#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10997	uniprotkb:Q9Y5Z0	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21003889|imex:IM-27028-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	-	"mimix:comment":not sure about the protein origin|comment:mint	-	figure legend:Fig. 2B, 3B, 3E, 3H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/07	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rigid:PSI9moQ5BKQ4wagMZs83nauCXk4	false	sufficient binding region:34-70(IPR001693)|mutation disrupting interaction rate:48-48,56-56|mutation disrupting interaction rate:48-48|mutation disrupting interaction rate:56-56	v5 tag:?-?|his tag:?-?|sufficient binding region:1-460	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P10997	uniprotkb:P56817	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004293|imex:IM-27028-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	crc64:377CE4C824ACEF05	figure legend:Fig. 2C, 3C, 3F, 3I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rigid:reZzCsx5UNSSPLb9r5zUKuididc	false	sufficient binding region:34-70(IPR001693)|mutation disrupting interaction rate:48-48,56-56|mutation disrupting interaction rate:48-48|mutation with no effect:56-56	mutation:46-46|his tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P12968	uniprotkb:P56817	intact:EBI-21004307|ensembl:ENSMUSP00000043956	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	psi-mi:iapp_mouse(display_long)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Iapp(gene name)|psi-mi:Iapp(display_short)	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004333|imex:IM-27028-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000041681(gene)|ensembl:ENSMUST00000041993(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|reactome:R-MMU-418555|reactome:R-MMU-419812|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|refseq:NP_034621.1	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	-	-	crc64:377CE4C824ACEF05	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:ZaHQSZf+Zrywmv2nETumqfWPVZk10090	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rigid:H9fp7A1aUdKTQB62wrfwfDy5UNc	false	sufficient binding region:45-74(IPR001693)	mutation:46-46|his tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Y5Z0	uniprotkb:P12968	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	intact:EBI-21004307|ensembl:ENSMUSP00000043956	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:iapp_mouse(display_long)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Iapp(gene name)|psi-mi:Iapp(display_short)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004347|imex:IM-27028-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	ensembl:ENSMUSG00000041681(gene)|ensembl:ENSMUST00000041993(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|reactome:R-MMU-418555|reactome:R-MMU-419812|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|refseq:NP_034621.1	-	-	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rogid:ZaHQSZf+Zrywmv2nETumqfWPVZk10090	rigid:H8d7wIwFzhyeDWBDjKra5uJC2wM	false	his tag:?-?|v5 tag:?-?|sufficient binding region:1-460	sufficient binding region:45-74(IPR001693)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Y5Z0	uniprotkb:P10997	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004354|imex:IM-27028-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	-	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig. 5|comment:Only mature insulin acted as an inhibitor, not the propeptide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:zkOR6nXRszHdRVD3VltrJ+Vv+XA	false	his tag:?-?|v5 tag:?-?|sufficient binding region:1-460	sufficient binding region:34-70(IPR001693)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Y5Z0	uniprotkb:P01308	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0435"(protease assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004354|imex:IM-27028-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	-	-	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	figure legend:Fig. 5|comment:Only mature insulin acted as an inhibitor, not the propeptide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rigid:zkOR6nXRszHdRVD3VltrJ+Vv+XA	false	his tag:?-?|v5 tag:?-?|sufficient binding region:1-460	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P10997	uniprotkb:P10997	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004377|imex:IM-27028-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	"mimix:comment":not sure about the protein origin|comment:mint	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:BBjpAdBwRFIGXy/POxEfN3wMtAs	false	sufficient binding region:34-70	sufficient binding region:34-70	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P56817	uniprotkb:P10997	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004385|imex:IM-27028-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:reZzCsx5UNSSPLb9r5zUKuididc	false	-	sufficient binding region:34-70	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P56817	uniprotkb:P10997	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004385|imex:IM-27028-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:reZzCsx5UNSSPLb9r5zUKuididc	false	-	sufficient binding region:34-70	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9Y5Z0	uniprotkb:P10997	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004394|imex:IM-27028-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	-	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:PSI9moQ5BKQ4wagMZs83nauCXk4	false	-	sufficient binding region:34-70	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9Y5Z0	uniprotkb:P10997	intact:EBI-11282723|uniprotkb:A8K7P1|uniprotkb:Q5DIH8|uniprotkb:Q8N2D4|uniprotkb:Q9H2V8|uniprotkb:Q9NZL1|uniprotkb:Q9NZL2|uniprotkb:Q9UJT6|ensembl:ENSP00000332979	intact:EBI-8526679|uniprotkb:Q14598|intact:MINT-8074874|uniprotkb:Q0ZD87|ensembl:ENSP00000240652|ensembl:ENSP00000437357	psi-mi:bace2_human(display_long)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)	psi-mi:iapp_human(display_long)|uniprotkb:IAPP(gene name)|psi-mi:IAPP(display_short)|uniprotkb:Amylin(gene name synonym)|uniprotkb:Diabetes-associated peptide(gene name synonym)|uniprotkb:Insulinoma amyloid peptide(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Rulifson et al. (2015)	pubmed:26840340|imex:IM-27028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21004394|imex:IM-27028-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036237.2|refseq:NP_620476.1|refseq:NP_620477.1|ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0031045"(dense core granule)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050435"(amyloid-beta metabolic process)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009121(Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|rcsb pdb:2EWY|rcsb pdb:3ZKG|rcsb pdb:3ZKI|rcsb pdb:3ZKM|rcsb pdb:3ZKN|rcsb pdb:3ZKQ|rcsb pdb:3ZKS|rcsb pdb:3ZKX|rcsb pdb:3ZL7|rcsb pdb:3ZLQ|rcsb pdb:4BEL|rcsb pdb:4BFB|rcsb pdb:6JSZ|rcsb pdb:6UJ0|rcsb pdb:6UJ1|rcsb pdb:7D5B|rcsb pdb:7D5U	refseq:NP_000406.1|refseq:NP_001316130.1|dip:DIP-29913N|ensembl:ENSG00000121351(gene)|ensembl:ENST00000240652(transcript)|ensembl:ENST00000539393(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016234"(inclusion body)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097647"(amylin receptor signaling pathway)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000443(Islet amyloid polypeptide)|interpro:IPR001693(Calcitonin-like)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|rcsb pdb:1KUW|rcsb pdb:2G48|rcsb pdb:2KB8|rcsb pdb:2L86|rcsb pdb:3DG1|rcsb pdb:3FPO|rcsb pdb:3FR1|rcsb pdb:3FTH|rcsb pdb:3FTK|rcsb pdb:3FTL|rcsb pdb:3FTR|rcsb pdb:3G7V|rcsb pdb:3G7W|rcsb pdb:3HGZ|rcsb pdb:5K5G|rcsb pdb:5KNZ|rcsb pdb:5KO0|rcsb pdb:5MGQ|rcsb pdb:6UCJ|rcsb pdb:6UCK|rcsb pdb:6VW2|rcsb pdb:6Y1A|rcsb pdb:6ZRF|rcsb pdb:6ZRQ|rcsb pdb:6ZRR|reactome:R-HSA-210745|reactome:R-HSA-418555|reactome:R-HSA-419812|reactome:R-HSA-9660821|reactome:R-HSA-977225	-	-	"mimix:comment":not sure about the protein origin|comment:mint	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/12/07	2018/12/10	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rogid:96US2nyXcc+hMG9Y4+Be1pxnJgw9606	rigid:PSI9moQ5BKQ4wagMZs83nauCXk4	false	-	sufficient binding region:34-70	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)