#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BXR5	uniprotkb:P20273-1	intact:EBI-16825459|ensembl:ENSP00000308925|ensembl:ENSP00000354459|ensembl:ENSP00000421483|ensembl:ENSP00000424923|ensembl:ENSP00000478206|ensembl:ENSP00000478985|uniprotkb:A8K7L1|uniprotkb:B3Y668|uniprotkb:D1CS21|uniprotkb:D1CS22|uniprotkb:Q32MI7|uniprotkb:Q32MI8|uniprotkb:Q5FWG4|uniprotkb:Q6UXL3	intact:EBI-16825452|ensembl:ENSP00000085219	psi-mi:tlr10_human(display_long)|uniprotkb:TLR10(gene name)|psi-mi:TLR10(display_short)|uniprotkb:UNQ315/PRO358(orf name)	psi-mi:p20273-1(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:SIGLEC2(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825443|imex:IM-26349-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027182|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2J67|reactome:R-HSA-168142|reactome:R-HSA-5603037|reactome:R-HSA-975871|ensembl:ENSG00000174123(gene)|ensembl:ENST00000308973(transcript)|ensembl:ENST00000361424(transcript)|ensembl:ENST00000506111(transcript)|ensembl:ENST00000508334(transcript)|ensembl:ENST00000613579(transcript)|ensembl:ENST00000622002(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|refseq:NP_001017388.1|refseq:NP_001182035.1|refseq:NP_001182036.1|refseq:NP_001182037.1|refseq:NP_112218.2|refseq:XP_011512063.1|refseq:XP_011512064.1	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|intact:EBI-78277(isoform-parent)	-	-	-	figure legend:figure 1B-2|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/05	rogid:1SOgVm8yLaCt8Csj814SNbd7W7Y9606	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	rigid:VDV83gE15xcCB8PHLwVquPEwZRw	false	-	fc-igg tag:c-c|sufficient binding region:20-687	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20273-1	uniprotkb:O60602	intact:EBI-16825452|ensembl:ENSP00000085219	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p20273-1(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:SIGLEC2(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825520|imex:IM-26349-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|intact:EBI-78277(isoform-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-3|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/05	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:UYNA5UWmxZSm32unkTfXb6OqObY	false	fc-igg tag:c-c|sufficient binding region:20-687	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BXR5	uniprotkb:P20138-1	intact:EBI-16825459|ensembl:ENSP00000308925|ensembl:ENSP00000354459|ensembl:ENSP00000421483|ensembl:ENSP00000424923|ensembl:ENSP00000478206|ensembl:ENSP00000478985|uniprotkb:A8K7L1|uniprotkb:B3Y668|uniprotkb:D1CS21|uniprotkb:D1CS22|uniprotkb:Q32MI7|uniprotkb:Q32MI8|uniprotkb:Q5FWG4|uniprotkb:Q6UXL3	intact:EBI-15186203|ensembl:ENSP00000262262	psi-mi:tlr10_human(display_long)|uniprotkb:TLR10(gene name)|psi-mi:TLR10(display_short)|uniprotkb:UNQ315/PRO358(orf name)	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825539|imex:IM-26349-141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027182|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2J67|reactome:R-HSA-168142|reactome:R-HSA-5603037|reactome:R-HSA-975871|ensembl:ENSG00000174123(gene)|ensembl:ENST00000308973(transcript)|ensembl:ENST00000361424(transcript)|ensembl:ENST00000506111(transcript)|ensembl:ENST00000508334(transcript)|ensembl:ENST00000613579(transcript)|ensembl:ENST00000622002(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|refseq:NP_001017388.1|refseq:NP_001182035.1|refseq:NP_001182036.1|refseq:NP_001182037.1|refseq:NP_112218.2|refseq:XP_011512063.1|refseq:XP_011512064.1	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	-	-	-	figure legend:figure 1B-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/05	rogid:1SOgVm8yLaCt8Csj814SNbd7W7Y9606	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rigid:+ObMVSnEH+81Ay4lT3RikxwntHc	false	-	fc-igg tag:c-c|sufficient binding region:18-259	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20138-1	uniprotkb:O60602	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825548|imex:IM-26349-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/05	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:jHhSYV15cnn48w56WkZaYcW/cvE	false	fc-igg tag:c-c|sufficient binding region:18-259	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15389	uniprotkb:O60602	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825632|imex:IM-26349-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:WZKE5MNJbrdHuZ2UjaVnHEz5JSo	false	fc-igg tag:c-c|sufficient binding region:17-434	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15389	uniprotkb:Q15399	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	intact:EBI-9009517|uniprotkb:D1CS39|uniprotkb:D1CS41|uniprotkb:O15452|uniprotkb:Q32MK3|uniprotkb:Q32MK4|uniprotkb:Q9UG90|ensembl:ENSP00000354932|ensembl:ENSP00000421259	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:tlr1_human(display_long)|uniprotkb:TLR1(gene name)|psi-mi:TLR1(display_short)|uniprotkb:KIAA0012(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825640|imex:IM-26349-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	refseq:NP_003254.2|refseq:XP_005262719.1|refseq:XP_016864060.1|refseq:XP_016864061.1|refseq:XP_011512044.1|refseq:XP_011512045.1|refseq:XP_011512046.1|refseq:XP_011512047.1|ensembl:ENSG00000174125(gene)|ensembl:ENST00000308979(transcript)|ensembl:ENST00000502213(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|rcsb pdb:1FYV|rcsb pdb:2Z7X|rcsb pdb:6NIH|reactome:R-HSA-1236974|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)	-	-	-	figure legend:figure 1B-8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rogid:eyLn10fWyLVCfZRFifSu23g8NXg9606	rigid:vNO/i3Fm7wes2cKQcjBZSVSN8I0	false	fc-igg tag:c-c|sufficient binding region:17-434	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O60603	uniprotkb:O15389	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825648|imex:IM-26349-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:Re6asHfdkwBRFOmeGGY5hOSZuWs	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15455	uniprotkb:O15389	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825656|imex:IM-26349-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:glXPVJypBzahyiQ5BCfAP1pMrec	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:O15389	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825664|imex:IM-26349-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:Jh6vyH+xiBrd0p4Z2p2tAONUl0k	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y2C9	uniprotkb:O15389	intact:EBI-13940779|ensembl:ENSP00000371376|ensembl:ENSP00000389600|uniprotkb:B3Y640|uniprotkb:B6CH35|uniprotkb:B6RFS4|uniprotkb:B6RFS5|uniprotkb:Q2NKL3	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr6_human(display_long)|uniprotkb:TLR6(gene name)|psi-mi:TLR6(display_short)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825672|imex:IM-26349-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000174130(gene)|ensembl:ENST00000381950(transcript)|ensembl:ENST00000436693(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:4OM7|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|refseq:NP_006059.2|refseq:XP_005262694.1|refseq:XP_011511914.1|refseq:XP_011511915.1|refseq:XP_011511916.1	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:ZxUgLMp8135g2wNoVV2aRrwE0NU9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:82zCflY3FamxXtoTQhdPujexkgk	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NYK1	uniprotkb:O15389	intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825680|imex:IM-26349-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-13|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:Shd+9wo0YMrm1kD/7ZcSdnu3900	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR97	uniprotkb:O15389	intact:EBI-16356363|ensembl:ENSP00000218032|uniprotkb:B3Y654|uniprotkb:D1CS70|uniprotkb:D1CS76|uniprotkb:Q495P4|uniprotkb:Q6UXL6|uniprotkb:Q9NYG9	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr8_human(display_long)|uniprotkb:TLR8(gene name)|psi-mi:TLR8(display_short)|uniprotkb:UNQ249/PRO286(orf name)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825688|imex:IM-26349-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101916(gene)|ensembl:ENST00000218032(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3W3G|rcsb pdb:3W3J|rcsb pdb:3W3K|rcsb pdb:3W3L|rcsb pdb:3W3M|rcsb pdb:3W3N|rcsb pdb:3WN4|rcsb pdb:4QBZ|rcsb pdb:4QC0|rcsb pdb:4R07|rcsb pdb:4R08|rcsb pdb:4R09|rcsb pdb:4R0A|rcsb pdb:4R6A|rcsb pdb:5AWA|rcsb pdb:5AWB|rcsb pdb:5AWC|rcsb pdb:5AWD|rcsb pdb:5AZ5|rcsb pdb:5HDH|rcsb pdb:5WYX|rcsb pdb:5WYZ|rcsb pdb:5Z14|rcsb pdb:5Z15|rcsb pdb:6KYA|rcsb pdb:6TY5|rcsb pdb:6V9U|rcsb pdb:6WML|rcsb pdb:6ZJZ|rcsb pdb:7CRF|reactome:R-HSA-1679131|reactome:R-HSA-168181|go:"GO:0032729"(positive regulation of interferon-gamma production)|dip:DIP-61413N|refseq:NP_057694.2|refseq:NP_619542.1|refseq:XP_011543831.1|refseq:XP_011543832.1	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:7kAKEx+yywW4vJGnHEzYINsI9+c9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:AGg0IBKxifs25LLdjqdlDZrYYXk	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR96	uniprotkb:O15389	intact:EBI-1762509|uniprotkb:Q6UVZ2|uniprotkb:Q9HD68|uniprotkb:Q9HD69|uniprotkb:Q9HD70|uniprotkb:Q9NYC2|uniprotkb:Q9NYC3|uniprotkb:B3Y661|ensembl:ENSP00000353874|uniprotkb:D1CS56	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr9_human(display_long)|uniprotkb:TLR9(gene name)|psi-mi:TLR9(display_short)|uniprotkb:UNQ5798/PRO19605(orf name)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825696|imex:IM-26349-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_059138.1|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|reactome:R-HSA-109704|reactome:R-HSA-1679131|reactome:R-HSA-168138|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|ensembl:ENSG00000239732(gene)|ensembl:ENST00000360658(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-52371N	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:WOPB/2EHfSvsi6erCk/Z1iERb/Q9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:LVqW8qq/OiDaBt1zl/EXwdCSOII	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BXR5	uniprotkb:O15389	intact:EBI-16825459|ensembl:ENSP00000308925|ensembl:ENSP00000354459|ensembl:ENSP00000421483|ensembl:ENSP00000424923|ensembl:ENSP00000478206|ensembl:ENSP00000478985|uniprotkb:A8K7L1|uniprotkb:B3Y668|uniprotkb:D1CS21|uniprotkb:D1CS22|uniprotkb:Q32MI7|uniprotkb:Q32MI8|uniprotkb:Q5FWG4|uniprotkb:Q6UXL3	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr10_human(display_long)|uniprotkb:TLR10(gene name)|psi-mi:TLR10(display_short)|uniprotkb:UNQ315/PRO358(orf name)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825704|imex:IM-26349-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027182|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2J67|reactome:R-HSA-168142|reactome:R-HSA-5603037|reactome:R-HSA-975871|ensembl:ENSG00000174123(gene)|ensembl:ENST00000308973(transcript)|ensembl:ENST00000361424(transcript)|ensembl:ENST00000506111(transcript)|ensembl:ENST00000508334(transcript)|ensembl:ENST00000613579(transcript)|ensembl:ENST00000622002(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|refseq:NP_001017388.1|refseq:NP_001182035.1|refseq:NP_001182036.1|refseq:NP_001182037.1|refseq:NP_112218.2|refseq:XP_011512063.1|refseq:XP_011512064.1	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1B-16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:1SOgVm8yLaCt8Csj814SNbd7W7Y9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:kizX0aSpuguz1jV9kJNB8P3O+SI	false	-	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15455	uniprotkb:O43699-3	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825730|imex:IM-26349-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1B-19|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:H0o6y7M73hdMRb4n1/1LABmI1BI	false	-	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:O43699-3	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825739|imex:IM-26349-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1B-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:RoEwN2YfHu2nWXyizYLol9P9zU4	false	-	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43699-3	uniprotkb:O60602	intact:EBI-12161783|ensembl:ENSP00000344064	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825748|imex:IM-26349-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	isoform-comment:No experimental confirmation available.	-	figure legend:figure 1B-21|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:PGDaMcNvUytZ6zuYX+/u8iXfBJo	false	fc-igg tag:c-c|sufficient binding region:27-331	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR97	uniprotkb:O43699-3	intact:EBI-16356363|ensembl:ENSP00000218032|uniprotkb:B3Y654|uniprotkb:D1CS70|uniprotkb:D1CS76|uniprotkb:Q495P4|uniprotkb:Q6UXL6|uniprotkb:Q9NYG9	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr8_human(display_long)|uniprotkb:TLR8(gene name)|psi-mi:TLR8(display_short)|uniprotkb:UNQ249/PRO286(orf name)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825756|imex:IM-26349-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101916(gene)|ensembl:ENST00000218032(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3W3G|rcsb pdb:3W3J|rcsb pdb:3W3K|rcsb pdb:3W3L|rcsb pdb:3W3M|rcsb pdb:3W3N|rcsb pdb:3WN4|rcsb pdb:4QBZ|rcsb pdb:4QC0|rcsb pdb:4R07|rcsb pdb:4R08|rcsb pdb:4R09|rcsb pdb:4R0A|rcsb pdb:4R6A|rcsb pdb:5AWA|rcsb pdb:5AWB|rcsb pdb:5AWC|rcsb pdb:5AWD|rcsb pdb:5AZ5|rcsb pdb:5HDH|rcsb pdb:5WYX|rcsb pdb:5WYZ|rcsb pdb:5Z14|rcsb pdb:5Z15|rcsb pdb:6KYA|rcsb pdb:6TY5|rcsb pdb:6V9U|rcsb pdb:6WML|rcsb pdb:6ZJZ|rcsb pdb:7CRF|reactome:R-HSA-1679131|reactome:R-HSA-168181|go:"GO:0032729"(positive regulation of interferon-gamma production)|dip:DIP-61413N|refseq:NP_057694.2|refseq:NP_619542.1|refseq:XP_011543831.1|refseq:XP_011543832.1	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1B-22|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:7kAKEx+yywW4vJGnHEzYINsI9+c9606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:gmiYzjU8OWd//bYfudvGBCfg3DA	false	-	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR96	uniprotkb:O43699-3	intact:EBI-1762509|uniprotkb:Q6UVZ2|uniprotkb:Q9HD68|uniprotkb:Q9HD69|uniprotkb:Q9HD70|uniprotkb:Q9NYC2|uniprotkb:Q9NYC3|uniprotkb:B3Y661|ensembl:ENSP00000353874|uniprotkb:D1CS56	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr9_human(display_long)|uniprotkb:TLR9(gene name)|psi-mi:TLR9(display_short)|uniprotkb:UNQ5798/PRO19605(orf name)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825764|imex:IM-26349-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_059138.1|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|reactome:R-HSA-109704|reactome:R-HSA-1679131|reactome:R-HSA-168138|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|ensembl:ENSG00000239732(gene)|ensembl:ENST00000360658(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-52371N	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1B-23|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:WOPB/2EHfSvsi6erCk/Z1iERb/Q9606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:nzGkAAzZlXzyq0VI0EnmBOrN8yU	false	-	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BXR5	uniprotkb:O43699-3	intact:EBI-16825459|ensembl:ENSP00000308925|ensembl:ENSP00000354459|ensembl:ENSP00000421483|ensembl:ENSP00000424923|ensembl:ENSP00000478206|ensembl:ENSP00000478985|uniprotkb:A8K7L1|uniprotkb:B3Y668|uniprotkb:D1CS21|uniprotkb:D1CS22|uniprotkb:Q32MI7|uniprotkb:Q32MI8|uniprotkb:Q5FWG4|uniprotkb:Q6UXL3	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr10_human(display_long)|uniprotkb:TLR10(gene name)|psi-mi:TLR10(display_short)|uniprotkb:UNQ315/PRO358(orf name)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825773|imex:IM-26349-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027182|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2J67|reactome:R-HSA-168142|reactome:R-HSA-5603037|reactome:R-HSA-975871|ensembl:ENSG00000174123(gene)|ensembl:ENST00000308973(transcript)|ensembl:ENST00000361424(transcript)|ensembl:ENST00000506111(transcript)|ensembl:ENST00000508334(transcript)|ensembl:ENST00000613579(transcript)|ensembl:ENST00000622002(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|refseq:NP_001017388.1|refseq:NP_001182035.1|refseq:NP_001182036.1|refseq:NP_001182037.1|refseq:NP_112218.2|refseq:XP_011512063.1|refseq:XP_011512064.1	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1B-24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:1SOgVm8yLaCt8Csj814SNbd7W7Y9606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:fiP06vtY4Gnnqy4Hk90PdCINa78	false	-	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15455	uniprotkb:Q9Y286	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-2801178|uniprotkb:Q9UJ86|uniprotkb:Q9NZQ1|uniprotkb:Q9Y502|uniprotkb:Q9UJ87|ensembl:ENSP00000323328	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:sigl7_human(display_long)|uniprotkb:AIRM1(gene name synonym)|uniprotkb:Adhesion inhibitory receptor molecule 1(gene name synonym)|uniprotkb:CDw328(gene name synonym)|uniprotkb:D-siglec(gene name synonym)|uniprotkb:QA79 membrane protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:SIGLEC7(gene name)|psi-mi:SIGLEC7(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825782|imex:IM-26349-143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	refseq:NP_055200.1|refseq:NP_057627.2|refseq:NP_001264130.1|ensembl:ENSG00000168995(gene)|ensembl:ENST00000317643(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1NKO|rcsb pdb:1O7S|rcsb pdb:1O7V|rcsb pdb:2DF3|rcsb pdb:2G5R|rcsb pdb:2HRL|reactome:R-HSA-198933	-	-	-	figure legend:figure 1B-25|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:H20Yt9dfFC/+5igLfK0gOpKtigo9606	rigid:TXZC13R4wkaj/xOIwC0hZ8HU/4Q	false	-	fc-igg tag:c-c|sufficient binding region:19-357	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y286	uniprotkb:O60602	intact:EBI-2801178|uniprotkb:Q9UJ86|uniprotkb:Q9NZQ1|uniprotkb:Q9Y502|uniprotkb:Q9UJ87|ensembl:ENSP00000323328	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:sigl7_human(display_long)|uniprotkb:AIRM1(gene name synonym)|uniprotkb:Adhesion inhibitory receptor molecule 1(gene name synonym)|uniprotkb:CDw328(gene name synonym)|uniprotkb:D-siglec(gene name synonym)|uniprotkb:QA79 membrane protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:SIGLEC7(gene name)|psi-mi:SIGLEC7(display_short)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825790|imex:IM-26349-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055200.1|refseq:NP_057627.2|refseq:NP_001264130.1|ensembl:ENSG00000168995(gene)|ensembl:ENST00000317643(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1NKO|rcsb pdb:1O7S|rcsb pdb:1O7V|rcsb pdb:2DF3|rcsb pdb:2G5R|rcsb pdb:2HRL|reactome:R-HSA-198933	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-26|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:H20Yt9dfFC/+5igLfK0gOpKtigo9606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:BAOjEA5HdYnVuIhcgPySJ9CWxbM	false	fc-igg tag:c-c|sufficient binding region:19-357	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y336	uniprotkb:O60602	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825800|imex:IM-26349-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-31|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:L2OG20Zd1/l0pEgW2FXmS/mI+sg	false	fc-igg tag:c-c|sufficient binding region:18-348	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y336	uniprotkb:Q15399	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	intact:EBI-9009517|uniprotkb:D1CS39|uniprotkb:D1CS41|uniprotkb:O15452|uniprotkb:Q32MK3|uniprotkb:Q32MK4|uniprotkb:Q9UG90|ensembl:ENSP00000354932|ensembl:ENSP00000421259	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:tlr1_human(display_long)|uniprotkb:TLR1(gene name)|psi-mi:TLR1(display_short)|uniprotkb:KIAA0012(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825809|imex:IM-26349-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	refseq:NP_003254.2|refseq:XP_005262719.1|refseq:XP_016864060.1|refseq:XP_016864061.1|refseq:XP_011512044.1|refseq:XP_011512045.1|refseq:XP_011512046.1|refseq:XP_011512047.1|ensembl:ENSG00000174125(gene)|ensembl:ENST00000308979(transcript)|ensembl:ENST00000502213(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|rcsb pdb:1FYV|rcsb pdb:2Z7X|rcsb pdb:6NIH|reactome:R-HSA-1236974|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)	-	-	-	figure legend:figure 1B-27|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rogid:eyLn10fWyLVCfZRFifSu23g8NXg9606	rigid:qZY8Oc/q8CaLRKIOYUIWiaRf4kQ	false	fc-igg tag:c-c|sufficient binding region:18-348	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O60603	uniprotkb:Q9Y336	intact:EBI-973722|ensembl:ENSP00000260010|ensembl:ENSP00000494425|ensembl:ENSP00000495339|uniprotkb:O15454|uniprotkb:Q8NI00|uniprotkb:B3Y612|uniprotkb:D1CS45|uniprotkb:D1CS48|uniprotkb:D1CS49	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr2_human(display_long)|uniprotkb:Toll/interleukin-1 receptor-like protein 4(gene name synonym)|uniprotkb:TLR2(gene name)|psi-mi:TLR2(display_short)|uniprotkb:TIL4(gene name synonym)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825817|imex:IM-26349-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137462(gene)|ensembl:ENST00000260010(transcript)|ensembl:ENST00000642580(transcript)|ensembl:ENST00000642700(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032570"(response to progesterone)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|mint:O60603|rcsb pdb:1FYW|rcsb pdb:1FYX|rcsb pdb:1O77|rcsb pdb:2Z7X|rcsb pdb:2Z80|rcsb pdb:6NIG|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9637628|reactome:R-HSA-1236974|refseq:NP_003255.2|refseq:XP_011530517.1|refseq:XP_011530518.1|refseq:XP_016864062.1|refseq:XP_016864063.1|refseq:XP_016864064.1|refseq:XP_016864065.1|refseq:NP_001305716.1|refseq:NP_001305718.1|refseq:NP_001305719.1|refseq:NP_001305720.1|refseq:NP_001305722.1|refseq:NP_001305725.1|refseq:NP_001305724.1|dip:DIP-35138N	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-28|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:6xdppMwVYR7qWpDocSsqwvocdU89606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:5xYh1ft4KnsgzjS5FbF5IrSieSw	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15455	uniprotkb:Q9Y336	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825825|imex:IM-26349-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-29|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:YxuGHTHNu6ZT4iCJm4l0JRQqS6g	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q9Y336	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825833|imex:IM-26349-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-30|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:ptLXMN/kxVxnJQN2TU4WbnYuYKY	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NYK1	uniprotkb:Q9Y336	intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825841|imex:IM-26349-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-32|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:N1u6ClNW3w9H885tUZ35Tyzr+hs	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR97	uniprotkb:Q9Y336	intact:EBI-16356363|ensembl:ENSP00000218032|uniprotkb:B3Y654|uniprotkb:D1CS70|uniprotkb:D1CS76|uniprotkb:Q495P4|uniprotkb:Q6UXL6|uniprotkb:Q9NYG9	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr8_human(display_long)|uniprotkb:TLR8(gene name)|psi-mi:TLR8(display_short)|uniprotkb:UNQ249/PRO286(orf name)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825849|imex:IM-26349-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000101916(gene)|ensembl:ENST00000218032(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3W3G|rcsb pdb:3W3J|rcsb pdb:3W3K|rcsb pdb:3W3L|rcsb pdb:3W3M|rcsb pdb:3W3N|rcsb pdb:3WN4|rcsb pdb:4QBZ|rcsb pdb:4QC0|rcsb pdb:4R07|rcsb pdb:4R08|rcsb pdb:4R09|rcsb pdb:4R0A|rcsb pdb:4R6A|rcsb pdb:5AWA|rcsb pdb:5AWB|rcsb pdb:5AWC|rcsb pdb:5AWD|rcsb pdb:5AZ5|rcsb pdb:5HDH|rcsb pdb:5WYX|rcsb pdb:5WYZ|rcsb pdb:5Z14|rcsb pdb:5Z15|rcsb pdb:6KYA|rcsb pdb:6TY5|rcsb pdb:6V9U|rcsb pdb:6WML|rcsb pdb:6ZJZ|rcsb pdb:7CRF|reactome:R-HSA-1679131|reactome:R-HSA-168181|go:"GO:0032729"(positive regulation of interferon-gamma production)|dip:DIP-61413N|refseq:NP_057694.2|refseq:NP_619542.1|refseq:XP_011543831.1|refseq:XP_011543832.1	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-33|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:7kAKEx+yywW4vJGnHEzYINsI9+c9606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:soB9j77Trbdq5I2Tdt3CIjYcwsA	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NR96	uniprotkb:Q9Y336	intact:EBI-1762509|uniprotkb:Q6UVZ2|uniprotkb:Q9HD68|uniprotkb:Q9HD69|uniprotkb:Q9HD70|uniprotkb:Q9NYC2|uniprotkb:Q9NYC3|uniprotkb:B3Y661|ensembl:ENSP00000353874|uniprotkb:D1CS56	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr9_human(display_long)|uniprotkb:TLR9(gene name)|psi-mi:TLR9(display_short)|uniprotkb:UNQ5798/PRO19605(orf name)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825858|imex:IM-26349-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_059138.1|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|reactome:R-HSA-109704|reactome:R-HSA-1679131|reactome:R-HSA-168138|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|ensembl:ENSG00000239732(gene)|ensembl:ENST00000360658(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-52371N	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-34|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:WOPB/2EHfSvsi6erCk/Z1iERb/Q9606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:vZIPKK4K1VyT92GBl6lllM6UlP0	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BXR5	uniprotkb:Q9Y336	intact:EBI-16825459|ensembl:ENSP00000308925|ensembl:ENSP00000354459|ensembl:ENSP00000421483|ensembl:ENSP00000424923|ensembl:ENSP00000478206|ensembl:ENSP00000478985|uniprotkb:A8K7L1|uniprotkb:B3Y668|uniprotkb:D1CS21|uniprotkb:D1CS22|uniprotkb:Q32MI7|uniprotkb:Q32MI8|uniprotkb:Q5FWG4|uniprotkb:Q6UXL3	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr10_human(display_long)|uniprotkb:TLR10(gene name)|psi-mi:TLR10(display_short)|uniprotkb:UNQ315/PRO358(orf name)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825866|imex:IM-26349-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027182|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2J67|reactome:R-HSA-168142|reactome:R-HSA-5603037|reactome:R-HSA-975871|ensembl:ENSG00000174123(gene)|ensembl:ENST00000308973(transcript)|ensembl:ENST00000361424(transcript)|ensembl:ENST00000506111(transcript)|ensembl:ENST00000508334(transcript)|ensembl:ENST00000613579(transcript)|ensembl:ENST00000622002(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|refseq:NP_001017388.1|refseq:NP_001182035.1|refseq:NP_001182036.1|refseq:NP_001182037.1|refseq:NP_112218.2|refseq:XP_011512063.1|refseq:XP_011512064.1	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1B-35|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:1SOgVm8yLaCt8Csj814SNbd7W7Y9606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:I8p7uxGvcVS3abVnxs04x3uzZ0o	false	-	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96LC7	uniprotkb:Q15399	intact:EBI-8502656|ensembl:ENSP00000345243|uniprotkb:Q3MIR5|uniprotkb:C9JJ33|intact:MINT-8020518|uniprotkb:Q96LC8|uniprotkb:A8K1I5|uniprotkb:F8W917|uniprotkb:C9JM10|uniprotkb:Q6UXI8|uniprotkb:A8K3C7|uniprotkb:Q96G54	intact:EBI-9009517|uniprotkb:D1CS39|uniprotkb:D1CS41|uniprotkb:O15452|uniprotkb:Q32MK3|uniprotkb:Q32MK4|uniprotkb:Q9UG90|ensembl:ENSP00000354932|ensembl:ENSP00000421259	psi-mi:sig10_human(display_long)|uniprotkb:SIGLEC10(gene name)|psi-mi:SIGLEC10(display_short)|uniprotkb:SLG2(gene name synonym)|uniprotkb:Siglec-like protein 2(gene name synonym)|uniprotkb:UNQ477/PRO940(orf name)	psi-mi:tlr1_human(display_long)|uniprotkb:TLR1(gene name)|psi-mi:TLR1(display_short)|uniprotkb:KIAA0012(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825874|imex:IM-26349-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|ensembl:ENSG00000142512(gene)|ensembl:ENST00000339313(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045087"(innate immune response)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001309034.1|refseq:NP_001164630.1|refseq:NP_001164627.1|refseq:NP_149121.2|refseq:NP_001164632.1|refseq:NP_001164628.1|refseq:NP_001164629.1	refseq:NP_003254.2|refseq:XP_005262719.1|refseq:XP_016864060.1|refseq:XP_016864061.1|refseq:XP_011512044.1|refseq:XP_011512045.1|refseq:XP_011512046.1|refseq:XP_011512047.1|ensembl:ENSG00000174125(gene)|ensembl:ENST00000308979(transcript)|ensembl:ENST00000502213(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|rcsb pdb:1FYV|rcsb pdb:2Z7X|rcsb pdb:6NIH|reactome:R-HSA-1236974|reactome:R-HSA-1461957|reactome:R-HSA-166058|reactome:R-HSA-168179|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)	-	comment:mint	-	figure legend:figure 1B-36|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:5p6tJjKKo4yBDAaU8FJiprRG5Vc9606	rogid:eyLn10fWyLVCfZRFifSu23g8NXg9606	rigid:mdWJ1OWWY/yYyaRQDzxpjCIHEcY	false	fc-igg tag:c-c|sufficient binding region:17-546	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96LC7	uniprotkb:O15455	intact:EBI-8502656|ensembl:ENSP00000345243|uniprotkb:Q3MIR5|uniprotkb:C9JJ33|intact:MINT-8020518|uniprotkb:Q96LC8|uniprotkb:A8K1I5|uniprotkb:F8W917|uniprotkb:C9JM10|uniprotkb:Q6UXI8|uniprotkb:A8K3C7|uniprotkb:Q96G54	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	psi-mi:sig10_human(display_long)|uniprotkb:SIGLEC10(gene name)|psi-mi:SIGLEC10(display_short)|uniprotkb:SLG2(gene name synonym)|uniprotkb:Siglec-like protein 2(gene name synonym)|uniprotkb:UNQ477/PRO940(orf name)	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825882|imex:IM-26349-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|ensembl:ENSG00000142512(gene)|ensembl:ENST00000339313(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045087"(innate immune response)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001309034.1|refseq:NP_001164630.1|refseq:NP_001164627.1|refseq:NP_149121.2|refseq:NP_001164632.1|refseq:NP_001164628.1|refseq:NP_001164629.1	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	-	comment:mint	-	figure legend:figure 1B-37|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:5p6tJjKKo4yBDAaU8FJiprRG5Vc9606	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rigid:liQSN+MNGWnOlbkePw5EJVdljrs	false	fc-igg tag:c-c|sufficient binding region:17-546	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96LC7	uniprotkb:Q9NR97	intact:EBI-8502656|ensembl:ENSP00000345243|uniprotkb:Q3MIR5|uniprotkb:C9JJ33|intact:MINT-8020518|uniprotkb:Q96LC8|uniprotkb:A8K1I5|uniprotkb:F8W917|uniprotkb:C9JM10|uniprotkb:Q6UXI8|uniprotkb:A8K3C7|uniprotkb:Q96G54	intact:EBI-16356363|ensembl:ENSP00000218032|uniprotkb:B3Y654|uniprotkb:D1CS70|uniprotkb:D1CS76|uniprotkb:Q495P4|uniprotkb:Q6UXL6|uniprotkb:Q9NYG9	psi-mi:sig10_human(display_long)|uniprotkb:SIGLEC10(gene name)|psi-mi:SIGLEC10(display_short)|uniprotkb:SLG2(gene name synonym)|uniprotkb:Siglec-like protein 2(gene name synonym)|uniprotkb:UNQ477/PRO940(orf name)	psi-mi:tlr8_human(display_long)|uniprotkb:TLR8(gene name)|psi-mi:TLR8(display_short)|uniprotkb:UNQ249/PRO286(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825890|imex:IM-26349-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|ensembl:ENSG00000142512(gene)|ensembl:ENST00000339313(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045087"(innate immune response)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001309034.1|refseq:NP_001164630.1|refseq:NP_001164627.1|refseq:NP_149121.2|refseq:NP_001164632.1|refseq:NP_001164628.1|refseq:NP_001164629.1	ensembl:ENSG00000101916(gene)|ensembl:ENST00000218032(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3W3G|rcsb pdb:3W3J|rcsb pdb:3W3K|rcsb pdb:3W3L|rcsb pdb:3W3M|rcsb pdb:3W3N|rcsb pdb:3WN4|rcsb pdb:4QBZ|rcsb pdb:4QC0|rcsb pdb:4R07|rcsb pdb:4R08|rcsb pdb:4R09|rcsb pdb:4R0A|rcsb pdb:4R6A|rcsb pdb:5AWA|rcsb pdb:5AWB|rcsb pdb:5AWC|rcsb pdb:5AWD|rcsb pdb:5AZ5|rcsb pdb:5HDH|rcsb pdb:5WYX|rcsb pdb:5WYZ|rcsb pdb:5Z14|rcsb pdb:5Z15|rcsb pdb:6KYA|rcsb pdb:6TY5|rcsb pdb:6V9U|rcsb pdb:6WML|rcsb pdb:6ZJZ|rcsb pdb:7CRF|reactome:R-HSA-1679131|reactome:R-HSA-168181|go:"GO:0032729"(positive regulation of interferon-gamma production)|dip:DIP-61413N|refseq:NP_057694.2|refseq:NP_619542.1|refseq:XP_011543831.1|refseq:XP_011543832.1	-	comment:mint	-	figure legend:figure 1B-38|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:5p6tJjKKo4yBDAaU8FJiprRG5Vc9606	rogid:7kAKEx+yywW4vJGnHEzYINsI9+c9606	rigid:sm2mKqRmg9qiJ8hjVu3g8o3znJ4	false	fc-igg tag:c-c|sufficient binding region:17-546	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15455	uniprotkb:Q96RL6-1	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-16825909|ensembl:ENSP00000412361	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:q96rl6-1(display_long)|uniprotkb:SIGLEC11(gene name)|psi-mi:SIGLEC11(display_short)|uniprotkb:UNQ9222/PRO28718(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825898|imex:IM-26349-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	ensembl:ENSG00000161640(gene)|ensembl:ENST00000447370(transcript)|intact:EBI-2797040(isoform-parent)	-	-	-	figure legend:figure 1B-39|comment:"The accession number given for Siglec11 on the  R+D web site is GenBank:AAK72907.  SwissProt entry Q96RL6 states:-\"The sequence AAK72907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.\". Thus the equivalent ECD sequence has been entered here."|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:DqBclXA8rXH7B+fuMcNf5iQbdH89606	rigid:xyZ6+s+x7kz0ITRP55jc4Z9e72o	false	-	fc-igg tag:c-c|sufficient binding region:30-555	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96RL6-1	uniprotkb:O60602	intact:EBI-16825909|ensembl:ENSP00000412361	intact:EBI-3505951|uniprotkb:B9VJ63|uniprotkb:D1CS80|uniprotkb:Q32MI2|uniprotkb:B1AZ05|uniprotkb:B3Y633|uniprotkb:O15456|uniprotkb:Q32MI3|uniprotkb:D3DTB8|ensembl:ENSP00000440643	psi-mi:q96rl6-1(display_long)|uniprotkb:SIGLEC11(gene name)|psi-mi:SIGLEC11(display_short)|uniprotkb:UNQ9222/PRO28718(orf name)	psi-mi:tlr5_human(display_long)|uniprotkb:TLR5(gene name)|psi-mi:TLR5(display_short)|uniprotkb:TIL3(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor-like protein 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825920|imex:IM-26349-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161640(gene)|ensembl:ENST00000447370(transcript)|intact:EBI-2797040(isoform-parent)	refseq:XP_011508239.1|refseq:NP_003259.2|refseq:XP_006711567.1|refseq:XP_006711568.1|refseq:XP_006711569.1|ensembl:ENSG00000187554(gene)|ensembl:ENST00000540964(transcript)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027176|interpro:IPR032675|interpro:IPR035897|mint:O60602|rcsb pdb:1P95|rcsb pdb:3J0A|reactome:R-HSA-168176|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-975871|refseq:XP_005273298.2|refseq:XP_005273299.2|refseq:XP_005273300.2|refseq:XP_016857697.1	-	-	-	figure legend:figure 1B-40|comment:"The accession number given for Siglec11 on the  R+D web site is GenBank:AAK72907.  SwissProt entry Q96RL6 states:-\"The sequence AAK72907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.\". Thus the equivalent ECD sequence has been entered here."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:DqBclXA8rXH7B+fuMcNf5iQbdH89606	rogid:vm46MUUuOOVpHlaw/cetggHo3eQ9606	rigid:jj5i4oNLIKIb8PiG/WBWHYe8dhI	false	fc-igg tag:c-c|sufficient binding region:30-555	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:O15389	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826699|imex:IM-26349-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	-	-	-	figure legend:figure 1F-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rigid:Jh6vyH+xiBrd0p4Z2p2tAONUl0k	false	his tag:c-c|sufficient binding region:24-631	fc-igg tag:c-c|sufficient binding region:17-434	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:O43699-3	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-12161783|ensembl:ENSP00000344064	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:o43699-3(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826725|imex:IM-26349-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	uniprotkb:O43699-3(isoform-parent)|ensembl:ENST00000346477(transcript)|ensembl:ENSG00000105492(gene)|intact:EBI-2814604(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:figure 1F-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:SjpKTiBWXiAG258PhGp1wzkPNiI9606	rigid:RoEwN2YfHu2nWXyizYLol9P9zU4	false	his tag:c-c|sufficient binding region:24-631	fc-igg tag:c-c|sufficient binding region:27-331	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q9Y286	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-2801178|uniprotkb:Q9UJ86|uniprotkb:Q9NZQ1|uniprotkb:Q9Y502|uniprotkb:Q9UJ87|ensembl:ENSP00000323328	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:sigl7_human(display_long)|uniprotkb:AIRM1(gene name synonym)|uniprotkb:Adhesion inhibitory receptor molecule 1(gene name synonym)|uniprotkb:CDw328(gene name synonym)|uniprotkb:D-siglec(gene name synonym)|uniprotkb:QA79 membrane protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:SIGLEC7(gene name)|psi-mi:SIGLEC7(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826738|imex:IM-26349-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_055200.1|refseq:NP_057627.2|refseq:NP_001264130.1|ensembl:ENSG00000168995(gene)|ensembl:ENST00000317643(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1NKO|rcsb pdb:1O7S|rcsb pdb:1O7V|rcsb pdb:2DF3|rcsb pdb:2G5R|rcsb pdb:2HRL|reactome:R-HSA-198933	-	-	-	figure legend:figure 1F-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:H20Yt9dfFC/+5igLfK0gOpKtigo9606	rigid:hl0TUW8RiO3Kc2uawBzf/PPgsRI	false	his tag:c-c|sufficient binding region:24-631	fc-igg tag:c-c|sufficient binding region:19-357	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q9Y336	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-12857926|ensembl:ENSP00000250360|uniprotkb:Q6GTU4|uniprotkb:Q9BYI9	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:sigl9_human(display_long)|uniprotkb:SIGLEC9(gene name)|psi-mi:SIGLEC9(display_short)|uniprotkb:CDw329(gene name synonym)|uniprotkb:Protein FOAP-9(gene name synonym)|uniprotkb:UNQ668/PRO1302(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826751|imex:IM-26349-147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000129450(gene)|ensembl:ENST00000250360(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001185487.1|refseq:NP_055256.1	-	-	-	figure legend:figure 1F-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:7mPpbrgj+B0lekR6RNy/IEGinz09606	rigid:ptLXMN/kxVxnJQN2TU4WbnYuYKY	false	his tag:c-c|sufficient binding region:24-631	fc-igg tag:c-c|sufficient binding region:18-348	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q96RL6-1	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-16825909|ensembl:ENSP00000412361	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:q96rl6-1(display_long)|uniprotkb:SIGLEC11(gene name)|psi-mi:SIGLEC11(display_short)|uniprotkb:UNQ9222/PRO28718(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826763|imex:IM-26349-149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000161640(gene)|ensembl:ENST00000447370(transcript)|intact:EBI-2797040(isoform-parent)	-	-	-	figure legend:figure 1F-5|comment:"The accession number given for Siglec11 on the  R+D web site is GenBank:AAK72907.  SwissProt entry Q96RL6 states:-\"The sequence AAK72907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.\". Thus the equivalent ECD sequence has been entered here."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:DqBclXA8rXH7B+fuMcNf5iQbdH89606	rigid:dJUd7fVdpLW24piZYe+cjkm9EKg	false	his tag:c-c|sufficient binding region:24-631	fc-igg tag:c-c|sufficient binding region:30-555	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:Q62230-1	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-16825979	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:q62230-1(display_long)|uniprotkb:Siglec1(gene name)|psi-mi:Siglec1(display_short)|uniprotkb:Sa(gene name synonym)|uniprotkb:Sn(gene name synonym)|uniprotkb:Sheep erythrocyte receptor(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825953|imex:IM-26349-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	intact:EBI-8401373(isoform-parent)	-	-	-	figure legend:Figure 1C-1|comment:"Mouse Siglec1 was stated on R+D website to have accession no \"GenBank: CAM18034.1\". The record for this entry has been removed, and the sequence is identical to UniProt Q62230-1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:jx43pNnwLwNuM/RSl5pkNddLp0U10090	rigid:bO9ZISyBTGIMOVtUjrC2bLHRIQc	false	-	fc-igg tag:c-c|sufficient binding region:20-1639	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:P35329	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-300059|uniprotkb:Q9JHL2|uniprotkb:Q9JJX9|uniprotkb:Q9JJY0|uniprotkb:Q9JJY1|uniprotkb:Q9R056|uniprotkb:Q9R094|uniprotkb:Q9WU51	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:cd22_mouse(display_long)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Siglec2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826046|imex:IM-26349-145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|refseq:NP_001036782.1|refseq:NP_033975.3|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:XP_006539556.1|refseq:XP_006539557.1|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-5690714|reactome:R-MMU-983695	-	-	-	figure legend:Figure 1C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	rigid:i0+dldswdZwV89Sz0t8L6zKoHDc	false	-	fc-igg tag:c-c|sufficient binding region:22-702	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35329	uniprotkb:Q9QUN7	intact:EBI-300059|uniprotkb:Q9JHL2|uniprotkb:Q9JJX9|uniprotkb:Q9JJY0|uniprotkb:Q9JJY1|uniprotkb:Q9R056|uniprotkb:Q9R094|uniprotkb:Q9WU51	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:cd22_mouse(display_long)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Siglec2(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826055|imex:IM-26349-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|refseq:NP_001036782.1|refseq:NP_033975.3|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:XP_006539556.1|refseq:XP_006539557.1|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-5690714|reactome:R-MMU-983695	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:3yxb/4lhKGRJBs/gaNMkOqYbC/I	false	fc-igg tag:c-c|sufficient binding region:22-702	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9JLF7	uniprotkb:P35329	intact:EBI-6548397	intact:EBI-300059|uniprotkb:Q9JHL2|uniprotkb:Q9JJX9|uniprotkb:Q9JJY0|uniprotkb:Q9JJY1|uniprotkb:Q9R056|uniprotkb:Q9R094|uniprotkb:Q9WU51	psi-mi:tlr5_mouse(display_long)|uniprotkb:Tlr5(gene name)|psi-mi:Tlr5(display_short)	psi-mi:cd22_mouse(display_long)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Siglec2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826063|imex:IM-26349-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0002224"(toll-like receptor signaling pathway)|interpro:IPR032675|refseq:NP_058624.2|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR027176|interpro:IPR035897|interpro:IPR017241(Toll-like receptor)	go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|refseq:NP_001036782.1|refseq:NP_033975.3|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:XP_006539556.1|refseq:XP_006539557.1|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-5690714|reactome:R-MMU-983695	-	-	-	figure legend:Figure 1C-4|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:qVr75SAtvL8gx4ZX/f/BE36W4AI10090	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	rigid:YAWF3FBq81Wz+RZw3TszC6OfqKw	false	-	fc-igg tag:c-c|sufficient binding region:22-702	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35329	uniprotkb:Q9EPW9	intact:EBI-300059|uniprotkb:Q9JHL2|uniprotkb:Q9JJX9|uniprotkb:Q9JJY0|uniprotkb:Q9JJY1|uniprotkb:Q9R056|uniprotkb:Q9R094|uniprotkb:Q9WU51	intact:EBI-3505985|uniprotkb:Q9WTQ4|ensembl:ENSMUSP00000062096	psi-mi:cd22_mouse(display_long)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Siglec2(gene name synonym)	psi-mi:tlr6_mouse(display_long)|uniprotkb:Tlr6(gene name)|psi-mi:Tlr6(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826072|imex:IM-26349-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|refseq:NP_001036782.1|refseq:NP_033975.3|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:XP_006539556.1|refseq:XP_006539557.1|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-5690714|reactome:R-MMU-983695	refseq:XP_006503922.1|refseq:XP_006503923.1|ensembl:ENSMUSG00000051498(gene)|ensembl:ENSMUST00000062315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3A79|reactome:R-MMU-5686938|refseq:NP_035734.3|refseq:XP_006503920.1|refseq:XP_006503921.1	-	-	-	figure legend:Figure 1C-5|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	rogid:GJ4AmgpZuV9PAH2XTpilTLifmT810090	rigid:dPGqr3F9qYdt1nKnKh5qRoPZ5E0	false	fc-igg tag:c-c|sufficient binding region:22-702	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P58681	uniprotkb:P35329	intact:EBI-16826090|ensembl:ENSMUSP00000061853|ensembl:ENSMUSP00000107789|ensembl:ENSMUSP00000107787|uniprotkb:Q923I1	intact:EBI-300059|uniprotkb:Q9JHL2|uniprotkb:Q9JJX9|uniprotkb:Q9JJY0|uniprotkb:Q9JJY1|uniprotkb:Q9R056|uniprotkb:Q9R094|uniprotkb:Q9WU51	psi-mi:tlr7_mouse(display_long)|uniprotkb:Tlr7(gene name)|psi-mi:Tlr7(display_short)	psi-mi:cd22_mouse(display_long)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Siglec2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826081|imex:IM-26349-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000044583(gene)|ensembl:ENSMUST00000060719(transcript)|ensembl:ENSMUST00000112161(transcript)|ensembl:ENSMUST00000112164(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR026880|interpro:IPR032675|interpro:IPR035897|interpro:IPR041283|reactome:R-MMU-1679131|reactome:R-MMU-168181|refseq:NP_001277684.1|refseq:NP_001277685.1|refseq:NP_001277686.1|refseq:NP_573474.1|refseq:XP_011246087.1|refseq:XP_011246088.1	go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|refseq:NP_001036782.1|refseq:NP_033975.3|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:XP_006539556.1|refseq:XP_006539557.1|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-5690714|reactome:R-MMU-983695	-	-	-	figure legend:Figure 1C-6|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/06	rogid:C6tiPsjxOgkivJqOjJkJGoU+hGU10090	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	rigid:VJxsxwvpDrVCIs2cCbHGM2CdLHA	false	-	fc-igg tag:c-c|sufficient binding region:22-702	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:Q63994-1	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-16826689|ensembl:ENSMUSP00000004728	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:q63994-1(display_long)|uniprotkb:Cd33(gene name)|psi-mi:Cd33(display_short)|uniprotkb:Siglec3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826162|imex:IM-26349-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	ensembl:ENSMUSG00000004609(gene)|ensembl:ENSMUST00000004728(transcript)|intact:EBI-17166471(isoform-parent)	-	-	-	figure legend:Figure 1C-7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:MTAL0N9hJlJT7fccL/a05mkSABI10090	rigid:2HM1bCRtcF4/P//GlfXJYKRZNE0	false	-	fc-igg tag:c-c|sufficient binding region:1..17-240	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q63994-1	uniprotkb:Q9QUN7	intact:EBI-16826689|ensembl:ENSMUSP00000004728	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:q63994-1(display_long)|uniprotkb:Cd33(gene name)|psi-mi:Cd33(display_short)|uniprotkb:Siglec3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826200|imex:IM-26349-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004609(gene)|ensembl:ENSMUST00000004728(transcript)|intact:EBI-17166471(isoform-parent)	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:MTAL0N9hJlJT7fccL/a05mkSABI10090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:MJEgXssE8Aw6qMtrEkf7qQRK32E	false	fc-igg tag:c-c|sufficient binding region:1..17-240	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q99MB1	uniprotkb:Q63994-1	intact:EBI-8399029|uniprotkb:Q91ZM4|intact:MINT-4138015|ensembl:ENSMUSP00000034056|ensembl:ENSMUSP00000126556|ensembl:ENSMUSP00000147738	intact:EBI-16826689|ensembl:ENSMUSP00000004728	psi-mi:tlr3_mouse(display_long)|uniprotkb:Tlr3(gene name)|psi-mi:Tlr3(display_short)	psi-mi:q63994-1(display_long)|uniprotkb:Cd33(gene name)|psi-mi:Cd33(display_short)|uniprotkb:Siglec3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826209|imex:IM-26349-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_569054.2|refseq:XP_006509341.1|refseq:XP_006509342.1|refseq:XP_006509343.1|refseq:XP_006509344.1|refseq:XP_006509345.1|refseq:XP_006509346.1|ensembl:ENSMUSG00000031639(gene)|ensembl:ENSMUST00000034056(transcript)|ensembl:ENSMUST00000167106(transcript)|ensembl:ENSMUST00000209772(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:Q99MB1|rcsb pdb:3CIG|rcsb pdb:3CIY|rcsb pdb:7C77	ensembl:ENSMUSG00000004609(gene)|ensembl:ENSMUST00000004728(transcript)|intact:EBI-17166471(isoform-parent)	-	comment:mint|function:"Participates in the innate immune response to microbial agents. May be involved in the recognition of ds-RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in defense against sytemic mouse cytomegalovirus infection"	-	figure legend:Figure 1C-9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:f7Kj6p7r8/wVrZJna7P+w6ySaQg10090	rogid:MTAL0N9hJlJT7fccL/a05mkSABI10090	rigid:1sV/mDp/Wirp20sCuzTL6GTQZwk	false	-	sufficient binding region:1..17-240|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9JLF7	uniprotkb:Q63994-1	intact:EBI-6548397	intact:EBI-16826689|ensembl:ENSMUSP00000004728	psi-mi:tlr5_mouse(display_long)|uniprotkb:Tlr5(gene name)|psi-mi:Tlr5(display_short)	psi-mi:q63994-1(display_long)|uniprotkb:Cd33(gene name)|psi-mi:Cd33(display_short)|uniprotkb:Siglec3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826328|imex:IM-26349-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0002224"(toll-like receptor signaling pathway)|interpro:IPR032675|refseq:NP_058624.2|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR027176|interpro:IPR035897|interpro:IPR017241(Toll-like receptor)	ensembl:ENSMUSG00000004609(gene)|ensembl:ENSMUST00000004728(transcript)|intact:EBI-17166471(isoform-parent)	-	-	-	figure legend:Figure 1C-10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:qVr75SAtvL8gx4ZX/f/BE36W4AI10090	rogid:MTAL0N9hJlJT7fccL/a05mkSABI10090	rigid:J5nWgXjIWp4K3RoeMlPsid/2DLg	false	-	sufficient binding region:1..17-240|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q63994-1	uniprotkb:Q9EPW9	intact:EBI-16826689|ensembl:ENSMUSP00000004728	intact:EBI-3505985|uniprotkb:Q9WTQ4|ensembl:ENSMUSP00000062096	psi-mi:q63994-1(display_long)|uniprotkb:Cd33(gene name)|psi-mi:Cd33(display_short)|uniprotkb:Siglec3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)	psi-mi:tlr6_mouse(display_long)|uniprotkb:Tlr6(gene name)|psi-mi:Tlr6(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826336|imex:IM-26349-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004609(gene)|ensembl:ENSMUST00000004728(transcript)|intact:EBI-17166471(isoform-parent)	refseq:XP_006503922.1|refseq:XP_006503923.1|ensembl:ENSMUSG00000051498(gene)|ensembl:ENSMUST00000062315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3A79|reactome:R-MMU-5686938|refseq:NP_035734.3|refseq:XP_006503920.1|refseq:XP_006503921.1	-	-	-	figure legend:Figure 1C-11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:MTAL0N9hJlJT7fccL/a05mkSABI10090	rogid:GJ4AmgpZuV9PAH2XTpilTLifmT810090	rigid:jL+qaWvV8Lm0vU2nl1RAaY2Ql9A	false	sufficient binding region:1..17-240|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q3Y597	uniprotkb:Q9EPW9	intact:EBI-16826358	intact:EBI-3505985|uniprotkb:Q9WTQ4|ensembl:ENSMUSP00000062096	psi-mi:q3y597_mouse(display_long)|uniprotkb:Siglech(gene name)|psi-mi:Siglech(display_short)|uniprotkb:Siglec-H(gene name synonym)	psi-mi:tlr6_mouse(display_long)|uniprotkb:Tlr6(gene name)|psi-mi:Tlr6(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826350|imex:IM-26349-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038024"(cargo receptor activity)|refseq:NP_848821.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)	refseq:XP_006503922.1|refseq:XP_006503923.1|ensembl:ENSMUSG00000051498(gene)|ensembl:ENSMUST00000062315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034150"(toll-like receptor 6 signaling pathway)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027187|interpro:IPR032675|interpro:IPR035897|rcsb pdb:3A79|reactome:R-MMU-5686938|refseq:NP_035734.3|refseq:XP_006503920.1|refseq:XP_006503921.1	-	-	-	figure legend:Figure 1C-22|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:hKLmrHEWVFbtFXC/JXx3v2qATac10090	rogid:GJ4AmgpZuV9PAH2XTpilTLifmT810090	rigid:kFc2gqgZBWwsO67K/pD6hQqOKw4	false	sufficient binding region:19..19-265..265|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:Q3Y597	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-16826358	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:q3y597_mouse(display_long)|uniprotkb:Siglech(gene name)|psi-mi:Siglech(display_short)|uniprotkb:Siglec-H(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826373|imex:IM-26349-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038024"(cargo receptor activity)|refseq:NP_848821.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)	-	-	-	figure legend:Figure 1C-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:hKLmrHEWVFbtFXC/JXx3v2qATac10090	rigid:2cUXFLEK1RImeLmgUc1BRlBlw3g	false	-	fc-igg tag:?-?|sufficient binding region:19..19-265..265	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q3Y597	uniprotkb:Q9QUN7	intact:EBI-16826358	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:q3y597_mouse(display_long)|uniprotkb:Siglech(gene name)|psi-mi:Siglech(display_short)|uniprotkb:Siglec-H(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826381|imex:IM-26349-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038024"(cargo receptor activity)|refseq:NP_848821.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-21|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:hKLmrHEWVFbtFXC/JXx3v2qATac10090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:dtEG9TPe5XmSPtenzjlUku3pnpw	false	fc-igg tag:?-?|sufficient binding region:19..19-265..265	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P58681	uniprotkb:Q3Y597	intact:EBI-16826090|ensembl:ENSMUSP00000061853|ensembl:ENSMUSP00000107789|ensembl:ENSMUSP00000107787|uniprotkb:Q923I1	intact:EBI-16826358	psi-mi:tlr7_mouse(display_long)|uniprotkb:Tlr7(gene name)|psi-mi:Tlr7(display_short)	psi-mi:q3y597_mouse(display_long)|uniprotkb:Siglech(gene name)|psi-mi:Siglech(display_short)|uniprotkb:Siglec-H(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826389|imex:IM-26349-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000044583(gene)|ensembl:ENSMUST00000060719(transcript)|ensembl:ENSMUST00000112161(transcript)|ensembl:ENSMUST00000112164(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR026880|interpro:IPR032675|interpro:IPR035897|interpro:IPR041283|reactome:R-MMU-1679131|reactome:R-MMU-168181|refseq:NP_001277684.1|refseq:NP_001277685.1|refseq:NP_001277686.1|refseq:NP_573474.1|refseq:XP_011246087.1|refseq:XP_011246088.1	go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038024"(cargo receptor activity)|refseq:NP_848821.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)	-	-	-	figure legend:Figure 1C-23|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:C6tiPsjxOgkivJqOjJkJGoU+hGU10090	rogid:hKLmrHEWVFbtFXC/JXx3v2qATac10090	rigid:Hm4qqHFw6vuth8UJFo6Ij0Cv3OE	false	-	fc-igg tag:?-?|sufficient binding region:19..19-265..265	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P58682	uniprotkb:Q3Y597	intact:EBI-16826405|ensembl:ENSMUSP00000036762|ensembl:ENSMUSP00000107793|uniprotkb:A2AHI9|uniprotkb:Q91XI7	intact:EBI-16826358	psi-mi:tlr8_mouse(display_long)|uniprotkb:Tlr8(gene name)|psi-mi:Tlr8(display_short)	psi-mi:q3y597_mouse(display_long)|uniprotkb:Siglech(gene name)|psi-mi:Siglech(display_short)|uniprotkb:Siglec-H(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826397|imex:IM-26349-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000040522(gene)|ensembl:ENSMUST00000049023(transcript)|ensembl:ENSMUST00000112170(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR026906|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1679131|go:"GO:0071260"(cellular response to mechanical stimulus)|refseq:NP_001300689.1|refseq:NP_001300690.1|refseq:NP_573475.2	go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038024"(cargo receptor activity)|refseq:NP_848821.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)	-	-	-	figure legend:Figure 1C-24|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:ODFik7knBbzxCOul2uSXprEW1sk10090	rogid:hKLmrHEWVFbtFXC/JXx3v2qATac10090	rigid:XQ0Y/kV7Llh9QG5XoHkVztIC6q0	false	-	fc-igg tag:?-?|sufficient binding region:19..19-265..265	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:Q6PJ50	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-16826509	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:q6pj50_mouse(display_long)|uniprotkb:Siglece(gene name)|psi-mi:Siglece(display_short)|uniprotkb:Siglecl1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826523|imex:IM-26349-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)	-	-	-	figure legend:Figure 1C-12|comment:The R+D protein accession ID - AAH23280, for Siglec-E, has an extra N-terminal Leucine and some sequence differences  as compared to the reviewed Uniprot entry-Q91Y57.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:ht3SGcnDYHusxLcNFVvt0aPdAx410090	rigid:VPV75oI8djLHdX7OnoTE+YSzen8	false	-	sufficient binding region:1..20-349..349|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QUK6	uniprotkb:Q6PJ50	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-16826509	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:q6pj50_mouse(display_long)|uniprotkb:Siglece(gene name)|psi-mi:Siglece(display_short)|uniprotkb:Siglecl1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826533|imex:IM-26349-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)	-	-	-	figure legend:Figure 1C-14, 4F, 5G|comment:The R+D protein accession ID - AAH23280, for Siglec-E, has an extra N-terminal Leucine and some sequence differences  as compared to the reviewed Uniprot entry-Q91Y57.|comment:Association is increased on Neu1−/− splenocytes.|comment:"Treatment with a sialidase inhibitor 2,3-dehydro-2-deoxy-N-glycolylneuraminic acid (NeuGc2en) abrogated the effect of LPS on this interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:ht3SGcnDYHusxLcNFVvt0aPdAx410090	rigid:Tk7dEOYkQ0UjPV+yZvXvc5Pa9/Q	false	-	sufficient binding region:1..20-349..349|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P58682	uniprotkb:Q6PJ50	intact:EBI-16826405|ensembl:ENSMUSP00000036762|ensembl:ENSMUSP00000107793|uniprotkb:A2AHI9|uniprotkb:Q91XI7	intact:EBI-16826509	psi-mi:tlr8_mouse(display_long)|uniprotkb:Tlr8(gene name)|psi-mi:Tlr8(display_short)	psi-mi:q6pj50_mouse(display_long)|uniprotkb:Siglece(gene name)|psi-mi:Siglece(display_short)|uniprotkb:Siglecl1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826542|imex:IM-26349-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000040522(gene)|ensembl:ENSMUST00000049023(transcript)|ensembl:ENSMUST00000112170(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR026906|interpro:IPR027175|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1679131|go:"GO:0071260"(cellular response to mechanical stimulus)|refseq:NP_001300689.1|refseq:NP_001300690.1|refseq:NP_573475.2	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)	-	-	-	figure legend:Figure 1C-15|comment:The R+D protein accession ID - AAH23280, for Siglec-E, has an extra N-terminal Leucine and some sequence differences  as compared to the reviewed Uniprot entry-Q91Y57.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:ODFik7knBbzxCOul2uSXprEW1sk10090	rogid:ht3SGcnDYHusxLcNFVvt0aPdAx410090	rigid:x18yg+477aaPbGOwIGIdbODPkJg	false	-	sufficient binding region:1..20-349..349|fc-igg tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q920G3	uniprotkb:Q9QUN7	intact:EBI-16826559|ensembl:ENSMUSP00000012798|ensembl:ENSMUSP00000113245	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:sigl5_mouse(display_long)|uniprotkb:Siglec5(gene name)|psi-mi:Siglec5(display_short)|uniprotkb:Siglecf(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin F(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826551|imex:IM-26349-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257948.1|refseq:NP_663556.1|ensembl:ENSMUSG00000039013(gene)|ensembl:ENSMUST00000012798(transcript)|ensembl:ENSMUST00000122423(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-17|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:uTySPON0fnzhfsqEL8hNyuLBbVs10090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:HhzMcIxfSCSKehIaKD8bPjPC7AM	false	fc-igg tag:c-c|sufficient binding region:18-347	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QUK6	uniprotkb:Q920G3	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-16826559|ensembl:ENSMUSP00000012798|ensembl:ENSMUSP00000113245	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:sigl5_mouse(display_long)|uniprotkb:Siglec5(gene name)|psi-mi:Siglec5(display_short)|uniprotkb:Siglecf(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin F(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826583|imex:IM-26349-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	refseq:NP_001257948.1|refseq:NP_663556.1|ensembl:ENSMUSG00000039013(gene)|ensembl:ENSMUST00000012798(transcript)|ensembl:ENSMUST00000122423(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-18, 5G|comment:"Treatment with a sialidase inhibitor 2,3-dehydro-2-deoxy-N-glycolylneuraminic acid (NeuGc2en) abrogated the effect of LPS on this interaction."|antagonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:uTySPON0fnzhfsqEL8hNyuLBbVs10090	rigid:b7QcPLlPfY/0poPOlwi4/11GF0I	false	-	fc-igg tag:c-c|sufficient binding region:18-347	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9JLF7	uniprotkb:Q920G3	intact:EBI-6548397	intact:EBI-16826559|ensembl:ENSMUSP00000012798|ensembl:ENSMUSP00000113245	psi-mi:tlr5_mouse(display_long)|uniprotkb:Tlr5(gene name)|psi-mi:Tlr5(display_short)	psi-mi:sigl5_mouse(display_long)|uniprotkb:Siglec5(gene name)|psi-mi:Siglec5(display_short)|uniprotkb:Siglecf(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin F(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826591|imex:IM-26349-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0002224"(toll-like receptor signaling pathway)|interpro:IPR032675|refseq:NP_058624.2|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR027176|interpro:IPR035897|interpro:IPR017241(Toll-like receptor)	refseq:NP_001257948.1|refseq:NP_663556.1|ensembl:ENSMUSG00000039013(gene)|ensembl:ENSMUST00000012798(transcript)|ensembl:ENSMUST00000122423(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-19|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/07	rogid:qVr75SAtvL8gx4ZX/f/BE36W4AI10090	rogid:uTySPON0fnzhfsqEL8hNyuLBbVs10090	rigid:XykRE4OKn8Xoe6D1YT5Ln78OTnw	false	-	fc-igg tag:c-c|sufficient binding region:18-347	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q6PJ50	uniprotkb:Q9QUN7	intact:EBI-16826509	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:q6pj50_mouse(display_long)|uniprotkb:Siglece(gene name)|psi-mi:Siglece(display_short)|uniprotkb:Siglecl1(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16843751|imex:IM-26349-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-13|comment:The R+D protein accession ID - AAH23280, for Siglec-E, has an extra N-terminal Leucine and some sequence differences  as compared to the reviewed Uniprot entry-Q91Y57.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/08	rogid:ht3SGcnDYHusxLcNFVvt0aPdAx410090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:wNPKTV2KwxAS+t3y2b12vKow7n4	false	sufficient binding region:1..20-349..349|fc-igg tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EPQ1	uniprotkb:Q920G3	intact:EBI-16825988|ensembl:ENSMUSP00000060793|ensembl:ENSMUSP00000142500|uniprotkb:Q9EPW5	intact:EBI-16826559|ensembl:ENSMUSP00000012798|ensembl:ENSMUSP00000113245	psi-mi:tlr1_mouse(display_long)|uniprotkb:Tlr1(gene name)|psi-mi:Tlr1(display_short)|uniprotkb:Toll/interleukin-1 receptor-like protein(gene name synonym)	psi-mi:sigl5_mouse(display_long)|uniprotkb:Siglec5(gene name)|psi-mi:Siglec5(display_short)|uniprotkb:Siglecf(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin F(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16844378|imex:IM-26349-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034130"(toll-like receptor 1 signaling pathway)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027190|interpro:IPR032675|interpro:IPR035897|reactome:R-MMU-1461957|reactome:R-MMU-5686938|ensembl:ENSMUSG00000044827(gene)|ensembl:ENSMUST00000059349(transcript)|ensembl:ENSMUST00000197315(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|refseq:NP_001263374.1|refseq:NP_109607.1|refseq:XP_006503914.1|refseq:XP_006503915.1|refseq:XP_006503916.1|refseq:XP_006503917.1|refseq:XP_006503919.1|refseq:XP_011239022.1	refseq:NP_001257948.1|refseq:NP_663556.1|ensembl:ENSMUSG00000039013(gene)|ensembl:ENSMUST00000012798(transcript)|ensembl:ENSMUST00000122423(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695	-	-	-	figure legend:Figure 1C-16|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/08	rogid:SJzHzj9x9KJSg4+71ezDe3QXDZo10090	rogid:uTySPON0fnzhfsqEL8hNyuLBbVs10090	rigid:iL4hzfL4mRspTQkCWgi8THIMgTA	false	-	fc-igg tag:c-c|sufficient binding region:18-347	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9QUK6	uniprotkb:Q91Y57	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-16826475|ensembl:ENSMUSP00000032667|uniprotkb:E9QMD1	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:sig12_mouse(display_long)|uniprotkb:Siglec12(gene name)|psi-mi:Siglec12(display_short)|uniprotkb:Siglec5(gene name synonym)|uniprotkb:Siglece(gene name synonym)|uniprotkb:Siglecl1(gene name synonym)|uniprotkb:Myeloid inhibitory siglec(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 5(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin E(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin-like 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826657|imex:IM-26349-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	ensembl:ENSMUSG00000030474(gene)|ensembl:ENSMUST00000032667(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060101"(negative regulation of phagocytosis, engulfment)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:NP_112458.2	-	-	-	figure legend:Figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/09	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:6ZLRgF1wN6Cfpfp3SmsajByEi0k10090	rigid:2YYh0XBAP/s5OKoZyA/Z+VmLL3c	false	-	fc-igg tag:c-c|sufficient binding region:1..20-349..349	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUK6	uniprotkb:Q91Y57	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-16826475|ensembl:ENSMUSP00000032667|uniprotkb:E9QMD1	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:sig12_mouse(display_long)|uniprotkb:Siglec12(gene name)|psi-mi:Siglec12(display_short)|uniprotkb:Siglec5(gene name synonym)|uniprotkb:Siglece(gene name synonym)|uniprotkb:Siglecl1(gene name synonym)|uniprotkb:Myeloid inhibitory siglec(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 5(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin E(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826676|imex:IM-26349-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	ensembl:ENSMUSG00000030474(gene)|ensembl:ENSMUST00000032667(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060101"(negative regulation of phagocytosis, engulfment)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:NP_112458.2	-	-	-	figure legend:Figure 1E, 3 A/G|antagonist:LPS|comment:shRNA silencing of Neu1 abrogated the LPS-induced disassociation of Siglec-E-TLR4 complexes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-d2sc)|taxid:10090(Mouse splenic myeloid dendritic cell)	-	2018/02/27	2018/03/07	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:6ZLRgF1wN6Cfpfp3SmsajByEi0k10090	rigid:2YYh0XBAP/s5OKoZyA/Z+VmLL3c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUK6	uniprotkb:Q91Y57	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-16826475|ensembl:ENSMUSP00000032667|uniprotkb:E9QMD1	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:sig12_mouse(display_long)|uniprotkb:Siglec12(gene name)|psi-mi:Siglec12(display_short)|uniprotkb:Siglec5(gene name synonym)|uniprotkb:Siglece(gene name synonym)|uniprotkb:Siglecl1(gene name synonym)|uniprotkb:Myeloid inhibitory siglec(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 5(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin E(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin-like 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826685|imex:IM-26349-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	ensembl:ENSMUSG00000030474(gene)|ensembl:ENSMUST00000032667(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060101"(negative regulation of phagocytosis, engulfment)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-6798695|interpro:IPR003598(Immunoglobulin subtype 2)|refseq:NP_112458.2	-	-	-	figure legend:Figure 1Ei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-d2sc)|taxid:10090(Mouse splenic myeloid dendritic cell)	-	2018/02/27	2018/03/07	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:6ZLRgF1wN6Cfpfp3SmsajByEi0k10090	rigid:2YYh0XBAP/s5OKoZyA/Z+VmLL3c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35657	uniprotkb:Q9QUK6	intact:EBI-16826908|ensembl:ENSMUSP00000007253|uniprotkb:O55220|uniprotkb:Q99KG9	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	psi-mi:neur1_mouse(display_long)|uniprotkb:Neu1(gene name)|psi-mi:Neu1(display_short)|uniprotkb:Neu(gene name synonym)|uniprotkb:G9 sialidase(gene name synonym)|uniprotkb:Lysosomal sialidase(gene name synonym)|uniprotkb:N-acetyl-alpha-neuraminidase 1(gene name synonym)	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826906|imex:IM-26349-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007038(gene)|ensembl:ENSMUST00000007253(transcript)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016997"(alpha-sialidase activity)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:2000291"(regulation of myoblast proliferation)|interpro:IPR011040(Neuraminidase)|interpro:IPR026856|interpro:IPR036278|reactome:R-MMU-1660662|reactome:R-MMU-4085001|reactome:R-MMU-6798695|refseq:NP_035023.3	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-d2sc)|taxid:10090(Mouse splenic myeloid dendritic cell)	-	2018/02/27	2018/03/08	rogid:LjcKs289dTSQBKTfShveeza1CdA10090	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rigid:on/5DhsFIN8pYnoj0lif+PxkVMs	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:O35657	uniprotkb:Q9QUK6	intact:EBI-16826908|ensembl:ENSMUSP00000007253|uniprotkb:O55220|uniprotkb:Q99KG9	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	psi-mi:neur1_mouse(display_long)|uniprotkb:Neu1(gene name)|psi-mi:Neu1(display_short)|uniprotkb:Neu(gene name synonym)|uniprotkb:G9 sialidase(gene name synonym)|uniprotkb:Lysosomal sialidase(gene name synonym)|uniprotkb:N-acetyl-alpha-neuraminidase 1(gene name synonym)	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Chen et al. (2014)	pubmed:25187624|imex:IM-26349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16826955|imex:IM-26349-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007038(gene)|ensembl:ENSMUST00000007253(transcript)|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016997"(alpha-sialidase activity)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:2000291"(regulation of myoblast proliferation)|interpro:IPR011040(Neuraminidase)|interpro:IPR026856|interpro:IPR036278|reactome:R-MMU-1660662|reactome:R-MMU-4085001|reactome:R-MMU-6798695|refseq:NP_035023.3	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	-	-	-	figure legend:Figure 3E|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-d2sc)|taxid:10090(Mouse splenic myeloid dendritic cell)	-	2018/02/27	2018/03/08	rogid:LjcKs289dTSQBKTfShveeza1CdA10090	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rigid:on/5DhsFIN8pYnoj0lif+PxkVMs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)