#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q05513	uniprotkb:Q15109	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563279|imex:IM-26666-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	-	figure legend:Fig. 1G|agonist:S100A11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/21	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rigid:x5knw0GjmrxTT6E22Tw+6hnU8nA	false	-	his tag:n-n|mutation with no effect:391-391|O-phospho-L-serine:391-391|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563292|imex:IM-26666-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2A|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:RAGE|comment:"TIRAP and MyD88, but not TRAM, were co-precipitated with overexpressed RAGE and RAGE was phosphorylated in HEK293 cells predominantly when the cells were treated with RAGE ligands, S100A11, S100A12, HMGB1 and AGE but not with a TLR4 ligand (LPS) and TLR2 ligands (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:8AwxZ8d38xwqGL+vsxlbaH1uXX8	false	32p radiolabel:?-?|his tag:c-c|necessary binding region:364-404|ha tag:c-c|myc tag:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563292|imex:IM-26666-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 2A|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:RAGE|comment:"TIRAP and MyD88, but not TRAM, were co-precipitated with overexpressed RAGE and RAGE was phosphorylated in HEK293 cells predominantly when the cells were treated with RAGE ligands, S100A11, S100A12, HMGB1 and AGE but not with a TLR4 ligand (LPS) and TLR2 ligands (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:8AwxZ8d38xwqGL+vsxlbaH1uXX8	false	32p radiolabel:?-?|his tag:c-c|necessary binding region:364-404|ha tag:c-c|myc tag:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q05513	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563292|imex:IM-26666-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	-	-	-	figure legend:Fig. 2A|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:RAGE|comment:"TIRAP and MyD88, but not TRAM, were co-precipitated with overexpressed RAGE and RAGE was phosphorylated in HEK293 cells predominantly when the cells were treated with RAGE ligands, S100A11, S100A12, HMGB1 and AGE but not with a TLR4 ligand (LPS) and TLR2 ligands (Figure 2A)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rigid:8AwxZ8d38xwqGL+vsxlbaH1uXX8	false	32p radiolabel:?-?|his tag:c-c|necessary binding region:364-404|ha tag:c-c|myc tag:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q9NWZ3	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563313|imex:IM-26666-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:Fig. 2B|agonist:AGE|comment:"AGE (100 µg/ml)-induced phosphorylation of RAGE at Ser391 is essential for recruitment of endogenous TIRAP and MyD88 (B: The results were confirmed by an independent and two related experiments.) and downstream signal transduction (C: The results were confirmed by an independent and two related experiments.) in HEK293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|mutation disrupting interaction strength:391-391|O-phospho-L-serine:391-391|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563313|imex:IM-26666-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2B|agonist:AGE|comment:"AGE (100 µg/ml)-induced phosphorylation of RAGE at Ser391 is essential for recruitment of endogenous TIRAP and MyD88 (B: The results were confirmed by an independent and two related experiments.) and downstream signal transduction (C: The results were confirmed by an independent and two related experiments.) in HEK293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|mutation disrupting interaction strength:391-391|O-phospho-L-serine:391-391|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563313|imex:IM-26666-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 2B|agonist:AGE|comment:"AGE (100 µg/ml)-induced phosphorylation of RAGE at Ser391 is essential for recruitment of endogenous TIRAP and MyD88 (B: The results were confirmed by an independent and two related experiments.) and downstream signal transduction (C: The results were confirmed by an independent and two related experiments.) in HEK293 cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|mutation disrupting interaction strength:391-391|O-phospho-L-serine:391-391|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q05513	uniprotkb:Q15109	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563427|imex:IM-26666-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	-	figure legend:Fig. 2A|comment:RAGE interacts exclusively with PKCzeta when HUVECs are treated with LPS and TLR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rigid:x5knw0GjmrxTT6E22Tw+6hnU8nA	false	-	32p radiolabel:?-?|his tag:c-c|necessary binding region:364-404|ha tag:c-c|myc tag:c-c|flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:Q9NWZ3	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563330|imex:IM-26666-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:Fig. 3A, Fig. S3|comment:"Application to HUVECs with RAGE ligands such as S100A11, S100A12, HMGB1, and AGE but not LPS and TLR2 ligands induced phosphorylation of endogenous RAGE, interaction with TIRAP, MyD88, and IRAK4, and transduction of signal to the downstream molecules (Figures 3A and 3B)."|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:n361L4jHxS4wsqfnAroBwWh1tIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563330|imex:IM-26666-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 3A, Fig. S3|comment:"Application to HUVECs with RAGE ligands such as S100A11, S100A12, HMGB1, and AGE but not LPS and TLR2 ligands induced phosphorylation of endogenous RAGE, interaction with TIRAP, MyD88, and IRAK4, and transduction of signal to the downstream molecules (Figures 3A and 3B)."|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:n361L4jHxS4wsqfnAroBwWh1tIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563330|imex:IM-26666-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 3A, Fig. S3|comment:"Application to HUVECs with RAGE ligands such as S100A11, S100A12, HMGB1, and AGE but not LPS and TLR2 ligands induced phosphorylation of endogenous RAGE, interaction with TIRAP, MyD88, and IRAK4, and transduction of signal to the downstream molecules (Figures 3A and 3B)."|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:n361L4jHxS4wsqfnAroBwWh1tIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q05513	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563330|imex:IM-26666-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	-	-	-	figure legend:Fig. 3A, Fig. S3|comment:"Application to HUVECs with RAGE ligands such as S100A11, S100A12, HMGB1, and AGE but not LPS and TLR2 ligands induced phosphorylation of endogenous RAGE, interaction with TIRAP, MyD88, and IRAK4, and transduction of signal to the downstream molecules (Figures 3A and 3B)."|agonist:S100A11|agonist:S100A12|agonist:HMGB1|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2018/05/21	2018/05/21	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rigid:n361L4jHxS4wsqfnAroBwWh1tIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q05513	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563402|imex:IM-26666-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	-	-	-	figure legend:Fig. 3A, Fig. S3|comment:RAGE interacts exclusively with PKCzeta when HUVECs are treated with LPS and TLR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rigid:x5knw0GjmrxTT6E22Tw+6hnU8nA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q8R4K2	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-3842721|uniprotkb:Q80WW1|ensembl:ENSMUSP00000074471	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_mouse(display_long)|uniprotkb:Irak4(gene name)|psi-mi:Irak4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563478|imex:IM-26666-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_084202.2|dip:DIP-48996N|ensembl:ENSMUSG00000059883(gene)|ensembl:ENSMUST00000074936(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q8R4K2|rcsb pdb:1WH4|rcsb pdb:2A9I|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9020702	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:wreOQx/3vm3HfDiUt8mriWGR6Lc10090	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q02956	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563478|imex:IM-26666-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q99836	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563478|imex:IM-26666-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:P58753	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563478|imex:IM-26666-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q02956	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563505|imex:IM-26666-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rigid:izBtZbEXvkkLEA/ZXxCAk3qEPc0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:P58753	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563505|imex:IM-26666-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:izBtZbEXvkkLEA/ZXxCAk3qEPc0	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62151	uniprotkb:Q8R4K2	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-3842721|uniprotkb:Q80WW1|ensembl:ENSMUSP00000074471	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_mouse(display_long)|uniprotkb:Irak4(gene name)|psi-mi:Irak4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563522|imex:IM-26666-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_084202.2|dip:DIP-48996N|ensembl:ENSMUSG00000059883(gene)|ensembl:ENSMUST00000074936(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q8R4K2|rcsb pdb:1WH4|rcsb pdb:2A9I|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9020702	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:wreOQx/3vm3HfDiUt8mriWGR6Lc10090	rigid:EXH7dDpCi8LD6xI35xvWBNjfiiQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q99JY1	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-6559589|uniprotkb:Q91ZW0	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_mouse(display_long)|uniprotkb:Tirap(gene name)|psi-mi:Tirap(display_short)|uniprotkb:Mal(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:MyD88 adapter-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563522|imex:IM-26666-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032658"(regulation of interleukin-15 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|reactome:R-MMU-166058|mint:Q99JY1|refseq:NP_473437.2|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:mzJj4bh3KEi7Mzz273bcpBFP+uk10090	rigid:EXH7dDpCi8LD6xI35xvWBNjfiiQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q02956	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563522|imex:IM-26666-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rigid:EXH7dDpCi8LD6xI35xvWBNjfiiQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q99836	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563522|imex:IM-26666-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:EXH7dDpCi8LD6xI35xvWBNjfiiQ	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02956	uniprotkb:Q62151	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563548|imex:IM-26666-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2018/05/21	2018/05/22	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rigid:nSk4IsRWRw8NtktGYc1Og1X4TMc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q8R4K2	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-3842721|uniprotkb:Q80WW1|ensembl:ENSMUSP00000074471	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_mouse(display_long)|uniprotkb:Irak4(gene name)|psi-mi:Irak4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563566|imex:IM-26666-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_084202.2|dip:DIP-48996N|ensembl:ENSMUSG00000059883(gene)|ensembl:ENSMUST00000074936(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q8R4K2|rcsb pdb:1WH4|rcsb pdb:2A9I|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9020702	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:wreOQx/3vm3HfDiUt8mriWGR6Lc10090	rigid:EToQarWeHE12nwd8ruOU7oLge4U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:P22366	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563566|imex:IM-26666-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	rigid:EToQarWeHE12nwd8ruOU7oLge4U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q02956	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563566|imex:IM-26666-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rigid:EToQarWeHE12nwd8ruOU7oLge4U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:P58753	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563566|imex:IM-26666-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:EToQarWeHE12nwd8ruOU7oLge4U	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62151	uniprotkb:Q8R4K2	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-3842721|uniprotkb:Q80WW1|ensembl:ENSMUSP00000074471	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_mouse(display_long)|uniprotkb:Irak4(gene name)|psi-mi:Irak4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563595|imex:IM-26666-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_084202.2|dip:DIP-48996N|ensembl:ENSMUSG00000059883(gene)|ensembl:ENSMUST00000074936(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q8R4K2|rcsb pdb:1WH4|rcsb pdb:2A9I|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9020702	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:wreOQx/3vm3HfDiUt8mriWGR6Lc10090	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q02956	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563595|imex:IM-26666-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:Q99836	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563595|imex:IM-26666-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62151	uniprotkb:P58753	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563595|imex:IM-26666-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|agonist:AGE|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:KiI1xXwVORVrt5QfShfSkg3X2ds	false	-	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02956	uniprotkb:Q62151	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	intact:EBI-6665091|uniprotkb:C5H3H4|uniprotkb:C5H3H5|uniprotkb:C5H3H7|uniprotkb:C5H3I0|uniprotkb:C5H7W3|uniprotkb:C5H7W4|uniprotkb:C5H7W5|uniprotkb:C5H7W6|uniprotkb:C5H7W7|uniprotkb:C5H7W8|uniprotkb:C5H7W9|uniprotkb:O35444|uniprotkb:Q2PGG1|uniprotkb:V5R4Y0|ensembl:ENSMUSP00000015596	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:rage_mouse(display_long)|uniprotkb:Ager(gene name)|psi-mi:Ager(display_short)|uniprotkb:Rage(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563590|imex:IM-26666-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	ensembl:ENSMUSG00000015452(gene)|ensembl:ENSMUST00000015596(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007611"(learning or memory)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014002"(astrocyte development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070379"(high mobility group box 1 binding)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q62151|rcsb pdb:4IM8|reactome:R-MMU-445989|reactome:R-MMU-879415|reactome:R-MMU-933542|interpro:IPR007110(Immunoglobulin-like)|refseq:NP_001258351.1|refseq:NP_001258352.1|refseq:NP_031451.2|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)	-	-	-	figure legend:Fig. 2D|comment:"Essential nature of TIRAP and MyD88 for RAGE signaling was demonstrated using TIRAP-down regulated NIH3T3 cells and MyD88-/- mouse fibroblasts (Figures S2D, 2D and 2E). Overexpression of TIRAP or MyD88 rescued the defective protein interaction and signal transduction in corresponding cells. These results indicate that TIRAP and MyD88 function as essential adaptor proteins for RAGE, binding to ligand-activated phosphorylated RAGE and transducing a signal from it."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/05/21	2018/05/22	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	rogid:KMBfC1LNceeO9w7/Ml/wcXVtBrg10090	rigid:nSk4IsRWRw8NtktGYc1Og1X4TMc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58753	uniprotkb:Q15109	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563691|imex:IM-26666-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	-	figure legend:Fig. S2A|agonist:S100A11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rigid:PXT18EwQoRNQCYrxLkMvvDLQ/iE	false	myc tag:n-n|ha tag:c-c	his tag:n-n|ha tag:n-n|sufficient binding region:364-404	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563713|imex:IM-26666-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404|mutation disrupting interaction strength:391-391|mutation increasing interaction strength:391-391	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563713|imex:IM-26666-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404|mutation disrupting interaction strength:391-391|mutation increasing interaction strength:391-391	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563746|imex:IM-26666-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563746|imex:IM-26666-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404	myc tag:n-n|ha tag:c-c|mutation disrupting interaction strength:118-131	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563772|imex:IM-26666-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404	mutation decreasing interaction strength:196-202|myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563772|imex:IM-26666-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. S2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:Z9gDNHUxTIl+j/OtmcmiNcWzoys	false	his tag:n-n|ha tag:n-n|sufficient binding region:364-404	myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05513	uniprotkb:Q15109	intact:EBI-295351|uniprotkb:Q15207|uniprotkb:Q5SYT5|uniprotkb:Q969S4|uniprotkb:A8K4N0|uniprotkb:A8MU64|uniprotkb:B7Z2J7|uniprotkb:E9PCW2|ensembl:ENSP00000367830	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	psi-mi:kpcz_human(display_long)|uniprotkb:PRKCZ(gene name)|psi-mi:PRKCZ(display_short)|uniprotkb:PKC2(gene name synonym)|uniprotkb:nPKC-zeta(gene name synonym)	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563978|imex:IM-26666-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028753.1|refseq:NP_001028754.1|refseq:NP_001229803.1|refseq:NP_002735.3|refseq:XP_016857288.1|ensembl:ENSG00000067606(gene)|ensembl:ENST00000378567(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034662|interpro:IPR034877|mint:Q05513|reactome:R-HSA-114604|reactome:R-HSA-2173791|reactome:R-HSA-5218921|reactome:R-HSA-5668599|reactome:R-HSA-9634635	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	-	-	-	figure legend:Fig. S1G|comment:"binding of PKCζ to RAGE was independent of the phosphorylation status (Figure 1G and S1G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/23	rogid:ZSNTfuQXROHgAT6oDLjP1Ij7KxY9606	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rigid:x5knw0GjmrxTT6E22Tw+6hnU8nA	false	ha tag:c-c	his tag:n-n|ha tag:n-n|sufficient binding region:364-404|mutation with no effect:391-391|mutation with no effect:391-391	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15109	uniprotkb:Q86XR7	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563824|imex:IM-26666-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88, TRAM and IRAK-4 when the receptor was activated by treatment with LBP-LPS, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rigid:OtbK0Eu0TqLNUfOqEV0sfuad/LU	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q9NWZ3	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563824|imex:IM-26666-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88, TRAM and IRAK-4 when the receptor was activated by treatment with LBP-LPS, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:OtbK0Eu0TqLNUfOqEV0sfuad/LU	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563824|imex:IM-26666-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88, TRAM and IRAK-4 when the receptor was activated by treatment with LBP-LPS, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:OtbK0Eu0TqLNUfOqEV0sfuad/LU	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563824|imex:IM-26666-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88, TRAM and IRAK-4 when the receptor was activated by treatment with LBP-LPS, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:OtbK0Eu0TqLNUfOqEV0sfuad/LU	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q9NWZ3	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563847|imex:IM-26666-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88 and IRAK-4 when the receptors were activated by treatment with AGE, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:P58753	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563847|imex:IM-26666-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88 and IRAK-4 when the receptors were activated by treatment with AGE, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15109	uniprotkb:Q99836	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20563847|imex:IM-26666-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"RAGE was co-precipitated with TIRAP, MyD88 and IRAK-4 when the receptors were activated by treatment with AGE, HMGB1-LPS and S100A8/Ap (weakly)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/05/22	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:GpCuVwnPrOjDhJJYWx8MAaFn0J8	false	his tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00206	uniprotkb:Q86XR7	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-525927|uniprotkb:B3Y698|ensembl:ENSP00000415139|uniprotkb:Q6JUT2	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tcam2_human(display_long)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)|uniprotkb:Toll-like receptor adaptor protein 3(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502(gene name synonym)|uniprotkb:TICAM2(gene name)|psi-mi:TICAM2(display_short)|uniprotkb:TIRP(gene name synonym)|uniprotkb:TIRAP3(gene name synonym)|uniprotkb:TRAM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20584941|imex:IM-26666-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_001157941.1|refseq:NP_067681.1|ensembl:ENSG00000243414(gene)|ensembl:ENST00000427199(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|rcsb pdb:2M1W|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|refseq:NP_001157940.1|dip:DIP-33488N	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"TLR4 was co-precipitated with TRAM in addition to the three proteins only when the receptors were activated by the ligands (Figure 4A and S5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:+VKC9HGfNztWtFzjO9FB2NTuChg9606	rigid:Yel/AYQYlFyS/V3E9iE1zEth9l8	false	ha tag:n-n|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00206	uniprotkb:Q9NWZ3	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20584941|imex:IM-26666-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"TLR4 was co-precipitated with TRAM in addition to the three proteins only when the receptors were activated by the ligands (Figure 4A and S5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:Yel/AYQYlFyS/V3E9iE1zEth9l8	false	ha tag:n-n|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00206	uniprotkb:P58753	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20584941|imex:IM-26666-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"TLR4 was co-precipitated with TRAM in addition to the three proteins only when the receptors were activated by the ligands (Figure 4A and S5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rigid:Yel/AYQYlFyS/V3E9iE1zEth9l8	false	ha tag:n-n|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00206	uniprotkb:Q99836	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-447677|uniprotkb:P78397|uniprotkb:Q53XS7|uniprotkb:B4DKH8|uniprotkb:B4DKU4|uniprotkb:J3KPU4|uniprotkb:J3KQ87|uniprotkb:J3KQJ6|uniprotkb:B4DQ60|uniprotkb:B4DQ72|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:myd88_human(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sakaguchi et al. (2010)	pubmed:21829704|imex:IM-26666	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20584941|imex:IM-26666-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_001166037.1|refseq:NP_001166039.1|refseq:NP_001166040.1|refseq:NP_002459.2|dip:DIP-31349N|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:Q99836|rcsb pdb:2JS7|rcsb pdb:2Z5V|rcsb pdb:3MOP|rcsb pdb:4DOM|rcsb pdb:4EO7|rcsb pdb:6I3N|rcsb pdb:7BEQ|rcsb pdb:7BER|rcsb pdb:7L6W|reactome:R-HSA-1236974|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-1810476|reactome:R-HSA-209543|reactome:R-HSA-3134963|reactome:R-HSA-5602498|reactome:R-HSA-5602680|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975155|reactome:R-HSA-975871|reactome:R-HSA-975138|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005121"(Toll binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0050830"(defense response to Gram-positive bacterium)	-	-	-	figure legend:Fig. 4A, Fig. S5B|comment:"TLR4 was co-precipitated with TRAM in addition to the three proteins only when the receptors were activated by the ligands (Figure 4A and S5B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/05/21	2018/06/04	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:Yel/AYQYlFyS/V3E9iE1zEth9l8	false	ha tag:n-n|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)