#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00444	uniprotkb:Q15468	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16749454|imex:IM-26455-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	-	-	comment:mint|comment:homomint	figure legend:nfa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/07/23	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rigid:kl1QbYIDHXlnsnLqP/4JrVXwYf8	false	sufficient binding region:570-970|enhanced green fluorescent protein tag:?-?|s tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O00444	uniprotkb:Q8TEP8	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	intact:EBI-2339778|uniprotkb:Q9H0F4|uniprotkb:Q8WYT8|uniprotkb:Q9NW27|uniprotkb:A0A060A9S4|intact:EBI-11329707|uniprotkb:B7ZMF0|uniprotkb:E9PF99|intact:EBI-10984660|ensembl:ENSP00000427550	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:ce192_human(display_long)|uniprotkb:CEP192(gene name)|psi-mi:CEP192(display_short)|uniprotkb:KIAA1569(gene name synonym)|uniprotkb:PP8407(orf name)	psi-mi:"MI:0096"(pull down)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16749454|imex:IM-26455-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	refseq:NP_115518.3|dip:DIP-52779N|ensembl:ENSG00000101639(gene)|ensembl:ENST00000506447(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|rcsb pdb:4N7Z|rcsb pdb:6FVI|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518	-	-	-	figure legend:nfa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/07/23	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rogid:XXxzXD9dfRTtgx/tKR0VhGAlPWc9606	rigid:kl1QbYIDHXlnsnLqP/4JrVXwYf8	false	sufficient binding region:570-970|enhanced green fluorescent protein tag:?-?|s tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O00444	uniprotkb:O94986	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	intact:EBI-311012|uniprotkb:Q6NTA0|uniprotkb:Q17RV1|ensembl:ENSP00000370337|uniprotkb:E7ER66|intact:EBI-11051708	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:ce152_human(display_long)|uniprotkb:CEP152(gene name)|psi-mi:CEP152(display_short)|uniprotkb:KIAA0912(gene name synonym)	psi-mi:"MI:0096"(pull down)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16749454|imex:IM-26455-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	refseq:NP_001181927.1|refseq:NP_055800.2|ensembl:ENSG00000103995(gene)|ensembl:ENST00000380950(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|interpro:IPR029598|rcsb pdb:4N7V|rcsb pdb:6CSU|rcsb pdb:6CSV|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006720500.1|dip:DIP-31701N	-	-	-	figure legend:nfa|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/07/23	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rogid:DRsdcItdRrPGvH+XWso5HudGwxw9606	rigid:kl1QbYIDHXlnsnLqP/4JrVXwYf8	false	sufficient binding region:570-970|enhanced green fluorescent protein tag:?-?|s tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750309|imex:IM-26455-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/01/30	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750322|imex:IM-26455-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Figs. 1D, 2B, 2C, 2E, Fig1 - figure supplement 2B|comment:The ser285ala,thr289ala PLK4 mutant is a non-degradable form of the protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/01/30	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	flag tag:?-?|necessary binding region:721-750	mutation with no effect:285-285,289-289|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750333|imex:IM-26455-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/01/30	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750364|imex:IM-26455-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/01/30	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:721-750	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:Q15468	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16752016|imex:IM-26455-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Fig3 -Supp. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/02/02	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rigid:Jix/hGgY9zbEQQSjZC5qafk3vxA	false	flag tag:?-?|sufficient binding region:441-880	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:Q15468	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16752029|imex:IM-26455-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Fig. 3 - Supp. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/02/02	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rigid:Jix/hGgY9zbEQQSjZC5qafk3vxA	false	flag tag:?-?|necessary binding region:721-750	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:Q15468	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16752041|imex:IM-26455-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Fig. 3- Supp 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/02/02	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rigid:Jix/hGgY9zbEQQSjZC5qafk3vxA	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:721-750	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16752053|imex:IM-26455-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/02/02	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	flag tag:?-?	enhanced green fluorescent protein tag:?-?|sufficient binding region:1-570|sufficient binding region:880-970	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16752068|imex:IM-26455-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 4C, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/02/02	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:721-750	flag tag:?-?|sufficient binding region:265-570|sufficient binding region:880-970(IPR036947)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16878528|imex:IM-26455-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/01/29	2018/03/14	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:721-750|mutation with no effect:733-733,743-743|mutation decreasing interaction strength:733-733,743-743|mutation decreasing interaction strength:737-737,739-739|mutation with no effect:733-733,736-736,743-743|mutation with no effect:733-733,740-740,743-743|mutation with no effect:733-733,736-736,740-740,743-743|mutation with no effect:733-733,740-740,743-743|s tag:?-?|ha tag:?-?	flag tag:?-?|sufficient binding region:1-570	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00444	uniprotkb:Q15468	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750351|imex:IM-26455-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	go:"GO:0005814"(centriole)	-	comment:mint|comment:homomint	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/01/30	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rigid:icftPMaM7FbvEVaZT4JlZlm46b0	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00444	uniprotkb:O94986	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	intact:EBI-311012|uniprotkb:Q6NTA0|uniprotkb:Q17RV1|ensembl:ENSP00000370337|uniprotkb:E7ER66|intact:EBI-11051708	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:ce152_human(display_long)|uniprotkb:CEP152(gene name)|psi-mi:CEP152(display_short)|uniprotkb:KIAA0912(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16750351|imex:IM-26455-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	refseq:NP_001181927.1|refseq:NP_055800.2|ensembl:ENSG00000103995(gene)|ensembl:ENST00000380950(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|interpro:IPR029598|rcsb pdb:4N7V|rcsb pdb:6CSU|rcsb pdb:6CSV|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006720500.1|dip:DIP-31701N	go:"GO:0005814"(centriole)	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2018/01/29	2018/01/30	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rogid:DRsdcItdRrPGvH+XWso5HudGwxw9606	rigid:icftPMaM7FbvEVaZT4JlZlm46b0	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16878475|imex:IM-26455-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	-	comment:mint|comment:homomint	-	figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.8x10^-7(molar)	2018/01/29	2018/03/14	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	sufficient binding region:720-751	sufficient binding region:880-970	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15468	uniprotkb:O00444	intact:EBI-7488405|uniprotkb:Q5T0C5|uniprotkb:Q68CN9|intact:MINT-8340696|ensembl:ENSP00000353544	intact:EBI-746202|uniprotkb:Q8IYF0|uniprotkb:Q96Q95|uniprotkb:B2RAL0|uniprotkb:B7Z837|uniprotkb:B7Z8G7|uniprotkb:Q9UD84|uniprotkb:Q9UDE2|ensembl:ENSP00000270861	psi-mi:stil_human(display_long)|uniprotkb:STIL(gene name)|psi-mi:STIL(display_short)|uniprotkb:SIL(gene name synonym)|uniprotkb:TAL-1-interrupting locus protein(gene name synonym)	psi-mi:plk4_human(display_long)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:PLK4(gene name)|psi-mi:PLK4(display_short)|uniprotkb:SAK(gene name synonym)|uniprotkb:STK18(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Arquint et al. (2014)	imex:IM-26455|pubmed:26188084	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16878452|imex:IM-26455-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269865.1|refseq:NP_001269866.1|refseq:NP_001269867.1|refseq:NP_001269868.1|refseq:XP_011540293.1|refseq:XP_011540294.1|refseq:NP_003026.2|refseq:NP_001041631.1|refseq:XP_006710897.1|dip:DIP-60580N|ensembl:ENSG00000123473(gene)|ensembl:ENST00000360380(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021915"(neural tube development)|go:"GO:0030900"(forebrain development)|go:"GO:0030903"(notochord development)|go:"GO:0033504"(floor plate development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051298"(centrosome duplication)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR026123|rcsb pdb:4YYP|rcsb pdb:5LHW|rcsb pdb:5LHZ	refseq:NP_001177728.1|refseq:NP_001177730.1|refseq:NP_055079.3|dip:DIP-34467N|rcsb pdb:5LHZ|rcsb pdb:6N45|rcsb pdb:6N46|rcsb pdb:6W38|rcsb pdb:6W3I|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|rcsb pdb:5LHY|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000142731(gene)|ensembl:ENST00000270861(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001741"(XY body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0060271"(cilium assembly)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|mint:O00444|rcsb pdb:2N19|rcsb pdb:3COK|rcsb pdb:4JXF|rcsb pdb:4N7V|rcsb pdb:4N7Z|rcsb pdb:4N9J|rcsb pdb:4YUR|rcsb pdb:4YYP	go:"GO:0005814"(centriole)	comment:mint|comment:homomint	-	figure legend:Fig1. - figure supplement 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/29	2018/03/14	rogid:DAbqhg3sYqsnUksDZb0k6SXtBl49606	rogid:xqjVEnoGXDk/+2AzLRAkyPK80OI9606	rigid:5Y/E7laZ9sBP/SxW8xF+WUGDKfk	false	flag tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:1-430|mutation disrupting interaction rate:154-154	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)