkpoint and replication regulator(gene name synonym)|uniprotkb:TopBP1-interacting, replication-stimulating protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001294954.1|refseq:NP_689472.3|ensembl:ENSG00000140534(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR026153|interpro:IPR032746|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000268138(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Gb8h9iKpxiRHMbJEmRW1d2Sx/7g9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y3D3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1049319|uniprotkb:Q96Q60|ensembl:ENSP00000362036|uniprotkb:B4E032	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rt16_human(display_long)|uniprotkb:MRPS16(gene name)|psi-mi:MRPS16(display_short)|uniprotkb:RPMS16(gene name synonym)|uniprotkb:CGI-132(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein bS16m(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057149.1|ensembl:ENSG00000182180(gene)|ensembl:ENST00000372945(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR000307(Ribosomal protein S16)|interpro:IPR023803|mint:Q9Y3D3|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|rcsb pdb:7A5F|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7A5G	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jejigKZMzvzmWuhMXnBB3lNsShU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P31483	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P40616	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1052746|uniprotkb:P80417|uniprotkb:Q53XB1|uniprotkb:B4DWW1|ensembl:ENSP00000261636|intact:EBI-11157530	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:arl1_human(display_long)|uniprotkb:ARL1(gene name)|psi-mi:ARL1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001168.1|ensembl:ENSG00000120805(gene)|ensembl:ENST00000261636(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P40616|rcsb pdb:1UPT|rcsb pdb:4DCN|rcsb pdb:5EE5|rcsb pdb:5J5C|reactome:R-HSA-6811440|interpro:IPR005225(Small GTP-binding protein)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4sRUSYrH1mt5ol85HlMNSEn1j9M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P11055	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5654298|uniprotkb:Q15492|ensembl:ENSP00000464317	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:myh3_human(display_long)|uniprotkb:Muscle embryonic myosin heavy chain(gene name synonym)|uniprotkb:Myosin heavy chain 3(gene name synonym)|uniprotkb:Myosin heavy chain, fast skeletal muscle, embryonic(gene name synonym)|uniprotkb:SMHCE(gene name synonym)|uniprotkb:MYH3(gene name)|psi-mi:MYH3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_011522172.1|refseq:XP_011522173.1|refseq:NP_002461.2|ensembl:ENSG00000109063(gene)|ensembl:ENST00000583535(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0007517"(muscle organ development)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0030017"(sarcomere)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032982"(myosin filament)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0060325"(face morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036000|interpro:IPR036961|mint:P11055|reactome:R-HSA-390522|interpro:IPR000048(IQ calmodulin-binding region)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3i0087p2Hd15WKkAZspyWd6L7qc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O00165	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P33992	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H2Y7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1211501|uniprotkb:Q6NSD9|uniprotkb:Q6PEK1|uniprotkb:Q86T43|uniprotkb:Q86T45|uniprotkb:Q86T50|uniprotkb:Q86T58|uniprotkb:Q86TA9|uniprotkb:Q96M37|uniprotkb:Q9H7B8|uniprotkb:B4DZ40|uniprotkb:E9PE29|ensembl:ENSP00000263805	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zn106_human(display_long)|uniprotkb:ZNF106(gene name)|psi-mi:ZNF106(display_short)|uniprotkb:SH3BP3(gene name synonym)|uniprotkb:ZFP106(gene name synonym)|uniprotkb:ZNF474(gene name synonym)|uniprotkb:Zinc finger protein 474(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001271235.1|refseq:NP_001271236.1|refseq:NP_071918.1|ensembl:ENSG00000103994(gene)|ensembl:ENST00000263805(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR042622	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:LdsJljbFU6M/RNAXcVwLx8TtOCk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43447	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O14686	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-996065|uniprotkb:O14687|intact:EBI-28986759|ensembl:ENSP00000301067	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:kmt2d_human(display_long)|uniprotkb:KMT2D(gene name)|psi-mi:KMT2D(display_short)|uniprotkb:ALL1-related protein(gene name synonym)|uniprotkb:ALR(gene name synonym)|uniprotkb:MLL2(gene name synonym)|uniprotkb:MLL4(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003473.3|refseq:XP_006719677.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1904837"(beta-catenin-TCF complex assembly)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|ensembl:ENSG00000167548(gene)|ensembl:ENST00000301067(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001555"(oocyte growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|interpro:IPR036910|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR037890|interpro:IPR041961|interpro:IPR041964|mint:O14686|rcsb pdb:3UVK|rcsb pdb:4ERQ|rcsb pdb:4Z4P|rcsb pdb:6O7G|reactome:R-HSA-201722|reactome:R-HSA-3214841|reactome:R-HSA-3769402|reactome:R-HSA-5617472|reactome:R-HSA-8936459|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|ensembl:ENSP00000301067|refseq:XP_005269219.1|dip:DIP-37875N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:eaCGHR6OqxzL66VYfOrzBWJApHY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99728	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-473181|ensembl:ENSP00000260947|uniprotkb:O43574|uniprotkb:Q53SS5|uniprotkb:F6MDH7|uniprotkb:F6MDH8|uniprotkb:F6MDH9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bard1_human(display_long)|uniprotkb:BARD1(gene name)|psi-mi:BARD1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BARD1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000138376(gene)|ensembl:ENST00000260947(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0019900"(kinase binding)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031441"(negative regulation of mRNA 3'-end processing)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|refseq:NP_001269472.1|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0085020"(protein K6-linked ubiquitination)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002110(Ankyrin)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR020683|interpro:IPR036420|interpro:IPR036770|interpro:IPR039503|mint:Q99728|rcsb pdb:1JM7|rcsb pdb:2NTE|rcsb pdb:2R1Z|rcsb pdb:3C5R|rcsb pdb:3FA2|rcsb pdb:6M14|rcsb pdb:7E8I|rcsb pdb:7JZV|rcsb pdb:7LYC|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689603|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-9663199|reactome:R-HSA-9699150|reactome:R-HSA-5693554|refseq:NP_000456.2|dip:DIP-5972N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:5dT1T3GUceuvwPpiTv5QW/QEDgE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q93074	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-394357|uniprotkb:O15410|uniprotkb:O75557|uniprotkb:Q9UHV6|uniprotkb:Q9UND7|ensembl:ENSP00000363193	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:med12_human(display_long)|uniprotkb:TRAP230(gene name synonym)|uniprotkb:MED12(gene name)|psi-mi:MED12(display_short)|uniprotkb:ARC240(gene name synonym)|uniprotkb:CAGH45(gene name synonym)|uniprotkb:HOPA(gene name synonym)|uniprotkb:KIAA0192(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 240 kDa component(gene name synonym)|uniprotkb:CAG repeat protein 45(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym)|uniprotkb:TNRC11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005111.2|ensembl:ENSG00000184634(gene)|ensembl:ENST00000374080(transcript)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:Q93074|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|dip:DIP-31459N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:soNqTi3/n+qnj+P4AX/cPJzTK2U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O95478	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2852366|ensembl:ENSP00000483484	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nsa2_human(display_long)|uniprotkb:NSA2(gene name)|psi-mi:NSA2(display_short)|uniprotkb:TINP1(gene name synonym)|uniprotkb:Hairy cell leukemia protein 1(gene name synonym)|uniprotkb:TGF-beta-inducible nuclear protein 1(gene name synonym)|uniprotkb:HUSSY-29(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055701.1|refseq:NP_001258594.1|ensembl:ENSG00000164346(gene)|ensembl:ENST00000610426(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR022309|interpro:IPR039411|mint:O95478	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:UHmCVn1q0LfipKMzSFQUzmVULD49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99590	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-3934011|uniprotkb:Q8IW59|uniprotkb:A6NEU9|uniprotkb:A6NLW5|ensembl:ENSP00000358374	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:scafb_human(display_long)|uniprotkb:SCAF11(gene name)|psi-mi:SCAF11(display_short)|uniprotkb:CASP11(gene name synonym)|uniprotkb:SFRS2IP(gene name synonym)|uniprotkb:SIP1(gene name synonym)|uniprotkb:SRSF2IP(gene name synonym)|uniprotkb:CTD-associated SR protein 11(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-40(gene name synonym)|uniprotkb:SC35-interacting protein 1(gene name synonym)|uniprotkb:SR-related and CTD-associated factor 11(gene name synonym)|uniprotkb:SRSF2-interacting protein(gene name synonym)|uniprotkb:Serine/arginine-rich splicing factor 2-interacting protein(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2-interacting protein(gene name synonym)|uniprotkb:Splicing regulatory protein 129(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_011537287.1|ensembl:ENSG00000139218(gene)|ensembl:ENST00000369367(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q99590|refseq:NP_004710.2|refseq:XP_005269287.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:cPrp7E+wNpF/uyL0fvRZTl8oO8o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H1B7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2130145|uniprotkb:Q8NDQ2|uniprotkb:Q96JG2|uniprotkb:Q9H3I7|intact:EBI-28987945|ensembl:ENSP00000238647	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:i2bpl_human(display_long)|uniprotkb:IRF2BPL(gene name)|psi-mi:IRF2BPL(display_short)|uniprotkb:C14orf4(gene name synonym)|uniprotkb:KIAA1865(gene name synonym)|uniprotkb:My039(orf name)|uniprotkb:EAP1(gene name synonym)|uniprotkb:Enhanced at puberty protein 1(gene name synonym)|uniprotkb:Interferon regulatory factor 2-binding protein-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_078772.1|ensembl:ENSP00000238647|ensembl:ENSG00000119669(gene)|ensembl:ENST00000238647(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR022750|interpro:IPR044882|rcsb pdb:2B9G|rcsb pdb:2CS3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Am6HBI/kGwqskhr3163mVz+3Bdk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P04075	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6ZSZ5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2825649|uniprotkb:Q6DD92|uniprotkb:O60274|uniprotkb:A8MV62|uniprotkb:B5ME81|intact:EBI-28968180|uniprotkb:I3L1I5|ensembl:ENSP00000499655	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:arhgi_human(display_long)|uniprotkb:ARHGEF18(gene name)|psi-mi:ARHGEF18(display_short)|uniprotkb:KIAA0521(gene name synonym)|uniprotkb:114 kDa Rho-specific guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Septin-associated RhoGEF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000594665|ensembl:ENSP00000470729|ensembl:ENST00000617428|ensembl:ENSP00000482647|ensembl:ENSP00000499655|refseq:XP_011526142.1|refseq:XP_006722768.1|refseq:XP_006722769.1|refseq:XP_011526140.1|refseq:XP_011526141.1|refseq:XP_006722771.1|refseq:NP_001124427.1|refseq:NP_056133.2|ensembl:ENSG00000104880(gene)|ensembl:ENST00000668164(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR035899|interpro:IPR037744|interpro:IPR041020|reactome:R-HSA-193648|reactome:R-HSA-2173791|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013149	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:smLgrs8rq5LPpMsYLt3ynoL45Iw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P08047	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-298336|uniprotkb:Q86TN8|uniprotkb:Q9H3Q5|uniprotkb:Q9NR51|uniprotkb:Q9NY21|uniprotkb:Q9NYE7|intact:EBI-28977878|ensembl:ENSP00000329357|uniprotkb:E4Z9M7|uniprotkb:G5E9M8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sp1_human(display_long)|uniprotkb:SP1(gene name)|psi-mi:SP1(display_short)|uniprotkb:TSFP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003100.1|refseq:NP_612482.2|ensembl:ENSG00000185591(gene)|ensembl:ENST00000327443(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1904828"(positive regulation of hydrogen sulfide biosynthetic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P08047|rcsb pdb:1SP1|rcsb pdb:1SP2|rcsb pdb:1VA1|rcsb pdb:1VA2|rcsb pdb:1VA3|rcsb pdb:6PV0|rcsb pdb:6PV1|rcsb pdb:6PV2|rcsb pdb:6PV3|rcsb pdb:6UCO|rcsb pdb:6UCP|reactome:R-HSA-1989781|reactome:R-HSA-2173796|reactome:R-HSA-2426168|reactome:R-HSA-2559585|reactome:R-HSA-6807505|reactome:R-HSA-9018519|ensembl:ENSP00000329357|ensembl:ENST00000426431|ensembl:ENSP00000404263|refseq:NP_001238754.1|refseq:XP_011536998.1|dip:DIP-36N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:mrIGsFyZTBVulhjVjVxNjFnTm5c9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NVE4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-749261|uniprotkb:Q8NE76|ensembl:ENSP00000328487	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ccd87_human(display_long)|uniprotkb:CCDC87(gene name)|psi-mi:CCDC87(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060689.2|ensembl:ENSP00000328487|ensembl:ENSG00000182791(gene)|ensembl:ENST00000333861(transcript)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0030154"(cell differentiation)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR037383	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:SfXyZIfbueunH5g/6biF1Pabyrc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q12873	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-523590|uniprotkb:Q9Y4I0|intact:EBI-28978117|ensembl:ENSP00000332628|uniprotkb:D3DTQ9|uniprotkb:E9PG89	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:chd3_human(display_long)|uniprotkb:ATP-dependent helicase CHD3(gene name synonym)|uniprotkb:Mi-2 autoantigen 240 kDa protein(gene name synonym)|uniprotkb:Mi2-alpha(gene name synonym)|uniprotkb:Zinc finger helicase(gene name synonym)|uniprotkb:CHD3(gene name)|psi-mi:CHD3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR023780|interpro:IPR027417|interpro:IPR036910|interpro:IPR038718|mint:Q12873|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-4551638|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191|ensembl:ENSG00000170004(gene)|ensembl:ENST00000330494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007051"(spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016605"(PML body)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0043044"|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|go:"GO:0070615"|interpro:IPR019787|interpro:IPR023779|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|ensembl:ENSP00000332628|ensembl:ENST00000358181|ensembl:ENSP00000350907|ensembl:ENST00000380358|ensembl:ENSP00000369716|refseq:NP_001005271.2|refseq:NP_001005273.1|refseq:NP_005843.2|dip:DIP-32496N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:UjefFUXiV28qhOP9BoIUansxl+k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UHB6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-351479|uniprotkb:Q2TAN7|uniprotkb:Q9BVF2|uniprotkb:Q9H8J1|uniprotkb:Q9HBN5|uniprotkb:Q9NX96|uniprotkb:Q9NXC3|uniprotkb:Q9NXU6|uniprotkb:Q9P0H8|uniprotkb:Q9UHB5|uniprotkb:B2RB09|ensembl:ENSP00000340184|uniprotkb:Q59FE8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lima1_human(display_long)|uniprotkb:PP624(orf name)|uniprotkb:LIMA1(gene name)|psi-mi:LIMA1(display_short)|uniprotkb:SREBP3(gene name synonym)|uniprotkb:Epithelial protein lost in neoplasm(gene name synonym)|uniprotkb:EPLIN(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001107018.1|refseq:NP_001107019.1|refseq:NP_057441.1|refseq:XP_011536757.1|ensembl:ENSG00000050405(gene)|ensembl:ENST00000341247(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031526"(brush border membrane)|go:"GO:0031529"(ruffle organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028740|mint:Q9UHB6|rcsb pdb:2D8Y|refseq:NP_001230704.1|refseq:XP_016874919.1|dip:DIP-29633N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sHqhe21LVzLJXgDMH6IcWukKNHE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P16989	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358193|uniprotkb:Q14121|uniprotkb:Q969N6|uniprotkb:Q96B76|uniprotkb:B2RBW6|intact:EBI-2560381|ensembl:ENSP00000228251	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ybox3_human(display_long)|uniprotkb:YBX3(gene name)|psi-mi:YBX3(display_short)|uniprotkb:CSDA(gene name synonym)|uniprotkb:Cold shock domain-containing protein A(gene name synonym)|uniprotkb:DBPA(gene name synonym)|uniprotkb:DNA-binding protein A(gene name synonym)|uniprotkb:Single-strand DNA-binding protein NF-GMB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0046622"(positive regulation of organ growth)|refseq:NP_001138898.1|refseq:NP_003642.3|dip:DIP-42489N|ensembl:ENSG00000060138(gene)|ensembl:ENST00000228251(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1905538"(polysome binding)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P16989	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:cWuhmwOBWe5HdgPG1gyN7KzN4Rs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NS69	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1047508|intact:EBI-1180569|ensembl:ENSP00000216034	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tom22_human(display_long)|uniprotkb:TOMM22(gene name)|psi-mi:TOMM22(display_short)|uniprotkb:TOM22(gene name synonym)|uniprotkb:Translocase of outer membrane 22 kDa subunit homolog(gene name synonym)|uniprotkb:1C9-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_064628.1|ensembl:ENSG00000100216(gene)|ensembl:ENST00000216034(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|interpro:IPR005683(Mitochondrial import translocase, subunit Tom22)|mint:Q9NS69|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DI3BGFSB04B1/mMHJsBpOsCxrYk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UJZ1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q01844	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-739737|uniprotkb:Q92635|uniprotkb:Q96FE8|uniprotkb:Q96MX4|uniprotkb:Q9BWA2|uniprotkb:Q5THL0|intact:EBI-28987207|ensembl:ENSP00000381031|intact:EBI-10985407|uniprotkb:B0QYK1|uniprotkb:Q96MN4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ews_human(display_long)|uniprotkb:EWSR1(gene name)|psi-mi:EWSR1(display_short)|uniprotkb:EWS(gene name synonym)|uniprotkb:EWS oncogene(gene name synonym)|uniprotkb:Ewing sarcoma breakpoint region 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001156757.1|refseq:NP_005234.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q01844|rcsb pdb:2CPE|interpro:IPR001876(Zinc finger, RanBP2-type)|ensembl:ENSG00000182944(gene)|ensembl:ENST00000397938(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001156759.1|refseq:NP_053733.2|refseq:NP_001156758.1|ensembl:ENST00000332035|ensembl:ENSP00000331699|ensembl:ENST00000333395|ensembl:ENSP00000327456|ensembl:ENSP00000381031|ensembl:ENST00000406548|ensembl:ENSP00000385726|ensembl:ENST00000414183|ensembl:ENSP00000400142|dip:DIP-34449N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7PxoTjcmcdUA3clzf0eW+iCFaS49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P08865	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-354112|uniprotkb:Q6NSD1|uniprotkb:Q6NXQ8|uniprotkb:Q86VC0|uniprotkb:P11085|uniprotkb:P12030|uniprotkb:Q16471|uniprotkb:Q6IPD1|uniprotkb:Q6IPD2|ensembl:ENSP00000346067	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rssa_human(display_long)|uniprotkb:RPSA(gene name)|psi-mi:RPSA(display_short)|uniprotkb:LAMBR(gene name synonym)|uniprotkb:LAMR1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Colon carcinoma laminin-binding protein(gene name synonym)|uniprotkb:NEM/1CHD4(gene name synonym)|uniprotkb:Multidrug resistance-associated protein MGr1-Ag(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)|uniprotkb:Small ribosomal subunit protein uS2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002286.2|refseq:NP_001291217.1|dip:DIP-32878N|ensembl:ENSG00000168028(gene)|ensembl:ENST00000301821(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0007155"(cell adhesion)|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZOJ|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043022"(ribosome binding)|go:"GO:0043236"(laminin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P08865|rcsb pdb:3BCH|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Jpv3I3G5C297fHfNwIqyB9Pf8/A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60783	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1045956|uniprotkb:Q5R358|ensembl:ENSP00000420714	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rt14_human(display_long)|uniprotkb:MRPS14(gene name)|psi-mi:MRPS14(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS14m(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071383.1|ensembl:ENSG00000120333(gene)|ensembl:ENST00000476371(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001209(Ribosomal protein S14)|mint:O60783|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|go:"GO:0005739"(mitochondrion)|reactome:R-HSA-5389840|reactome:R-HSA-5419276	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:IW06v3pp8xJJXxPcizKjsNIZi/I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H9A5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1054261|uniprotkb:Q9BU30|uniprotkb:Q9H5J7|uniprotkb:Q9H8X1|uniprotkb:Q9H9W0|uniprotkb:Q9HAH3|uniprotkb:Q9UFJ2|uniprotkb:B7Z7L1|uniprotkb:F8WAF2|intact:EBI-2562025|ensembl:ENSP00000330060	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cno10_human(display_long)|uniprotkb:CNOT10(gene name)|psi-mi:CNOT10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001243670.1|refseq:NP_056257.1|refseq:NP_001243671.1|ensembl:ENSG00000182973(gene)|ensembl:ENST00000328834(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039740|mint:Q9H9A5|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-46839N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:92BjBXGyxALldfF9AVpP+EFN38k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60884	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P25205	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96QR8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2880222|ensembl:ENSP00000379051|uniprotkb:A4D2L7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:purb_human(display_long)|uniprotkb:PURB(gene name)|psi-mi:PURB(display_short)|uniprotkb:Purine-rich element-binding protein B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000146676(gene)|ensembl:ENST00000395699(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030499|mint:Q96QR8|go:"GO:0046332"(SMAD binding)|refseq:NP_150093.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:C29M3TyoXYI3mhCdaSsYC2kt8ek9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92552	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2211879|uniprotkb:Q6P1S1|uniprotkb:B4DRT2|ensembl:ENSP00000261413	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rt27_human(display_long)|uniprotkb:MRPS27(gene name)|psi-mi:MRPS27(display_short)|uniprotkb:KIAA0264(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS27(gene name synonym)|uniprotkb:Mitochondrial ribosomal protein S27(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001273677.1|refseq:NP_055899.2|dip:DIP-44136N|ensembl:ENSG00000113048(gene)|ensembl:ENST00000261413(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019843"(rRNA binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0097177"(mitochondrial ribosome binding)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019266|interpro:IPR034913|mint:Q92552|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:reHIDm6Of3ERJMBRxVlVntHyRlY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6NUQ4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372318|uniprotkb:A6NNF2|uniprotkb:Q53SW1|uniprotkb:Q69YH4|uniprotkb:Q8WZ37|uniprotkb:Q9NXH2|uniprotkb:Q8NC45|uniprotkb:B3KUI9|uniprotkb:B5MCD8|ensembl:ENSP00000238788|ensembl:ENSP00000319469|uniprotkb:D6W547	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tm214_human(display_long)|uniprotkb:TMEM214(gene name)|psi-mi:TMEM214(display_short)|uniprotkb:PP446(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000119777(gene)|ensembl:ENST00000238788(transcript)|ensembl:ENST00000321326(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR019308|mint:Q6NUQ4|refseq:NP_001077059.1|refseq:NP_060197.4	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Yx4jp39AqeiXqOJVzMMRqRgk8449606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96AE4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-711404|uniprotkb:Q12828|ensembl:ENSP00000359804	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fubp1_human(display_long)|uniprotkb:FUBP1(gene name)|psi-mi:FUBP1(display_short)|uniprotkb:DNA helicase V(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q96AE4|rcsb pdb:1J4W|rcsb pdb:2KXH|rcsb pdb:4LIJ|rcsb pdb:6Y24|rcsb pdb:6Y2C|rcsb pdb:6Y2D|ensembl:ENSG00000162613(gene)|ensembl:ENST00000370768(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|refseq:NP_003893.2|refseq:NP_001290362.1|refseq:XP_016858232.1|dip:DIP-47273N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:38IaQgYv8qLMAryXO0lbfzgjjsM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P84098	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-916524|uniprotkb:P14118|uniprotkb:P22908|uniprotkb:Q502Y6|uniprotkb:Q7Z6E4|uniprotkb:B2R4K2|ensembl:ENSP00000225430	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl19_human(display_long)|uniprotkb:RPL19(gene name)|psi-mi:RPL19(display_short)|uniprotkb:Large ribosomal subunit protein eL19(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000972.1|ensembl:ENSG00000108298(gene)|ensembl:ENST00000225430(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|mint:P84098|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O95059	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366542|uniprotkb:Q53X97|ensembl:ENSP00000295959|ensembl:ENSP00000412894|ensembl:ENSP00000419909	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpp14_human(display_long)|uniprotkb:RPP14(gene name)|psi-mi:RPP14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001092253.1|refseq:NP_008973.1|refseq:XP_011531615.1|ensembl:ENSG00000163684(gene)|ensembl:ENST00000295959(transcript)|ensembl:ENST00000445193(transcript)|ensembl:ENST00000466547(transcript)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|interpro:IPR002759(Ribonuclease P-related)|interpro:IPR038085|rcsb pdb:6AHR|rcsb pdb:6AHU|reactome:R-HSA-6784531|reactome:R-HSA-6791226|refseq:XP_016861130.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:AkWjhZHJfUFybIAsMV1uGgXEKIs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P41214	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055793|uniprotkb:Q5SY40|uniprotkb:Q8IXV3|uniprotkb:Q96DG3|uniprotkb:Q96TG7|uniprotkb:Q9NR27|uniprotkb:Q9NSN0|uniprotkb:Q9NV18|uniprotkb:Q9NZ21|ensembl:ENSP00000271764	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:eif2d_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated antigen 56(gene name synonym)|uniprotkb:EIF2D(gene name)|psi-mi:EIF2D(display_short)|uniprotkb:HCA56(gene name synonym)|uniprotkb:LGTN(gene name synonym)|uniprotkb:Ligatin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001188407.1|refseq:NP_008824.2|ensembl:ENSG00000143486(gene)|ensembl:ENST00000271764(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR001950(Translation initiation factor SUI1)|interpro:IPR002478(PUA)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR015947(PUA-like)|interpro:IPR036877|interpro:IPR036885|interpro:IPR039757|interpro:IPR039759|interpro:IPR041366|rcsb pdb:5OA3|rcsb pdb:5OA9|rcsb pdb:5W2F	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:p7wBLAZglRxmmVdFyFNT2RPj+6Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q969Q0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2877705|ensembl:ENSP00000346012|uniprotkb:Q3B7A5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl36l_human(display_long)|uniprotkb:RPL36AL(gene name)|psi-mi:RPL36AL(display_short)|uniprotkb:Large ribosomal subunit protein eL42-like(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000165502(gene)|ensembl:ENST00000298289(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000552(Ribosomal protein L44e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|mint:Q969Q0|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-9633012|refseq:NP_000992.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:+jT5oFy79StEavkvHz6j/36g/qg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P62273	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1054121|uniprotkb:P30054|uniprotkb:A8MZ73|ensembl:ENSP00000245458|ensembl:ENSP00000495033	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rs29_human(display_long)|uniprotkb:RPS29(gene name)|psi-mi:RPS29(display_short)|uniprotkb:Small ribosomal subunit protein uS14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001023.1|refseq:NP_001025172.1|ensembl:ENSG00000213741(gene)|ensembl:ENST00000245458(transcript)|ensembl:ENST00000556230(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR001209(Ribosomal protein S14)|interpro:IPR018271|interpro:IPR039744|interpro:IPR043140|mint:P62273|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:vMgvFs6gwidbpv837yH2u0sSIAU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y5A9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2878081|uniprotkb:B4E1G7|uniprotkb:A6NKG4|uniprotkb:Q5VSZ9|uniprotkb:Q8TDH0|uniprotkb:Q9BUJ5|uniprotkb:A8K966|uniprotkb:D3DPM8|ensembl:ENSP00000362918|ensembl:ENSP00000444660	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ythd2_human(display_long)|uniprotkb:HGRG8(gene name synonym)|uniprotkb:CLL-associated antigen KW-14(gene name synonym)|uniprotkb:High-glucose-regulated protein 8(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-2(gene name synonym)|uniprotkb:YTHDF2(gene name)|psi-mi:YTHDF2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001166299.1|refseq:NP_001166599.1|refseq:NP_057342.2|ensembl:ENSG00000198492(gene)|ensembl:ENST00000373812(transcript)|ensembl:ENST00000542507(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045087"(innate immune response)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070925"(organelle assembly)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:2000232"(regulation of rRNA processing)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR007275(YT521-B-like protein)|mint:Q9Y5A9|rcsb pdb:4RDO|rcsb pdb:4WQN|rcsb pdb:4RDN	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:PF4C2t/728HqnrTyBQDJydH0G709606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P42356	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-723050|uniprotkb:Q7Z625|uniprotkb:Q9UPG2|ensembl:ENSP00000255882|intact:EBI-11053324	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pi4ka_human(display_long)|uniprotkb:PIK4CA(gene name synonym)|uniprotkb:PI4KA(gene name)|psi-mi:PI4KA(display_short)|uniprotkb:PIK4(gene name synonym)|uniprotkb:Phosphatidylinositol 4-Kinase III alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000241973(gene)|ensembl:ENST00000255882(transcript)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0044803"(multi-organism membrane organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0046786"(viral replication complex formation and maintenance)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR042236|rcsb pdb:6BQ1|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016301"(kinase activity)|refseq:NP_477352.3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:tm7wwZPJEvFMfK9xHMPLW9oYtzk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WY22	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-359348|uniprotkb:Q8WY23|ensembl:ENSP00000340761|ensembl:ENSP00000500359	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bri3b_human(display_long)|uniprotkb:BRI3BP(gene name)|psi-mi:BRI3BP(display_short)|uniprotkb:KG19(gene name synonym)|uniprotkb:Cervical cancer 1 proto-oncogene-binding protein KG19(gene name synonym)|uniprotkb:HCCRBP-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_542193.3|ensembl:ENSG00000184992(gene)|ensembl:ENST00000341446(transcript)|ensembl:ENST00000672415(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR033367	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:O9epHcfM1m7xNvrm6ELo0fRRGV49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13751	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2529833|uniprotkb:O14947|uniprotkb:Q14733|uniprotkb:Q9UJK4|uniprotkb:Q9UJL1|uniprotkb:D3DT88|ensembl:ENSP00000348384|ensembl:ENSP00000355997|ensembl:ENSP00000375778	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lamb3_human(display_long)|uniprotkb:Epiligrin subunit bata(gene name synonym)|uniprotkb:Kalinin subunit beta(gene name synonym)|uniprotkb:Nicein subunit beta(gene name synonym)|uniprotkb:LAMB3(gene name)|psi-mi:LAMB3(display_short)|uniprotkb:LAMNB1(gene name synonym)|uniprotkb:Laminin-5 subunit beta(gene name synonym)|uniprotkb:Laminin B1k chain(gene name synonym)|uniprotkb:Kalinin B1 chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000196878(gene)|ensembl:ENST00000356082(transcript)|ensembl:ENST00000367030(transcript)|ensembl:ENST00000391911(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0008544"(epidermis development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043256"(laminin complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|mint:Q13751|reactome:R-HSA-1474228|reactome:R-HSA-2022090|reactome:R-HSA-2214320|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-446107|reactome:R-HSA-8874081|refseq:NP_000219.2|refseq:NP_001017402.1|refseq:NP_001121113.1|refseq:XP_005273181.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sZg1IU7enqhMRqryIrBkYRSP8/k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96T88	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1548946|uniprotkb:Q8J022|uniprotkb:Q9H6S6|uniprotkb:Q9P115|uniprotkb:Q9P1U7|uniprotkb:A0JBR2|uniprotkb:A8K024|uniprotkb:B2RBA9|uniprotkb:Q2HIX7|ensembl:ENSP00000478348|ensembl:ENSP00000478601|ensembl:ENSP00000484739|ensembl:ENSP00000485604|ensembl:ENSP00000498698	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:uhrf1_human(display_long)|uniprotkb:UHRF1(gene name)|psi-mi:UHRF1(display_short)|uniprotkb:ICBP90(gene name synonym)|uniprotkb:NP95(gene name synonym)|uniprotkb:RNF106(gene name synonym)|uniprotkb:Ubiquitin-like PHD and RING finger domain-containing protein 1(gene name synonym)|uniprotkb:Ubiquitin-like-containing PHD and RING finger domains protein 1(gene name synonym)|uniprotkb:Inverted CCAAT box-binding protein of 90 kDa(gene name synonym)|uniprotkb:Transcription factor ICBP90(gene name synonym)|uniprotkb:Nuclear zinc finger protein Np95(gene name synonym)|uniprotkb:Nuclear protein 95(gene name synonym)|uniprotkb:RING finger protein 106(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UHRF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001276979.1|refseq:NP_001276980.1|refseq:NP_001276981.1|refseq:NP_037414.3|refseq:NP_001041666.1|ensembl:ENSG00000276043(gene)|ensembl:ENST00000612630(transcript)|ensembl:ENST00000615884(transcript)|ensembl:ENST00000616255(transcript)|ensembl:ENST00000624301(transcript)|ensembl:ENST00000650932(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044729"(hemi-methylated DNA-binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR000626(Ubiquitin)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003105(SRA-YDG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015947(PUA-like)|interpro:IPR017907|interpro:IPR019787|interpro:IPR021991|interpro:IPR029071|interpro:IPR036987|mint:Q96T88|rcsb pdb:2FAZ|rcsb pdb:2L3R|rcsb pdb:2LGG|rcsb pdb:2LGK|rcsb pdb:2LGL|rcsb pdb:2PB7|rcsb pdb:3ASK|rcsb pdb:3ASL|rcsb pdb:3BI7|rcsb pdb:3CLZ|rcsb pdb:3DB3|rcsb pdb:3DB4|rcsb pdb:3DWH|rcsb pdb:3FL2|rcsb pdb:3SHB|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3SOX|rcsb pdb:3T6R|rcsb pdb:3ZVY|rcsb pdb:3ZVZ|rcsb pdb:4GY5|rcsb pdb:4QQD|rcsb pdb:5C6D|rcsb pdb:5IAY|rcsb pdb:5XPI|rcsb pdb:5YY9|rcsb pdb:5YYA|rcsb pdb:6B9M|rcsb pdb:6IIW|rcsb pdb:6VCS|rcsb pdb:6VED|rcsb pdb:6VYJ|rcsb pdb:6W92|reactome:R-HSA-5334118|interpro:IPR001841(Zinc finger, RING-type)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:AbWLjSoRl82HTcjZlG4DRavDdGc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14680	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13428	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396105|uniprotkb:Q6SC72|uniprotkb:Q7Z5W9|uniprotkb:Q96A52|uniprotkb:Q99408|uniprotkb:Q99860|uniprotkb:A0JLU0|uniprotkb:B4E111|intact:EBI-28974716|ensembl:ENSP00000367028|ensembl:ENSP00000421655	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tcof_human(display_long)|uniprotkb:TCOF1(gene name)|psi-mi:TCOF1(display_short)|uniprotkb:Treacher Collins syndrome protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000347.2|refseq:NP_001008657.1|refseq:NP_001128715.1|refseq:NP_001128716.1|refseq:NP_001128717.1|refseq:NP_001182070.1|ensembl:ENST00000323668|ensembl:ENSP00000325223|ensembl:ENSP00000367028|ensembl:ENST00000394269|ensembl:ENSP00000377811|ensembl:ENST00000427724|ensembl:ENSP00000390717|ensembl:ENST00000439160|ensembl:ENSP00000406888|ensembl:ENST00000445265|ensembl:ENSP00000409944|ensembl:ENSP00000421655|ensembl:ENST00000643257|ensembl:ENSP00000493815|refseq:XP_005268562.1|ensembl:ENSG00000070814(gene)|ensembl:ENST00000377797(transcript)|ensembl:ENST00000504761(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003993(Treacher Collins syndrome, treacle)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR017859|mint:Q13428|dip:DIP-32953N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:eRazgHpn5CwQVFH5hRnA/sVp24M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96E14	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2555534|uniprotkb:B3KVZ6|uniprotkb:Q49AE2|uniprotkb:Q8TBL0|ensembl:ENSP00000310356	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rmi2_human(display_long)|uniprotkb:C16orf75(gene name synonym)|uniprotkb:BLM-associated protein of 18 kDa(gene name synonym)|uniprotkb:RMI2(gene name)|psi-mi:RMI2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_689521.1|ensembl:ENSG00000175643(gene)|ensembl:ENST00000312499(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0033045"(regulation of sister chromatid segregation)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR032245|rcsb pdb:3MXN|rcsb pdb:3NBH|rcsb pdb:4DAY|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|dip:DIP-56480N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:C+BkMgfVWJYrYzHyitGVU1nwnQg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P24468	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2795198|uniprotkb:B6ZGU1|uniprotkb:Q03754|uniprotkb:B4DQJ2|uniprotkb:Q3KQR7|ensembl:ENSP00000377721	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cot2_human(display_long)|uniprotkb:NR2F2(gene name)|psi-mi:NR2F2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:TFCOUP2(gene name synonym)|uniprotkb:COUP transcription factor II(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 2(gene name synonym)|uniprotkb:Apolipoprotein A-I regulatory protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_066285.1|refseq:NP_001138627.1|refseq:NP_001138628.1|refseq:NP_001138629.1|ensembl:ENSG00000185551(gene)|ensembl:ENST00000394166(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0009956"(radial pattern formation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0032355"(response to estradiol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060173"(limb development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:3CJW|reactome:R-HSA-381340|dip:DIP-29713N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XsZyqUr06sQQaD3oXAA3IEa6Dug9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13247	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-745230|uniprotkb:Q13244|uniprotkb:Q13245|uniprotkb:Q96J06|uniprotkb:Q9UJB8|uniprotkb:Q9Y3N7|uniprotkb:B7Z6J3|uniprotkb:E1P5W6|ensembl:ENSP00000244020	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srsf6_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP55(gene name synonym)|uniprotkb:SRSF6(gene name)|psi-mi:SRSF6(display_short)|uniprotkb:SRP55(gene name synonym)|uniprotkb:SFRS6(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006266.2|ensembl:ENSG00000124193(gene)|ensembl:ENST00000244020(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061041"(regulation of wound healing)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029541|interpro:IPR034511|interpro:IPR035979|mint:Q13247|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:vU4nobP3g/hsgnll0mQgjJcME2k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P47914	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-714039|uniprotkb:Q6IPY3|ensembl:ENSP00000418346|ensembl:ENSP00000418868|ensembl:ENSP00000420673|ensembl:ENSP00000294189|ensembl:ENSP00000417048|ensembl:ENSP00000418153|uniprotkb:B2R4M8|uniprotkb:A8K0H3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl29_human(display_long)|uniprotkb:Cell surface heparin-binding protein HIP(gene name synonym)|uniprotkb:RPL29(gene name)|psi-mi:RPL29(display_short)|uniprotkb:Large ribosomal subunit protein eL29(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000294189(transcript)|ensembl:ENST00000466397(transcript)|ensembl:ENST00000475248(transcript)|ensembl:ENST00000479017(transcript)|ensembl:ENST00000492277(transcript)|ensembl:ENST00000495383(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007566"(embryo implantation)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045296"(cadherin binding)|interpro:IPR002673(Ribosomal protein L29e)|mint:P47914|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|ensembl:ENSG00000162244(gene)|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000983.1|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XZUSMDDzycAi6QEXYbljXaeVg0U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P10515	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6UN15	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1021914|uniprotkb:Q0VGE0|uniprotkb:Q499Y4|uniprotkb:Q49AU3|uniprotkb:Q7Z608|uniprotkb:Q8WVN3|uniprotkb:Q96F80|uniprotkb:Q9H077|intact:EBI-11535474|ensembl:ENSP00000336752|uniprotkb:B4DIR3|uniprotkb:G3XAD6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fip1_human(display_long)|uniprotkb:Factor interacting with PAP(gene name synonym)|uniprotkb:FIP1-like 1 protein(gene name synonym)|uniprotkb:Rearranged in hypereosinophilia(gene name synonym)|uniprotkb:FIP1L1(gene name)|psi-mi:FIP1L1(display_short)|uniprotkb:FIP1(gene name synonym)|uniprotkb:RHE(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000306932|ensembl:ENSP00000302993|ensembl:ENSP00000336752|ensembl:ENST00000358575|ensembl:ENSP00000351383|ensembl:ENST00000507922|ensembl:ENSP00000425456|refseq:NP_001128409.1|refseq:NP_001128410.1|refseq:NP_112179.2|ensembl:ENSG00000145216(gene)|ensembl:ENST00000337488(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR007854(Fip1)|mint:Q6UN15|rcsb pdb:7K95|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|reactome:R-HSA-9673766|dip:DIP-42503N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:41uK1l8RV99q4k4Z7K9zeG3TJHA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y3B9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055610|intact:EBI-28979625|ensembl:ENSP00000355899	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rrp15_human(display_long)|uniprotkb:Ribosomal RNA-processing protein 15(gene name synonym)|uniprotkb:RRP15(gene name)|psi-mi:RRP15(display_short)|uniprotkb:KIAA0507(gene name synonym)|uniprotkb:CGI-115(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000355899|refseq:NP_057136.2|ensembl:ENSG00000067533(gene)|ensembl:ENST00000366932(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR012459(Protein of unknown function DUF1665)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:EJQFG76HKEYeJ6LwFd5zaUmoScw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P40429	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-720205|uniprotkb:A8K505|ensembl:ENSP00000375730	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl13a_human(display_long)|uniprotkb:23 kDa highly basic protein(gene name synonym)|uniprotkb:RPL13A(gene name)|psi-mi:RPL13A(display_short)|uniprotkb:Large ribosomal subunit protein uL13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_036555.1|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|rcsb pdb:6OLF|ensembl:ENSG00000142541(gene)|ensembl:ENST00000391857(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR036899|mint:P40429|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|refseq:NP_001257420.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:pcKDTEBZXxtm1MAH+4nv0p3PqFs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P17987	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P25490	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-765538|uniprotkb:Q14935|ensembl:ENSP00000262238	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tyy1_human(display_long)|uniprotkb:Yin and yang 1(gene name synonym)|uniprotkb:Delta transcription factor(gene name synonym)|uniprotkb:NF-E1(gene name synonym)|uniprotkb:YY1(gene name)|psi-mi:YY1(display_short)|uniprotkb:INO80S(gene name synonym)|uniprotkb:INO80 complex subunit S(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003394.1|dip:DIP-150N|ensembl:ENSG00000100811(gene)|rcsb pdb:1UBD|rcsb pdb:1ZNM|rcsb pdb:4C5I|reactome:R-HSA-5617472|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-8866910|reactome:R-HSA-9018519|ensembl:ENST00000262238(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006403"(RNA localization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010225"(response to UV-C)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0051276"(chromosome organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017114(Transcription factor yin and yang)|interpro:IPR036236|mint:P25490	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:OncFlxfcbNZGN68Sk39CRh9oQHc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96N67	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q2TAK8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-10748689|uniprotkb:A1L489|uniprotkb:B5ME02|uniprotkb:B7ZLY8|uniprotkb:J3KQD6|uniprotkb:Q13109|uniprotkb:Q5XKB9|uniprotkb:Q8N2I4|uniprotkb:Q96A67|ensembl:ENSP00000467083|ensembl:ENSP00000467287	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pwp3a_human(display_long)|uniprotkb:PWWP3A(gene name)|psi-mi:PWWP3A(display_short)|uniprotkb:EXPAND1(gene name synonym)|uniprotkb:MUM1(gene name synonym)|uniprotkb:Mutated melanoma-associated antigen 1(gene name synonym)|uniprotkb:PWWP domain-containing protein MUM1(gene name synonym)|uniprotkb:Protein expandere(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_116242.2|refseq:XP_011526687.1|ensembl:ENSG00000160953(gene)|ensembl:ENST00000591337(transcript)|ensembl:ENST00000591806(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0031491"(nucleosome binding)|interpro:IPR033368|interpro:IPR035504|interpro:IPR040263|rcsb pdb:3PMI	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:+8GYGrHv5pShcZd+IJZ5GwRvxW89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P00338	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H2U1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1047643|uniprotkb:Q70JU3|uniprotkb:Q8IYE5|uniprotkb:Q9P240|uniprotkb:B2RB00|ensembl:ENSP00000417078	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dhx36_human(display_long)|uniprotkb:DEAD/H box polypeptide 36(gene name synonym)|uniprotkb:DEAH-box protein 36(gene name synonym)|uniprotkb:G4-resolvase-1(gene name synonym)|uniprotkb:RNA helicase associated with AU-rich element protein(gene name synonym)|uniprotkb:MLE-like protein 1(gene name synonym)|uniprotkb:DHX36(gene name)|psi-mi:DHX36(display_short)|uniprotkb:DDX36(gene name synonym)|uniprotkb:KIAA1488(gene name synonym)|uniprotkb:MLEL1(gene name synonym)|uniprotkb:RHAU(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001107869.1|refseq:NP_065916.2|go:"GO:0006359"(regulation of transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0005829"(cytosol)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070883"(pre-miRNA binding)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902064"(regulation of transcription from RNA polymerase II promoter involved in spermatogenesis)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904582"(positive regulation of intracellular mRNA localization)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR027417|ensembl:ENSG00000174953(gene)|ensembl:ENST00000496811(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001503"(ossification)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|rcsb pdb:2N16|rcsb pdb:2N21|rcsb pdb:6Q6R|reactome:R-HSA-3134963|mint:Q9H2U1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CvYmO1OB0zu5ZCYzQmKvCYGc3+k9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q3B726	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1642554|uniprotkb:A0PJ45|uniprotkb:B7Z724|ensembl:ENSP00000222567	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpa43_human(display_long)|uniprotkb:POLR1F(gene name)|psi-mi:POLR1F(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit F(gene name synonym)|uniprotkb:TWISTNB(gene name synonym)|uniprotkb:Twist neighbor protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001002926.1|ensembl:ENSG00000105849(gene)|ensembl:ENST00000222567(transcript)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005736"(RNA polymerase I complex)|interpro:IPR036898|interpro:IPR041178|interpro:IPR041901|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Dh5USsPRiE7XJFM90H43I/IzodY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6XZF7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2483419|ensembl:ENSP00000315659|uniprotkb:Q8IVY3|uniprotkb:Q9Y2L3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dnmbp_human(display_long)|uniprotkb:DNMBP(gene name)|psi-mi:DNMBP(display_short)|uniprotkb:KIAA1010(gene name synonym)|uniprotkb:Scaffold protein Tuba(gene name synonym)|uniprotkb:ARHGEF36(gene name synonym)|uniprotkb:TUBA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000107554(gene)|ensembl:ENST00000324109(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007568"(aging)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0098793"(presynapse)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035469|interpro:IPR035817|interpro:IPR035818|interpro:IPR035819|interpro:IPR035820|interpro:IPR035899|interpro:IPR036028|mint:Q6XZF7|rcsb pdb:1UG1|rcsb pdb:1UHC|rcsb pdb:4CC2|rcsb pdb:4CC3|rcsb pdb:4CC4|rcsb pdb:4CC7|rcsb pdb:4GLM|reactome:R-HSA-9013148|refseq:XP_011537861.1|refseq:NP_056036.1|refseq:NP_001305255.1|refseq:NP_001305256.1|dip:DIP-53822N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Pnps+8tUGF35nxMUaPgDr5hzRzc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q7KZI7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NUL3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722938|uniprotkb:Q6AHY7|uniprotkb:Q96HM0|uniprotkb:Q96HM1|uniprotkb:Q9NVI5|uniprotkb:Q9UGG6|uniprotkb:A0A0A0MTC5|uniprotkb:E9PF26|uniprotkb:B7Z1I6|uniprotkb:B7Z292|uniprotkb:B7Z8B4|uniprotkb:E7ER74|uniprotkb:E9PEI3|uniprotkb:E9PF50|ensembl:ENSP00000428756	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:stau2_human(display_long)|uniprotkb:STAU2(gene name)|psi-mi:STAU2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001157852.1|refseq:NP_001157853.1|refseq:NP_001157854.1|refseq:NP_001157855.1|refseq:NP_001157856.1|refseq:NP_001157857.1|refseq:NP_055208.2|ensembl:ENSG00000040341(gene)|ensembl:ENST00000524300(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044464|interpro:IPR044473|interpro:IPR044474|interpro:IPR044476	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:iFcd8pLhQK+8ihFUCf4sl2f0bgw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13724	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-720141|uniprotkb:Q17RN9|uniprotkb:Q8TCT5|uniprotkb:A8K938|ensembl:ENSP00000410992|uniprotkb:F5H6D0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mogs_human(display_long)|uniprotkb:Processing A-glucosidase I(gene name synonym)|uniprotkb:MOGS(gene name)|psi-mi:MOGS(display_short)|uniprotkb:GCS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001139630.1|refseq:NP_006293.2|ensembl:ENSG00000115275(gene)|ensembl:ENST00000448666(transcript)|go:"GO:0004573"(Glc3Man9GlcNAc2 oligosaccharide glucosidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0015926"(glucosidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004888(Glycoside hydrolase, family 63)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR031335|interpro:IPR031631|interpro:IPR038518|mint:Q13724|reactome:R-HSA-4793954|reactome:R-HSA-532668|reactome:R-HSA-9683686|reactome:R-HSA-9694548	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:odbL3NUcP483ilKg/CMVn2GtdVs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13322	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BW27	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-716392|intact:EBI-2563151|uniprotkb:Q9H9U1|uniprotkb:Q8NDI4|uniprotkb:B4DMQ3|uniprotkb:B4DPW1|ensembl:ENSP00000245544	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nup85_human(display_long)|uniprotkb:PCNT1(gene name synonym)|uniprotkb:Nucleoporin Nup85(gene name synonym)|uniprotkb:85 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup75(gene name synonym)|uniprotkb:Pericentrin-1(gene name synonym)|uniprotkb:FROUNT(gene name synonym)|uniprotkb:NUP85(gene name)|psi-mi:NUP85(display_short)|uniprotkb:NUP75(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_079120.1|refseq:NP_001290205.1|ensembl:ENSG00000125450(gene)|ensembl:ENST00000245544(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0072006"(nephron development)|interpro:IPR011502(Nucleoporin, Nup85-like)|mint:Q9BW27|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:MWeo3e2aXVKhP1gFV8ZZrgyFSeI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49848	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1560206|uniprotkb:A4D2B2|uniprotkb:A4D2B3|uniprotkb:Q6AI29|uniprotkb:D6W5U2|uniprotkb:B4DT11|ensembl:ENSP00000344537|ensembl:ENSP00000389575|ensembl:ENSP00000416396	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:taf6_human(display_long)|uniprotkb:Transcription initiation factor TFIID 70 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 80 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit E(gene name synonym)|uniprotkb:TAF6(gene name)|psi-mi:TAF6(display_short)|uniprotkb:TAF2E(gene name synonym)|uniprotkb:TAFII70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_006716163.1|refseq:NP_005632.1|refseq:NP_647476.1|refseq:NP_001177344.1|dip:DIP-773N|ensembl:ENSG00000106290(gene)|ensembl:ENST00000344095(transcript)|ensembl:ENST00000452041(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005829"(cytosol)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0071339"(MLL1 complex)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037796|rcsb pdb:5FUR|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGH|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENST00000453269(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:oGsdH9+tG2BXsR+jr7hBuCCAS809606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9HCG8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-373289|uniprotkb:Q05DC2|uniprotkb:Q4G135|uniprotkb:Q52LF0|uniprotkb:Q6PEX2|uniprotkb:Q7Z6I0|uniprotkb:Q9H5L3|uniprotkb:Q9H6Q6|intact:EBI-2561242|ensembl:ENSP00000387006	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cwc22_human(display_long)|uniprotkb:CWC22(gene name)|psi-mi:CWC22(display_short)|uniprotkb:fSAPb(gene name synonym)|uniprotkb:KIAA1604(gene name synonym)|uniprotkb:NCM(gene name synonym)|uniprotkb:Nucampholin homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_065994.1|refseq:XP_005246783.1|ensembl:ENSG00000163510(gene)|ensembl:ENST00000410053(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7DVQ|reactome:R-HSA-72163|go:"GO:0016607"(nuclear speck)|dip:DIP-31268N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:LQcs0QFEY4f8ha4jLuOAyz/N5ic9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P45880	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60313	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96JM3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2560420|uniprotkb:Q8NC88|uniprotkb:B3KU06|uniprotkb:Q6P181|uniprotkb:Q9BST0|ensembl:ENSP00000354730|ensembl:ENSP00000496699	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:chap1_human(display_long)|uniprotkb:CHAMP(gene name synonym)|uniprotkb:CHAMP1(gene name)|psi-mi:CHAMP1(display_short)|uniprotkb:C13orf8(gene name synonym)|uniprotkb:CAMP(gene name synonym)|uniprotkb:KIAA1802(gene name synonym)|uniprotkb:ZNF828(gene name synonym)|uniprotkb:Zinc finger protein 828(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001157616.1|refseq:NP_001157617.1|refseq:NP_115812.1|ensembl:ENSG00000198824(gene)|ensembl:ENST00000361283(transcript)|ensembl:ENST00000643483(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0016604"(nuclear body)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0090543"(Flemming body)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR039330|mint:Q96JM3|rcsb pdb:6EKJ|rcsb pdb:6EKL|rcsb pdb:5XPT|rcsb pdb:5XPU	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Di1yMiufHKsy384vPjOgdncmQXw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P19012	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-739566|uniprotkb:Q53XV8|uniprotkb:Q9BUG4|uniprotkb:B3KQY1|uniprotkb:B3KRA2|uniprotkb:E0CX14|ensembl:ENSP00000254043|ensembl:ENSP00000377546	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:k1c15_human(display_long)|uniprotkb:KRT15(gene name)|psi-mi:KRT15(display_short)|uniprotkb:KRTB(gene name synonym)|uniprotkb:Cytokeratin-15(gene name synonym)|uniprotkb:Keratin-15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002266.2|ensembl:ENSG00000171346(gene)|ensembl:ENST00000254043(transcript)|ensembl:ENST00000393976(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P19012|reactome:R-HSA-6805567|reactome:R-HSA-6809371	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:WrZQBYQvrWcfrR5ojWXrXp6spPE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TF68	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6115971|uniprotkb:O15407|uniprotkb:Q7Z722|uniprotkb:Q8N938|ensembl:ENSP00000354592|ensembl:ENSP00000380019	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zn384_human(display_long)|uniprotkb:ZNF384(gene name)|psi-mi:ZNF384(display_short)|uniprotkb:CAGH1(gene name synonym)|uniprotkb:CIZ(gene name synonym)|uniprotkb:NMP4(gene name synonym)|uniprotkb:TNRC1(gene name synonym)|uniprotkb:CAG repeat protein 1(gene name synonym)|uniprotkb:CAS-interacting zinc finger protein(gene name synonym)|uniprotkb:Nuclear matrix transcription factor 4(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000319770|ensembl:ENSP00000321650|ensembl:ENSP00000354592|ensembl:ENSP00000380019|ensembl:ENST00000355772|ensembl:ENSP00000348018|refseq:NP_001035009.1|refseq:NP_001129206.1|refseq:NP_597733.2|refseq:XP_016874430.1|refseq:XP_016874431.1|refseq:XP_016874432.1|refseq:XP_016874438.1|refseq:XP_016874439.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8TF68|ensembl:ENSG00000126746(gene)|ensembl:ENST00000361959(transcript)|ensembl:ENST00000396801(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:6TO45205H9niXg8StUmIooVLC289606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P61313	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-443462|ensembl:ENSP00000309334|ensembl:ENSP00000346867|ensembl:ENSP00000388529|ensembl:ENSP00000416692|ensembl:ENSP00000483260|ensembl:ENSP00000493759|uniprotkb:Q642I1|uniprotkb:Q9H2E5|uniprotkb:P39030|uniprotkb:P41051|uniprotkb:Q6IPX6|uniprotkb:Q8WYP2|uniprotkb:Q96C44|uniprotkb:Q5U0C0|intact:EBI-2877712	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl15_human(display_long)|uniprotkb:RPL15(gene name)|psi-mi:RPL15(display_short)|uniprotkb:EC45(gene name synonym)|uniprotkb:Large ribosomal subunit protein eL15(gene name synonym)|uniprotkb:TCBAP0781(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000174748(gene)|ensembl:ENST00000307839(transcript)|ensembl:ENST00000354811(transcript)|ensembl:ENST00000413699(transcript)|ensembl:ENST00000415719(transcript)|ensembl:ENST00000611050(transcript)|ensembl:ENST00000644185(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|interpro:IPR000439(Ribosomal protein L15e)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR020925|interpro:IPR024794|mint:P61313|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_002939.2|refseq:NP_001240308.1|refseq:NP_001240309.1|refseq:NP_001240311.1|refseq:NP_001240312.1|refseq:NP_001240313.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wllGpJicgC5uwkZV6e4QRwDcrBo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15372	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-709735|ensembl:ENSP00000429931	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8IU81	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6115514|uniprotkb:Q53EL7|uniprotkb:Q6DC95|uniprotkb:Q9BRZ9|uniprotkb:Q9Y4P4|ensembl:ENSP00000307265	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:i2bp1_human(display_long)|uniprotkb:IRF2BP1(gene name)|psi-mi:IRF2BP1(display_short)|uniprotkb:Probable E3 ubiquitin-protein ligase IRF2BP1(gene name synonym)|uniprotkb:Probable RING-type E3 ubiquitin transferase IRF2BP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056464.1|ensembl:ENSG00000170604(gene)|ensembl:ENST00000302165(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR018957|interpro:IPR022750|interpro:IPR044882|mint:Q8IU81	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:0ooWsKsxvLQtWbTA3FsVfO+6TBA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8N1B4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P61764	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-960169|uniprotkb:Q28208|uniprotkb:Q62759|uniprotkb:Q64320|uniprotkb:Q96TG8|uniprotkb:B1AM97|uniprotkb:Q68CM6|ensembl:ENSP00000362396	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:stxb1_human(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short)|uniprotkb:UNC18A(gene name synonym)|uniprotkb:Protein unc-18 homolog 1(gene name synonym)|uniprotkb:Protein unc-18 homolog A(gene name synonym)|uniprotkb:N-Sec1(gene name synonym)|uniprotkb:p67(gene name synonym)|uniprotkb:MUNC18-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001027392.1|refseq:NP_003156.1|ensembl:ENSG00000136854(gene)|ensembl:ENST00000373299(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0002576"(platelet degranulation)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0005739"(mitochondrion)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007412"(axon target recognition)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030424"(axon)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050821"(protein stabilization)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|go:"GO:0106022"(positive regulation of vesicle docking)|go:"GO:1903296"(positive regulation of glutamate secretion, neurotransmission)|go:"GO:2000367"(regulation of acrosomal vesicle exocytosis)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|mint:P61764|rcsb pdb:6L03|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|reactome:R-HSA-422356|reactome:R-HSA-6794361|reactome:R-HSA-888590	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:yUYi89hDkfMdQ1BdH52swZQFCLk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NZM5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-720156|uniprotkb:Q9BTC6|uniprotkb:Q9HAX6|uniprotkb:Q9NPP1|uniprotkb:Q9NPR4|uniprotkb:Q9UFI2|ensembl:ENSP00000246802	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nop53_human(display_long)|uniprotkb:NOP53(gene name)|psi-mi:NOP53(display_short)|uniprotkb:GLT(gene name synonym)|uniprotkb:GLTSCR2(gene name synonym)|uniprotkb:Glioma tumor suppressor candidate region gene 2 protein(gene name synonym)|uniprotkb:PICT1(gene name synonym)|uniprotkb:Protein interacting with carboxyl terminus 1(gene name synonym)|uniprotkb:p60(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056525.2|ensembl:ENSG00000105373(gene)|ensembl:ENST00000246802(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006364"(rRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0003723"(RNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902570"(protein localization to nucleolus)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990173"(protein localization to nucleoplasm)|interpro:IPR011687(P60-like)|mint:Q9NZM5|go:"GO:0050821"(protein stabilization)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:64EYf68f9eP9SfPBJhjbxuJcn2g9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14331	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2515248|ensembl:ENSP00000226798|ensembl:ENSP00000483471|ensembl:ENSP00000489690|ensembl:ENSP00000490541|uniprotkb:A8K775	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:frg1_human(display_long)|uniprotkb:FRG1(gene name)|psi-mi:FRG1(display_short)|uniprotkb:FSHD region gene 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR008999(Actin_cross-linking)|interpro:IPR010414(FRG1-like)|mint:Q14331|rcsb pdb:6ZYM|rcsb pdb:7A5P|go:"GO:0071013"(catalytic step 2 spliceosome)|ensembl:ENSG00000109536(gene)|ensembl:ENSG00000275145(gene)|ensembl:ENSG00000283153(gene)|ensembl:ENSG00000283630(gene)|ensembl:ENST00000226798(transcript)|ensembl:ENST00000620886(transcript)|ensembl:ENST00000636590(transcript)|ensembl:ENST00000637998(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007517"(muscle organ development)|go:"GO:0015030"(Cajal body)|go:"GO:0030018"(Z disc)|go:"GO:0051015"(actin filament binding)|go:"GO:0055120"(striated muscle dense body)|refseq:NP_004468.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BRCawumXfDpZ6xqljS6j8tgxHzc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9ULW0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1037322|uniprotkb:Q9H1R4|uniprotkb:Q9NRA3|uniprotkb:Q9UFN9|uniprotkb:Q9UL00|uniprotkb:Q9Y2M1|intact:EBI-2554635|uniprotkb:Q96RR5|intact:EBI-28976825|ensembl:ENSP00000300403	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tpx2_human(display_long)|uniprotkb:TPX2(gene name)|psi-mi:TPX2(display_short)|uniprotkb:C20orf1(gene name synonym)|uniprotkb:C20orf2(gene name synonym)|uniprotkb:DIL2(gene name synonym)|uniprotkb:HCA519(gene name synonym)|uniprotkb:Restricted expression proliferation-associated protein 100(gene name synonym)|uniprotkb:Differentially expressed in cancerous and non-cancerous lung cells 2(gene name synonym)|uniprotkb:Protein fls353(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 519(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 90(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	dip:DIP-36727N|refseq:NP_036244.2|ensembl:ENSP00000300403|ensembl:ENST00000340513|ensembl:ENSP00000341145|refseq:XP_011526999.1|refseq:XP_011527001.1|dip:DIP-46212N|ensembl:ENSG00000088325(gene)|ensembl:ENST00000300403(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006915"(apoptotic process)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043203"(axon hillock)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR009675(Targeting for Xklp2)|interpro:IPR015128(Aurora-A binding)|interpro:IPR027329|interpro:IPR027330|mint:Q9ULW0|rcsb pdb:1OL5|rcsb pdb:3E5A|rcsb pdb:3HA6|rcsb pdb:4C3P|rcsb pdb:5LXM|rcsb pdb:6BJC|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|reactome:R-HSA-6804756|reactome:R-HSA-8854518	go:"GO:0005634"(nucleus)	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dQbYLMi2nP9JPEbdDMk4R4arVxw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86WA8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2513996|ensembl:ENSP00000285737|uniprotkb:Q96K43|uniprotkb:Q8N3B9|uniprotkb:Q0D2H6|uniprotkb:Q8NCE9|uniprotkb:B7ZKL7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lonp2_human(display_long)|uniprotkb:LONP2(gene name)|psi-mi:LONP2(display_short)|uniprotkb:LONP(gene name synonym)|uniprotkb:Lon protease-like protein 2(gene name synonym)|uniprotkb:Peroxisomal Lon protease(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000102910(gene)|ensembl:ENST00000285737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008233"(peptidase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019899"(enzyme binding)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027501|reactome:R-HSA-390471|reactome:R-HSA-9033241|refseq:NP_001287877.1|refseq:NP_113678.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:WyZglDz2aZOpnRVtWTrAf62G0pA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H7H0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-749353|intact:EBI-948255|uniprotkb:Q9BSH1|uniprotkb:Q9BZH2|uniprotkb:Q9BZH3|ensembl:ENSP00000343041	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:met17_human(display_long)|uniprotkb:METT11D1(gene name synonym)|uniprotkb:Protein RSM22 homolog, mitochondrial(gene name synonym)|uniprotkb:METTL17(gene name)|psi-mi:METTL17(display_short)|uniprotkb:Methyltransferase 11 domain-containing protein 1(gene name synonym)|uniprotkb:False p73 target gene protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001025162.1|refseq:NP_073571.1|ensembl:ENSG00000165792(gene)|ensembl:ENST00000339374(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006412"(translation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR015324(Ribosomal protein Rsm22, bacterial-type)|interpro:IPR029063|mint:Q9H7H0	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RAj8jOqwthd7a0Xzi5FWhVKc8OI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H8H2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-395655|uniprotkb:Q5K6N2|uniprotkb:Q5K6N3|uniprotkb:Q5K6N4|uniprotkb:Q5VZJ4|uniprotkb:Q5VZJ9|uniprotkb:Q96E91|uniprotkb:Q96NY2|uniprotkb:Q96SX5|uniprotkb:Q9H5K6|ensembl:ENSP00000361226|ensembl:ENSP00000361232	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx31_human(display_long)|uniprotkb:DEAD box protein 31(gene name synonym)|uniprotkb:Helicain(gene name synonym)|uniprotkb:DDX31(gene name)|psi-mi:DDX31(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_073616.6|refseq:NP_619526.1|ensembl:ENSG00000125485(gene)|ensembl:ENST00000372153(transcript)|ensembl:ENST00000372159(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|refseq:NP_001309269.1|refseq:NP_001309273.1|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|mint:Q9H8H2|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR025313	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:HaC4SAnIvujAJVEcn/88Wij/zTM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BXY0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5280229|uniprotkb:B2RB44|uniprotkb:Q5U5T1|uniprotkb:Q86UC4|uniprotkb:Q96SY6|ensembl:ENSP00000353246	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mak16_human(display_long)|uniprotkb:MAK16(gene name)|psi-mi:MAK16(display_short)|uniprotkb:RBM13(gene name synonym)|uniprotkb:NNP78(gene name synonym)|uniprotkb:Protein RBM13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_115898.2|ensembl:ENSG00000198042(gene)|ensembl:ENST00000360128(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR006958(Mak16 protein)|interpro:IPR029004|mint:Q9BXY0	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Zedk3AV8WcIUeBxPWbFlL6HztIA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NVU7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1043768|uniprotkb:Q32Q11|uniprotkb:Q68D52|uniprotkb:Q7Z5U4|uniprotkb:Q9H831|uniprotkb:Q9H9P6|ensembl:ENSP00000348596	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sda1_human(display_long)|uniprotkb:SDAD1(gene name)|psi-mi:SDAD1(display_short)|uniprotkb:SDA1 domain-containing protein 1(gene name synonym)|uniprotkb:Nucleolar protein 130(gene name synonym)|uniprotkb:NUC130(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060585.2|ensembl:ENSG00000198301(gene)|ensembl:ENST00000356260(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0015031"(protein transport)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR007949(SDA1)|interpro:IPR012977(Region of unknown function, nucleolar NUC130/133, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027312|refseq:XP_005263162.1|refseq:NP_001275912.1|refseq:NP_001275913.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BdU6Lfg2n/VgrR2SDw2idumu5WQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UFW8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-723153|uniprotkb:O15183|ensembl:ENSP00000381428|ensembl:ENSP00000381429|ensembl:ENSP00000418769|ensembl:ENSP00000420374|ensembl:ENSP00000502581|uniprotkb:D3DU38	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cgbp1_human(display_long)|uniprotkb:p20-CGGBP DNA-binding protein(gene name synonym)|uniprotkb:20 kDa CGG-binding protein(gene name synonym)|uniprotkb:CGGBP1(gene name)|psi-mi:CGGBP1(display_short)|uniprotkb:CGGBP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001008391.1|refseq:NP_001182237.1|refseq:NP_003654.3|ensembl:ENSG00000163320(gene)|ensembl:ENST00000309534(transcript)|ensembl:ENST00000398392(transcript)|ensembl:ENST00000462901(transcript)|ensembl:ENST00000482016(transcript)|ensembl:ENST00000675130(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042802"(identical protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR033375|mint:Q9UFW8|refseq:XP_016862844.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1sg3JQWhmEQX9snN5SG1OjdRP1A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P55072	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8IY81	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-744088|uniprotkb:Q8N3A3|uniprotkb:Q8WXX1|uniprotkb:Q9BWM4|uniprotkb:Q9NXT6|uniprotkb:D3DU22|uniprotkb:B2RCA5|ensembl:ENSP00000396673	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spb1_human(display_long)|uniprotkb:FTSJ3(gene name)|psi-mi:FTSJ3(display_short)|uniprotkb:SB92(orf name)|uniprotkb:Protein ftsJ homolog 3(gene name synonym)|uniprotkb:Putative rRNA methyltransferase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060117.3|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR024576|interpro:IPR028589|interpro:IPR029063|mint:Q8IY81|reactome:R-HSA-6791226|ensembl:ENSG00000108592(gene)|ensembl:ENST00000427159(transcript)|go:"GO:0000453"(enzyme-directed rRNA 2'-O-methylation)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008650"("rRNA (uridine-2'-O-)-methyltransferase activity")|go:"GO:0016435"("rRNA (guanine) methyltransferase activity")|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031167"(rRNA methylation)|go:"GO:0062105"(RNA 2'-O-methyltransferase activity)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR012920(Spb1, C-terminal)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:KIeyMWn9Zktm5lV7XI7v2bRA8og9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8NEY8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-474076|uniprotkb:Q86YT2|uniprotkb:Q8IXN3|uniprotkb:Q8TB09|uniprotkb:Q96NB9|uniprotkb:Q9NXL4|uniprotkb:Q9P0P6|uniprotkb:Q9P0R9|uniprotkb:E9PAX8|ensembl:ENSP00000378935|ensembl:ENSP00000479913	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pphln_human(display_long)|uniprotkb:Gastric cancer antigen Ga50(gene name synonym)|uniprotkb:HSPC206(orf name)|uniprotkb:HSPC232(orf name)|uniprotkb:PPHLN1(gene name)|psi-mi:PPHLN1(display_short)|uniprotkb:CDC7 expression repressor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001137259.1|refseq:NP_001137260.1|refseq:NP_057572.5|refseq:NP_958846.1|refseq:NP_958847.1|refseq:NP_958848.1|refseq:NP_958923.1|dip:DIP-49051N|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0031424"(keratinization)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0097355"(protein localization to heterochromatin)|interpro:IPR028851|mint:Q8NEY8|rcsb pdb:6SWG|ensembl:ENSG00000134283(gene)|ensembl:ENST00000395568(transcript)|ensembl:ENST00000610488(transcript)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:+s8KstGQ7d91qe3DDnpKYMJon7o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TCB0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2831730|uniprotkb:B7ZAG3|uniprotkb:Q14496|uniprotkb:D3DQ80|ensembl:ENSP00000359783	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ifi44_human(display_long)|uniprotkb:IFI44(gene name)|psi-mi:IFI44(display_short)|uniprotkb:MTAP44(gene name synonym)|uniprotkb:Microtubule-associated protein 44(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006408.3|ensembl:ENSG00000137965(gene)|ensembl:ENST00000370747(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006955"(immune response)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|interpro:IPR006571(TLDc)|interpro:IPR024644|interpro:IPR027417	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:8WC3TPSpHflhjOOQwwmw6wM0+G89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NYL2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-602273|uniprotkb:Q53SX1|uniprotkb:Q580W8|uniprotkb:Q59GY5|uniprotkb:Q86YW8|uniprotkb:Q9HCC4|uniprotkb:Q9HCC5|uniprotkb:Q9HDD2|uniprotkb:Q9NYE9|intact:EBI-1058916|uniprotkb:B3KPG2|ensembl:ENSP00000364361|ensembl:ENSP00000387259	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:m3k20_human(display_long)|uniprotkb:Human cervical cancer suppressor gene 4 protein(gene name synonym)|uniprotkb:Leucine zipper- and sterile alpha motif-containing kinase(gene name synonym)|uniprotkb:MLK-like mitogen-activated protein triple kinase(gene name synonym)|uniprotkb:MLTK(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase MLT(gene name synonym)|uniprotkb:Mixed lineage kinase-related kinase(gene name synonym)|uniprotkb:Sterile alpha motif- and leucine zipper-containing kinase AZK(gene name synonym)|uniprotkb:ZAK(gene name synonym)|uniprotkb:HCCS4(orf name)|uniprotkb:MAP3K20(gene name)|psi-mi:MAP3K20(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057737.2|refseq:NP_598407.1|refseq:XP_005246697.1|refseq:XP_016859812.1|refseq:XP_016859813.1|ensembl:ENST00000375213(transcript)|ensembl:ENST00000409176(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007254"(JNK cascade)|go:"GO:0008219"(cell death)|go:"GO:0030154"(cell differentiation)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060173"(limb development)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904291"(positive regulation of mitotic DNA damage checkpoint)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|mint:Q9NYL2|rcsb pdb:5HES|rcsb pdb:5X5O|rcsb pdb:6JUT|rcsb pdb:6JUU|ensembl:ENSG00000091436(gene)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:r8AGxedcm7rLHlwHGc0wKwzHXbM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TAF3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P04844	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-719731|uniprotkb:Q5JYR6|uniprotkb:Q9UBE1|uniprotkb:Q6IBA5|uniprotkb:Q96E21|uniprotkb:Q9BUQ3|ensembl:ENSP00000237530	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpn2_human(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:RIBIIR(gene name synonym)|uniprotkb:RPN2(gene name)|psi-mi:RPN2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001129243.1|refseq:NP_002942.2|ensembl:ENSG00000118705(gene)|ensembl:ENST00000237530(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P04844|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:NP_001311234.1|refseq:NP_001311235.1|refseq:NP_001311228.1|refseq:NP_001311230.1|refseq:NP_001311231.1|refseq:NP_001311232.1|refseq:NP_001311233.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7bTuuEb3ykWQvkI/5DKpga48s/w9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NZC9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5457961|uniprotkb:A6NEH0|uniprotkb:Q53R00|uniprotkb:Q96AY1|uniprotkb:Q9NXQ5|uniprotkb:Q9UFH3|uniprotkb:Q9UI93|ensembl:ENSP00000349823|ensembl:ENSP00000350940	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:smal1_human(display_long)|uniprotkb:SMARCAL1(gene name)|psi-mi:SMARCAL1(display_short)|uniprotkb:HARP(gene name synonym)|uniprotkb:HepA-related protein(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2-like 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001120679.1|refseq:NP_054859.2|refseq:XP_005246688.1|refseq:XP_005246689.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031297"(replication fork processing)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0048478"(replication fork protection)|go:"GO:0070615"|ensembl:ENSG00000138375(gene)|ensembl:ENST00000357276(transcript)|ensembl:ENST00000358207(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR010003(HepA-related)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR030101|interpro:IPR038718|mint:Q9NZC9|rcsb pdb:4MQV|go:"GO:0090656"(t-circle formation)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sUz7fctEmC8ajY7I9H474RGxhag9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H9Y2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-9996007|uniprotkb:Q5VSK7|uniprotkb:Q6AHX1|uniprotkb:Q8WXZ8|ensembl:ENSP00000359688	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpf1_human(display_long)|uniprotkb:RPF1(gene name)|psi-mi:RPF1(display_short)|uniprotkb:BXDC5(gene name synonym)|uniprotkb:Brix domain-containing protein 5(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_079341.2|ensembl:ENSG00000117133(gene)|ensembl:ENST00000370654(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR007109(Brix)|interpro:IPR044281|go:"GO:0000460"(maturation of 5.8S rRNA)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lPJHR67nRalKzyv8rBOSx3duAvE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75817	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366574|uniprotkb:Q9BV74|uniprotkb:A4D2E0|ensembl:ENSP00000304353	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pop7_human(display_long)|uniprotkb:POP7(gene name)|psi-mi:POP7(display_short)|uniprotkb:RPP20(gene name synonym)|uniprotkb:Ribonucleases P/MRP protein subunit POP7 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005828.2|ensembl:ENSG00000172336(gene)|ensembl:ENST00000303151(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR014612(RNase P/MRP, subunit p20)|interpro:IPR036882|rcsb pdb:6AHR|rcsb pdb:6AHU|rcsb pdb:6CWX|rcsb pdb:6LT7|reactome:R-HSA-6784531	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4mEMPOJULq64MzFbKwpTygnJckY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q03252	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2830427|uniprotkb:O75292|uniprotkb:Q14734|uniprotkb:Q96DF6|ensembl:ENSP00000327054|intact:EBI-11044751|intact:EBI-20728818	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lmnb2_human(display_long)|uniprotkb:LMNB2(gene name)|psi-mi:LMNB2(display_short)|uniprotkb:LMN2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000176619(gene)|ensembl:ENST00000325327(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:Q03252|rcsb pdb:2LLL|rcsb pdb:5BNW|refseq:NP_116126.3|dip:DIP-57724N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Jt7rEo5Br8HidU+VAc0L6rtBU889606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15382	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q7Z739	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2849837|uniprotkb:Q659A3|uniprotkb:B3KXL4|uniprotkb:Q63Z37|ensembl:ENSP00000473496	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ythd3_human(display_long)|uniprotkb:YTHDF3(gene name)|psi-mi:YTHDF3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_689971.4|refseq:NP_001264742.1|refseq:NP_001264743.1|refseq:NP_001264744.1|refseq:NP_001264745.1|refseq:NP_001264746.1|refseq:NP_001264747.1|ensembl:ENSG00000185728(gene)|ensembl:ENST00000539294(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1901163"(regulation of trophoblast cell migration)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q7Z739|rcsb pdb:6ZOT	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:M1/1RMOQiQ7kD+J9KMmEq9RZebw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P26368	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-742339|uniprotkb:Q96HC5|intact:EBI-946034|ensembl:ENSP00000307863	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:u2af2_human(display_long)|uniprotkb:U2AF2(gene name)|psi-mi:U2AF2(display_short)|uniprotkb:U2AF65(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor large subunit(gene name synonym)|uniprotkb:U2 auxiliary factor 65 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005634"(nucleus)|refseq:NP_001012496.1|refseq:NP_009210.1|ensembl:ENSG00000063244(gene)|ensembl:ENST00000308924(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|rcsb pdb:2HZC|rcsb pdb:2M0G|rcsb pdb:2U2F|rcsb pdb:2YH0|rcsb pdb:2YH1|rcsb pdb:3VAF|rcsb pdb:3VAG|rcsb pdb:3VAH|rcsb pdb:3VAI|rcsb pdb:3VAJ|rcsb pdb:3VAK|rcsb pdb:3VAL|rcsb pdb:3VAM|rcsb pdb:4FXW|rcsb pdb:4TU7|rcsb pdb:4TU8|rcsb pdb:4TU9|rcsb pdb:5EV1|rcsb pdb:5EV2|rcsb pdb:5EV3|rcsb pdb:5EV4|rcsb pdb:5W0G|rcsb pdb:5W0H|rcsb pdb:6TR0|rcsb pdb:6XLV|rcsb pdb:6XLW|rcsb pdb:6XLX|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:2G4B|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006529(U2 snRNP auxilliary factor, large subunit, splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P26368|rcsb pdb:1JMT|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:1U2F|go:"GO:0005654"(nucleoplasm)|dip:DIP-2154N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:HBYwOej94CoGGN7vPbk0AnbO61Q9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96Q15	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1049832|uniprotkb:O43305|uniprotkb:Q13284|uniprotkb:Q8NFX2|uniprotkb:Q96QV0|uniprotkb:Q96RW3|ensembl:ENSP00000402515	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:smg1_human(display_long)|uniprotkb:Lambda/iota protein kinase C-interacting protein(gene name synonym)|uniprotkb:61E3.4(gene name synonym)|uniprotkb:SMG1(gene name)|psi-mi:SMG1(display_short)|uniprotkb:ATX(gene name synonym)|uniprotkb:KIAA0421(gene name synonym)|uniprotkb:LIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055907.3|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR031559|interpro:IPR035175|interpro:IPR036940|interpro:IPR039414|mint:Q96Q15|rcsb pdb:6L53|rcsb pdb:6L54|rcsb pdb:6SYT|rcsb pdb:6Z3R|reactome:R-HSA-975957|ensembl:ENSG00000157106(gene)|ensembl:ENST00000446231(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032204"(regulation of telomere maintenance)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:u7doCYezlcCUKq//xhk0TZ2TD009606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6SPF0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-8833536|uniprotkb:Q96IM4|uniprotkb:Q6PIS7|uniprotkb:Q6P0R3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:samd1_human(display_long)|uniprotkb:SAMD1(gene name)|psi-mi:SAMD1(display_short)|uniprotkb:Atherin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	mint:Q6SPF0|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|refseq:NP_612361.1|go:"GO:0005737"(cytoplasm)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|rcsb pdb:6LUI|rcsb pdb:6LUJ|rcsb pdb:6LUK|go:"GO:0003682"(chromatin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Cav/ZfHiZJ1xCBI6jAYrzv+CmZ49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O00629	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6NZY4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1263058|uniprotkb:Q7L2P6|uniprotkb:Q8N2K5|uniprotkb:Q96SK7|uniprotkb:Q9NSS2|uniprotkb:Q9NSS3|ensembl:ENSP00000488055|ensembl:ENSP00000500728	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zchc8_human(display_long)|uniprotkb:ZCCHC8(gene name)|psi-mi:ZCCHC8(display_short)|uniprotkb:TRAMP-like complex RNA-binding factor ZCCHC8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060082.2|ensembl:ENSG00000033030(gene)|ensembl:ENST00000633063(transcript)|ensembl:ENST00000672018(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016076"(snRNA catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0031499"(TRAMP complex)|go:"GO:0034470"(ncRNA processing)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR006568(PSP, proline-rich)|mint:Q6NZY4|rcsb pdb:5LXR|rcsb pdb:5LXY|rcsb pdb:6C90	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dtjoaLAUgEGavPmqaJLPnLPHLP49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43747	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-447609|uniprotkb:O75709|uniprotkb:O75842|uniprotkb:Q9UG09|uniprotkb:Q9Y3U4|ensembl:ENSP00000299980|ensembl:ENSP00000454523	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ap1g1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:AP1G1(gene name)|psi-mi:AP1G1(display_short)|uniprotkb:ADTG(gene name synonym)|uniprotkb:CLAPG1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001025178.1|refseq:NP_001119.3|ensembl:ENSG00000166747(gene)|ensembl:ENST00000299980(transcript)|ensembl:ENST00000569748(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:O43747|rcsb pdb:1IU1|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:E0niV91xZ1PV6Pr6Koq3Xs+9nKg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BRJ6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-751612|ensembl:ENSP00000350011|ensembl:ENSP00000380286|ensembl:ENSP00000380288	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cg050_human(display_long)|uniprotkb:FP15621(orf name)|uniprotkb:C7orf50(gene name)|psi-mi:C7orf50(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001127867.1|refseq:NP_001127868.1|refseq:NP_115726.1|refseq:NP_001305181.1|ensembl:ENSG00000146540(gene)|ensembl:ENST00000357429(transcript)|ensembl:ENST00000397098(transcript)|ensembl:ENST00000397100(transcript)|interpro:IPR019327|mint:Q9BRJ6|go:"GO:0003723"(RNA binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:POftCOri0Nj8YUd5Kc3nNMDb41A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8N6R0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1053295|uniprotkb:A6NFK0|uniprotkb:Q53EZ6|uniprotkb:O94940|uniprotkb:Q5TGP9|uniprotkb:Q5TGQ0|uniprotkb:Q8N2P8|uniprotkb:Q96J11|uniprotkb:Q96SQ0|uniprotkb:Q9Y2Z1|uniprotkb:Q9Y3M6|uniprotkb:A8K6S5|intact:EBI-1059000|ensembl:ENSP00000354920	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:efnmt_human(display_long)|uniprotkb:METTL13(gene name)|psi-mi:METTL13(display_short)|uniprotkb:EEF1AKNMT(gene name synonym)|uniprotkb:FEAT(gene name synonym)|uniprotkb:KIAA0859(gene name synonym)|uniprotkb:Methyltransferase-like protein 13(gene name synonym)|uniprotkb:CGI-01(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001007240.1|refseq:NP_055770.1|refseq:NP_057019.3|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR029063|mint:Q8N6R0|rcsb pdb:5WCJ|ensembl:ENSG00000010165(gene)|ensembl:ENST00000361735(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BAuWTz48t+/xwoky1nsCnGWtp/c9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P30153	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9HBM6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-751601|uniprotkb:Q9Y2S3|uniprotkb:B2RUZ9|ensembl:ENSP00000339917	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:taf9b_human(display_long)|uniprotkb:Transcription initiation factor TFIID subunit 9-like(gene name synonym)|uniprotkb:Transcription-associated factor TAFII31L(gene name synonym)|uniprotkb:Neuronal cell death-related protein 7(gene name synonym)|uniprotkb:TAF9B(gene name)|psi-mi:TAF9B(display_short)|uniprotkb:TAF9L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057059.2|ensembl:ENSG00000187325(gene)|ensembl:ENST00000341864(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR003162(Transcription factor TAFII-31)|interpro:IPR009072(Histone-fold)|mint:Q9HBM6|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-5689880|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:8+i5lmcx4OcgCEbk2F9MS8bYhos9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BQL6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-4403029|uniprotkb:D3DW10|uniprotkb:Q8IX34|uniprotkb:Q8IYH2|uniprotkb:Q9NWM2|uniprotkb:Q9NXQ3|ensembl:ENSP00000217289	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ferm1_human(display_long)|uniprotkb:FERMT1(gene name)|psi-mi:FERMT1(display_short)|uniprotkb:C20orf42(gene name synonym)|uniprotkb:KIND1(gene name synonym)|uniprotkb:URP1(gene name synonym)|uniprotkb:Kindlerin(gene name synonym)|uniprotkb:Kindlin syndrome protein(gene name synonym)|uniprotkb:Kindlin-1(gene name synonym)|uniprotkb:Unc-112-related protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060141.3|ensembl:ENSG00000101311(gene)|ensembl:ENST00000217289(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0051886"(negative regulation of timing of anagen)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071711"(basement membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:2000647"(negative regulation of stem cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR035963|interpro:IPR037843|interpro:IPR037837|interpro:IPR040790	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lfWyDOEGRWkHX1dFHQ+F1PEukU89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14160	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15024	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-371841|uniprotkb:Q96E72|ensembl:ENSP00000265564	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:exos7_human(display_long)|uniprotkb:KIAA0116(gene name synonym)|uniprotkb:RRP42(gene name synonym)|uniprotkb:EXOSC7(gene name)|psi-mi:EXOSC7(display_short)|uniprotkb:Ribosomal RNA-processing protein 42(gene name synonym)|uniprotkb:Exosome component 7(gene name synonym)|uniprotkb:p8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055819.2|ensembl:ENSG00000075914(gene)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|ensembl:ENST00000265564(transcript)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|mint:Q15024|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|go:"GO:0034475"(U4 snRNA 3'-end processing)|dip:DIP-31266N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:gFGj7nvYM3a56Pu7vryrP+XfUxE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P63165	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O00566	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5235884|uniprotkb:A0AVJ8|ensembl:ENSP00000244230	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mpp10_human(display_long)|uniprotkb:MPHOSPH10(gene name)|psi-mi:MPHOSPH10(display_short)|uniprotkb:MPP10(gene name synonym)|uniprotkb:M phase phosphoprotein 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005782.1|ensembl:ENSG00000124383(gene)|ensembl:ENST00000244230(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034457"(Mpp10 complex)|interpro:IPR012173(U3 small nucleolar ribonucleoprotein complex, subunit Mpp10p)|mint:O00566|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:xkz11U1x5r2joVtVq6JG4asO1Qw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15381	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-721638|uniprotkb:Q96EM7|uniprotkb:B4DMC4|uniprotkb:B4DP98|ensembl:ENSP00000281701	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nvl_human(display_long)|uniprotkb:NVL(gene name)|psi-mi:NVL(display_short)|uniprotkb:NVL2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002524.2|refseq:NP_996671.1|refseq:NP_001230075.1|refseq:NP_001230076.1|ensembl:ENSG00000143748(gene)|ensembl:ENST00000281701(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904749"(regulation of protein localization to nucleolus)|go:"GO:1990275"(preribosome binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR031996|interpro:IPR038100|interpro:IPR041569|mint:O15381|rcsb pdb:2X8A|rcsb pdb:6RO1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3xAHor7LoQCGSzrRQWhKaEuqd9A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H9F9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-769418|uniprotkb:Q86WF7|uniprotkb:Q8IUY5|uniprotkb:Q8N724|uniprotkb:Q9BRN0|uniprotkb:Q9BVB7|ensembl:ENSP00000243903	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:arp5_human(display_long)|uniprotkb:Sarcoma antigen NY-SAR-16(gene name synonym)|uniprotkb:ACTR5(gene name)|psi-mi:ACTR5(display_short)|uniprotkb:ARP5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_079131.3|dip:DIP-34297N|ensembl:ENSG00000101442(gene)|ensembl:ENST00000243903(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043044"|go:"GO:0070914"(UV-damage excision repair)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR027664|interpro:IPR043129|rcsb pdb:6HTS|reactome:R-HSA-5689603|reactome:R-HSA-5696394	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ewlnWvZMDIX84KfZ6XIXXm9NBVI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q2TAL8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2798044|uniprotkb:Q8TEA5|uniprotkb:Q4G0F7|uniprotkb:Q7L621|ensembl:ENSP00000350094|ensembl:ENSP00000378830|ensembl:ENSP00000412890	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:qric1_human(display_long)|uniprotkb:QRICH1(gene name)|psi-mi:QRICH1(display_short)|uniprotkb:Glutamine-rich protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001307509.1|refseq:NP_001307510.1|refseq:NP_001307511.1|refseq:NP_001307512.1|refseq:NP_001307513.1|refseq:NP_001307514.1|refseq:XP_011532165.1|refseq:NP_060200.2|refseq:NP_942581.1|ensembl:ENSG00000198218(gene)|ensembl:ENST00000357496(transcript)|ensembl:ENST00000395443(transcript)|ensembl:ENST00000424300(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0140467"(integrated stress response signaling)|interpro:IPR021893	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lZutsiEMc3Fpej5M2vhosiQZnoA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P61224	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q16666	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2867186|uniprotkb:Q9UH78|uniprotkb:Q96AJ5|uniprotkb:Q5T3W7|uniprotkb:Q5T3X2|uniprotkb:Q5T3W8|uniprotkb:Q5T3X0|uniprotkb:Q8NEQ7|uniprotkb:Q8N9E5|uniprotkb:Q5T3X1|uniprotkb:Q59GX0|uniprotkb:B4DJT8|uniprotkb:H3BLV7|ensembl:ENSP00000295809	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:if16_human(display_long)|uniprotkb:IFI16(gene name)|psi-mi:IFI16(display_short)|uniprotkb:IFNGIP1(gene name synonym)|uniprotkb:Interferon-inducible myeloid differentiation transcriptional activator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001193496.1|refseq:NP_005522.2|dip:DIP-42868N|ensembl:ENST00000295809(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042149"(cellular response to glucose starvation)|ensembl:ENSG00000163565(gene)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR004020(Pyrin)|interpro:IPR004021(HIN-200/IF120x)|interpro:IPR011029(DEATH-like)|interpro:IPR040205|mint:Q16666|rcsb pdb:2OQ0|rcsb pdb:3B6Y|rcsb pdb:3RLN|rcsb pdb:3RLO|rcsb pdb:3RNU|rcsb pdb:4QGU|reactome:R-HSA-1834941|reactome:R-HSA-3270619	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lZOhepRgcTRzXg7sDjJ44MWzbbY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P28288	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92888	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-465400|uniprotkb:O00513|uniprotkb:Q8N4J4|uniprotkb:Q96BF4|uniprotkb:Q96F17|uniprotkb:Q9BSB1|uniprotkb:Q6NX52|ensembl:ENSP00000346532	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:arhg1_human(display_long)|uniprotkb:ARHGEF1(gene name)|psi-mi:ARHGEF1(display_short)|uniprotkb:115 kDa guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Sub1.5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004697.2|refseq:NP_945328.1|refseq:NP_945353.1|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000076928(gene)|ensembl:ENST00000354532(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q92888|rcsb pdb:1IAP|rcsb pdb:1SHZ|rcsb pdb:3AB3|rcsb pdb:3ODO|rcsb pdb:3ODW|rcsb pdb:3ODX|rcsb pdb:3P6A	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XIZmflM2cr80ZBD3FO21IDMnInE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NR28	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-517508|uniprotkb:Q96LV0|uniprotkb:Q9BT11|uniprotkb:Q9HAV6|uniprotkb:B2RDQ0|ensembl:ENSP00000442360|ensembl:ENSP00000499058|uniprotkb:Q6W3F3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dbloh_human(display_long)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_620308.1|refseq:NP_063940.1|ensembl:ENST00000464942(transcript)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000650715(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|rcsb pdb:1FEW|dip:DIP-27627N|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1OXQ|rcsb pdb:1TW6|rcsb pdb:1XB0|rcsb pdb:1XB1|rcsb pdb:3D9U|rcsb pdb:3UIH|rcsb pdb:3UIJ|rcsb pdb:4TX5|rcsb pdb:6JX6|reactome:R-HSA-111457|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-9627069	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NVH2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11276282|uniprotkb:B4DLZ6|uniprotkb:B7WNP6|uniprotkb:B7WPB6|uniprotkb:Q8N4K7|uniprotkb:Q8WUH5|uniprotkb:Q9H9V3|uniprotkb:Q9NVU5|uniprotkb:Q9UFC6|uniprotkb:Q9UFM3|ensembl:ENSP00000355961	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:int7_human(display_long)|uniprotkb:INTS7(gene name)|psi-mi:INTS7(display_short)|uniprotkb:C1orf73(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001186738.1|refseq:NP_001186740.1|refseq:NP_001186741.1|refseq:NP_056249.1|ensembl:ENSG00000143493(gene)|ensembl:ENST00000366994(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0016180"(snRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0032039"(integrator complex)|go:"GO:0034472"(snRNA 3'-end processing)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033060|mint:Q9NVH2|rcsb pdb:7CUN|reactome:R-HSA-6807505	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:PqhjJZUeAkdQHmckoWrwfsPUUeI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TD57	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1642346|uniprotkb:O00437|uniprotkb:O15437|uniprotkb:O43326|uniprotkb:Q3C0H2|uniprotkb:Q8WUP9|uniprotkb:Q9UEM3|uniprotkb:Q9UEM5|uniprotkb:Q9UG35|ensembl:ENSP00000261383	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dyh3_human(display_long)|uniprotkb:DNAH3(gene name)|psi-mi:DNAH3(display_short)|uniprotkb:DNAHC3B(gene name synonym)|uniprotkb:Axonemal beta dynein heavy chain 3(gene name synonym)|uniprotkb:Ciliary dynein heavy chain 3(gene name synonym)|uniprotkb:Dnahc3-b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060009.1|refseq:NP_001334815.1|interpro:IPR041466|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|ensembl:ENSG00000158486(gene)|ensembl:ENST00000261383(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005858"(axonemal dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060285"(cilium-dependent cell motility)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BomHzIjBCu3Jke8U0dYF+Pz8hW89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P51617	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P48380	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-742557|uniprotkb:Q5JTL7|uniprotkb:Q5JTL8|uniprotkb:Q6NW13|uniprotkb:Q8WTU4|uniprotkb:Q95HL5|uniprotkb:Q95HL6|uniprotkb:A8K0H5|uniprotkb:D3DRH8|uniprotkb:D3DRH9|ensembl:ENSP00000371434|ensembl:ENSP00000482598	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rfx3_human(display_long)|uniprotkb:Regulatory factor X 3(gene name synonym)|uniprotkb:RFX3(gene name)|psi-mi:RFX3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002910.1|refseq:NP_602304.1|refseq:NP_001269045.1|refseq:NP_001269046.1|ensembl:ENSG00000080298(gene)|ensembl:ENST00000382004(transcript)|ensembl:ENST00000617270(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0060271"(cilium assembly)|go:"GO:0060285"(cilium-dependent cell motility)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0072560"(type B pancreatic cell maturation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000078"(positive regulation of type B pancreatic cell development)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR007668(RFX1 transcription activation region)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ZaJnW0P0U9zhzPKADzUpbtwJptI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BRJ2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2514313|ensembl:ENSP00000483030|uniprotkb:Q6ZMJ5|uniprotkb:A1L436	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rm45_human(display_long)|uniprotkb:MRPL45(gene name)|psi-mi:MRPL45(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL45(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000277936(gene)|ensembl:ENST00000621878(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR032710|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|dip:DIP-53786N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:9NtO1r7W7U9BW3vB9RTRbwehBZ49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UIF9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-934890|uniprotkb:O00536|uniprotkb:O15030|uniprotkb:Q96H26|uniprotkb:B3KN66|uniprotkb:Q68DI8|ensembl:ENSP00000446880	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:baz2a_human(display_long)|uniprotkb:BAZ2A(gene name)|psi-mi:BAZ2A(display_short)|uniprotkb:KIAA0314(gene name synonym)|uniprotkb:TIP5(gene name synonym)|uniprotkb:Transcription termination factor I-interacting protein 5(gene name synonym)|uniprotkb:hWALp3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_038477.2|ensembl:ENSG00000076108(gene)|ensembl:ENST00000551812(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0042393"(histone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070577"(lysine-acetylated histone binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017956|interpro:IPR018359|interpro:IPR018501|interpro:IPR019787|interpro:IPR028940|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037374|mint:Q9UIF9|rcsb pdb:4LZ2|rcsb pdb:4Q6F|rcsb pdb:4QBM|rcsb pdb:4QF2|rcsb pdb:5AGQ|rcsb pdb:5MGJ|rcsb pdb:5MGK|rcsb pdb:5MGL|rcsb pdb:5MGM|rcsb pdb:5OR8|rcsb pdb:5T8R|rcsb pdb:6FAP|rcsb pdb:6FG6|rcsb pdb:6FGF|rcsb pdb:6FGG|rcsb pdb:6FGH|rcsb pdb:6FGI|rcsb pdb:6FGL|rcsb pdb:6FGV|rcsb pdb:6FGW|rcsb pdb:6FHU|rcsb pdb:6FI0|rcsb pdb:6FKP|reactome:R-HSA-427413	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:KfCpUyqOdz/VMjAKhvKyV9Ft1vs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WXE1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-747353|uniprotkb:Q8NHQ2|uniprotkb:Q8WUG7|uniprotkb:Q96CL3|uniprotkb:Q9HA30|uniprotkb:A8K6A3|uniprotkb:A8K714|uniprotkb:B2RCE7|uniprotkb:Q69YK9|uniprotkb:B4DU92|uniprotkb:B5MEB7|ensembl:ENSP00000323099	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:atrip_human(display_long)|uniprotkb:ATM and Rad3-related-interacting protein(gene name synonym)|uniprotkb:ATRIP(gene name)|psi-mi:ATRIP(display_short)|uniprotkb:AGS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_115542.2|refseq:NP_569055.1|dip:DIP-46495N|refseq:NP_001257951.1|refseq:NP_001257952.1|ensembl:ENSG00000164053(gene)|ensembl:ENST00000320211(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR033349|mint:Q8WXE1|rcsb pdb:4IGK|rcsb pdb:4NB3|rcsb pdb:5YZ0|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-69473	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:VVllxHySIT6EGlT6SQhPePAXbsI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H5Q4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1043912|ensembl:ENSP00000355471|uniprotkb:Q9H626	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tfb2m_human(display_long)|uniprotkb:TFB2M(gene name)|psi-mi:TFB2M(display_short)|uniprotkb:NS5ATP5(gene name synonym)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2"(gene name synonym)|uniprotkb:Mitochondrial 12S rRNA dimethylase 2(gene name synonym)|uniprotkb:Mitochondrial transcription factor B2(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071761.1|ensembl:ENST00000366514(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006391"(transcription initiation from mitochondrial promoter)|go:"GO:0031167"(rRNA methylation)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR016861(Mitochondrial dimethyladenosine transferase 2, mitochondrial precursor)|interpro:IPR020598|interpro:IPR029063|mint:Q9H5Q4|rcsb pdb:6ERO|rcsb pdb:6ERP|rcsb pdb:6ERQ|reactome:R-HSA-163282|reactome:R-HSA-2151201|ensembl:ENSG00000162851(gene)|dip:DIP-50540N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:qg7FnDzaxjvzpH+KxQFk52NyvUI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y4A0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2839089|uniprotkb:B2RAJ3|uniprotkb:Q32MC2|uniprotkb:A8K3G4|ensembl:ENSP00000333350	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:jerkl_human(display_long)|uniprotkb:JRKL(gene name)|psi-mi:JRKL(display_short)|uniprotkb:Human homolog of mouse jerky gene protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003763.2|refseq:NP_001248762.1|ensembl:ENSG00000183340(gene)|ensembl:ENST00000332349(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007417"(central nervous system development)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)|interpro:IPR036397	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:eQHO3dbR/7Qa+KtcIXPLI9kfw4I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96JC1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P19447	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14566	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q16656	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2547810|ensembl:ENSP00000223190|ensembl:ENSP00000376922|ensembl:ENSP00000376924|uniprotkb:Q15305|uniprotkb:A8K4C6|uniprotkb:B4DDV6|uniprotkb:Q96AN2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nrf1_human(display_long)|uniprotkb:NRF1(gene name)|psi-mi:NRF1(display_short)|uniprotkb:Alpha palindromic-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000106459(gene)|ensembl:ENST00000223190(transcript)|ensembl:ENST00000393230(transcript)|ensembl:ENST00000393232(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019525|interpro:IPR019526|interpro:IPR039142|reactome:R-HSA-1989781|reactome:R-HSA-2151201|go:"GO:0005634"(nucleus)|refseq:NP_001280092.1|refseq:NP_001280093.1|refseq:NP_001035199.1|refseq:NP_005002.3|dip:DIP-56958N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:QvOptENwVbP2E1Z8ExTOmbx00NE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P62906	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356860|uniprotkb:P52859|uniprotkb:P53025|uniprotkb:Q5TZT6|uniprotkb:Q8J013|uniprotkb:B2R801|ensembl:ENSP00000363018	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl10a_human(display_long)|uniprotkb:RPL10A(gene name)|psi-mi:RPL10A(display_short)|uniprotkb:NEDD6(gene name synonym)|uniprotkb:CSA-19(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 6(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_009035.3|ensembl:ENSG00000198755(gene)|ensembl:ENST00000322203(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|mint:P62906|rcsb pdb:4UG0|rcsb pdb:4V6X|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8|rcsb pdb:6OLG|rcsb pdb:6QZP|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6PK04	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-714654|ensembl:ENSP00000329360|ensembl:ENSP00000458884	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cc137_human(display_long)|uniprotkb:CCDC137(gene name)|psi-mi:CCDC137(display_short)|uniprotkb:cPERP-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_954981.1|ensembl:ENSG00000185298(gene)|ensembl:ENST00000329214(transcript)|ensembl:ENST00000575223(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|interpro:IPR026680|mint:Q6PK04	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:e64Y/4oJpFqmYZEO1lOUHeLwy0I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q53GS9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:AMLhskNenuv+zqXSa7VesSbbVK89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BWJ5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2555428|uniprotkb:Q7RTV1|uniprotkb:B2R568|ensembl:ENSP00000356541	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sf3b5_human(display_long)|uniprotkb:SF3B10(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 10 kDa subunit(gene name synonym)|uniprotkb:SF3B5(gene name)|psi-mi:SF3B5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_112577.1|ensembl:ENSG00000169976(gene)|ensembl:ENST00000367569(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR009846(Splicing factor 3B subunit 5/RDS3 complex subunit 10)|interpro:IPR017089(Splicing factor 3B, subunit 5)|mint:Q9BWJ5|rcsb pdb:5IFE|rcsb pdb:5O9Z|rcsb pdb:5Z56|rcsb pdb:5Z58|rcsb pdb:5ZYA|rcsb pdb:6AH0|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5Z57	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wuQBsSytGhSg64IQSmEJXe+26zQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96MW7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-9091586|uniprotkb:Q6PIF9|uniprotkb:Q6P4D2|ensembl:ENSP00000386186	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tigd1_human(display_long)|uniprotkb:TIGD1(gene name)|psi-mi:TIGD1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_663748.1|dip:DIP-61581N|ensembl:ENSG00000221944(gene)|ensembl:ENST00000408957(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)|interpro:IPR036397	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:tqCmDv+EG6oT8f6QQfrNJKjMeGg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6UB35	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1046835|intact:EBI-28986171|ensembl:ENSP00000356290|uniprotkb:Q2TBF3|uniprotkb:Q8WVW0|uniprotkb:Q96HG8|uniprotkb:Q9H789|uniprotkb:Q9UFU8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:c1tm_human(display_long)|uniprotkb:MTHFD1L(gene name)|psi-mi:MTHFD1L(display_short)|uniprotkb:FTHFSDC1(gene name synonym)|uniprotkb:Formyltetrahydrofolate synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000120254(gene)|ensembl:ENST00000367321(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006760"(folic acid-containing compound metabolic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0015942"(formate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR027417|interpro:IPR036291|reactome:R-HSA-196757|refseq:NP_001229696.1|refseq:NP_001229697.1|refseq:NP_001229698.1|refseq:NP_056255.2|ensembl:ENST00000367307|ensembl:ENSP00000356276|ensembl:ENSP00000356290	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:lJRND1kcMEF99+fT1b+X8hfuLHM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96I25	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-740272|uniprotkb:Q96GY6|ensembl:ENSP00000369218|ensembl:ENSP00000388638	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spf45_human(display_long)|uniprotkb:45 kDa-splicing factor(gene name synonym)|uniprotkb:RNA-binding motif protein 17(gene name synonym)|uniprotkb:RBM17(gene name)|psi-mi:RBM17(display_short)|uniprotkb:SPF45(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001139019.1|refseq:NP_116294.1|ensembl:ENSG00000134453(gene)|ensembl:ENST00000379888(transcript)|ensembl:ENST00000446108(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0043484"(regulation of RNA splicing)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034653|interpro:IPR035979|interpro:IPR040052|mint:Q96I25|rcsb pdb:2PE8|rcsb pdb:2PEH|rcsb pdb:5LSO|rcsb pdb:6HIP|reactome:R-HSA-72163|dip:DIP-29409N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Vhyfu0XQEzUpy7smEsSHj1s5O+49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O60563	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q93096	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1058467|uniprotkb:O00648|uniprotkb:Q49A54|uniprotkb:B2R6C8|intact:EBI-1640492|ensembl:ENSP00000485687|ensembl:ENSP00000497588|ensembl:ENSP00000500859|ensembl:ENSP00000500952	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tp4a1_human(display_long)|uniprotkb:PTP4A1(gene name)|psi-mi:PTP4A1(display_short)|uniprotkb:PRL1(gene name synonym)|uniprotkb:PTPCAAX1(gene name synonym)|uniprotkb:"PTP(CAAXI)"(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 4a1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase of regenerating liver 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003454.1|ensembl:ENSG00000112245(gene)|ensembl:ENST00000626021(transcript)|ensembl:ENST00000648894(transcript)|ensembl:ENST00000672924(transcript)|ensembl:ENST00000673199(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1RXD|rcsb pdb:1XM2|rcsb pdb:5BX1|refseq:XP_016866759.1|refseq:XP_016866760.1|refseq:XP_011534413.1|refseq:XP_011534414.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Eza5NsYNd+5ml6QEEmkQv5pAZ789606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WUB8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-716462|uniprotkb:Q2YDA3|uniprotkb:Q9BXD2|uniprotkb:Q53HG8|uniprotkb:Q9NV26|ensembl:ENSP00000341805	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:phf10_human(display_long)|uniprotkb:XAP135(gene name synonym)|uniprotkb:PHF10(gene name)|psi-mi:PHF10(display_short)|uniprotkb:BAF45A(gene name synonym)|uniprotkb:BRG1-associated factor 45a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060758.2|refseq:NP_579866.2|ensembl:ENSG00000130024(gene)|ensembl:ENST00000339209(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0071564"(npBAF complex)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR038045|mint:Q8WUB8	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:QppOFkomM0Lm/7EjW4Fov8NhB049606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:A6NIE6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-20562335	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rn3p2_human(display_long)|uniprotkb:RNA polymerase I transcription factor homolog pseudogene 2(gene name synonym)|uniprotkb:RRN3P2(gene name)|psi-mi:RRN3P2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|interpro:IPR007991(RNA polymerase I specific transcription initiation factor RRN3)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:folZeXEMkhwupRFnHyVWCYQUDrs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q969S2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-10281234|uniprotkb:Q8N842|uniprotkb:Q7Z3Q7|uniprotkb:Q8NG52|uniprotkb:B4DFR7|ensembl:ENSP00000284503|ensembl:ENSP00000394023|ensembl:ENSP00000397538	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:neil2_human(display_long)|uniprotkb:NEIL2(gene name)|psi-mi:NEIL2(display_short)|uniprotkb:DNA glycosylase/AP lyase Neil2(gene name synonym)|uniprotkb:"DNA-(apurinic or apyrimidinic site) lyase Neil2"(gene name synonym)|uniprotkb:Endonuclease VIII-like 2(gene name synonym)|uniprotkb:Nei homolog 2(gene name synonym)|uniprotkb:Nei-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001129218.1|refseq:NP_001129219.1|refseq:NP_001129220.1|refseq:NP_659480.1|refseq:XP_005272439.1|refseq:XP_005272440.1|ensembl:ENSG00000154328(gene)|ensembl:ENST00000284503(transcript)|ensembl:ENST00000436750(transcript)|ensembl:ENST00000455213(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045008"(depyrimidination)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|interpro:IPR000214(DNA glycosylase/AP lyase, zinc finger domain)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR012319(DNA glycosylase/AP lyase, catalytic domain)|interpro:IPR015886(DNA glycosylase/AP lyase, H2TH DNA-binding)|rcsb pdb:1VZP|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-5649702|refseq:XP_016868790.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:bWAqzKuu40UonYnDe4ASEOjCtwQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UQB8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13769	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5280316|uniprotkb:O60839|uniprotkb:Q9UPZ5|ensembl:ENSP00000380969|ensembl:ENSP00000380970|ensembl:ENSP00000380971|ensembl:ENSP00000420306	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:thoc5_human(display_long)|uniprotkb:THOC5(gene name)|psi-mi:THOC5(display_short)|uniprotkb:C22orf19(gene name synonym)|uniprotkb:KIAA0983(gene name synonym)|uniprotkb:Functional spliceosome-associated protein 79(gene name synonym)|uniprotkb:NF2/meningioma region protein pK1.3(gene name synonym)|uniprotkb:Placental protein 39.2(gene name synonym)|uniprotkb:hTREX90(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001002877.1|refseq:NP_001002878.1|refseq:NP_001002879.1|refseq:NP_003669.4|ensembl:ENSG00000100296(gene)|ensembl:ENST00000397871(transcript)|ensembl:ENST00000397872(transcript)|ensembl:ENST00000397873(transcript)|ensembl:ENST00000490103(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0000347"(THO complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0060215"(primitive hemopoiesis)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|interpro:IPR019163|mint:Q13769|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:JoeUa2WhtV/dR2HSjUEBAHDZZtw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13123	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P31151	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-357520|uniprotkb:Q6FGE3|uniprotkb:Q5SY67|uniprotkb:Q9H1E2|ensembl:ENSP00000357711|ensembl:ENSP00000357712	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:s10a7_human(display_long)|uniprotkb:S100A7(gene name)|psi-mi:S100A7(display_short)|uniprotkb:PSOR1(gene name synonym)|uniprotkb:S100A7C(gene name synonym)|uniprotkb:S100 calcium-binding protein A7(gene name synonym)|uniprotkb:Psoriasin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000143556(gene)|ensembl:ENST00000368722(transcript)|ensembl:ENST00000368723(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008544"(epidermis development)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051238"(sequestering of metal ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028477|interpro:IPR034325|mint:P31151|rcsb pdb:1PSR|rcsb pdb:2PSR|rcsb pdb:2WND|rcsb pdb:2WOR|rcsb pdb:2WOS|rcsb pdb:3PSR|rcsb pdb:4AQJ|reactome:R-HSA-6798695|reactome:R-HSA-6799990|refseq:NP_002954.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/v8+XQ7rCMTYzq9k/KqjcSm/G0A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96PV6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-739546|intact:EBI-954056|uniprotkb:Q8NCX6|uniprotkb:Q8IZ27|uniprotkb:B0VJY9|intact:EBI-28984630|ensembl:ENSP00000318374|ensembl:ENSP00000478337|ensembl:ENSP00000478975|ensembl:ENSP00000480663|uniprotkb:A0A087WTE7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:leng8_human(display_long)|uniprotkb:LENG8(gene name)|psi-mi:LENG8(display_short)|uniprotkb:KIAA1932(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_443157.1|ensembl:ENSG00000167615(gene)|ensembl:ENSG00000274305(gene)|ensembl:ENSG00000276458(gene)|ensembl:ENSG00000276681(gene)|ensembl:ENST00000326764(transcript)|ensembl:ENST00000617180(transcript)|ensembl:ENST00000621306(transcript)|ensembl:ENST00000622672(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR005062(SAC3/GANP/Nin1/mts3/eIF-3 p25)|mint:Q96PV6|ensembl:ENSP00000318374|ensembl:ENST00000610314|ensembl:ENSP00000484494|ensembl:ENST00000611866|ensembl:ENSP00000479293|ensembl:ENST00000616932|ensembl:ENSP00000477813|ensembl:ENSP00000480663|ensembl:ENST00000617420|ensembl:ENSP00000481040|ensembl:ENSP00000478337|ensembl:ENSP00000478975|refseq:XP_011524717.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:kwgKuV5NW0hITukndsYeyQHTdd09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75529	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1785876|uniprotkb:Q8IW31|uniprotkb:Q5TDI6|uniprotkb:Q5TDI5|ensembl:ENSP00000258281	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:taf5l_human(display_long)|uniprotkb:TAF5L(gene name)|psi-mi:TAF5L(display_short)|uniprotkb:PAF65B(gene name synonym)|uniprotkb:PCAF-associated factor 65 beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001020418.1|refseq:NP_055224.1|refseq:XP_005273156.1|dip:DIP-28147N|ensembl:ENSG00000135801(gene)|ensembl:ENST00000258281(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|interpro:IPR001680(WD40 repeat)|interpro:IPR007582(WD40 associated region in TFIID subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037264|interpro:IPR037783|interpro:IPR037826|mint:O75529|reactome:R-HSA-3214847	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3D2y64CWMvwok3BvV2CpH6iX84E9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UJX2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396137|uniprotkb:O75433|uniprotkb:Q9BS73|uniprotkb:B4E3A2|uniprotkb:B7WP05|uniprotkb:Q53FN2|uniprotkb:A8K6E5|uniprotkb:D3DQB7|ensembl:ENSP00000378350	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cdc23_human(display_long)|uniprotkb:CDC23(gene name)|psi-mi:CDC23(display_short)|uniprotkb:ANAPC8(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 8(gene name synonym)|uniprotkb:Cyclosome subunit 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004652.2|dip:DIP-32959N|ensembl:ENSG00000094880(gene)|ensembl:ENST00000394886(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR007192(Cdc23)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX2|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:uTZL2UHzZHLoKnio/1LcuSzZpW09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96JP5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1052613|uniprotkb:Q86V47|uniprotkb:Q96JP4|uniprotkb:Q96QA3|uniprotkb:A6NHC4|uniprotkb:A8MSG7|ensembl:ENSP00000339030	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zfp91_human(display_long)|uniprotkb:ZFP91(gene name)|psi-mi:ZFP91(display_short)|uniprotkb:FKSG11(orf name)|uniprotkb:ZNF757(gene name synonym)|uniprotkb:Zinc finger protein 757(gene name synonym)|uniprotkb:Zinc finger protein 91 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZFP91(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001183980.1|refseq:NP_444251.1|ensembl:ENSG00000186660(gene)|ensembl:ENST00000316059(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q96JP5|rcsb pdb:2M9A|go:"GO:0004842"(ubiquitin-protein transferase activity)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:oQuzxnamj/z05P/rG8EXnXTjzz89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15022	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1264675|uniprotkb:Q96BD9|ensembl:ENSP00000316578	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:suz12_human(display_long)|uniprotkb:CHET9(gene name synonym)|uniprotkb:JJAZ1(gene name synonym)|uniprotkb:KIAA0160(gene name synonym)|uniprotkb:SUZ12(gene name)|psi-mi:SUZ12(display_short)|uniprotkb:Suppressor of zeste 12 protein homolog(gene name synonym)|uniprotkb:Joined to JAZF1 protein(gene name synonym)|uniprotkb:Chromatin precipitated E2F target 9 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	dip:DIP-38524N|refseq:NP_056170.2|ensembl:ENSG00000178691(gene)|ensembl:ENST00000322652(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0021510"(spinal cord development)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0098532"(histone H3-K27 trimethylation)|interpro:IPR019135|mint:Q15022|go:"GO:0031490"(chromatin DNA binding)|rcsb pdb:4W2R|rcsb pdb:5HYN|rcsb pdb:5IJ7|rcsb pdb:5IJ8|rcsb pdb:5LS6|rcsb pdb:5WAI|rcsb pdb:5WAK|rcsb pdb:5WG6|rcsb pdb:6B3W|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6NQ3|rcsb pdb:6WKR|rcsb pdb:7AT8|rcsb pdb:7KSO|rcsb pdb:7KSR|rcsb pdb:7KTP|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214841|reactome:R-HSA-4551638|reactome:R-HSA-5617472|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9710421	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7jhDQNr4267eYuG9wRUpTfGgT2g9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49454	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-968343|ensembl:ENSP00000355922|uniprotkb:Q13171|uniprotkb:Q13246|uniprotkb:Q5VVM7|intact:EBI-2563723|intact:EBI-21028103	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cenpf_human(display_long)|uniprotkb:CENPF(gene name)|psi-mi:CENPF(display_short)|uniprotkb:Kinetochore protein CENPF(gene name synonym)|uniprotkb:Mitosin(gene name synonym)|uniprotkb:AH antigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007517"(muscle organ development)|ensembl:ENSG00000117724(gene)|ensembl:ENST00000366955(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0001822"(kidney development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0042493"|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR018302|interpro:IPR018463|interpro:IPR019513|interpro:IPR043513|mint:P49454|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-156711|refseq:NP_057427.3|refseq:XP_016855575.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:gPlJiOCF1/MAVT80oKwlQlLgluo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P32969	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358122|ensembl:ENSP00000346022|ensembl:ENSP00000400467|ensembl:ENSP00000494697	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl9_human(display_long)|uniprotkb:RPL9(gene name)|psi-mi:RPL9(display_short)|uniprotkb:RPL9P7(gene name)|psi-mi:RPL9P7(display_short)|uniprotkb:RPL9P8(gene name)|psi-mi:RPL9P8(display_short)|uniprotkb:RPL9P9(gene name)|psi-mi:RPL9P9(display_short)|uniprotkb:Large ribosomal subunit protein uL6(gene name synonym)|uniprotkb:OK/SW-cl.103(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000652.2|refseq:NP_001020092.1|ensembl:ENSG00000163682(gene)|ensembl:ENST00000295955(transcript)|ensembl:ENST00000449470(transcript)|ensembl:ENST00000645496(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|mint:P32969|rcsb pdb:2CQL|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:v0thFydYo0aEqBblJoqQX8b7JCA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y5B6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2557602|uniprotkb:Q9NYQ0|uniprotkb:Q96DU8|uniprotkb:D3DSE7|ensembl:ENSP00000328992|ensembl:ENSP00000458262|ensembl:ENSP00000458892	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:paxb1_human(display_long)|uniprotkb:PAXBP1(gene name)|psi-mi:PAXBP1(display_short)|uniprotkb:C21orf66(gene name synonym)|uniprotkb:GC-rich sequence DNA-binding factor 1(gene name synonym)|uniprotkb:GCFC(gene name synonym)|uniprotkb:GCFC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_037461.2|refseq:NP_057715.2|ensembl:ENSG00000159086(gene)|ensembl:ENSG00000263141(gene)|ensembl:ENST00000331923(transcript)|ensembl:ENST00000573680(transcript)|ensembl:ENST00000574159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000288"(positive regulation of myoblast proliferation)|interpro:IPR012890(GC-rich sequence DNA-binding factor-like)|interpro:IPR022783	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:SYrCt+PvgtLbYgHiN2ZP7yPEnIk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q12874	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:fNjNguUOXqApr46rOAEpTs2geqY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P61604	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-711483|uniprotkb:O95421|uniprotkb:Q04984|uniprotkb:Q53X54|ensembl:ENSP00000233893|uniprotkb:Q9UDH0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ch10_human(display_long)|uniprotkb:HSPE1(gene name)|psi-mi:HSPE1(display_short)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:Early-pregnancy factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR020818|interpro:IPR037124|mint:P61604|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|reactome:R-HSA-9013408|ensembl:ENSG00000115541(gene)|ensembl:ENST00000233893(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011032(GroES-like)|interpro:IPR018369|refseq:NP_002148.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BmnGoMnA2QIr3Dr0fElMtTgRztA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P48594	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1055490|uniprotkb:A8K847|ensembl:ENSP00000343445	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:spb4_human(display_long)|uniprotkb:Squamous cell carcinoma antigen 2(gene name synonym)|uniprotkb:Leupin(gene name synonym)|uniprotkb:SERPINB4(gene name)|psi-mi:SERPINB4(display_short)|uniprotkb:SCCA2(gene name synonym)|uniprotkb:PI11(gene name synonym)|uniprotkb:Peptidase inhibitor 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_778206.1|refseq:NP_002965.1|refseq:XP_011524440.1|ensembl:ENSG00000206073(gene)|ensembl:ENST00000341074(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042185|mint:P48594|interpro:IPR042178	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:1kO3L409kom3vIvMuAuBuGZhiH89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q14444	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1047080|uniprotkb:Q15074|intact:EBI-1171814|uniprotkb:Q6IMN4|uniprotkb:A6NMY7|uniprotkb:Q6IMN7|uniprotkb:Q9BV09|intact:EBI-2562858|intact:EBI-3449178|uniprotkb:D3DR06|ensembl:ENSP00000340329|ensembl:ENSP00000434150	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:capr1_human(display_long)|uniprotkb:CAPRIN1(gene name)|psi-mi:CAPRIN1(display_short)|uniprotkb:GPIAP1(gene name synonym)|uniprotkb:GPIP137(gene name synonym)|uniprotkb:M11S1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Cell cycle-associated protein 1(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:RNG105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005889.3|refseq:NP_976240.1|ensembl:ENSG00000135387(gene)|ensembl:ENST00000341394(transcript)|ensembl:ENST00000532820(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q14444|rcsb pdb:4WBE|rcsb pdb:4WBP|rcsb pdb:6TA7|refseq:XP_016873238.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3c6ZdBClP/D6jIi8NfzBkMc61pI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H4H8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2556127|uniprotkb:B4E1I7|uniprotkb:Q9BVM8|uniprotkb:Q96DF5|uniprotkb:Q6P457|uniprotkb:Q5THR2|uniprotkb:Q68EN1|uniprotkb:Q7Z6H0|uniprotkb:Q96N89|ensembl:ENSP00000481465	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fa83d_human(display_long)|uniprotkb:C20orf129(gene name synonym)|uniprotkb:Spindle protein CHICA(gene name synonym)|uniprotkb:FAM83D(gene name)|psi-mi:FAM83D(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000101447(gene)|ensembl:ENST00000619850(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1902480"(protein localization to mitotic spindle)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR012461(Protein of unknown function DUF1669)|mint:Q9H4H8|rcsb pdb:5E0L|rcsb pdb:5E0M|refseq:NP_112181.3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:tD2KUDcvOurIb+8BZXc+h04jnEs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P27482	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-747537|uniprotkb:Q5SQI4|uniprotkb:B2R9V6|ensembl:ENSP00000315299	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:call3_human(display_long)|uniprotkb:Calmodulin-related protein NB-1(gene name synonym)|uniprotkb:CaM-like protein(gene name synonym)|uniprotkb:CALML3(gene name)|psi-mi:CALML3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005176.1|ensembl:ENSG00000178363(gene)|ensembl:ENST00000315238(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P27482|rcsb pdb:1GGZ	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7yRRBYvsbUxzIvnYaNmaIJ42i5Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NP72	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722247|uniprotkb:Q53FX8|uniprotkb:Q6FIH1|uniprotkb:B3KMC7|uniprotkb:D3DRW1|intact:EBI-2859793|uniprotkb:Q56UN9|uniprotkb:B7Z333|ensembl:ENSP00000349415|ensembl:ENSP00000507542	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rab18_human(display_long)|uniprotkb:RAB18(gene name)|psi-mi:RAB18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_067075.1|refseq:NP_001243339.1|refseq:NP_001243340.1|refseq:NP_001243341.1|refseq:NP_001243344.1|dip:DIP-60514N|ensembl:ENSG00000099246(gene)|ensembl:ENST00000356940(transcript)|ensembl:ENST00000682082(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|mint:Q9NP72|rcsb pdb:1X3S|reactome:R-HSA-6798695|reactome:R-HSA-6811436|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:xw6DaP3FsJo34UZC/jqjJEWfSeg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13492	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2803688|uniprotkb:Q86XZ9|uniprotkb:O60700|uniprotkb:Q6GMQ6|intact:EBI-28967113|ensembl:ENSP00000377015|uniprotkb:B4DTM3|uniprotkb:E9PN05|uniprotkb:F8VPG7|uniprotkb:Q4LE54	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pical_human(display_long)|uniprotkb:CALM(gene name synonym)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:PICALM(gene name)|psi-mi:PICALM(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000356360|ensembl:ENSP00000348718|ensembl:ENSP00000377015|ensembl:ENST00000526033|ensembl:ENSP00000433846|ensembl:ENST00000528398|ensembl:ENSP00000434884|ensembl:ENST00000532317|ensembl:ENSP00000436958|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0005634"(nucleus)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q13492|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9696264|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0032050"(clathrin heavy chain binding)|ensembl:ENSG00000073921(gene)|ensembl:ENST00000393346(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:0055072"(iron ion homeostasis)|refseq:NP_001008660.1|refseq:NP_001193875.1|refseq:NP_001193876.1|refseq:NP_009097.2|refseq:XP_005274388.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:UIZhYyYqmBCyN4xwPCl9PeCdK8Q9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O00410	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P35637	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P62241	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-351811|uniprotkb:Q6IRL7|uniprotkb:P09058|ensembl:ENSP00000379888	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rs8_human(display_long)|uniprotkb:RPS8(gene name)|psi-mi:RPS8(display_short)|uniprotkb:Small ribosomal subunit protein eS8(gene name synonym)|uniprotkb:OK/SW-cl.83(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001003.1|ensembl:ENSG00000142937(gene)|ensembl:ENST00000396651(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|mint:P62241|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:6G5H|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975957|reactome:R-HSA-975956	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3rpCBdQyRWR+TCKnupbnCp30jKE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NQZ2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-714067|uniprotkb:Q6FI82|ensembl:ENSP00000254803	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:sas10_human(display_long)|uniprotkb:CRLZ1(gene name synonym)|uniprotkb:Disrupter of silencing SAS10(gene name synonym)|uniprotkb:UTP3 homolog(gene name synonym)|uniprotkb:Charged amino acid-rich leucine zipper 1(gene name synonym)|uniprotkb:UTP3(gene name)|psi-mi:UTP3(display_short)|uniprotkb:SAS10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000132467(gene)|ensembl:ENST00000254803(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0007420"(brain development)|go:"GO:0032040"(small-subunit processome)|interpro:IPR007146(Small-subunit processome, Utp3)|interpro:IPR018972|mint:Q9NQZ2|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_065101.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jfZVDuLFaOgL/g/mUSMktGbsVhQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9P0U4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-949911|ensembl:ENSP00000285106|uniprotkb:Q8N2W4|uniprotkb:Q96BC8|uniprotkb:Q9P2V7|uniprotkb:B2RC03	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:cxxc1_human(display_long)|uniprotkb:CFP1(gene name synonym)|uniprotkb:PHD finger and CXXC domain-containing protein 1(gene name synonym)|uniprotkb:CXXC1(gene name)|psi-mi:CXXC1(display_short)|uniprotkb:CGBP(gene name synonym)|uniprotkb:PCCX1(gene name synonym)|uniprotkb:PHF18(gene name synonym)|uniprotkb:CpG-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000154832(gene)|ensembl:ENST00000285106(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|reactome:R-HSA-381038|interpro:IPR022056|interpro:IPR037869|mint:Q9P0U4|rcsb pdb:3QMB|rcsb pdb:3QMC|rcsb pdb:3QMD|rcsb pdb:3QMG|rcsb pdb:3QMH|rcsb pdb:3QMI|refseq:NP_001095124.1|refseq:NP_055408.2|refseq:XP_011524242.1|refseq:XP_016881207.1|dip:DIP-50001N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nWwPX7OlafdCMD8Qg+hETjNkKgY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P36776	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BTC0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-739985|uniprotkb:O15043|uniprotkb:A8MY65|uniprotkb:Q3ZTL7|uniprotkb:Q3ZTL8|uniprotkb:Q4VXS1|uniprotkb:Q4VXS2|uniprotkb:Q4VXV8|uniprotkb:Q96D72|uniprotkb:Q9BQW0|uniprotkb:Q9BW03|uniprotkb:Q9H4G6|uniprotkb:Q9H4G7|uniprotkb:Q9NTU8|uniprotkb:Q9NUM8|uniprotkb:Q9UFB6|uniprotkb:B9EH82|uniprotkb:Q4VXV9|uniprotkb:E1P5I1|intact:EBI-28975591|ensembl:ENSP00000266070|ensembl:ENSP00000378752	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:dido1_human(display_long)|uniprotkb:DIDO1(gene name)|psi-mi:DIDO1(display_short)|uniprotkb:Death-associated transcription factor 1(gene name synonym)|uniprotkb:C20orf158(gene name synonym)|uniprotkb:DATF1(gene name synonym)|uniprotkb:KIAA0333(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000266070|ensembl:ENST00000354665|ensembl:ENSP00000346692|ensembl:ENST00000370366|ensembl:ENSP00000359391|ensembl:ENST00000370368|ensembl:ENSP00000359394|ensembl:ENST00000370371|ensembl:ENSP00000359397|ensembl:ENST00000395340|ensembl:ENSP00000378749|ensembl:ENSP00000378752|refseq:NP_001180298.1|refseq:NP_001180299.1|refseq:NP_071388.2|refseq:NP_149072.2|refseq:NP_542986.1|refseq:NP_542987.2|ensembl:ENSG00000101191(gene)|ensembl:ENST00000266070(transcript)|ensembl:ENST00000395343(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003618(Transcription elongation factor S-II, central region)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR033082|interpro:IPR036575|mint:Q9BTC0|rcsb pdb:2M3H|rcsb pdb:4L7X|reactome:R-HSA-1221632|refseq:XP_011526811.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:xtp4cq/633PxqppXYlVvameuI7M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9HAN9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-3917542|uniprotkb:Q8TAE9|uniprotkb:Q9H6B6|uniprotkb:Q9H247|uniprotkb:B1AN63|ensembl:ENSP00000366410|ensembl:ENSP00000435134	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nmna1_human(display_long)|uniprotkb:NMNAT1(gene name)|psi-mi:NMNAT1(display_short)|uniprotkb:NMNAT(gene name synonym)|uniprotkb:Nicotinate-nucleotide adenylyltransferase 1(gene name synonym)|uniprotkb:Nicotinamide-nucleotide adenylyltransferase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001284707.1|refseq:NP_073624.2|ensembl:ENSG00000173614(gene)|ensembl:ENST00000377205(transcript)|ensembl:ENST00000462686(transcript)|go:"GO:0000309"(nicotinamide-nucleotide adenylyltransferase activity)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0009435"(NAD biosynthetic process)|go:"GO:0009611"(response to wounding)|go:"GO:0016604"(nuclear body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|interpro:IPR004821(Cytidyltransferase-related)|interpro:IPR005248(Probable nicotinate-nucleotide adenylyltransferase)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|mint:Q9HAN9|rcsb pdb:1GZU|rcsb pdb:1KKU|rcsb pdb:1KQN|rcsb pdb:1KQO|rcsb pdb:1KR2|reactome:R-HSA-196807|refseq:XP_016857596.1|dip:DIP-60881N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:KwV9lz04z3ptlVpKu3b534Yekpc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O94842	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99496	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722416|uniprotkb:Q5TEN1|uniprotkb:Q5TEN2|uniprotkb:B2RBS7|uniprotkb:B3KRH1|ensembl:ENSP00000356480	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ring2_human(display_long)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING finger protein BAP-1(gene name synonym)|uniprotkb:Protein DinG(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2-interacting protein 3(gene name synonym)|uniprotkb:RNF2(gene name)|psi-mi:RNF2(display_short)|uniprotkb:BAP1(gene name synonym)|uniprotkb:DING(gene name synonym)|uniprotkb:HIPI3(gene name synonym)|uniprotkb:RING1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_009143.1|refseq:XP_011508153.1|refseq:XP_011508154.1|dip:DIP-40034N|ensembl:ENSG00000121481(gene)|ensembl:ENST00000367510(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q99496|rcsb pdb:2H0D|rcsb pdb:3GS2|rcsb pdb:3H8H|rcsb pdb:3IXS|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:pqAjSEwOUdfuogKW6fodqsUSHIk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q86Y91	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-10965357|uniprotkb:A0A0C4DGP2|uniprotkb:A0A0C4DGP5|ensembl:ENSP00000465992|uniprotkb:A6NJI2|uniprotkb:D5L6I1|uniprotkb:B9EGM8|uniprotkb:B7ZM49	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ki18b_human(display_long)|uniprotkb:KIF18B(gene name)|psi-mi:KIF18B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001251503.1|refseq:NP_001252506.1|ensembl:ENSG00000186185(gene)|ensembl:ENST00000593135(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000235"(astral microtubule)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0019894"(kinesin binding)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0051301"(cell division)|go:"GO:0051302"(regulation of cell division)|go:"GO:0061673"(mitotic spindle astral microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990752"(microtubule end)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q86Y91|reactome:R-HSA-6811434|reactome:R-HSA-983189	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/0rTh9dAkPBM20+jP0Jc/xrNEx89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UBU9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-398874|uniprotkb:Q99799|uniprotkb:Q9UQL2|uniprotkb:B4E269|ensembl:ENSP00000436679|ensembl:ENSP00000294172	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nxf1_human(display_long)|uniprotkb:NXF1(gene name)|psi-mi:NXF1(display_short)|uniprotkb:TAP(gene name synonym)|uniprotkb:Tip-associating protein(gene name synonym)|uniprotkb:Tip-associated protein(gene name synonym)|uniprotkb:mRNA export factor TAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001074960.1|refseq:NP_006353.2|ensembl:ENSP00000294172|ensembl:ENST00000531709|ensembl:ENSP00000453885|ensembl:ENSP00000436679|dip:DIP-31789N|ensembl:ENST00000294172(transcript)|ensembl:ENST00000532297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0015031"(protein transport)|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042405"(nuclear inclusion body)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR005637(TAP, C-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015245(Tap, RNA-binding)|interpro:IPR018222|interpro:IPR030217|interpro:IPR032675|interpro:IPR032710|interpro:IPR035979|mint:Q9UBU9|rcsb pdb:1FO1|rcsb pdb:1FT8|rcsb pdb:1GO5|rcsb pdb:1JKG|rcsb pdb:1JN5|rcsb pdb:1KOH|rcsb pdb:1KOO|rcsb pdb:1OAI|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:3RW6|rcsb pdb:3RW7|rcsb pdb:4WYK|rcsb pdb:6E5U|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|ensembl:ENSG00000162231(gene)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:a983QBMgsm07FV/IcYsO37Sk0hU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NPI1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-711221|uniprotkb:Q4VC09|uniprotkb:Q8N2L9|uniprotkb:Q96KA4|uniprotkb:Q9BV48|uniprotkb:Q9UH59|intact:EBI-2560548|ensembl:ENSP00000378180	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:brd7_human(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Protein CELTIX-1(gene name synonym)|uniprotkb:BRD7(gene name)|psi-mi:BRD7(display_short)|uniprotkb:BP75(gene name synonym)|uniprotkb:CELTIX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001167455.1|refseq:NP_037395.2|dip:DIP-32509N|ensembl:ENSG00000166164(gene)|ensembl:ENST00000394688(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:Q9NPI1|rcsb pdb:2I7K|rcsb pdb:5MQ1|rcsb pdb:6PPA|rcsb pdb:6V0Q|rcsb pdb:6V16|rcsb pdb:6V17|rcsb pdb:6V1E|rcsb pdb:6V1F|rcsb pdb:6V1H|reactome:R-HSA-6804758	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:F1N3XsdbpPy8TgHdMLSmnhdKNYs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P78345	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366493|uniprotkb:Q53F71|uniprotkb:Q8NHS8|uniprotkb:B3KPY0|uniprotkb:D3DRT8|ensembl:ENSP00000367439|ensembl:ENSP00000367444|ensembl:ENSP00000367445|ensembl:ENSP00000478982	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpp38_human(display_long)|uniprotkb:RPP38(gene name)|psi-mi:RPP38(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001091059.1|refseq:NP_006405.2|refseq:NP_892117.1|refseq:NP_001252530.1|refseq:XP_011517595.1|ensembl:ENSG00000152464(gene)|ensembl:ENST00000378197(transcript)|ensembl:ENST00000378202(transcript)|ensembl:ENST00000378203(transcript)|ensembl:ENST00000616640(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR029064|interpro:IPR042848|rcsb pdb:6AHR|rcsb pdb:6AHU|reactome:R-HSA-6784531|reactome:R-HSA-6791226|refseq:XP_006717426.1|refseq:XP_006717427.1|refseq:XP_016870968.1|refseq:XP_016870969.1|refseq:XP_016870970.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:bXwC7yDxlK7pxJPKe79uhkVMBj09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UH17	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2967317|uniprotkb:O95618|uniprotkb:Q7Z6D6|uniprotkb:Q5IFJ4|uniprotkb:Q9UE74|uniprotkb:Q7Z2N3|uniprotkb:B0QYD2|uniprotkb:Q20WL1|ensembl:ENSP00000327459	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:abc3b_human(display_long)|uniprotkb:APOBEC3B(gene name)|psi-mi:APOBEC3B(display_short)|uniprotkb:Phorbolin-1-related protein(gene name synonym)|uniprotkb:Phorbolin-2/3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001257340.1|refseq:NP_004891.4|ensembl:ENSG00000179750(gene)|ensembl:ENST00000333467(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004126"(cytidine deaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016554"(cytidine to uridine editing)|go:"GO:0045087"(innate immune response)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0047844"(deoxycytidine deaminase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0070383"(DNA cytosine deamination)|go:"GO:0080111"(DNA demethylation)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|mint:Q9UH17|rcsb pdb:2NBQ|rcsb pdb:5CQD|rcsb pdb:5CQH|rcsb pdb:5CQI|rcsb pdb:5CQK|rcsb pdb:5SXG|rcsb pdb:5SXH|rcsb pdb:5TD5|rcsb pdb:5TKM|rcsb pdb:6NFK|rcsb pdb:6NFL|rcsb pdb:6NFM|reactome:R-HSA-72200|reactome:R-HSA-75094|go:"GO:0005634"(nucleus)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:EkvglCMEqq4MYpZfnTa21mmxTqs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UKL0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-926563|uniprotkb:Q15044|uniprotkb:Q6P2I9|uniprotkb:Q86VG5|intact:EBI-11087913|uniprotkb:J3KN32|ensembl:ENSP00000262241	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rcor1_human(display_long)|uniprotkb:RCOR1(gene name)|psi-mi:RCOR1(display_short)|uniprotkb:KIAA0071(gene name synonym)|uniprotkb:RCOR(gene name synonym)|uniprotkb:Protein CoREST(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055971.2|dip:DIP-35263N|ensembl:ENSG00000089902(gene)|ensembl:ENST00000262241(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|mint:Q9UKL0|rcsb pdb:2IW5|rcsb pdb:2UXN|rcsb pdb:2UXX|rcsb pdb:2V1D|rcsb pdb:2X0L|rcsb pdb:2XAF|rcsb pdb:2XAG|rcsb pdb:2XAH|rcsb pdb:2XAJ|rcsb pdb:2XAQ|rcsb pdb:2XAS|rcsb pdb:2Y48|rcsb pdb:3ZMS|rcsb pdb:3ZMT|rcsb pdb:3ZMU|rcsb pdb:3ZMV|rcsb pdb:3ZMZ|rcsb pdb:3ZN0|rcsb pdb:3ZN1|rcsb pdb:4BAY|rcsb pdb:4KUM|rcsb pdb:4UV8|rcsb pdb:4UV9|rcsb pdb:4UVA|rcsb pdb:4UVB|rcsb pdb:4UVC|rcsb pdb:4UXN|rcsb pdb:4XBF|rcsb pdb:5H6Q|rcsb pdb:5H6R|rcsb pdb:5L3B|rcsb pdb:5L3C|rcsb pdb:5L3D|rcsb pdb:5L3E|rcsb pdb:5L3F|rcsb pdb:5L3G|rcsb pdb:5LBQ|rcsb pdb:5LGN|rcsb pdb:5LGT|rcsb pdb:5LGU|rcsb pdb:5LHG|rcsb pdb:5LHH|rcsb pdb:5LHI|rcsb pdb:5X60|rcsb pdb:5YJB|rcsb pdb:6K3E|rcsb pdb:6KGK|rcsb pdb:6KGL|rcsb pdb:6KGM|rcsb pdb:6KGN|rcsb pdb:6S35|rcsb pdb:6TE1|rcsb pdb:6VYP|rcsb pdb:6W4K|rcsb pdb:6WC6|rcsb pdb:7CDC|rcsb pdb:7CDD|rcsb pdb:7CDE|rcsb pdb:7CDF|rcsb pdb:7CDG|reactome:R-HSA-3214815|reactome:R-HSA-8943724|reactome:R-HSA-9679191|reactome:R-HSA-983231	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:B1KfnjicGzKdWGnGGrZwjgpMQ309606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49711	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-932887|uniprotkb:Q53XI7|uniprotkb:B5MC38|uniprotkb:Q59EL8|ensembl:ENSP00000264010|ensembl:ENSP00000493495|ensembl:ENSP00000494408|ensembl:ENSP00000494538|ensembl:ENSP00000495348	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ctcf_human(display_long)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)|uniprotkb:CTCF(gene name)|psi-mi:CTCF(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006556.1|refseq:NP_001177951.1|refseq:XP_016878357.1|dip:DIP-35252N|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P49711|rcsb pdb:1X6H|rcsb pdb:2CT1|rcsb pdb:5K5H|rcsb pdb:5K5I|rcsb pdb:5K5J|rcsb pdb:5K5L|rcsb pdb:5KKQ|rcsb pdb:5T00|rcsb pdb:5T0U|rcsb pdb:5UND|rcsb pdb:5YEF|rcsb pdb:5YEG|rcsb pdb:5YEH|rcsb pdb:5YEL|rcsb pdb:6QNX|reactome:R-HSA-5617472|ensembl:ENSG00000102974(gene)|ensembl:ENST00000264010(transcript)|ensembl:ENST00000642819(transcript)|ensembl:ENST00000644753(transcript)|ensembl:ENST00000645699(transcript)|ensembl:ENST00000646076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hy9n/DVCzpfSi0EGigAjOZUvnIU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96FV9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1765605|uniprotkb:Q15219|uniprotkb:B2RBP6|uniprotkb:Q64I72|uniprotkb:Q64I73|intact:EBI-28984554|ensembl:ENSP00000261600	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:thoc1_human(display_long)|uniprotkb:hTREX84(gene name synonym)|uniprotkb:THOC1(gene name)|psi-mi:THOC1(display_short)|uniprotkb:HPR1(gene name synonym)|uniprotkb:Nuclear matrix protein p84(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005122.2|ensembl:ENSP00000261600|ensembl:ENSG00000079134(gene)|ensembl:ENST00000261600(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000346"(transcription export complex)|go:"GO:0000347"(THO complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0031297"(replication fork processing)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0048297"(negative regulation of isotype switching to IgA isotypes)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR021861|mint:Q96FV9|rcsb pdb:1WXP|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:D+lk5iFzcmd1bQRa2cx/nUyq4sI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5VZL5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2514659|intact:EBI-28984130|ensembl:ENSP00000322915|uniprotkb:A0JP19|uniprotkb:O43308|uniprotkb:A0JP20|uniprotkb:Q5T5E2|uniprotkb:Q7L3Q4|uniprotkb:Q5T5E1|intact:EBI-2556245	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zmym4_human(display_long)|uniprotkb:ZMYM4(gene name)|psi-mi:ZMYM4(display_short)|uniprotkb:KIAA0425(gene name synonym)|uniprotkb:ZNF262(gene name synonym)|uniprotkb:Zinc finger protein 262(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000146463(gene)|ensembl:ENST00000314607(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|refseq:XP_016858292.1|refseq:XP_016858293.1|refseq:XP_011540725.1|refseq:XP_011540727.1|refseq:NP_005086.2|ensembl:ENSP00000322915|refseq:XP_005271388.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:jc8YwR+37J3uD08cXiUnOA2hHEI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15554	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P82650	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1050752|ensembl:ENSP00000418008|ensembl:ENSP00000505414|uniprotkb:Q9H3I1	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rt22_human(display_long)|uniprotkb:MRPS22(gene name)|psi-mi:MRPS22(display_short)|uniprotkb:C3orf5(gene name synonym)|uniprotkb:RPMS22(gene name synonym)|uniprotkb:GK002(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein mS22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_064576.1|ensembl:ENSG00000175110(gene)|ensembl:ENST00000495075(transcript)|ensembl:ENST00000680020(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR019374|mint:P82650|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:T0htF4/rvOZUZ3RcuCjWvEg9iTE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P46939	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:metWqbqGtzonNZ1mgNjlFrenuI89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96PZ2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2870239|uniprotkb:Q5RKS9|uniprotkb:A8K5Y8|uniprotkb:Q68DK9|uniprotkb:Q5XKM2|uniprotkb:Q6IPR7|uniprotkb:Q9H5Y1|ensembl:ENSP00000355264|ensembl:ENSP00000406683|ensembl:ENSP00000431631|ensembl:ENSP00000432821|ensembl:ENSP00000433154|ensembl:ENSP00000434435|ensembl:ENSP00000436128|ensembl:ENSP00000501617|ensembl:ENSP00000501771|ensembl:ENSP00000501786|ensembl:ENSP00000501909|ensembl:ENSP00000502754|ensembl:ENSP00000507215|ensembl:ENSP00000501952	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:f111a_human(display_long)|uniprotkb:FAM111A(gene name)|psi-mi:FAM111A(display_short)|uniprotkb:KIAA1895(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001299838.1|refseq:NP_001299839.1|refseq:NP_001299840.1|refseq:NP_001135991.1|refseq:NP_001135992.1|refseq:NP_001135993.1|refseq:NP_071357.2|refseq:NP_942144.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006508"(proteolysis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008233"(peptidase activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0031297"(replication fork processing)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|ensembl:ENSG00000166801(gene)|ensembl:ENST00000361723(transcript)|ensembl:ENST00000420244(transcript)|ensembl:ENST00000527629(transcript)|ensembl:ENST00000528737(transcript)|ensembl:ENST00000529985(transcript)|ensembl:ENST00000531147(transcript)|ensembl:ENST00000531408(transcript)|ensembl:ENST00000533703(transcript)|ensembl:ENST00000674617(transcript)|ensembl:ENST00000675163(transcript)|ensembl:ENST00000675806(transcript)|ensembl:ENST00000676340(transcript)|ensembl:ENST00000676459(transcript)|ensembl:ENST00000682018(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0003697"(single-stranded DNA binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ZDxYb1745J5BeGQA6d1YOPxZDRA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8IVW6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-5458329|uniprotkb:O95443|uniprotkb:Q59HC9|uniprotkb:Q6P9C9|ensembl:ENSP00000477878	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ari3b_human(display_long)|uniprotkb:ARID3B(gene name)|psi-mi:ARID3B(display_short)|uniprotkb:BDP(gene name synonym)|uniprotkb:DRIL2(gene name synonym)|uniprotkb:Bright and dead ringer protein(gene name synonym)|uniprotkb:Bright-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001294868.1|refseq:NP_006456.1|ensembl:ENSG00000179361(gene)|ensembl:ENST00000622429(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR023334|mint:Q8IVW6|interpro:IPR036431	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wlZYnH9qjM7VzFUtrNLlqJhRXx49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99959	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-702235|intact:EBI-2692870|uniprotkb:D3DUW9|uniprotkb:Q99960|uniprotkb:Q4VC01|uniprotkb:B8QFA1|uniprotkb:B8QGS6|uniprotkb:B8QGS7|uniprotkb:A0AV37|ensembl:ENSP00000070846	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pkp2_human(display_long)|uniprotkb:PKP2(gene name)|psi-mi:PKP2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004563.2|refseq:NP_001005242.2|ensembl:ENSG00000057294(gene)|ensembl:ENST00000070846(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002159"(desmosome assembly)|go:"GO:0002934"(desmosome organization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|mint:Q99959|rcsb pdb:3TT9|reactome:R-HSA-6805567|reactome:R-HSA-6809371	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:kwGWMlk4SDz0xARlBMD1dY9fehQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15294	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-539828|uniprotkb:Q7Z3K0|uniprotkb:Q8WWM8|uniprotkb:Q96CC1|uniprotkb:Q9UG57|ensembl:ENSP00000362824	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ogt1_human(display_long)|uniprotkb:O-linked N-acetylglucosamine transferase 110 kDa subunit(gene name synonym)|uniprotkb:O-GlcNAc transferase subunit p110(gene name synonym)|uniprotkb:OGT(gene name)|psi-mi:OGT(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_858058.1|refseq:NP_858059.1|rcsb pdb:3PE3|rcsb pdb:3PE4|rcsb pdb:3TAX|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4CDR|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4GZ5|rcsb pdb:4GZ6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:1W3B|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:4XI9|rcsb pdb:4XIF|rcsb pdb:5BNW|rcsb pdb:5C1D|rcsb pdb:5HGV|rcsb pdb:5LVV|rcsb pdb:5LWV|rcsb pdb:5NPR|rcsb pdb:5NPS|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:6E37|rcsb pdb:6EOU|rcsb pdb:6IBO|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|rcsb pdb:6Q4M|rcsb pdb:6TKA|reactome:R-HSA-3214847|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-5689603|rcsb pdb:6MA1|ensembl:ENSG00000147162(gene)|ensembl:ENST00000373719(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016262"(protein N-acetylglucosaminyltransferase activity)|go:"GO:0016485"(protein processing)|go:"GO:0017122"(protein N-acetylglucosaminyltransferase complex)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097363"(protein O-GlcNAc transferase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR029489|interpro:IPR037919|mint:O15294|go:"GO:0042995"(cell projection)|refseq:XP_016885396.1|refseq:XP_016885397.1|dip:DIP-33491N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:NmuVFHeg1QRYMbVav6e7fRJft5U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P54198	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372342|uniprotkb:Q05BU9|uniprotkb:Q8IXN2|ensembl:ENSP00000263208	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hira_human(display_long)|uniprotkb:HIRA(gene name)|psi-mi:HIRA(display_short)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym)|uniprotkb:DGCR1(gene name synonym)|uniprotkb:HIR(gene name synonym)|uniprotkb:TUPLE1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003316.3|dip:DIP-29240N|ensembl:ENSG00000100084(gene)|ensembl:ENST00000263208(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:P54198|rcsb pdb:2I32|rcsb pdb:5YJE|reactome:R-HSA-2559584	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:en6l6z4CNWhF4Wlj5ou4DDTfETg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y3C6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2557649|uniprotkb:Q5TDC9|uniprotkb:O15001|ensembl:ENSP00000362803	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ppil1_human(display_long)|uniprotkb:PPIL1(gene name)|psi-mi:PPIL1(display_short)|uniprotkb:Rotamase PPIL1(gene name synonym)|uniprotkb:CYPL1(gene name synonym)|uniprotkb:CGI-124(orf name)|uniprotkb:UNQ2425/PRO4984(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057143.1|ensembl:ENSG00000137168(gene)|ensembl:ENST00000373699(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|interpro:IPR044666|rcsb pdb:1XWN|rcsb pdb:2K7N|rcsb pdb:2X7K|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|reactome:R-HSA-72163|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4Wx4abxOz/ayhkwVy/JYzA3d+SE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NVI7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:IZKJEVLLS/DFINgBgO5frizN1P49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P61586	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q53F19	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6657994|uniprotkb:Q9NXZ4|uniprotkb:B3KWG7|uniprotkb:Q96FK1|uniprotkb:Q7L406|ensembl:ENSP00000373657	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ncbp3_human(display_long)|uniprotkb:C17orf85(gene name synonym)|uniprotkb:Protein ELG(gene name synonym)|uniprotkb:NCBP3(gene name)|psi-mi:NCBP3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_016880318.1|refseq:NP_001107590.1|ensembl:ENSG00000074356(gene)|ensembl:ENST00000389005(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0016607"(nuclear speck)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0051028"(mRNA transport)|go:"GO:0051607"(defense response to virus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR019416	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:R4Oebjb9RKooXqVvOAkkNMmPYq49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UHR4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q06265	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-347966|ensembl:ENSP00000243498|uniprotkb:Q12883|uniprotkb:Q86Y41|uniprotkb:Q86Y48|uniprotkb:Q4W5P5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:exos9_human(display_long)|uniprotkb:EXOSC9(gene name)|psi-mi:EXOSC9(display_short)|uniprotkb:PMSCL1(gene name synonym)|uniprotkb:Exosome component 9(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Autoantigen PM/Scl 1(gene name synonym)|uniprotkb:Polymyositis/scleroderma autoantigen 75 kDa(gene name synonym)|uniprotkb:P75 polymyositis-scleroderma overlap syndrome-associated autoantigen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006955"(immune response)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034473"(U1 snRNA 3'-end processing)|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0034476"(U5 snRNA 3'-end processing)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071038"(nuclear polyadenylation-dependent tRNA catabolic process)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|go:"GO:0071035"(nuclear polyadenylation-dependent rRNA catabolic process)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR033100|interpro:IPR036345|mint:Q06265|rcsb pdb:2NN6|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226|ensembl:ENSG00000123737(gene)|ensembl:ENST00000243498(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|refseq:NP_001029366.1|refseq:NP_005024.2|dip:DIP-31286N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:COzGZISdlfGlht1FhyxPhzbV9hY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43707	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-351526|uniprotkb:O76048|uniprotkb:D6PXK4|ensembl:ENSP00000252699|ensembl:ENSP00000489220|uniprotkb:A4K467	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:actn4_human(display_long)|uniprotkb:ACTN4(gene name)|psi-mi:ACTN4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004915.2|ensembl:ENSG00000130402(gene)|ensembl:ENSG00000282844(gene)|ensembl:ENST00000252699(transcript)|ensembl:ENST00000634960(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:O43707|rcsb pdb:1WLX|rcsb pdb:1YDI|rcsb pdb:2R0O|rcsb pdb:6O31|rcsb pdb:6OA6|reactome:R-HSA-114608|reactome:R-HSA-373753|dip:DIP-33179N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:kTYezA2lEtL/AQPfCQ8BE79nzow9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6PJT7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-740660|uniprotkb:B4DXU8|uniprotkb:B4DZW7|ensembl:ENSP00000251038|uniprotkb:A8MY46|uniprotkb:Q6MZU4|uniprotkb:Q6PJ32|uniprotkb:Q6PUI6|uniprotkb:Q6PUI8|uniprotkb:Q86TQ5|uniprotkb:Q86TW0|uniprotkb:Q86TW1|uniprotkb:Q8NCZ3|uniprotkb:Q8TDE2|uniprotkb:Q9HAC9|uniprotkb:Q9Y5A0|uniprotkb:Q8NCT6|intact:EBI-2857849|uniprotkb:B4E2H4|uniprotkb:G3V5R4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zc3he_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-37(gene name synonym)|uniprotkb:ZC3H14(gene name)|psi-mi:ZC3H14(display_short)|uniprotkb:Mammalian suppressor of tau pathology-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001153575.1|refseq:NP_001153576.1|refseq:NP_079100.2|refseq:NP_997543.1|refseq:NP_997544.1|refseq:NP_997545.2|ensembl:ENSG00000100722(gene)|ensembl:ENST00000251038(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008143"("poly(A) binding")|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR040366|refseq:XP_005268125.1|refseq:NP_001313236.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:X2bh/uBtNVh/Wy30Sk+M3ijrZoM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6RFH5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722366|uniprotkb:Q9BRC9|uniprotkb:Q9H6X8|uniprotkb:Q9NVY2|uniprotkb:A8K8G5|ensembl:ENSP00000278856|ensembl:ENSP00000432119|ensembl:ENSP00000435726	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr74_human(display_long)|uniprotkb:NOP seven-associated protein 1(gene name synonym)|uniprotkb:WDR74(gene name)|psi-mi:WDR74(display_short)|uniprotkb:NSA1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060563.2|refseq:XP_005274112.1|refseq:NP_001294906.1|ensembl:ENSG00000133316(gene)|ensembl:ENST00000278856(transcript)|ensembl:ENST00000525239(transcript)|ensembl:ENST00000529106(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037379|mint:Q6RFH5	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:KGh4kcZ85zi1yj6Ow10pW3h7ECM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q1KMD3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1059150|uniprotkb:Q8N3B3|ensembl:ENSP00000301785	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hnrl2_human(display_long)|uniprotkb:HNRNPUL2(gene name)|psi-mi:HNRNPUL2(display_short)|uniprotkb:HNRPUL2(gene name synonym)|uniprotkb:Scaffold-attachment factor A2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001073027.1|ensembl:ENSG00000214753(gene)|ensembl:ENST00000301785(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q1KMD3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:TOoq1VTfNNzysqSyPH9MHLbSKPA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75448	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-394523|uniprotkb:Q14143|uniprotkb:Q9NNY5|uniprotkb:A8K4S5|uniprotkb:B3KMR9|ensembl:ENSP00000377686	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:med24_human(display_long)|uniprotkb:TRAP100(gene name synonym)|uniprotkb:MED24(gene name)|psi-mi:MED24(display_short)|uniprotkb:DRIP100(gene name synonym)|uniprotkb:KIAA0130(gene name synonym)|uniprotkb:Mediator complex subunit 24(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 100 kDa component(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein 4(gene name synonym)|uniprotkb:Vitamin D3 receptor-interacting protein complex 100 kDa component(gene name synonym)|uniprotkb:Activator-recruited cofactor 100 kDa component(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 4(gene name synonym)|uniprotkb:ARC100(gene name synonym)|uniprotkb:CRSP4(gene name synonym)|uniprotkb:THRAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:XP_016880955.1|refseq:NP_001072986.1|refseq:NP_055630.2|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR021429|mint:O75448|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|reactome:R-HSA-1989781|reactome:R-HSA-212436|reactome:R-HSA-381340|ensembl:ENSG00000008838(gene)|ensembl:ENST00000394128(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016592"(mediator complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|refseq:NP_001254726.1|dip:DIP-31462N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:H0iGOXcj8Qe1FOU7pOXkhaAS+pc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P52294	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15291	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-592823|uniprotkb:A8K272|uniprotkb:Q7Z6D8|uniprotkb:Q8NDZ7|ensembl:ENSP00000264515	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rbbp5_human(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001180201.1|refseq:NP_001180202.1|refseq:NP_005048.2|dip:DIP-29224N|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q15291|rcsb pdb:3P4F|rcsb pdb:4X8N|rcsb pdb:4X8P|rcsb pdb:5F6K|rcsb pdb:5F6L|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KM7|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:7BRE|reactome:R-HSA-201722|reactome:R-HSA-3214841|reactome:R-HSA-3769402|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UBL3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-540797|uniprotkb:O60659|uniprotkb:O60660|uniprotkb:Q96B62|ensembl:ENSP00000340896|uniprotkb:A8K7C3|uniprotkb:D3DSW9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ash2l_human(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001098684.1|refseq:NP_004665.2|ensembl:ENSG00000129691(gene)|ensembl:ENST00000343823(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q9UBL3|rcsb pdb:3RSN|rcsb pdb:3S32|rcsb pdb:3TOJ|rcsb pdb:4RIQ|rcsb pdb:4X8P|rcsb pdb:5F6K|rcsb pdb:5F6L|rcsb pdb:6E2H|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:7BRE|reactome:R-HSA-201722|reactome:R-HSA-3214841|reactome:R-HSA-3769402|reactome:R-HSA-5617472|reactome:R-HSA-8936459|rcsb pdb:4X8N|refseq:NP_001248761.1|dip:DIP-29222N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ZUYI3M78nGeeb8K2eIiDSw1uWeo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q460N5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-15575162|ensembl:ENSP00000418194|uniprotkb:B4E2H0|uniprotkb:Q460N4|uniprotkb:Q8J027|uniprotkb:Q9H9X9|uniprotkb:Q9NV60|uniprotkb:Q9ULF2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:par14_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 14(gene name synonym)|uniprotkb:PARP14(gene name)|psi-mi:PARP14(display_short)|uniprotkb:BAL2(gene name synonym)|uniprotkb:KIAA1268(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 8(gene name synonym)|uniprotkb:B aggressive lymphoma protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000173193(gene)|ensembl:ENST00000474629(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0070403"(NAD+ binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:1902216"(positive regulation of interleukin-4-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR002589(Appr-1-p processing)|go:"GO:0045087"(innate immune response)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034517|interpro:IPR037197|interpro:IPR043472|mint:Q460N5|rcsb pdb:3GOY|rcsb pdb:3Q6Z|rcsb pdb:3Q71|rcsb pdb:3SE2|rcsb pdb:3SMI|rcsb pdb:3SMJ|rcsb pdb:3VFQ|rcsb pdb:4ABK|rcsb pdb:4ABL|rcsb pdb:4D86|rcsb pdb:4F1L|rcsb pdb:4F1Q|rcsb pdb:4PY4|rcsb pdb:5LXP|rcsb pdb:5LYH|rcsb pdb:5NQE|rcsb pdb:5O2D|rcsb pdb:5QHT|rcsb pdb:5QHU|rcsb pdb:5QHV|rcsb pdb:5QHW|rcsb pdb:5QHX|rcsb pdb:5QHY|rcsb pdb:5QHZ|rcsb pdb:5QI0|rcsb pdb:5QI1|rcsb pdb:5QI2|rcsb pdb:5QI3|rcsb pdb:5QI4|rcsb pdb:5QI5|rcsb pdb:5QI6|rcsb pdb:5QI7|rcsb pdb:5QI8|rcsb pdb:5QI9|rcsb pdb:5QIA|rcsb pdb:5V7T|rcsb pdb:5V7W|rcsb pdb:6FYM|rcsb pdb:6FZM|rcsb pdb:6G0W|rcsb pdb:6WE2|rcsb pdb:6WE3|rcsb pdb:6WE4|rcsb pdb:7D2C|rcsb pdb:7L9Y|rcsb pdb:7LUN|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|refseq:NP_060024.2|dip:DIP-61130N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wNYDgvryexaU14HiLwBsNJYxMFU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P55884	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13243	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-720503|uniprotkb:O14797|uniprotkb:Q16662|uniprotkb:Q49AD6|uniprotkb:Q6FGE0|ensembl:ENSP00000377892|ensembl:ENSP00000451088|ensembl:ENSP00000452123	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srsf5_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP40(gene name synonym)|uniprotkb:Delayed-early protein HRS(gene name synonym)|uniprotkb:SRSF5(gene name)|psi-mi:SRSF5(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:SRP40(gene name synonym)|uniprotkb:SFRS5(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0003729"(mRNA binding)|refseq:NP_001034554.1|refseq:NP_008856.2|refseq:NP_001307143.1|dip:DIP-46894N|ensembl:ENSG00000100650(gene)|ensembl:ENST00000394366(transcript)|ensembl:ENST00000553521(transcript)|ensembl:ENST00000557154(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979|mint:Q13243|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|go:"GO:0005654"(nucleoplasm)|reactome:R-HSA-73856	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:q+kwVNXjDcA8o9hJ+BDF0S5ZSlY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P27635	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-352398|uniprotkb:A3KQT0|uniprotkb:Q16470|uniprotkb:Q2HXT7|uniprotkb:Q53FH7|uniprotkb:Q6FGN8|uniprotkb:Q8TDA5|intact:EBI-3046680|uniprotkb:D3DWW6|ensembl:ENSP00000341730|ensembl:ENSP00000358832	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl10_human(display_long)|uniprotkb:RPL10(gene name)|psi-mi:RPL10(display_short)|uniprotkb:QM(gene name synonym)|uniprotkb:Protein QM(gene name synonym)|uniprotkb:Tumor suppressor QM(gene name synonym)|uniprotkb:Laminin receptor homolog(gene name synonym)|uniprotkb:DXS648E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL16(gene name synonym)|uniprotkb:Ribosomal protein L10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001243506.2|refseq:NP_001243509.2|refseq:NP_001290553.1|refseq:NP_001290554.1|refseq:NP_001290555.1|ensembl:ENSG00000147403(gene)|ensembl:ENST00000344746(transcript)|ensembl:ENST00000369817(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|refseq:NP_006004.3|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|mint:P27635|rcsb pdb:2PA2|rcsb pdb:5AJ0|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6W6L|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|go:"GO:0016020"(membrane)|reactome:R-HSA-975957|dip:DIP-1133N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H3U1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96JB5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-718818|uniprotkb:Q53FA2|uniprotkb:Q9H3F8|uniprotkb:Q9H8G0|uniprotkb:Q9HBR9|uniprotkb:D3DTU1|uniprotkb:D3DTU2|uniprotkb:B7Z6N4|uniprotkb:F5H3I5|ensembl:ENSP00000344683	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ck5p3_human(display_long)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym)|uniprotkb:Protein HSF-27(gene name synonym)|uniprotkb:CDK5RAP3(gene name)|psi-mi:CDK5RAP3(display_short)|uniprotkb:IC53(gene name synonym)|uniprotkb:MSTP016(orf name)|uniprotkb:OK/SW-cl.114(orf name)|uniprotkb:PP1553(orf name)|uniprotkb:LXXLL/leucine-zipper-containing ARF-binding protein(gene name synonym)|uniprotkb:LZAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_788276.1|refseq:NP_001265126.1|refseq:XP_011523599.1|refseq:NP_001265127.1|refseq:NP_001265145.1|refseq:NP_001265146.1|ensembl:ENSG00000108465(gene)|ensembl:ENST00000338399(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|interpro:IPR008491(Protein of unknown function DUF773)|refseq:XP_016880653.1|refseq:XP_016880654.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:K1S/DQ6fYeOm+MiiGicED0chJAw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15287	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-395959|uniprotkb:A8K1P0|uniprotkb:B4DDU8|uniprotkb:B4DZU7|uniprotkb:B7ZA17|uniprotkb:O75308|uniprotkb:Q32P25|uniprotkb:Q8WY42|uniprotkb:Q9NYG3|ensembl:ENSP00000301730|ensembl:ENSP00000315859|ensembl:ENSP00000380275|ensembl:ENSP00000457723|ensembl:ENSP00000457820	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rnps1_human(display_long)|uniprotkb:SR-related protein LDC2(gene name synonym)|uniprotkb:RNPS1(gene name)|psi-mi:RNPS1(display_short)|uniprotkb:LDC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006702.1|refseq:NP_542161.1|refseq:NP_001273554.1|refseq:NP_001273555.1|refseq:NP_001273556.1|ensembl:ENSG00000205937(gene)|ensembl:ENST00000301730(transcript)|ensembl:ENST00000320225(transcript)|ensembl:ENST00000397086(transcript)|ensembl:ENST00000565678(transcript)|ensembl:ENST00000568631(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034201|interpro:IPR035979|mint:Q15287|rcsb pdb:4A8X|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|refseq:XP_005255105.1|refseq:XP_005255106.1|refseq:XP_016878363.1|dip:DIP-32943N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nANu/nh/pD/F6dYE2Sa28OegPGs9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q5T3I0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2372076|uniprotkb:Q5T3I1|uniprotkb:Q6ZUE7|uniprotkb:Q8IWG8|uniprotkb:Q9NXH4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:gptc4_human(display_long)|uniprotkb:GPATCH4(gene name)|psi-mi:GPATCH4(display_short)|uniprotkb:GPATC4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR000467(D111/G-patch)|mint:Q5T3I0|go:"GO:0003723"(RNA binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:R2hFHYGQh2jmLbLg+BNATVimtNA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9HCK8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1169146|uniprotkb:Q68DQ0|uniprotkb:Q8N3Z9|uniprotkb:Q8NCY4|uniprotkb:Q8TBR9|uniprotkb:Q96F26|uniprotkb:Q4G0D8|uniprotkb:Q6DKH9|uniprotkb:Q6P440|uniprotkb:Q6ZNL7|ensembl:ENSP00000451601|ensembl:ENSP00000495070|ensembl:ENSP00000495240	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:chd8_human(display_long)|uniprotkb:ATP-dependent helicase CHD8(gene name synonym)|uniprotkb:Helicase with SNF2 domain 1(gene name synonym)|uniprotkb:CHD8(gene name)|psi-mi:CHD8(display_short)|uniprotkb:HELSNF1(gene name synonym)|uniprotkb:KIAA1564(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENST00000430710|ensembl:ENSP00000406288|ensembl:ENSP00000451601|ensembl:ENSP00000495070|ensembl:ENST00000645929|ensembl:ENSP00000494402|ensembl:ENSP00000495240|refseq:NP_001164100.1|refseq:NP_065971.2|go:"GO:0035064"(methylated histone binding)|go:"GO:0035176"(social behavior)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048565"(digestive tract development)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070615"|ensembl:ENSG00000100888(gene)|ensembl:ENST00000557364(transcript)|ensembl:ENST00000643469(transcript)|ensembl:ENST00000646647(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023780|interpro:IPR027417|interpro:IPR034724|interpro:IPR037259|interpro:IPR038718|mint:Q9HCK8|rcsb pdb:2CKA|rcsb pdb:2DL6|reactome:R-HSA-3769402|go:"GO:0071339"(MLL1 complex)|dip:DIP-38021N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:QwADLvHNwK00OAboBtAkqaICd489606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q00577	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15050	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-749186|uniprotkb:Q9BUX8|ensembl:ENSP00000322396	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rrs1_human(display_long)|uniprotkb:RRS1(gene name)|psi-mi:RRS1(display_short)|uniprotkb:KIAA0112(gene name synonym)|uniprotkb:RRR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055984.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007023(Ribosomal biogenesis regulatory protein)|mint:Q15050|go:"GO:0003723"(RNA binding)|ensembl:ENSG00000179041(gene)|ensembl:ENST00000320270(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000794"(condensed nuclear chromosome)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:0Nm9UoIGLBiqOGl0E2BA0S5EXIU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H9L3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-751335|uniprotkb:Q64KA2|uniprotkb:D3DVC6|ensembl:ENSP00000323424|ensembl:ENSP00000357202	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:i20l2_human(display_long)|uniprotkb:ISG20L2(gene name)|psi-mi:ISG20L2(display_short)|uniprotkb:HSD38(orf name)|uniprotkb:HSD-38(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001290024.1|refseq:XP_005245573.1|refseq:XP_006711623.1|refseq:XP_006711624.1|reactome:R-HSA-6791226|interpro:IPR037433|mint:Q9H9L3|ensembl:ENSG00000143319(gene)|ensembl:ENST00000313146(transcript)|ensembl:ENST00000368219(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR034933|interpro:IPR036397	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:i/TZBz8UuJIRm7WZZKjHYU75AS89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q07020	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-352694|intact:EBI-8456577|intact:MINT-8429255|uniprotkb:F8VWC5|uniprotkb:Q8WTZ6|ensembl:ENSP00000447001	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl18_human(display_long)|uniprotkb:RPL18(gene name)|psi-mi:RPL18(display_short)|uniprotkb:Large ribosomal subunit protein eL18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_000970.1|ensembl:ENSG00000063177(gene)|ensembl:ENST00000549920(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|mint:Q07020|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001257419.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:GgzBcLEQgBqbApFlaQIU2jktkAE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15371	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WVB6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1237523|uniprotkb:Q7Z6Y6|uniprotkb:Q9BR83|uniprotkb:Q9BRG5|uniprotkb:Q9H7K3|uniprotkb:B7ZBA2|uniprotkb:Q7Z6Y4|uniprotkb:D3DU68|intact:EBI-28984493|ensembl:ENSP00000262315	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ctf18_human(display_long)|uniprotkb:CHTF18(gene name)|psi-mi:CHTF18(display_short)|uniprotkb:CTF18(gene name synonym)|uniprotkb:C16orf41(gene name synonym)|uniprotkb:CHL12(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071375.1|refseq:XP_011520875.1|ensembl:ENSP00000262315|ensembl:ENST00000455171|ensembl:ENSP00000406252|refseq:XP_005255528.1|ensembl:ENSG00000127586(gene)|ensembl:ENST00000262315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q8WVB6|reactome:R-HSA-174411	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:cIuesMN9KfDCiavKy3XvnYV+IA09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P18583	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1053513|uniprotkb:O14487|uniprotkb:O95981|uniprotkb:Q14120|uniprotkb:Q9H7B1|uniprotkb:Q9P070|uniprotkb:Q9P072|uniprotkb:Q9UKP9|uniprotkb:Q9UPY0|uniprotkb:D3DSF5|uniprotkb:D3DSF6|uniprotkb:E7ETE8|uniprotkb:E7EU67|uniprotkb:E7EVW3|uniprotkb:E9PFQ2|uniprotkb:Q6PKE0|intact:EBI-28988950|ensembl:ENSP00000348984	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:son_human(display_long)|uniprotkb:SON3(gene name synonym)|uniprotkb:Negative regulatory element-binding protein(gene name synonym)|uniprotkb:Protein DBP-5(gene name synonym)|uniprotkb:Bax antagonist selected in saccharomyces 1(gene name synonym)|uniprotkb:SON(gene name)|psi-mi:SON(display_short)|uniprotkb:C21orf50(gene name synonym)|uniprotkb:DBP5(gene name synonym)|uniprotkb:KIAA1019(gene name synonym)|uniprotkb:NREBP(gene name synonym)|uniprotkb:HSPC310(orf name)|uniprotkb:HSPC312(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001278340.1|refseq:NP_001278341.1|refseq:NP_115571.2|refseq:NP_620305.2|ensembl:ENSG00000159140(gene)|ensembl:ENST00000356577(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000467(D111/G-patch)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032922|interpro:IPR036322|mint:P18583|ensembl:ENST00000300278|ensembl:ENSP00000300278|ensembl:ENSP00000348984|ensembl:ENST00000381679|ensembl:ENSP00000371095|ensembl:ENST00000455528|ensembl:ENSP00000399783|dip:DIP-42289N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XHPM2q25vXRqEK7eQpWvJ6Uzc3U9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P82663	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1046734|uniprotkb:Q9H7P5|ensembl:ENSP00000253686|uniprotkb:B4DFJ5|uniprotkb:B4DQG6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rt25_human(display_long)|uniprotkb:MRPS25(gene name)|psi-mi:MRPS25(display_short)|uniprotkb:RPMS25(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS25(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_071942.1|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000131368(gene)|ensembl:ENST00000253686(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR040049|mint:P82663|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DQMtBaQJW2Ic025zsKJYfN4aj1I9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UKV3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396258|uniprotkb:O75158|uniprotkb:Q9UG91|uniprotkb:Q9UKV1|uniprotkb:Q9UKV2|uniprotkb:D3DS45|uniprotkb:B2RTT4|ensembl:ENSP00000262710	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:acinu_human(display_long)|uniprotkb:ACIN1(gene name)|psi-mi:ACIN1(display_short)|uniprotkb:ACINUS(gene name synonym)|uniprotkb:KIAA0670(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001158286.1|refseq:NP_001158287.1|refseq:NP_001158288.1|refseq:NP_001158289.1|refseq:NP_055792.1|refseq:XP_005267475.1|ensembl:ENSG00000100813(gene)|ensembl:ENST00000262710(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034257|interpro:IPR035979|interpro:IPR036361|mint:Q9UKV3|rcsb pdb:6G6S|reactome:R-HSA-111465|interpro:IPR032552|dip:DIP-32963N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dzHCIefdTYTGEk+qXNwlK2Phybw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BVJ6	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-473284|uniprotkb:B4DQ08|uniprotkb:E9PEL7|uniprotkb:Q5JYF1|uniprotkb:A8MVQ1|uniprotkb:A8K7A3|ensembl:ENSP00000377944	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ut14a_human(display_long)|uniprotkb:Serologically defined colon cancer antigen 16(gene name synonym)|uniprotkb:Antigen NY-CO-16(gene name synonym)|uniprotkb:UTP14A(gene name)|psi-mi:UTP14A(display_short)|uniprotkb:SDCCAG16(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000156697(gene)|ensembl:ENST00000394422(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0032040"(small-subunit processome)|interpro:IPR006709(Small-subunit processome, Utp14)|mint:Q9BVJ6|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_001159693.1|refseq:NP_006640.2|dip:DIP-32505N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:vBBHvYYgh4LYP335ktHlQ77Dkfc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q13535	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-968983|ensembl:ENSP00000343741|uniprotkb:Q7KYL3|uniprotkb:Q93051|uniprotkb:Q9BXK4|uniprotkb:Q59HB2	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:atr_human(display_long)|uniprotkb:ATR(gene name)|psi-mi:ATR(display_short)|uniprotkb:FRP1(gene name synonym)|uniprotkb:Ataxia telangiectasia and Rad3-related protein(gene name synonym)|uniprotkb:FRAP-related protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000175054(gene)|ensembl:ENST00000350721(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031297"(replication fork processing)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042493"|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021133|interpro:IPR036940|mint:Q13535|rcsb pdb:5YZ0|reactome:R-HSA-1221632|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001175.2|refseq:XP_016862132.1|dip:DIP-35308N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ZYzDNmnxcK+RJN42KfgQZlxGACU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8N6H7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11137470|uniprotkb:Q3LIF2|uniprotkb:B4DX29|uniprotkb:Q96SX7|uniprotkb:B7Z9M7|uniprotkb:Q8N3I1|uniprotkb:D3DQQ9|ensembl:ENSP00000434442	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:arfg2_human(display_long)|uniprotkb:ARFGAP2(gene name)|psi-mi:ARFGAP2(display_short)|uniprotkb:GTPase-activating protein ZNF289(gene name synonym)|uniprotkb:ZNF289(gene name synonym)|uniprotkb:Zinc finger protein 289(gene name synonym)|uniprotkb:Nbla10535(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001229761.1|refseq:NP_115765.2|ensembl:ENSG00000149182(gene)|ensembl:ENST00000524782(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048205"(COPI coating of Golgi vesicle)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q8N6H7|rcsb pdb:2P57|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-9013148	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:75iMXzEM9Fi3qlCDuwZ/Y9sUOls9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y6J9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-743984|uniprotkb:Q96HA6|uniprotkb:B2RAT0|ensembl:ENSP00000294168	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:taf6l_human(display_long)|uniprotkb:PCAF-associated factor 65-alpha(gene name synonym)|uniprotkb:TAF6L(gene name)|psi-mi:TAF6L(display_short)|uniprotkb:PAF65A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006464.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0030914"|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR037796|mint:Q9Y6J9|reactome:R-HSA-3214847|ensembl:ENSG00000162227(gene)|ensembl:ENST00000294168(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:ZcrK24blWTsAkCgruDbSiUflbtA9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8N9T8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-724923|uniprotkb:Q2M1R5|uniprotkb:Q2M1R7|uniprotkb:Q7L5J7|uniprotkb:Q96G92|uniprotkb:Q9BU50|uniprotkb:Q9H6I1|uniprotkb:Q9H978|ensembl:ENSP00000320917	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:kri1_human(display_long)|uniprotkb:KRI1(gene name)|psi-mi:KRI1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_075384.3|ensembl:ENSG00000129347(gene)|ensembl:ENST00000312962(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|interpro:IPR018034|interpro:IPR024626|mint:Q8N9T8	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sIRmrP/c3tSmEAj1usRGN3R3Bh09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NV31	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-747481|uniprotkb:Q53G10|uniprotkb:B3KQ67|ensembl:ENSP00000326981|ensembl:ENSP00000385217	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:imp3_human(display_long)|uniprotkb:BRMS2(gene name synonym)|uniprotkb:IMP3(gene name)|psi-mi:IMP3(display_short)|uniprotkb:C15orf12(gene name synonym)|uniprotkb:MRPS4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_060755.1|go:"GO:0030684"(preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034457"(Mpp10 complex)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR022801|interpro:IPR036986|mint:Q9NV31|rcsb pdb:2CQJ|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0030515"(snoRNA binding)|ensembl:ENSG00000177971(gene)|ensembl:ENST00000314852(transcript)|ensembl:ENST00000403490(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7tf5HEal59lCqBIvQaFLksqchAw9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8IWI9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q2KHR3	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-11048246|uniprotkb:Q6ZUR5|uniprotkb:Q6ZU30|ensembl:ENSP00000382241	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:qser1_human(display_long)|uniprotkb:QSER1(gene name)|psi-mi:QSER1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001070254.1|ensembl:ENSG00000060749(gene)|ensembl:ENST00000399302(transcript)|interpro:IPR025451|mint:Q2KHR3	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:vDgZ99Lo5fIvl2ef739OtWP/QLQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92804	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2255091|uniprotkb:B2R837|uniprotkb:Q92751|intact:EBI-3867593|uniprotkb:Q86X94|ensembl:ENSP00000474096|ensembl:ENSP00000480040	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rbp56_human(display_long)|uniprotkb:TAF15(gene name)|psi-mi:TAF15(display_short)|uniprotkb:RBP56(gene name synonym)|uniprotkb:TAF2N(gene name synonym)|uniprotkb:RNA-binding protein 56(gene name synonym)|uniprotkb:68 kDa TATA-binding protein-associated factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_003478.1|refseq:NP_631961.1|dip:DIP-52760N|ensembl:ENSG00000270647(gene)|ensembl:ENSG00000276833(gene)|ensembl:ENST00000605844(transcript)|ensembl:ENST00000617382(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034870|interpro:IPR034875|interpro:IPR035979|interpro:IPR036443|mint:Q92804|rcsb pdb:2MMY|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:9+wyDu+1dvocxFI4GKvLqkvChDc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y6K5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-6115729|uniprotkb:Q2HJ14|uniprotkb:Q9H3P5|ensembl:ENSP00000228928	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:oas3_human(display_long)|uniprotkb:OAS3(gene name)|psi-mi:OAS3(display_short)|uniprotkb:p100 OAS(gene name synonym)|uniprotkb:P/OKcl.4(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_006178.2|ensembl:ENSG00000111331(gene)|ensembl:ENST00000228928(transcript)|go:"GO:0001730"(2'-5'-oligoadenylate synthetase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035395"("negative regulation of chemokine (C-X-C motif) ligand 9 production")|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0060700"(regulation of ribonuclease activity)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR006116(2-5-oligoadenylate synthetase, ubiquitin-like region)|interpro:IPR006117(2-5-oligoadenylate synthetase, conserved site)|interpro:IPR018952|interpro:IPR026774|interpro:IPR043518|interpro:IPR043519|rcsb pdb:4S3N|reactome:R-HSA-877300|reactome:R-HSA-8983711|reactome:R-HSA-909733	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:7/yDwZr/Wibns/WevqiaT7bCskY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H6F5	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-721289|uniprotkb:B4DY99|ensembl:ENSP00000227520	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ccd86_human(display_long)|uniprotkb:Cytokine-induced protein with coiled-coil domain(gene name synonym)|uniprotkb:CYCLON(gene name synonym)|uniprotkb:CCDC86(gene name)|psi-mi:CCDC86(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_077003.1|ensembl:ENSG00000110104(gene)|ensembl:ENST00000227520(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|interpro:IPR005579(Cgr1)|interpro:IPR026570|mint:Q9H6F5	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:dRd5UWPzAehh8OFqkWrMMCnYYug9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92925	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96I24	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-954200|ensembl:ENSP00000318177|uniprotkb:Q92946|uniprotkb:Q9BVB6|intact:EBI-1760333|intact:EBI-1965411|uniprotkb:A3KFL0|uniprotkb:A3KFK8	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fubp3_human(display_long)|uniprotkb:FUBP3(gene name)|psi-mi:FUBP3(display_short)|uniprotkb:FBP3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000107164(gene)|ensembl:ENST00000319725(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q96I24|refseq:NP_003925.1|dip:DIP-50124N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:xdCa+teqFaSxKNTpCJWQ5gcd0sQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15047	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-540779|uniprotkb:A6NP62|uniprotkb:Q6PIF3|uniprotkb:Q8TAJ6|intact:EBI-28969638|ensembl:ENSP00000262519|ensembl:ENSP00000507683	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:set1a_human(display_long)|uniprotkb:KMT2F(gene name synonym)|uniprotkb:SET domain-containing protein 1A(gene name synonym)|uniprotkb:Set1/Ash2 histone methyltransferase complex subunit SET1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 2F(gene name synonym)|uniprotkb:SETD1A(gene name)|psi-mi:SETD1A(display_short)|uniprotkb:KIAA0339(gene name synonym)|uniprotkb:SET1(gene name synonym)|uniprotkb:SET1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055527.1|refseq:XP_006721169.1|ensembl:ENSP00000262519|ensembl:ENSP00000507683|reactome:R-HSA-8936459|reactome:R-HSA-3214841|ensembl:ENSG00000099381(gene)|ensembl:ENST00000262519(transcript)|ensembl:ENST00000684162(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001214(SET)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024657|interpro:IPR034467|interpro:IPR035979|interpro:IPR037841|interpro:IPR044570|mint:O15047|go:"GO:0048188"(Set1C/COMPASS complex)|rcsb pdb:3S8S|rcsb pdb:3UVN|rcsb pdb:4EWR|refseq:XP_005255780.1|refseq:XP_016879398.1|dip:DIP-33494N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:nx0uWEVFas1w2NmuG73lCObAULE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H7B2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NQ55	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1048540|uniprotkb:Q9BW97|uniprotkb:Q9H170|uniprotkb:C9J3F9|ensembl:ENSP00000253107	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ssf1_human(display_long)|uniprotkb:Peter Pan homolog(gene name synonym)|uniprotkb:PPAN(gene name)|psi-mi:PPAN(display_short)|uniprotkb:SSF1(gene name synonym)|uniprotkb:BXDC3(gene name synonym)|uniprotkb:Brix domain-containing protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001035754.1|refseq:NP_064615.3|ensembl:ENSG00000130810(gene)|ensembl:ENST00000253107(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR007109(Brix)|mint:Q9NQ55	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wIgMQj/xJrj5eExsyZD6BeamQOQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O15213	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-9995439|uniprotkb:A6NDP5|uniprotkb:Q5HYZ0|uniprotkb:Q5STK5|uniprotkb:Q5STR3|ensembl:ENSP00000363746|ensembl:ENSP00000372695|ensembl:ENSP00000399454|ensembl:ENSP00000402869|ensembl:ENSP00000405614	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:wdr46_human(display_long)|uniprotkb:WDR46(gene name)|psi-mi:WDR46(display_short)|uniprotkb:BING4(gene name synonym)|uniprotkb:C6orf11(gene name synonym)|uniprotkb:WD repeat-containing protein BING4(gene name synonym)|uniprotkb:FP221(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001157739.1|refseq:NP_005443.3|ensembl:ENSG00000204221(gene)|ensembl:ENSG00000206284(gene)|ensembl:ENSG00000226916(gene)|ensembl:ENSG00000227057(gene)|ensembl:ENSG00000236222(gene)|ensembl:ENST00000374617(transcript)|ensembl:ENST00000383208(transcript)|ensembl:ENST00000432609(transcript)|ensembl:ENST00000432933(transcript)|ensembl:ENST00000457382(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0032040"(small-subunit processome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR040315|mint:O15213|reactome:R-HSA-6790901|reactome:R-HSA-6791226|interpro:IPR012952(BING4, C-terminal)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:BYhBAazSJnKN4c7RgWU2WygOk4o9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49959	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P51116	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99575	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-366741|uniprotkb:Q15037|uniprotkb:A8K5W9|intact:EBI-2560204|ensembl:ENSP00000339529|ensembl:ENSP00000385787	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pop1_human(display_long)|uniprotkb:POP1(gene name)|psi-mi:POP1(display_short)|uniprotkb:KIAA0061(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001139332.1|refseq:NP_001139333.1|refseq:NP_055844.2|ensembl:ENSG00000104356(gene)|ensembl:ENST00000349693(transcript)|ensembl:ENST00000401707(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0005730"(nucleolus)|go:"GO:0008033"(tRNA processing)|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR009723(Ribonuclease P/MRP, POP1)|interpro:IPR012590(POPLD)|interpro:IPR039182|mint:Q99575|rcsb pdb:6AHR|rcsb pdb:6AHU|reactome:R-HSA-6784531	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:XJxSr17TfVuetXKgpQPjs2QKMV49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H4L4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2880236|ensembl:ENSP00000314029|ensembl:ENSP00000403712|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000161956(gene)|ensembl:ENST00000321337(transcript)|ensembl:ENST00000429205(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016926"(protein desumoylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR037945|interpro:IPR038765|mint:Q9H4L4|reactome:R-HSA-6791226|refseq:NP_056485.2|dip:DIP-47511N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P38432	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9UQR1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2688184|uniprotkb:Q58EY5|uniprotkb:O43591|uniprotkb:O00389|uniprotkb:D3DN27|ensembl:ENSP00000420448|ensembl:ENSP00000353863|ensembl:ENSP00000419322|ensembl:ENSP00000420335|uniprotkb:Q6PJ98	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:zn148_human(display_long)|uniprotkb:ZBP89(gene name synonym)|uniprotkb:Transcription factor ZBP-89(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 89(gene name synonym)|uniprotkb:ZNF148(gene name)|psi-mi:ZNF148(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_068799.2|ensembl:ENST00000360647(transcript)|ensembl:ENST00000484491(transcript)|ensembl:ENST00000485866(transcript)|ensembl:ENST00000492394(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006968"(cellular defense response)|go:"GO:0007276"(gamete generation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021762"(substantia nigra development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9UQR1|ensembl:ENSG00000163848(gene)|refseq:NP_001335353.1|refseq:NP_001335354.1|refseq:NP_001335355.1|refseq:NP_001335356.1|refseq:NP_001335357.1|refseq:NP_001335358.1|refseq:NP_001335359.1|refseq:NP_001335360.1|refseq:NP_001335361.1|refseq:NP_001335362.1|ensembl:ENSP00000353863|ensembl:ENSP00000420335|ensembl:ENSP00000420448|ensembl:ENSP00000419322	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:2H8lAaonZqAnCWDtUN8q55+03h49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q6KC79	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4|ensembl:ENSP00000282516	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym)|uniprotkb:SCC2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056199.2|refseq:NP_597677.2|refseq:XP_016864819.1|dip:DIP-29199N|ensembl:ENSG00000164190(gene)|ensembl:ENST00000282516(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001656"(metanephros development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|interpro:IPR033031|rcsb pdb:6WG3|rcsb pdb:6WGE|reactome:R-HSA-2470946|interpro:IPR024986	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P49750	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-712871|ensembl:ENSP00000324463|uniprotkb:P49752|uniprotkb:Q96I64|uniprotkb:Q9P1V7	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ylpm1_human(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:ZAP113(gene name synonym)|uniprotkb:YLPM1(gene name)|psi-mi:YLPM1(display_short)|uniprotkb:C14orf170(gene name synonym)|uniprotkb:ZAP3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000119596(gene)|ensembl:ENST00000325680(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|interpro:IPR027417|refseq:NP_062535.2|ensembl:ENSP00000324463|dip:DIP-53676N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:3w+7odPC5D2UQYimwmCgTBbvWR49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P08240	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-726981|ensembl:ENSP00000328023|uniprotkb:Q9BVJ4|uniprotkb:A6NIB3|uniprotkb:B2R5Z8|uniprotkb:B4E0H3|uniprotkb:E9PJS4	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:srpra_human(display_long)|uniprotkb:SRPRA(gene name)|psi-mi:SRPRA(display_short)|uniprotkb:Docking protein alpha(gene name synonym)|uniprotkb:SRPR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	rcsb pdb:2FH5|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0016020"(membrane)|rcsb pdb:2GO5|go:"GO:0045047"(protein targeting to ER)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000897(Signal recognition particle, SRP54 subunit, GTPase)|rcsb pdb:5L3Q|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007222(Signal recognition particle receptor, alpha subunit, N-terminal)|interpro:IPR011012(Longin-like)|interpro:IPR013822(Signal recognition particle, SRP54 subunit, helical bundle)|interpro:IPR027417|interpro:IPR036225|interpro:IPR042101|mint:P08240|rcsb pdb:6Y32|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-381038|ensembl:ENSG00000182934(gene)|ensembl:ENST00000332118(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005785"(signal recognition particle receptor complex)|refseq:NP_001171313.1|refseq:NP_003130.2	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:4ag/lxPfDGSDWhpnuwQynTvCpuU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O75691	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-356062|uniprotkb:Q9H3H4|ensembl:ENSP00000261637	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:utp20_human(display_long)|uniprotkb:UTP20(gene name)|psi-mi:UTP20(display_short)|uniprotkb:DRIM(gene name synonym)|uniprotkb:Down-regulated in metastasis protein(gene name synonym)|uniprotkb:Protein Key-1A6(gene name synonym)|uniprotkb:Novel nucleolar protein 73(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055318.2|ensembl:ENSG00000120800(gene)|ensembl:ENST00000261637(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006364"(rRNA processing)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0032040"(small-subunit processome)|interpro:IPR011430(Down-regulated in metastasis)|interpro:IPR016024(Armadillo-type fold)|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:OxTEfw2MtOijthWHjRtqIqUUjjg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8NDF8	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2803971|uniprotkb:Q9NW67|uniprotkb:Q9Y6C0|uniprotkb:B4DV38	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:papd5_human(display_long)|uniprotkb:"Non-canonical poly(A) RNA polymerase PAPD5"(gene name synonym)|uniprotkb:TUT3(gene name synonym)|uniprotkb:Terminal guanylyltransferase(gene name synonym)|uniprotkb:TENT4B(gene name)|psi-mi:TENT4B(display_short)|uniprotkb:GLD4(gene name synonym)|uniprotkb:PAP-associated domain-containing protein 5(gene name synonym)|uniprotkb:PAPD5(gene name synonym)|uniprotkb:TRF4-2(gene name synonym)|uniprotkb:Terminal uridylyltransferase 3(gene name synonym)|uniprotkb:Topoisomerase-related function protein 4-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001035375.2|refseq:NP_001035374.2|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0031499"(TRAMP complex)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0043629"(ncRNA polyadenylation)|go:"GO:0043630"(ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070568"(guanylyltransferase activity)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071050"("sno(s)RNA polyadenylation")|go:"GO:0071076"(RNA 3' uridylation)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR040136|interpro:IPR043519|dip:DIP-59183N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Dy+EsRClygf3oq2i8AdtST3ENS49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O95793	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-358174|uniprotkb:Q6GTM4|uniprotkb:Q9H5B5|intact:EBI-366174|uniprotkb:Q9H5B4|uniprotkb:Q9Y3Q2|uniprotkb:A8K9Z4|ensembl:ENSP00000360922|uniprotkb:E1P5Y1|uniprotkb:E1P608|uniprotkb:Q5JW29	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:stau1_human(display_long)|uniprotkb:STAU1(gene name)|psi-mi:STAU1(display_short)|uniprotkb:STAU(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001309856.1|refseq:NP_001309858.1|refseq:NP_001309859.1|refseq:NP_001032405.1|refseq:NP_004593.2|refseq:NP_059346.2|refseq:NP_059347.2|refseq:NP_059348.2|refseq:NP_001306063.1|refseq:NP_001306064.1|ensembl:ENSG00000124214(gene)|ensembl:ENST00000371856(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|refseq:XP_005260584.1|go:"GO:0099010"(modification of postsynaptic structure)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR032478|interpro:IPR044475|mint:O95793|rcsb pdb:4DKK|rcsb pdb:6HTU|rcsb pdb:6SDW|rcsb pdb:6SDY	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:uYjbWja/hG5M/3likHLe00Z2FgY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:O43395	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q01831	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372610|uniprotkb:B4DIP3|uniprotkb:E9PH69|uniprotkb:Q53GT7|uniprotkb:Q96AX0|ensembl:ENSP00000285021|uniprotkb:E9PB96	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:xpc_human(display_long)|uniprotkb:Xeroderma pigmentosum group C-complementing protein(gene name synonym)|uniprotkb:p125(gene name synonym)|uniprotkb:XPC(gene name)|psi-mi:XPC(display_short)|uniprotkb:XPCC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004619.3|ensembl:ENSG00000154767(gene)|ensembl:ENST00000285021(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000404"(heteroduplex DNA loop binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010224"(response to UV-B)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071942"(XPC complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990731"(UV-damage excision repair, DNA incision)|interpro:IPR004583(DNA repair protein Rad4)|interpro:IPR018026|interpro:IPR018325|interpro:IPR018326|interpro:IPR018327|interpro:IPR018328|interpro:IPR036985|go:"GO:0042493"|interpro:IPR038765|interpro:IPR042488|mint:Q01831|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2OBH|rcsb pdb:2RVB|reactome:R-HSA-3108214|reactome:R-HSA-5696394|reactome:R-HSA-5696395|dip:DIP-31225N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:PP5XknINbZu7HQiFuOLzUQoaixg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q92769	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-301821|uniprotkb:Q5SRI8|uniprotkb:Q5SZ86|uniprotkb:Q8NEH4|uniprotkb:B4DL58|ensembl:ENSP00000430432|uniprotkb:E1P561|uniprotkb:B3KRS5	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:hdac2_human(display_long)|uniprotkb:HDAC2(gene name)|psi-mi:HDAC2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035094"(response to nicotine)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042220"(response to cocaine)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043044"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q92769|rcsb pdb:3MAX|rcsb pdb:4LXZ|rcsb pdb:4LY1|rcsb pdb:5IWG|rcsb pdb:5IX0|rcsb pdb:6G3O|rcsb pdb:6WBW|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000196591(gene)|ensembl:ENST00000519065(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|rcsb pdb:6WHN|rcsb pdb:6WHO|rcsb pdb:6WHQ|rcsb pdb:6WHZ|rcsb pdb:6WI3|rcsb pdb:6XDM|rcsb pdb:6XEB|rcsb pdb:6XEC|rcsb pdb:7KBG|rcsb pdb:7KBH|rcsb pdb:7LTG|rcsb pdb:7LTK|rcsb pdb:7LTL|reactome:R-HSA-193670|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9615017|reactome:R-HSA-9619665|reactome:R-HSA-9679191|reactome:R-HSA-983231|rcsb pdb:6WBZ|refseq:NP_001518.3|dip:DIP-24220N|refseq:XP_011534090.1|refseq:XP_016866288.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:K4PpGz9E9/TrQZsgvrJuc+uYCn89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q1ED39	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-9977982|uniprotkb:O43328|uniprotkb:Q5FWF3|ensembl:ENSP00000219837	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:knop1_human(display_long)|uniprotkb:KNOP1(gene name)|psi-mi:KNOP1(display_short)|uniprotkb:C16orf88(gene name synonym)|uniprotkb:FAM191A(gene name synonym)|uniprotkb:TSG118(gene name synonym)|uniprotkb:Protein FAM191A(gene name synonym)|uniprotkb:Testis-specific gene 118 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001013009.2|refseq:NP_001335457.1|refseq:NP_001335458.1|refseq:NP_001335459.1|refseq:NP_001335460.1|ensembl:ENSG00000103550(gene)|ensembl:ENST00000219837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|interpro:IPR028124	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:DbTowYDo0km0cUlAS8TTL5JIyyQ9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q52LR7	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-769498|uniprotkb:Q7L9J1|uniprotkb:Q96RR7|uniprotkb:Q9NUT8|uniprotkb:Q9NVR1|uniprotkb:Q9UFM9|uniprotkb:B3KWT7|uniprotkb:D3DP89|ensembl:ENSP00000258484	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:epc2_human(display_long)|uniprotkb:EPC-like(gene name synonym)|uniprotkb:EPC2(gene name)|psi-mi:EPC2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_056445.3|ensembl:ENSG00000135999(gene)|ensembl:ENST00000258484(transcript)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016573"(histone acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|interpro:IPR009607(Enhancer of polycomb, C-terminal)|interpro:IPR019542|interpro:IPR024943	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:/xsgjMFT0Dh3fQalLVsbGJ1kEn89606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q96T58	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-765739|uniprotkb:Q9UQ01|uniprotkb:Q9Y556|uniprotkb:Q9H9A8|uniprotkb:Q9NWH5|intact:EBI-28975565|ensembl:ENSP00000364912	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:mint_human(display_long)|uniprotkb:SPEN homolog(gene name synonym)|uniprotkb:SMART/HDAC1-associated repressor protein(gene name synonym)|uniprotkb:KIAA0929(gene name synonym)|uniprotkb:MINT(gene name synonym)|uniprotkb:SHARP(gene name synonym)|uniprotkb:SPEN(gene name)|psi-mi:SPEN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055816.2|ensembl:ENSP00000364912|dip:DIP-34569N|ensembl:ENSG00000065526(gene)|ensembl:ENST00000375759(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR010912(Spen paralogue and orthologue C-terminal, metazoa)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR034172|interpro:IPR034173|interpro:IPR034174|interpro:IPR034175|interpro:IPR035979|mint:Q96T58|rcsb pdb:1OW1|rcsb pdb:2RT5|rcsb pdb:4P6Q|reactome:R-HSA-9013422|go:"GO:0005654"(nucleoplasm)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:m7bdkKVATaG4dkFG/BYXRn4jOIk9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9NY93	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8WTT2	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-2512539|ensembl:ENSP00000360412|uniprotkb:Q9H9D8|uniprotkb:Q9H5M6	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:noc3l_human(display_long)|uniprotkb:NOC3L(gene name)|psi-mi:NOC3L(display_short)|uniprotkb:AD24(gene name synonym)|uniprotkb:C10orf117(gene name synonym)|uniprotkb:FAD24(gene name synonym)|uniprotkb:NOC3-like protein(gene name synonym)|uniprotkb:Nucleolar complex-associated protein 3-like protein(gene name synonym)|uniprotkb:Factor for adipocyte differentiation 24(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045444"(fat cell differentiation)|interpro:IPR005612(CBF)|interpro:IPR011501(Nucleolar complex-associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016903(Nucleolar complex-associated protein 3)|mint:Q8WTT2|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000173145(gene)|ensembl:ENST00000371361(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|refseq:NP_071896.8	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:s78IiBuQQjc0emiM/UkEMhzThVc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9Y5J1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:l873IUyfCql4N9VelHPuUEqpzRY9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:P62910	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-438408|ensembl:ENSP00000380156|ensembl:ENSP00000380158|ensembl:ENSP00000388674|ensembl:ENSP00000416429|uniprotkb:P02433|uniprotkb:B2R4Q3	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:rl32_human(display_long)|uniprotkb:RPL32(gene name)|psi-mi:RPL32(display_short)|uniprotkb:Large ribosomal subunit protein eL32(gene name synonym)|uniprotkb:PP9932(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	ensembl:ENSG00000144713(gene)|ensembl:ENST00000396953(transcript)|ensembl:ENST00000396957(transcript)|ensembl:ENST00000429711(transcript)|ensembl:ENST00000435983(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR001515(Ribosomal protein L32e)|interpro:IPR018263|interpro:IPR036351|mint:P62910|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000985.1|refseq:NP_001007074.1|refseq:NP_001007075.1	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:8Yhph2ETzWYd07yJcq1cVqsSRjo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9H4M9	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-490691|uniprotkb:O14611|uniprotkb:Q2M3Q4|uniprotkb:Q9UNR3|ensembl:ENSP00000320516|ensembl:ENSP00000352354	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ehd1_human(display_long)|uniprotkb:Testilin(gene name synonym)|uniprotkb:CDABP0131(orf name)|uniprotkb:EHD1(gene name)|psi-mi:EHD1(display_short)|uniprotkb:PAST(gene name synonym)|uniprotkb:PAST1(gene name synonym)|uniprotkb:PAST homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_006786.2|refseq:XP_011543041.1|refseq:NP_001269373.1|refseq:NP_001269374.1|ensembl:ENSG00000110047(gene)|ensembl:ENST00000320631(transcript)|ensembl:ENST00000359393(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q9H4M9|rcsb pdb:2JQ6|rcsb pdb:2KFF|rcsb pdb:2KFG|rcsb pdb:2KFH|rcsb pdb:2KSP|reactome:R-HSA-983231	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:txUfRMtv6SbBqKKJ1DVM6K/pj2Y9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q15397	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-725523|uniprotkb:Q547G7|uniprotkb:Q5SZY9|uniprotkb:Q6IB47|uniprotkb:Q96B27|uniprotkb:Q96L78|uniprotkb:Q96L79|uniprotkb:Q96L80|uniprotkb:A8K804|ensembl:ENSP00000380982	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:pum3_human(display_long)|uniprotkb:PUM3(gene name)|psi-mi:PUM3(display_short)|uniprotkb:cPERP-C(gene name synonym)|uniprotkb:HBV X-transactivated gene 5 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 5(gene name synonym)|uniprotkb:KIAA0020(gene name synonym)|uniprotkb:Minor histocompatibility antigen HA-8(gene name synonym)|uniprotkb:PUF-A(gene name synonym)|uniprotkb:XTP5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_055693.4|ensembl:ENSG00000080608(gene)|ensembl:ENST00000397885(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006417"(regulation of translation)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012959(CPL)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|interpro:IPR040059|mint:Q15397|rcsb pdb:4WZR|rcsb pdb:4WZW	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:CjfVWg+3P3ai0EiHgeH8usbvgxg9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q969Z0	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q99613	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q9BZE4	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1056249|uniprotkb:O95446|uniprotkb:Q9NVJ8|uniprotkb:B3KMC5|uniprotkb:B4DY13|uniprotkb:B7Z7A3|uniprotkb:Q5T3R8|ensembl:ENSP00000354040	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:gtpb4_human(display_long)|uniprotkb:GTPBP4(gene name)|psi-mi:GTPBP4(display_short)|uniprotkb:CRFG(gene name synonym)|uniprotkb:NOG1(gene name synonym)|uniprotkb:Chronic renal failure gene protein(gene name synonym)|uniprotkb:GTP-binding protein NGB(gene name synonym)|uniprotkb:Nucleolar GTP-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_036473.2|ensembl:ENSG00000107937(gene)|ensembl:ENST00000360803(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033342"(negative regulation of collagen binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR010674(Nucleolar GTP-binding 1)|interpro:IPR012973(NOG, C-terminal)|interpro:IPR024926|interpro:IPR027417|interpro:IPR031167|interpro:IPR041623|mint:Q9BZE4|rcsb pdb:6LSS|rcsb pdb:6LU8	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:wTcBrIj6c27um4RnJH81grRgutc9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46013	uniprotkb:Q8TDD1	intact:EBI-876367|uniprotkb:Q5VWH2|ensembl:ENSP00000357643	intact:EBI-1052503|uniprotkb:Q86YT8|uniprotkb:Q9BRZ1|ensembl:ENSP00000304072	psi-mi:ki67_human(display_long)|uniprotkb:MKI67(gene name)|psi-mi:MKI67(display_short)|uniprotkb:Antigen identified by monoclonal antibody Ki-67(gene name synonym)	psi-mi:ddx54_human(display_long)|uniprotkb:DEAD box protein 54(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DP97(gene name synonym)|uniprotkb:DEAD box RNA helicase 97 kDa(gene name synonym)|uniprotkb:DDX54(gene name)|psi-mi:DDX54(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sobecki et al. (2016)	pubmed:26949251|imex:IM-26415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20562326|imex:IM-26415-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139438.1|refseq:NP_002408.3|dip:DIP-28132N|ensembl:ENSG00000148773(gene)|ensembl:ENST00000368654(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR012568(K167R)|interpro:IPR029334|mint:P46013|rcsb pdb:1R21|rcsb pdb:2AFF|rcsb pdb:5J28	refseq:NP_001104792.1|refseq:NP_076977.3|ensembl:ENSG00000123064(gene)|ensembl:ENST00000306014(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012541(DBP10CT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR033517|mint:Q8TDD1|go:"GO:0003724"(RNA helicase activity)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.6, Fig.6-FS2, FS1,SD1|comment:"To investigate possible molecular functions of Ki-67, we identified interacting proteins. To do this, we expressed FLAG-tagged versions of full-length human Ki-67 or an unrelated protein (TRIM39) in U2OS cells, and pulled down proteins from nuclear extracts with anti-FLAG antibody (Figure 6—figure supplement 1). These were analysed by label-free mass spectrometry. This approach identified 406 proteins specific to the Ki-67 pulldown (Figure 6—figure supplement 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/05/18	2020/08/14	rogid:kyrLLOv4HSqah1Y6HtzebG978Kw9606	rogid:VzxEkRaOIND08jGJk3yyoztesjo9606	rigid:XN9L/8vSsQdh8jnnXCMKY96hJWc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0102"(sequence tag identification)