#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0018"(two hybrid) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976398|imex:IM-26922-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false sufficient binding region:290-460 mutation:95-95 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0486"(UniProt) intact:EBI-20976458|imex:IM-26922-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 2A, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false yellow fluorescent protein tag:?-? mutation:95-95|cyan fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:1016"(fluorescence recovery after photobleaching) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976475|imex:IM-26922-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 2C, 2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false yellow fluorescent protein tag:?-? cyan fluorescent protein tag:?-?|mutation:95-95 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P10909-5 uniprotkb:P05067-PRO_0000000092 intact:EBI-10961636 intact:EBI-821758 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:1016"(fluorescence recovery after photobleaching) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20977153|imex:IM-26922-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) intact:EBI-77613(chain-parent) - - chain-seq-start:672|chain-seq-end:713 figure legend:Fig. 8A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606 rigid:tJNnYVxSi6GL2QdTbPXjx+XfDAo false yellow fluorescent protein tag:?-? cyan fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976522|imex:IM-26922-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false ha tag:?-?|sufficient binding region:315-381 myc tag:?-?|mutation:95-95 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976717|imex:IM-26922-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 3B, 4A-C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false ha tag:?-?|sufficient binding region:315-381 mutation:95-95|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976884|imex:IM-26922-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 4E-G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false ha tag:?-? mutation:95-95|myc tag:?-?|sufficient binding region:19-82|mutation with no effect:95-95 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:P05067-PRO_0000000092 intact:EBI-10961636 intact:EBI-821758 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20977163|imex:IM-26922-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) intact:EBI-77613(chain-parent) - - chain-seq-start:672|chain-seq-end:713 figure legend:"Fig. 8(7)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606 rigid:tJNnYVxSi6GL2QdTbPXjx+XfDAo false ha tag:?-? cyan fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976736|imex:IM-26922-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false sufficient binding region:290-460(IPR016015)|yellow fluorescent protein tag:?-? mutation:95-95|cyan fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976756|imex:IM-26922-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/11/23 2018/11/26 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false sufficient binding region:290-460(IPR016015)|yellow fluorescent protein tag:?-? mutation:95-95|cyan fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JLC3 uniprotkb:Q06890 intact:EBI-20976777|ensembl:ENSMUSP00000099300|ensembl:ENSMUSP00000110917|uniprotkb:Q545U8 intact:EBI-774758|ensembl:ENSMUSP00000022616 psi-mi:msrb1_mouse(display_long)|uniprotkb:Selenoprotein R(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:Msrb1(gene name)|psi-mi:Msrb1(display_short)|uniprotkb:Sepr(gene name synonym)|uniprotkb:Sepx1(gene name synonym) psi-mi:clus_mouse(display_long)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)|uniprotkb:Clustrin(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Clu(gene name)|psi-mi:Clu(display_short)|uniprotkb:Apoj(gene name synonym)|uniprotkb:Msgp-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20976809|imex:IM-26922-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000075705(gene)|ensembl:ENSMUST00000101800(transcript)|ensembl:ENSMUST00000115262(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:2KV1|reactome:R-MMU-5676934|refseq:NP_001333597.1|refseq:NP_038787.1 refseq:NP_038520.2|refseq:XP_006518567.1|ensembl:ENSMUSG00000022037(gene)|ensembl:ENSMUST00000022616(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0017038"(protein import)|go:"GO:0030426"(growth cone)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0071944"(cell periphery)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:Q06890|reactome:R-MMU-114608|reactome:R-MMU-166665|reactome:R-MMU-6803157|reactome:R-MMU-977606|go:"GO:0042583"(chromaffin granule) - - - figure legend:Fig. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain-cerebellum)|taxid:10090(Mus musculus brain cerebellum) - 2018/11/23 2018/11/26 rogid:0YLmynpsIJy2Mi/0yK7sqbdSsH410090 rogid:wP6AESslzICF3ojv9a+vJUn61VA10090 rigid:OU6X5ke7p9EkVr5pSQv5uYHpdQQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0096"(pull down) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20976834|imex:IM-26922-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/11/23 2019/04/24 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false glutathione s tranferase tag:?-?|sufficient binding region:315-381 his tag:?-?|mutation:95-95 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P10909-5 uniprotkb:Q9NZV6 intact:EBI-10961636 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:p10909-5(display_long)|uniprotkb:CLU(gene name)|psi-mi:CLU(display_short)|uniprotkb:APOJ(gene name synonym)|uniprotkb:Aging-associated gene 4 protein(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:CLI(gene name synonym)|uniprotkb:Complement cytolysis inhibitor(gene name synonym)|uniprotkb:Complement-associated protein SP-40,40(gene name synonym)|uniprotkb:KUB1(gene name synonym)|uniprotkb:Ku70-binding protein 1(gene name synonym)|uniprotkb:NA1/NA2(gene name synonym)|uniprotkb:Testosterone-repressed prostate message 2(gene name synonym)|uniprotkb:AAG4(orf name)|uniprotkb:CLU36(isoform synonym)|uniprotkb:Sulfated glycoprotein 2(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0096"(pull down) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20976900|imex:IM-26922-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1104674(isoform-parent) ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 4, H, 4I|comment:"Weak metal chelating agent ethylenediaminetetraacetic acid (CHEBI:64755) has no effect"|antagonist:"Selenocystine (CHEBI:28553)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/11/23 2019/04/25 rogid:ijjKjIUzqQgzJzFw2EZoPRHxC4I9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 rigid:BJ6Mh5HGj3L0aZ58OPbXI6is+UU false ha tag:?-?|sufficient binding region:315-381 mutation:95-95|his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) chebi:"CHEBI:49033" uniprotkb:Q9NZV6 intact:EBI-20977130 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:methionine s-oxide(display_short)|psi-mi:"CHEBI:49033"(display_long)|intact:methionine sulfoxide(synonym)|intact:"2-amino-4-(methylsulfinyl)butanoic acid"(iupac name) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0979"(oxidoreductase assay) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20977137|imex:IM-26922-27 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/11/23 2018/11/26 - rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:49033" uniprotkb:O75153 intact:EBI-20977130 intact:EBI-308505|uniprotkb:Q6AHY2|uniprotkb:Q6P3X7|uniprotkb:Q6ZUG8|uniprotkb:Q8N4U7|uniprotkb:Q9BTA3|uniprotkb:Q9H979|ensembl:ENSP00000388872|ensembl:ENSP00000458986 psi-mi:methionine s-oxide(display_short)|psi-mi:"CHEBI:49033"(display_long)|intact:methionine sulfoxide(synonym)|intact:"2-amino-4-(methylsulfinyl)butanoic acid"(iupac name) psi-mi:clu_human(display_long)|uniprotkb:CLUH(gene name)|psi-mi:CLUH(display_short)|uniprotkb:KIAA0664(gene name synonym) psi-mi:"MI:0979"(oxidoreductase assay) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20977141|imex:IM-26922-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:1343"(enzyme regulator) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056044.3|ensembl:ENSG00000132361(gene)|ensembl:ENST00000435359(transcript)|ensembl:ENST00000570628(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0048312"(intracellular distribution of mitochondria)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR023231|interpro:IPR025697|interpro:IPR027523|interpro:IPR028275|interpro:IPR033646 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/11/23 2018/11/26 - rogid:9605WkS82JBvT0JZ1fkpxe3SqRc9606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75153 uniprotkb:Q9NZV6 intact:EBI-308505|uniprotkb:Q6AHY2|uniprotkb:Q6P3X7|uniprotkb:Q6ZUG8|uniprotkb:Q8N4U7|uniprotkb:Q9BTA3|uniprotkb:Q9H979|ensembl:ENSP00000388872|ensembl:ENSP00000458986 intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1 psi-mi:clu_human(display_long)|uniprotkb:CLUH(gene name)|psi-mi:CLUH(display_short)|uniprotkb:KIAA0664(gene name synonym) psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name) psi-mi:"MI:0979"(oxidoreductase assay) Chen et al. (2012) pubmed:23805218|imex:IM-26922 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20977141|imex:IM-26922-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:1343"(enzyme regulator) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056044.3|ensembl:ENSG00000132361(gene)|ensembl:ENST00000435359(transcript)|ensembl:ENST00000570628(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0048312"(intracellular distribution of mitochondria)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR023231|interpro:IPR025697|interpro:IPR027523|interpro:IPR028275|interpro:IPR033646 ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/11/23 2018/11/26 rogid:9605WkS82JBvT0JZ1fkpxe3SqRc9606 rogid:DR4z/+yUfitTjUy4b722w3qyTk89606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)