#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96S15 uniprotkb:P55735 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762947|imex:IM-26277-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N - - - figure legend:Figure 1A-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606 rigid:GZ3boYF/I67Z3xTI7o+WkcIL4Ic false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96S15 uniprotkb:P58004 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762947|imex:IM-26277-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Figure 1A-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:GZ3boYF/I67Z3xTI7o+WkcIL4Ic false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96S15 uniprotkb:P58005 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-16179942|ensembl:ENSP00000441927|uniprotkb:B7Z7P9|uniprotkb:Q96AD1 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sesn3_human(display_long)|uniprotkb:SESN3(gene name)|psi-mi:SESN3(display_short)|uniprotkb:SEST3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762947|imex:IM-26277-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000149212(gene)|ensembl:ENST00000536441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|refseq:NP_001258523.1|refseq:NP_653266.2|dip:DIP-62045N - - - figure legend:Figure 1A-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:9MxzlQ+s+B26xLkf1UiqekFclcE9606 rigid:GZ3boYF/I67Z3xTI7o+WkcIL4Ic false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6PJI9 uniprotkb:P55735 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1 psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762955|imex:IM-26277-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N - - - figure legend:Figure 1A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606 rigid:IrK6Y4okR777GGlyKv/XSBtbqC8 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6PJI9 uniprotkb:P58004 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762955|imex:IM-26277-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Figure 1A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:IrK6Y4okR777GGlyKv/XSBtbqC8 false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXC5 uniprotkb:Q9Y6P5 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 intact:EBI-16179977|ensembl:ENSP00000349061|uniprotkb:Q2M2B7|uniprotkb:Q5T316|uniprotkb:Q9NV00|uniprotkb:Q9UPD5|uniprotkb:Q9Y6P6 psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:sesn1_human(display_long)|uniprotkb:SESN1(gene name)|psi-mi:SESN1(display_short)|uniprotkb:PA26(gene name synonym)|uniprotkb:SEST1(gene name synonym)|uniprotkb:p53-regulated protein PA26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762963|imex:IM-26277-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N ensembl:ENSG00000080546(gene)|ensembl:ENST00000356644(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|reactome:R-HSA-9639288|refseq:NP_001186862.1|refseq:NP_001186863.1|refseq:NP_055269.1|dip:DIP-62046N - - - figure legend:Figure 1A-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rogid:g6P/Kjg8YHAxSKbdpe7K5kx16B89606 rigid:Z4O+m5+6SbJI2qvkN8W1nCBuDUU false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXC5 uniprotkb:P55735 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1 psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762963|imex:IM-26277-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N - - - figure legend:Figure 1A-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606 rigid:Z4O+m5+6SbJI2qvkN8W1nCBuDUU false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXC5 uniprotkb:P58004 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16762963|imex:IM-26277-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Figure 1A-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:Z4O+m5+6SbJI2qvkN8W1nCBuDUU false flag tag:?-? - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96S15 uniprotkb:Q6PJI9 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763042|imex:IM-26277-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 - - - figure legend:Figure 1B-1|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rigid:QgmXkGY5qG9j21uc+eX/IG4vQX4 false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q96S15 uniprotkb:Q12980 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763042|imex:IM-26277-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N - - - figure legend:Figure 1B-1|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rigid:QgmXkGY5qG9j21uc+eX/IG4vQX4 false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q6PJI9 uniprotkb:Q9Y6P5 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 intact:EBI-16179977|ensembl:ENSP00000349061|uniprotkb:Q2M2B7|uniprotkb:Q5T316|uniprotkb:Q9NV00|uniprotkb:Q9UPD5|uniprotkb:Q9Y6P6 psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:sesn1_human(display_long)|uniprotkb:SESN1(gene name)|psi-mi:SESN1(display_short)|uniprotkb:PA26(gene name synonym)|uniprotkb:SEST1(gene name synonym)|uniprotkb:p53-regulated protein PA26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763068|imex:IM-26277-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 ensembl:ENSG00000080546(gene)|ensembl:ENST00000356644(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|reactome:R-HSA-9639288|refseq:NP_001186862.1|refseq:NP_001186863.1|refseq:NP_055269.1|dip:DIP-62046N - - - figure legend:Figure 1B-2|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rogid:g6P/Kjg8YHAxSKbdpe7K5kx16B89606 rigid:HUvR47WiJTSl0HNv8TosL11zCI8 false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P58004 uniprotkb:Q6PJI9 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763108|imex:IM-26277-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 - - - figure legend:Figure 1B-3|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rigid:b5mXpX8h94kdtY4oE33L25sjrJA false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P58004 uniprotkb:Q12980 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763108|imex:IM-26277-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N - - - figure legend:Figure 1B-3|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rigid:b5mXpX8h94kdtY4oE33L25sjrJA false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P58005 uniprotkb:Q6PJI9 intact:EBI-16179942|ensembl:ENSP00000441927|uniprotkb:B7Z7P9|uniprotkb:Q96AD1 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 psi-mi:sesn3_human(display_long)|uniprotkb:SESN3(gene name)|psi-mi:SESN3(display_short)|uniprotkb:SEST3(gene name synonym) psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763132|imex:IM-26277-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149212(gene)|ensembl:ENST00000536441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|refseq:NP_001258523.1|refseq:NP_653266.2|dip:DIP-62045N ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 - - - figure legend:Figure 1B-4|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:9MxzlQ+s+B26xLkf1UiqekFclcE9606 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rigid:gWU32X4dMtRoriAzKEZJThzKBzs false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:P58005 uniprotkb:Q12980 intact:EBI-16179942|ensembl:ENSP00000441927|uniprotkb:B7Z7P9|uniprotkb:Q96AD1 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 psi-mi:sesn3_human(display_long)|uniprotkb:SESN3(gene name)|psi-mi:SESN3(display_short)|uniprotkb:SEST3(gene name synonym) psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763132|imex:IM-26277-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149212(gene)|ensembl:ENST00000536441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|reactome:R-HSA-5628897|refseq:NP_001258523.1|refseq:NP_653266.2|dip:DIP-62045N refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N - - - figure legend:Figure 1B-4|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:9MxzlQ+s+B26xLkf1UiqekFclcE9606 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rigid:gWU32X4dMtRoriAzKEZJThzKBzs false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q12980 uniprotkb:O75140 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 intact:EBI-11102814|uniprotkb:Q5THY9|uniprotkb:Q68DR1|uniprotkb:Q5THZ0|uniprotkb:Q6PEZ1|uniprotkb:Q5THZ1|uniprotkb:Q5THZ3|uniprotkb:Q9UH13|uniprotkb:Q6MZX3|uniprotkb:A6H8V6|uniprotkb:Q5K3V5|uniprotkb:Q9UGV8|uniprotkb:A8MPX9|uniprotkb:B9EGN9|uniprotkb:B4DH93|intact:EBI-28971100|ensembl:ENSP00000371546|ensembl:ENSP00000498382 psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:depd5_human(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:DEP domain-containing protein 5(gene name synonym)|uniprotkb:KIAA0645(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763584|imex:IM-26277-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N ensembl:ENST00000382111|ensembl:ENSP00000371545|ensembl:ENSP00000371546|ensembl:ENST00000400242|ensembl:ENSP00000383101|ensembl:ENST00000400248|ensembl:ENSP00000383107|ensembl:ENST00000400249|ensembl:ENSP00000383108|ensembl:ENST00000535622|ensembl:ENSP00000440210|ensembl:ENST00000642696|ensembl:ENSP00000495917|ensembl:ENST00000644331|ensembl:ENSP00000494406|ensembl:ENST00000645711|ensembl:ENSP00000493489|ensembl:ENST00000646755|ensembl:ENSP00000496532|ensembl:ENSP00000498382|refseq:NP_001007189.1|refseq:NP_001129501.1|refseq:NP_001229825.1|refseq:NP_001229826.1|refseq:NP_055477.1|refseq:XP_005261919.1|refseq:XP_011528859.1|refseq:XP_011528860.1|refseq:XP_011528861.1|refseq:XP_011528865.1|ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR027244|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:XP_016884598.1|refseq:XP_016884599.1|refseq:XP_016884600.1|dip:DIP-62050N - - - figure legend:Supp Figure 1B|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/09 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606 rigid:Ifnn+9tQHAI052d+XOvZfjSYStM false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q12980 uniprotkb:Q6PJI9 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763584|imex:IM-26277-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 - - - figure legend:Supp Figure 1B|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/09 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 rigid:Ifnn+9tQHAI052d+XOvZfjSYStM false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q12980 uniprotkb:P58004 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763584|imex:IM-26277-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Supp Figure 1B|comment:One band present may show the presence of HA-Mios, but it cannot be distinguished from HA-WRD24.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/09 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:Ifnn+9tQHAI052d+XOvZfjSYStM false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:O75140 uniprotkb:Q12980 intact:EBI-11102814|uniprotkb:Q5THY9|uniprotkb:Q68DR1|uniprotkb:Q5THZ0|uniprotkb:Q6PEZ1|uniprotkb:Q5THZ1|uniprotkb:Q5THZ3|uniprotkb:Q9UH13|uniprotkb:Q6MZX3|uniprotkb:A6H8V6|uniprotkb:Q5K3V5|uniprotkb:Q9UGV8|uniprotkb:A8MPX9|uniprotkb:B9EGN9|uniprotkb:B4DH93|intact:EBI-28971100|ensembl:ENSP00000371546|ensembl:ENSP00000498382 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 psi-mi:depd5_human(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:DEP domain-containing protein 5(gene name synonym)|uniprotkb:KIAA0645(gene name synonym) psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763161|imex:IM-26277-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000382111|ensembl:ENSP00000371545|ensembl:ENSP00000371546|ensembl:ENST00000400242|ensembl:ENSP00000383101|ensembl:ENST00000400248|ensembl:ENSP00000383107|ensembl:ENST00000400249|ensembl:ENSP00000383108|ensembl:ENST00000535622|ensembl:ENSP00000440210|ensembl:ENST00000642696|ensembl:ENSP00000495917|ensembl:ENST00000644331|ensembl:ENSP00000494406|ensembl:ENST00000645711|ensembl:ENSP00000493489|ensembl:ENST00000646755|ensembl:ENSP00000496532|ensembl:ENSP00000498382|refseq:NP_001007189.1|refseq:NP_001129501.1|refseq:NP_001229825.1|refseq:NP_001229826.1|refseq:NP_055477.1|refseq:XP_005261919.1|refseq:XP_011528859.1|refseq:XP_011528860.1|refseq:XP_011528861.1|refseq:XP_011528865.1|ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR027244|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:XP_016884598.1|refseq:XP_016884599.1|refseq:XP_016884600.1|dip:DIP-62050N refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N - - - figure legend:Figure 1 C/D, Supp. figure 1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rigid:mAwdD6nWv2zrHuTmjHudiTRfmrM false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75140 uniprotkb:Q8WTW4 intact:EBI-11102814|uniprotkb:Q5THY9|uniprotkb:Q68DR1|uniprotkb:Q5THZ0|uniprotkb:Q6PEZ1|uniprotkb:Q5THZ1|uniprotkb:Q5THZ3|uniprotkb:Q9UH13|uniprotkb:Q6MZX3|uniprotkb:A6H8V6|uniprotkb:Q5K3V5|uniprotkb:Q9UGV8|uniprotkb:A8MPX9|uniprotkb:B9EGN9|uniprotkb:B4DH93|intact:EBI-28971100|ensembl:ENSP00000371546|ensembl:ENSP00000498382 intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2 psi-mi:depd5_human(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:DEP domain-containing protein 5(gene name synonym)|uniprotkb:KIAA0645(gene name synonym) psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763161|imex:IM-26277-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000382111|ensembl:ENSP00000371545|ensembl:ENSP00000371546|ensembl:ENST00000400242|ensembl:ENSP00000383101|ensembl:ENST00000400248|ensembl:ENSP00000383107|ensembl:ENST00000400249|ensembl:ENSP00000383108|ensembl:ENST00000535622|ensembl:ENSP00000440210|ensembl:ENST00000642696|ensembl:ENSP00000495917|ensembl:ENST00000644331|ensembl:ENSP00000494406|ensembl:ENST00000645711|ensembl:ENSP00000493489|ensembl:ENST00000646755|ensembl:ENSP00000496532|ensembl:ENSP00000498382|refseq:NP_001007189.1|refseq:NP_001129501.1|refseq:NP_001229825.1|refseq:NP_001229826.1|refseq:NP_055477.1|refseq:XP_005261919.1|refseq:XP_011528859.1|refseq:XP_011528860.1|refseq:XP_011528861.1|refseq:XP_011528865.1|ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR027244|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:XP_016884598.1|refseq:XP_016884599.1|refseq:XP_016884600.1|dip:DIP-62050N ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N - - - figure legend:Figure 1 C/D, Supp. figure 1A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606 rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606 rigid:mAwdD6nWv2zrHuTmjHudiTRfmrM false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:Q9NXC5 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763168|imex:IM-26277-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N - - - figure legend:Figure 1 C/D/E, Supp.figure 1A/E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rigid:M4ptwb03xF6rOvCJshO5aLgdNxA false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:P58004 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763176|imex:IM-26277-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Figure 1 D|comment:"Amino acid deprivation strongly increased the GATOR2 (Mios/WDR24)-Sestrin2 interaction."|agonist:Amino acid deprivation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:Q9NXC5 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763176|imex:IM-26277-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N - - - figure legend:Figure 1 D|comment:"Amino acid deprivation strongly increased the GATOR2 (Mios/WDR24)-Sestrin2 interaction."|agonist:Amino acid deprivation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NXC5 uniprotkb:P58004 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763230|imex:IM-26277-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:figure 1E, Supp. figure 1E.|agonist:amino acid deprivation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/08 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:Z82HSpsRHTvjb/Cdk4m2gndgQM4 false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:P58004 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763240|imex:IM-26277-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Figure 1 F, Supp. figure 1C|agonist:glucose deprivation|comment:"Glucose deprivation led to a modest increase in the amount of Sestrin2 bound to GATOR2 (WDR24), albeit to a much lesser extent than that caused by amino acid starvation."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:iWah43a5/PXKGTYnmvWu1zDrRNE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:Q12980 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763270|imex:IM-26277-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N - - - figure legend:Supplementary Figure 1 A|comment:"The band for NPRL3 is only visible after \"high exposure\"."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:SesntEp9nxFuoCGuZ06jHWqueek9606 rigid:85JlZAKeUoRaQ0F9+OTcsSex98M false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:Q9NXC5 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763270|imex:IM-26277-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N - - - figure legend:Supplementary Figure 1 A|comment:"The band for NPRL3 is only visible after \"high exposure\"."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rigid:85JlZAKeUoRaQ0F9+OTcsSex98M false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92574 uniprotkb:P49815 intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897 intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8 psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym) psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763691|imex:IM-26277-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1 refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1 - - - figure legend:Supp.figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2018/02/09 rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606 rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606 rigid:FrBXCSnimJENxHO37xNuWWmtagU false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:P58004 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763720|imex:IM-26277-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N - - - figure legend:Supp. fig 3B|comment:This interaction was seen when cells were starved of amino acids. Concanamycin A, which decreased mTORC1 signaling, also reduced the interaction between Sestrin2 and GATOR2 in the absence of amino acids.|antagonist:Concanamycin A|agonist:amino acid deprivation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606 rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96S15 uniprotkb:Q9NXC5 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-16763720|imex:IM-26277-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N - - - figure legend:Supp. fig 3B|comment:This interaction was seen when cells were starved of amino acids. Concanamycin A, which decreased mTORC1 signaling, also reduced the interaction between Sestrin2 and GATOR2 in the absence of amino acids.|antagonist:Concanamycin A|agonist:amino acid deprivation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rigid:jjh7oYEvvJg+kJ2ZHY6l2mbS6AE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NXC5 uniprotkb:Q96S15 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chantranupong et al. (2014) imex:IM-26277|pubmed:25263562 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16764439|imex:IM-26277-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N - - - figure legend:Supp. fig 3B-2|comment:This interaction was seen when cells were restimulated with amino acids after starvation.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/02/01 2019/07/08 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 rigid:M4ptwb03xF6rOvCJshO5aLgdNxA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)