#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56817	uniprotkb:Q9Y287	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tsachaki et al. (2013)	pubmed:23701002|imex:IM-27006	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21011933|imex:IM-27006-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/18	2018/12/18	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:+g7ZGnU0UL/hEcgQeM01ELSFnKE	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P56817	uniprotkb:Q9Y287	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tsachaki et al. (2013)	pubmed:23701002|imex:IM-27006	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21011944|imex:IM-27006-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/18	2018/12/18	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:+g7ZGnU0UL/hEcgQeM01ELSFnKE	false	-	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9Y287	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tsachaki et al. (2013)	pubmed:23701002|imex:IM-27006	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21011960|imex:IM-27006-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/12/18	2018/12/18	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:+g7ZGnU0UL/hEcgQeM01ELSFnKE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P56817	uniprotkb:Q9Y287	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Tsachaki et al. (2013)	pubmed:23701002|imex:IM-27006	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21011973|imex:IM-27006-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005783"(endoplasmic reticulum)	crc64:377CE4C824ACEF05	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/18	2018/12/18	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:+g7ZGnU0UL/hEcgQeM01ELSFnKE	false	-	myc tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)