#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0A9D4 uniprotkb:P0ABK5 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730135|imex:IM-26607-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - - crc64:20ADDE911845AE72 figure legend:Fig. 1A, 2C, 3A, 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false his tag:n-n|glutathione s tranferase tag:n-n binding-associated region:?-? 3 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:597326" uniprotkb:P0A9D4 intact:EBI-8852014 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name) psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730135|imex:IM-26607-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N - inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L - figure legend:Fig. 1A, 2C, 3A, 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 - false binding-associated region:?-? his tag:n-n|glutathione s tranferase tag:n-n - 3 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0ABK5 uniprotkb:P0ABK5 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730150|imex:IM-26607-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - crc64:20ADDE911845AE72 crc64:20ADDE911845AE72 figure legend:Fig. 1A, 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false binding-associated region:?-? binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:597326" uniprotkb:P0ABK5 intact:EBI-8852014 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730150|imex:IM-26607-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L crc64:20ADDE911845AE72 figure legend:Fig. 1A, 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false binding-associated region:?-? binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:597326" uniprotkb:P0ABK5 intact:EBI-8852014 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730150|imex:IM-26607-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L crc64:20ADDE911845AE72 figure legend:Fig. 1A, 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false binding-associated region:?-? binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0A9D4 uniprotkb:P0ABK5 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730165|imex:IM-26607-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - - crc64:20ADDE911845AE72 figure legend:Fig. 1A, 2C, 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false sufficient binding region:264-273 binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:597326" uniprotkb:P0A9D4 intact:EBI-8852014 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name) psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730165|imex:IM-26607-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N - inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L - figure legend:Fig. 1A, 2C, 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 - false binding-associated region:?-? sufficient binding region:264-273 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0A9D4 uniprotkb:P0ABK5 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 intact:EBI-553933|uniprotkb:P11096|uniprotkb:P21546|ensemblbacteria:AAC75467|ensemblbacteria:BAA16288 psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:cysk_ecoli(display_long)|uniprotkb:O-acetylserine sulfhydrylase A(gene name synonym)|uniprotkb:"O-acetylserine (thiol)-lyase A"(gene name synonym)|uniprotkb:Sulfate starvation-induced protein 5(gene name synonym)|uniprotkb:cysK(gene name)|psi-mi:cysK(display_short)|uniprotkb:cysZ(gene name synonym)|uniprotkb:b2414(locus name)|uniprotkb:JW2407(locus name)|uniprotkb:S-carboxymethylcysteine synthase(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730214|imex:IM-26607-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N refseq:NP_416909.1|refseq:WP_000034402.1|dip:DIP-36170N|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050272"(S-carboxymethylcysteine synthase activity)|go:"GO:0080146"(L-cysteine desulfhydrase activity)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005856(Cysteine synthase K/M)|interpro:IPR005859(Cysteine synthase A)|interpro:IPR036052|rcsb pdb:5J43|rcsb pdb:5J5V|ensemblbacteria:AAC75467(transcript)|ensemblbacteria:b2414(gene)|ensemblbacteria:BAA16288(gene)|ensemblbacteria:BAA16288(transcript)|go:"GO:0004124"(cysteine synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0008652"(cellular amino acid biosynthetic process)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0016740"(transferase activity) - - crc64:20ADDE911845AE72 figure legend:Fig. 2A, 2B, 3|comment:The complex dissociates at OAS concentrations in excess of 50 um|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 rogid:gzmmdLj100pnY3s+a8Gc+7pfhUs83333 - false his tag:n-n|glutathione s tranferase tag:n-n binding-associated region:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:17981" uniprotkb:P0A9D4 intact:EBI-20730197|chebi:"CHEBI:12724"|chebi:"CHEBI:7668"|chebi:"CHEBI:44568"|chebi:"CHEBI:12710"|chebi:"CHEBI:12685"|chebi:"CHEBI:21938" intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 psi-mi:o-acetyl-l-serine(display_short)|psi-mi:"CHEBI:17981"(display_long)|intact:"L-Serine, acetate (ester)"(synonym)|intact:O-acetyl-L-serine(synonym)|intact:O-Acetyl-L-serine(synonym)|intact:O3-acetyl-L-serine(synonym)|intact:O3-Acetyl-L-serine(synonym)|intact:O-acetyl-L-serine(iupac name) psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730214|imex:IM-26607-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:1160"(allosteric effector) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N - - - figure legend:Fig. 2A, 2B, 3|comment:The complex dissociates at OAS concentrations in excess of 50 um|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 - false - his tag:n-n|glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:597326" uniprotkb:P0A9D4 intact:EBI-8852014 intact:EBI-1133237|uniprotkb:P05796|uniprotkb:Q2M7S1|ensemblbacteria:AAC76631|ensemblbacteria:BAE77685 psi-mi:"pyridoxal 5'-phosphate(2-)"(display_short)|psi-mi:"CHEBI:597326"(display_long)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-)"(synonym)|intact:pyridoxal 5'-phosphate(synonym)|intact:pyridoxal 5'-phosphate dianion(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate"(iupac name) psi-mi:cyse_ecoli(display_long)|uniprotkb:cysE(gene name)|psi-mi:cysE(display_short)|uniprotkb:b3607(locus name)|uniprotkb:JW3582(locus name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Wang et al. (2012) pubmed:22179612|imex:IM-26607 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20730214|imex:IM-26607-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:WP_001277561.1|refseq:NP_418064.1|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0009001"(serine O-acetyltransferase activity)|go:"GO:0009333"(cysteine synthase complex)|go:"GO:0010165"(response to X-ray)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005881(Serine O-acetyltransferase)|interpro:IPR010493(Serine acetyltransferase, N-terminal)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR018357|interpro:IPR042122|rcsb pdb:1T3D|ensemblbacteria:AAC76631(transcript)|ensemblbacteria:b3607(gene)|ensemblbacteria:BAE77685(gene)|ensemblbacteria:BAE77685(transcript)|go:"GO:0005829"(cytosol)|dip:DIP-9377N - inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-L - figure legend:Fig. 2A, 2B, 3|comment:The complex dissociates at OAS concentrations in excess of 50 um|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/09/07 2018/09/07 - rogid:cAGfAq1TTxuRyY8knlY4hb6woBY83333 - false binding-associated region:?-? his tag:n-n|glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)