#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25025	uniprotkb:O00231	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:BgQKXK7gMMihacRCI+g/pBnRN309606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P25787	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q2Q1W2	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-20944560|ensembl:ENSP00000373272	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:lin41_human(display_long)|uniprotkb:TRIM71(gene name)|psi-mi:TRIM71(display_short)|uniprotkb:LIN41(gene name synonym)|uniprotkb:Protein lin-41 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 71(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	go:"GO:0000932"(P-body)|go:"GO:0001843"(neural tube closure)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021915"(neural tube development)|go:"GO:0030371"(translation repressor activity)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|ensembl:ENSG00000206557(gene)|ensembl:ENST00000383763(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001258(NHL repeat)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR017907|reactome:R-HSA-983168|go:"GO:2000177"(regulation of neural precursor cell proliferation)|refseq:NP_001034200.1	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:izMxqn2edwFjstdEEyoWRDBnFVk9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q9UFH2	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-20863988|ensembl:ENSP00000374490|uniprotkb:O00431|uniprotkb:O15206|uniprotkb:Q2M2Y1|uniprotkb:Q6ZRQ2|uniprotkb:Q8N7Q7	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:dyh17_human(display_long)|uniprotkb:Axonemal beta dynein heavy chain 17(gene name synonym)|uniprotkb:Axonemal dynein heavy chain-like protein 1(gene name synonym)|uniprotkb:Ciliary dynein heavy chain 17(gene name synonym)|uniprotkb:Ciliary dynein heavy chain-like protein 1(gene name synonym)|uniprotkb:DNAH17(gene name)|psi-mi:DNAH17(display_short)|uniprotkb:DNAHL1(gene name synonym)|uniprotkb:DNEL2(gene name synonym)|uniprotkb:Dynein axonemal light chain 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000187775(gene)|ensembl:ENST00000389840(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005858"(axonemal dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0031514"(motile cilium)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036157"(outer dynein arm)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060285"(cilium-dependent cell motility)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041589|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q9UFH2|interpro:IPR041466|refseq:NP_775899.3	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:PD2SBvKNoOcHzeB+YzqMg5RFE3A9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q9BPW8	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-307125|uniprotkb:O43800|uniprotkb:B2RAY3|ensembl:ENSP00000216121	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:nips1_human(display_long)|uniprotkb:NIPSNAP1(gene name)|psi-mi:NIPSNAP1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_001189431.1|refseq:NP_003625.2|ensembl:ENSG00000184117(gene)|ensembl:ENST00000216121(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0097060"(synaptic membrane)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:Q9BPW8	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:mOosuRNhEeYvVB5cUbkMzTJ7X7s9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:O15127	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-712703|uniprotkb:Q9BQE8|intact:EBI-28966746|ensembl:ENSP00000268099|uniprotkb:B2RDF0	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:scam2_human(display_long)|uniprotkb:SCAMP2(gene name)|psi-mi:SCAMP2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSP00000268099|ensembl:ENSG00000140497(gene)|ensembl:ENST00000268099(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O15127|refseq:NP_005688.2	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:wV3Omfpe2RLQlt8LYk8XUiuf20o9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P50552	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-748201|uniprotkb:Q6PIZ1|uniprotkb:Q93035|uniprotkb:B2RBT9|intact:EBI-28992147|ensembl:ENSP00000245932	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:vasp_human(display_long)|uniprotkb:VASP(gene name)|psi-mi:VASP(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_003361.1|ensembl:ENSP00000245932|ensembl:ENSG00000125753(gene)|ensembl:ENST00000245932(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P50552|rcsb pdb:1EGX|rcsb pdb:1JNG|rcsb pdb:1USD|rcsb pdb:1USE|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-446353|dip:DIP-44105N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:G8ONp2lhbQKUCrDKnx8AMIKSNHA9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P46940	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P63104	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q00610	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q14847	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:O15144	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-352356|uniprotkb:Q92801|uniprotkb:Q9P1D4|ensembl:ENSP00000295685|ensembl:ENSP00000327137	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:arpc2_human(display_long)|uniprotkb:ARPC2(gene name)|psi-mi:ARPC2(display_short)|uniprotkb:ARC34(gene name synonym)|uniprotkb:PRO2446(orf name)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_005722.1|refseq:NP_690601.1|go:"GO:0005925"(focal adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|mint:O15144|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|go:"GO:0005885"(Arp2/3 protein complex)|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|reactome:R-HSA-3928662|ensembl:ENSG00000163466(gene)|ensembl:ENST00000295685(transcript)|ensembl:ENST00000315717(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|dip:DIP-33197N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:v5OozQTt614rvrBBoUavbAzjgZ49606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q9Y490	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944532|imex:IM-27124-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:E4kRALDtVyS5fwx6NZ8wa/YOYjk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P17987	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q12931	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P61981	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P55072	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q9H0B6	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-726994|ensembl:ENSP00000314837|ensembl:ENSP00000377631|ensembl:ENSP00000399403|uniprotkb:Q9H9C8|uniprotkb:Q9HA20|uniprotkb:B2RDY4|uniprotkb:A8MXL7	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:klc2_human(display_long)|uniprotkb:KLC2(gene name)|psi-mi:KLC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000174996(gene)|ensembl:ENST00000316924(transcript)|ensembl:ENST00000394067(transcript)|ensembl:ENST00000417856(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0016938"(kinesin I complex)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045296"(cadherin binding)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q9H0B6|rcsb pdb:3CEQ|rcsb pdb:3EDT|reactome:R-HSA-2132295|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|refseq:NP_001128246.1|refseq:NP_001128247.1|refseq:NP_001128248.1|refseq:NP_073733.1|refseq:NP_001305663.1|refseq:XP_005274240.1|dip:DIP-40381N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:VjzT5tI182sjUbhjxC1bK9GSMHo9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P04083	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:QKmqz+UsAof35B/so2qKLQjn2v09606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P13796	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-698036|uniprotkb:Q5TBN4|uniprotkb:B2R613|uniprotkb:B4DUA0|ensembl:ENSP00000315757|ensembl:ENSP00000381581	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:plsl_human(display_long)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:LC64P(gene name synonym)|uniprotkb:LCP1(gene name)|psi-mi:LCP1(display_short)|uniprotkb:PLS2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_002289.2|refseq:XP_005266431.1|dip:DIP-34767N|ensembl:ENSG00000136167(gene)|ensembl:ENST00000323076(transcript)|ensembl:ENST00000398576(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|rcsb pdb:2D85|rcsb pdb:5JOJ|rcsb pdb:5JOL|reactome:R-HSA-8950505	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:1uy1zhroB3GHUiAwLjEdP5Rz1xM9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P06396	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-351506|uniprotkb:Q8WVV7|ensembl:ENSP00000362924|uniprotkb:Q5T0I2|uniprotkb:A8MUD1|uniprotkb:B7Z373|uniprotkb:A2A418|uniprotkb:A8MYN7|uniprotkb:B7Z5V1|uniprotkb:F5H1A8	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:gels_human(display_long)|uniprotkb:GSN(gene name)|psi-mi:GSN(display_short)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:AGEL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_000168.1|refseq:NP_001121134.1|refseq:NP_001121136.1|refseq:NP_001121137.1|refseq:NP_001121138.1|refseq:NP_001121139.1|refseq:NP_937895.1|refseq:XP_011516888.1|refseq:XP_011516889.1|refseq:XP_011516890.1|refseq:XP_011516891.1|refseq:XP_011516892.1|refseq:XP_011516893.1|refseq:XP_011516894.1|refseq:XP_011516895.1|ensembl:ENSG00000148180(gene)|ensembl:ENST00000373818(transcript)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P06396|rcsb pdb:1C0F|rcsb pdb:1C0G|rcsb pdb:1D4X|rcsb pdb:1DEJ|rcsb pdb:1EQY|rcsb pdb:1ESV|rcsb pdb:1H1V|rcsb pdb:1KCQ|rcsb pdb:1MDU|rcsb pdb:1NLV|rcsb pdb:1NM1|rcsb pdb:1NMD|rcsb pdb:1P8X|rcsb pdb:1SOL|rcsb pdb:1T44|rcsb pdb:1YAG|rcsb pdb:1YVN|rcsb pdb:2FF3|rcsb pdb:2FF6|rcsb pdb:2FH1|rcsb pdb:2FH2|rcsb pdb:2FH3|rcsb pdb:2FH4|rcsb pdb:3A5L|rcsb pdb:3A5M|rcsb pdb:3A5N|rcsb pdb:3A5O|rcsb pdb:3CI5|rcsb pdb:3CIP|rcsb pdb:3CJB|rcsb pdb:3CJC|rcsb pdb:3FFK|rcsb pdb:3FFN|rcsb pdb:3TU5|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4S10|rcsb pdb:4Z94|rcsb pdb:5DD2|rcsb pdb:5FAE|rcsb pdb:5FAF|rcsb pdb:5H3M|rcsb pdb:5H3N|rcsb pdb:5O2Z|rcsb pdb:5UBO|rcsb pdb:5ZZ0|rcsb pdb:6H1F|rcsb pdb:6JCO|rcsb pdb:6JEG|rcsb pdb:6JEH|rcsb pdb:6LJE|rcsb pdb:6LJF|rcsb pdb:6Q9R|rcsb pdb:6Q9Z|rcsb pdb:6QBF|rcsb pdb:1P8Z|rcsb pdb:6QW3|reactome:R-HSA-264870|reactome:R-HSA-6798695|reactome:R-HSA-9662361|reactome:R-HSA-977225|refseq:NP_001244958.1|refseq:NP_001244959.1|refseq:NP_001121135.2|refseq:XP_005252000.1|refseq:XP_005252001.1|refseq:XP_005252002.1|refseq:XP_006717142.1|refseq:XP_016870135.1|refseq:XP_016870136.1|refseq:XP_016870137.1|dip:DIP-2196N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:uACf9A+H6LAOAZSMGYqeDwUL1Mc9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:O15145	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-351829|uniprotkb:O00554|ensembl:ENSP00000228825	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:arpc3_human(display_long)|uniprotkb:ARPC3(gene name)|psi-mi:ARPC3(display_short)|uniprotkb:ARC21(gene name synonym)|uniprotkb:Arp2/3 complex 21 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000111229(gene)|ensembl:ENST00000228825(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031941"(filamentous actin)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0061850"(growth cone leading edge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR007204(ARP2/3 complex, 21 kDa p21-Arc subunit)|interpro:IPR036753|mint:O15145|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|refseq:NP_001274151.1|refseq:NP_001265485.1|dip:DIP-33187N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:u4h1270mPo3E3GBrEurYtpUYTQM9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P46940	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:P63104	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q00610	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q14847	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-742828|uniprotkb:Q96ED2|uniprotkb:Q96IG0|ensembl:ENSP00000325240|ensembl:ENSP00000392853|uniprotkb:B4DGQ0	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:lasp1_human(display_long)|uniprotkb:Metastatic lymph node gene 50 protein(gene name synonym)|uniprotkb:LASP1(gene name)|psi-mi:LASP1(display_short)|uniprotkb:MLN50(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_006139.1|refseq:NP_001258537.1|ensembl:ENSG00000002834(gene)|ensembl:ENST00000318008(transcript)|ensembl:ENST00000435347(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006811"(ion transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR035630|interpro:IPR036028|mint:Q14847|rcsb pdb:3I35	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:Oa+FdJXeQhahYTqVrHYk6yBrUWI9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:O15144	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-352356|uniprotkb:Q92801|uniprotkb:Q9P1D4|ensembl:ENSP00000295685|ensembl:ENSP00000327137	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:arpc2_human(display_long)|uniprotkb:ARPC2(gene name)|psi-mi:ARPC2(display_short)|uniprotkb:ARC34(gene name synonym)|uniprotkb:PRO2446(orf name)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	refseq:NP_005722.1|refseq:NP_690601.1|go:"GO:0005925"(focal adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|mint:O15144|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|go:"GO:0005885"(Arp2/3 protein complex)|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|reactome:R-HSA-3928662|ensembl:ENSG00000163466(gene)|ensembl:ENST00000295685(transcript)|ensembl:ENST00000315717(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|dip:DIP-33197N	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:v5OozQTt614rvrBBoUavbAzjgZ49606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P25025	uniprotkb:Q9Y490	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	intact:EBI-2462036|uniprotkb:A6NMY0|uniprotkb:Q86YD0|uniprotkb:Q9NZQ2|uniprotkb:Q9UHH8|uniprotkb:Q9UPX3|intact:EBI-28967697|ensembl:ENSP00000316029	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:tln1_human(display_long)|uniprotkb:TLN1(gene name)|psi-mi:TLN1(display_short)|uniprotkb:KIAA1027(gene name synonym)|uniprotkb:TLN(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944542|imex:IM-27124-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	ensembl:ENSP00000316029|refseq:NP_006280.3|ensembl:ENSG00000137076(gene)|ensembl:ENST00000314888(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:Q9Y490|rcsb pdb:1SYQ|rcsb pdb:2MWN|rcsb pdb:4DJ9|rcsb pdb:6R9T|reactome:R-HSA-114608|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381038|reactome:R-HSA-399955|reactome:R-HSA-445355|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Table 1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rogid:C7FGaR2291KB6hBSloee5L8lYgA9606	rigid:P0e7c8nc7P5nknmM5BzG0+Dxe6Y	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944618|imex:IM-27124-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 2A|comment:"The interaction of IQGAP1 with CXCR2 was verified by immunoprecipation followed by western blot analysis (Figure 2A and 2B). In support of the proteomics analyses, western blot analysis shows an apparently equal amount of immunoreactive IQGAP1 co-IPs with CXCR2 in untreated cells and cells stimulated with CXCL8 for 1 min. Interestingly, IQGAP1 no longer co-IPs with CXCR2 following 5 mins of CXCL8 stimulation (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944636|imex:IM-27124-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60953	uniprotkb:P46940	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974614|imex:IM-27124-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Fig. 5A|comment:"These experiments demonstrated that co-immunoprecipitation of Cdc42 with IQGAP1 is slightly enhanced with CXCL8 stimulation (Figure 5A)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2019/06/24	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rigid:J3EZh6cVe+xuNhVzW/el+2nQbDg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974642|imex:IM-27124-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. S2|comment:"The interaction of IQGAP1 with CXCR2 was verified by immunoprecipation followed by western blot analysis (Figure 2A and 2B). In support of the proteomics analyses, western blot analysis shows an apparently equal amount of immunoreactive IQGAP1 co-IPs with CXCR2 in untreated cells and cells stimulated with CXCL8 for 1 min. Interestingly, IQGAP1 no longer co-IPs with CXCR2 following 5 mins of CXCL8 stimulation (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/22	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944628|imex:IM-27124-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 2B|comment:"The interaction of IQGAP1 with CXCR2 was verified by immunoprecipation followed by western blot analysis (Figure 2A and 2B). In support of the proteomics analyses, western blot analysis shows an apparently equal amount of immunoreactive IQGAP1 co-IPs with CXCR2 in untreated cells and cells stimulated with CXCL8 for 1 min. Interestingly, IQGAP1 no longer co-IPs with CXCR2 following 5 mins of CXCL8 stimulation (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P60953	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974621|imex:IM-27124-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	-	-	-	figure legend:Fig. 5|comment:"These experiments demonstrated that co-immunoprecipitation of Cdc42 with IQGAP1 is slightly enhanced with CXCL8 stimulation (Figure 5A)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/22	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rigid:TvNThnMCPUGJrK52b6C8s8R6x/Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974621|imex:IM-27124-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 5|comment:"These experiments demonstrated that co-immunoprecipitation of Cdc42 with IQGAP1 is slightly enhanced with CXCL8 stimulation (Figure 5A)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/22	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:TvNThnMCPUGJrK52b6C8s8R6x/Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944648|imex:IM-27124-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	go:"GO:0032587"(ruffle membrane)	-	-	figure legend:Fig. 2C,D|comment:"In unstimulated cells, IQGAP1 is localized just below the plasma membrane and accumulates in membrane ruffles with CXCR2 upon 1 min of CXCL8 stimulation (Figure 2C). Consistent with the immunoprecipitation experiments, confocal analyses demonstrate that upon global ligand stimulation with IL-8, IQGAP1 localizes to membrane where CXCR2 is also localized over a time course of 30 minutes (Figure 2C and 2D)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hl_60)|taxid:9606(Homo sapiens acute myeloid leukemia cell line)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944659|imex:IM-27124-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 2E,F|comment:"In confocal microscopy experiments analyzing the co-localization of IQGAP1 and CXCR2 in polarized normal human neutrophils responding to a gradient of IL-8 chemokine in Zigmond chamber assays, immunofluorescence staining indicated that about 60% of the IQGAP1 was observed to be overlapping with CXCR2 in confocal microscopy. Most of this overlap was concentrated on the leading edge of the cells polarized toward the direction of a CXCL8 gradient (Figure 2E and 2F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-neutrophil)|taxid:9606(Homo sapiens polymorphonuclear neutrophil)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944705|imex:IM-27124-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 3, Fig. S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	glutathione s tranferase tag:?-?|sufficient binding region:44-160	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20944714|imex:IM-27124-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/21	2018/11/21	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	sufficient binding region:2-863	glutathione s tranferase tag:?-?|sufficient binding region:313-360	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46940	uniprotkb:P25025	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	intact:EBI-2835281|uniprotkb:Q8IUZ1|uniprotkb:Q9P2T7|uniprotkb:Q9P2T6|ensembl:ENSP00000319635	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:cxcr2_human(display_long)|uniprotkb:CXCR2(gene name)|psi-mi:CXCR2(display_short)|uniprotkb:IL8RB(gene name synonym)|uniprotkb:CDw128b(gene name synonym)|uniprotkb:GRO/MGSA receptor(gene name synonym)|uniprotkb:High affinity interleukin-8 receptor B(gene name synonym)|uniprotkb:IL-8 receptor type 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974647|imex:IM-27124-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	ensembl:ENSG00000180871(gene)|ensembl:ENST00000318507(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004918"(interleukin-8 receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|refseq:NP_001161770.1|refseq:NP_001548.1|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038112"(interleukin-8-mediated signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042629"(mast cell granule)|go:"GO:0043117"(positive regulation of vascular permeability)|refseq:XP_005246587.1|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072173"(metanephric tubule morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|interpro:IPR000057(Interleukin 8B receptor)|interpro:IPR000174(Interleukin-8 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4Q3H|rcsb pdb:5TYT|rcsb pdb:6KVA|rcsb pdb:6KVF|rcsb pdb:6LFM|rcsb pdb:6LFO|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|refseq:XP_016859479.1|refseq:XP_016859480.1|refseq:XP_016859481.1|dip:DIP-3782N	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/21	2018/11/22	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rogid:T16V0LpaqMIhUJlknnqmSVxX39o9606	rigid:LQbwGc77wmbhd1srl6/PwEpWE4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60953	uniprotkb:P46940	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Neel et al. (2010)	imex:IM-27124|pubmed:21876773	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20974652|imex:IM-27124-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:Fig. S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/21	2019/06/24	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	rigid:J3EZh6cVe+xuNhVzW/el+2nQbDg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)