#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0018"(two hybrid)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254121|imex:IM-26894-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0018"(two hybrid)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254134|imex:IM-26894-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Supplementary Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/09	2019/03/12	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257262|imex:IM-26894-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/09	2019/03/13	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	-	sufficient binding region:23-339(IPR017853)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257322|imex:IM-26894-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Figure 1F|comment:"Four sites of N-linked glycosylation within the ECD were also able to be mutated without abrogating IL-13Ra2 ECD-Chi3l1/YKL-40 binding (Figure 1F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/09	2019/03/13	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	sufficient binding region:26-344	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254248|imex:IM-26894-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	go:"GO:0009986"(cell surface)|go:"GO:0005737"(cytoplasm)	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 3A, Supplementary Figure 1D|comment:"Chi3l1 and IL-13Ra2 can be seen together on the surface and in the cytoplasm of the cell (Figures 1C and S1D)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/12	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257401|imex:IM-26894-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	go:"GO:0009986"(cell surface)|go:"GO:0005737"(cytoplasm)	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 3A|comment:"Chi3l1, IL-13Rα2, and IL-13 colocalize in tissue sections (Figure 3A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q61362	uniprotkb:P20109	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20559598|ensembl:ENSMUSP00000020650	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257401|imex:IM-26894-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	go:"GO:0009986"(cell surface)|go:"GO:0005737"(cytoplasm)	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 3A|comment:"Chi3l1, IL-13Rα2, and IL-13 colocalize in tissue sections (Figure 3A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254377|imex:IM-26894-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Supplementary figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/12	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21254382|imex:IM-26894-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Supplementary figure 1Ei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/12	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21256740|imex:IM-26894-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2018/05/09	2019/03/13	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21256764|imex:IM-26894-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2018/05/09	2019/03/13	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21256810|imex:IM-26894-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257044|imex:IM-26894-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung_epithelium)|taxid:10090(Mouse lung epithelial cells)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257091|imex:IM-26894-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 1C|comment:"Chi3l1 and IL-13Ra2 can be seen together on the surface and in the cytoplasm of the cell (Figures 1C and S1D)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2018/05/09	2019/03/13	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q14627	uniprotkb:P36222	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257130|imex:IM-26894-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:23.0x10^-12(molar)	2018/05/09	2019/05/16	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	his tag:n-n|sufficient binding region:29-331	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88786	uniprotkb:Q61362	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257468|imex:IM-26894-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	-	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	figure legend:Figure 3B-1|comment:Interaction only seen in IL-13 Tg mice, and not WT.   Chi3l1, IL-13Ra2, and IL-13  participate in a multimeric complex, because the immunoprecipitation of any one of the three always immunoprecipitated the other two.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88786	uniprotkb:P20109	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-20559598|ensembl:ENSMUSP00000020650	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257468|imex:IM-26894-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	-	-	-	figure legend:Figure 3B-1|comment:Interaction only seen in IL-13 Tg mice, and not WT.   Chi3l1, IL-13Ra2, and IL-13  participate in a multimeric complex, because the immunoprecipitation of any one of the three always immunoprecipitated the other two.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61362	uniprotkb:P20109	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20559598|ensembl:ENSMUSP00000020650	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257492|imex:IM-26894-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 3B-2|comment:Interaction only seen in IL-13 Tg mice, and not WT.   Chi3l1, IL-13Ra2, and IL-13  participate in a multimeric complex, because the immunoprecipitation of any one of the three always immunoprecipitated the other two.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257492|imex:IM-26894-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Figure 3B-2|comment:Interaction only seen in IL-13 Tg mice, and not WT.   Chi3l1, IL-13Ra2, and IL-13  participate in a multimeric complex, because the immunoprecipitation of any one of the three always immunoprecipitated the other two.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20109	uniprotkb:Q61362	intact:EBI-20559598|ensembl:ENSMUSP00000020650	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257499|imex:IM-26894-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	-	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	figure legend:Figure 3B-3|comment:This interaction was seen in WT and IL-13 Tg mice.|comment:"The  molecule detected by an antibody to  \"h13119\" or similar, has been assumed to mean  Chi3l1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/05/21	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20109	uniprotkb:O88786	intact:EBI-20559598|ensembl:ENSMUSP00000020650	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257499|imex:IM-26894-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	-	-	figure legend:Figure 3B-3|comment:This interaction was seen in WT and IL-13 Tg mice.|comment:"The  molecule detected by an antibody to  \"h13119\" or similar, has been assumed to mean  Chi3l1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/09	2019/05/21	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:xBMo0DGu4P5w3IbNPgqYF0ooxJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88786	uniprotkb:P35225	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257552|imex:IM-26894-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	-	-	-	figure legend:Fig 3D|comment:Added recombinant Chi3l1 increased the amount of -iL-13Ra2 precipitated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rigid:bU896X1fs0x/GtZUqX0raV9js3A	false	-	sufficient binding region:21-132|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88786	uniprotkb:Q61362	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257604|imex:IM-26894-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	-	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	figure legend:Fig 3D-2|comment:"Cell lysates were treated with recombinant (Human) Chi3l1. The Chi3l1  detected here is probably a mixture of exogenous  and endogenous forms."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rigid:8SwBqzf9jJ0rbe5+ASEtkkSX6zs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88786	uniprotkb:P36222	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257604|imex:IM-26894-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	-	-	-	figure legend:Fig 3D-2|comment:"Cell lysates were treated with recombinant (Human) Chi3l1. The Chi3l1  detected here is probably a mixture of exogenous  and endogenous forms."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rigid:8SwBqzf9jJ0rbe5+ASEtkkSX6zs	false	-	sufficient binding region:29-331|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61362	uniprotkb:O88786	intact:EBI-8392424|uniprotkb:Q8BKL8|uniprotkb:Q4FJW9|intact:MINT-4090719|uniprotkb:Q99J84|uniprotkb:B0FEU7|uniprotkb:D3Z2P2|uniprotkb:Q3U291|ensembl:ENSMUSP00000080717	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:ch3l1_mouse(display_long)|uniprotkb:Breast regression protein 39(gene name synonym)|uniprotkb:Chil1(gene name synonym)|uniprotkb:Chi3l1(gene name)|psi-mi:Chi3l1(display_short)|uniprotkb:Brp39(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:BRP39 protein(gene name synonym)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257616|imex:IM-26894-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031721.2|refseq:XP_006529174.1|ensembl:ENSMUSG00000064246(gene)|ensembl:ENSMUST00000082060(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|mint:Q61362|rcsb pdb:5XEP|reactome:R-MMU-6798695	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	-	comment:mint|function:May play an important role in the capacity of cells to respond to and cope with changes in their environment. May play a role in tissue remodeling and defense against pathogens	-	figure legend:Fig 3D-3|comment:"As no Human recombinant Chi3l1 has been added in this assay (LHS band)  the endogenous form of Chi3l1 must  have been detected here."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:vfTEjvey7dOkQXYuh+FeLLDMa3w10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:MQmM8xRjpvk15u+XN96/qK9bGcA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35225	uniprotkb:Q14627	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257737|imex:IM-26894-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 3F-2|comment:"Deletion of amino acids corresponding to site II (IL-13Ra2dS2) and site III (IL-13Ra2dS3) of IL-13Ra2, the reported IL-13 binding sites in IL-13Ra2 (Lupardus et al., 2010  ), abrogates IL-13 binding without abrogating Ch13l1 binding (Figure 3F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:wPMlTdJsawR38ioaYml0+k5Ti7c	false	sufficient binding region:21-132|his tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36222	uniprotkb:Q14627	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	He et al. (2013)	imex:IM-26894|pubmed:23972995	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21257726|imex:IM-26894-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 3F-1|comment:"Deletion of amino acids corresponding to site II (IL-13Ra2dS2) and site III (IL-13Ra2dS3) of IL-13Ra2, the reported IL-13 binding sites in IL-13Ra2 (Lupardus et al., 2010  ), abrogates IL-13 binding without abrogating Ch13l1 binding (Figure 3F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/09	2019/03/13	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lV6yhIehyiRiDkkVLO6gRBxg8fM	false	his tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)