#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067-4	uniprotkb:Q96FE5	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Stein et al. (2012)	imex:IM-27143|pubmed:22133804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006739|imex:IM-27143-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	isoform-comment:A major isoform.	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2018/12/17	2018/12/17	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:SgT0QevEwTHd+q3Y9GS4BvkRdXA	false	-	v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05067-4	uniprotkb:Q96FE5	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stein et al. (2012)	imex:IM-27143|pubmed:22133804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006753|imex:IM-27143-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	isoform-comment:A major isoform.	-	figure legend:Fig. 1B, 2A, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2018/12/17	2018/12/17	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:SgT0QevEwTHd+q3Y9GS4BvkRdXA	false	-	sufficient binding region:353-576|necessary binding region:42-551|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96FE5	uniprotkb:Q96FE5	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stein et al. (2012)	imex:IM-27143|pubmed:22133804	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006770|imex:IM-27143-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2018/12/17	2018/12/17	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:PyDnbzJBYYcOSL4SVtXdmcRD264	false	v5 tag:n-n	sufficient binding region:353-576|necessary binding region:42-551|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)