#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92915-2 uniprotkb:Q9UQD0 intact:EBI-12836320|ensembl:ENSP00000365301 intact:EBI-2682072|uniprotkb:B9VWG8|uniprotkb:Q9UPB2|uniprotkb:Q9NYX2|uniprotkb:O95788|ensembl:ENSP00000346534 psi-mi:q92915-2(display_long)|uniprotkb:FGF14(gene name)|psi-mi:FGF14(display_short)|uniprotkb:FHF4(gene name synonym)|uniprotkb:Fibroblast growth factor homologous factor 4(gene name synonym)|uniprotkb:Isoform 1B(isoform synonym) psi-mi:scn8a_human(display_long)|uniprotkb:MED(gene name synonym)|uniprotkb:Sodium channel protein type VIII subunit alpha(gene name synonym)|uniprotkb:Voltage-gated sodium channel subunit alpha Nav1.6(gene name synonym)|uniprotkb:SCN8A(gene name)|psi-mi:SCN8A(display_short) psi-mi:"MI:1204"(split firefly luciferase complementation) Shavkunov et al. (2012) pubmed:22364545|imex:IM-26292 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16718605|imex:IM-26292-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102466(gene)|ensembl:ENST00000376131(transcript)|uniprotkb:Q92915-2(isoform-parent)|intact:EBI-10489272(isoform-parent) refseq:XP_011536953.1|refseq:NP_001171455.1|refseq:NP_055006.1|ensembl:ENSP00000346534|ensembl:ENST00000355133|ensembl:ENSP00000347255|ensembl:ENST00000545061|ensembl:ENSP00000440360|ensembl:ENST00000599343|ensembl:ENSP00000476447|ensembl:ENST00000627620|ensembl:ENSP00000487583|ensembl:ENST00000662684|ensembl:ENSP00000499636|ensembl:ENSG00000196876(gene)|ensembl:ENST00000354534(transcript)|go:"GO:0001518"(voltage-gated sodium channel complex)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042552"(myelination)|go:"GO:0043194"(axon initial segment)|go:"GO:0086010"(membrane depolarization during action potential)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001696(Na+ channel)|interpro:IPR005821(Ion transport)|interpro:IPR008054(Na+ channel 8)|interpro:IPR010526(Sodium ion transport-associated)|interpro:IPR024583|interpro:IPR027359|interpro:IPR043203|interpro:IPR044564|reactome:R-HSA-445095|reactome:R-HSA-5576892|refseq:XP_006719619.1|refseq:NP_001317189.1|refseq:XP_016875283.1 - isoform-comment:"Variant in position: 44:W->C (in a colorectal cancer)." - figure legend:Fig. 1B, 1C, 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2018/01/08 2018/01/08 rogid:le11lQLoZWsdWtMy4jwkWdXjN1o9606 rogid:QNQrdR2/1eHCtZ8Ud06+akmB64E9606 rigid:xQ6u0EN9GxTvr21KkS372aLNEdA false v5 tag:c-c|his tag:c-c|luciferase-n:n-n|mutation decreasing interaction strength:160-160,158-158 his tag:c-c|v5 tag:c-c|sufficient binding region:1763-1976|fusion protein:c-c|luciferase-c:c-c - - psi-mi:"MI:1220"(tag visualisation by luciferase assay) psi-mi:"MI:1220"(tag visualisation by luciferase assay)