#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16820	uniprotkb:P05067-4	intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Jefferson et al. (2011)	pubmed:21646356|imex:IM-26685	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20766636|imex:IM-26685-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	go:"GO:0004222"(metalloendopeptidase activity)	-	isoform-comment:A major isoform.	figure legend:Fig. 2, Supp Fig 2|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/09/26	2018/09/26	rogid:nDkbvnrqRM45H231bQ8XUntenNM9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rigid:9NTCM6Ig200DzbOCb/C/Voa4mdk	false	his tag:?-?	his tag:n-n|sufficient binding region:1-669	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16820	uniprotkb:P05067-8	intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6	intact:EBI-302661|ensembl:ENSP00000350578	psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym)	psi-mi:p05067-8(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 751(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Jefferson et al. (2011)	pubmed:21646356|imex:IM-26685	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20766649|imex:IM-26685-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000357903(transcript)|uniprotkb:P05067-8(isoform-parent)	go:"GO:0004222"(metalloendopeptidase activity)	-	isoform-comment:A major isoform.	figure legend:Fig. 2, Supp Fig 2|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/09/26	2018/09/26	rogid:nDkbvnrqRM45H231bQ8XUntenNM9606	rogid:57q3srlDHXNbvCGNjGwV4qMD1dU9606	rigid:C2ADWc61PgmSOXcSs9Op4Nh6cGc	false	his tag:?-?	his tag:n-n|sufficient binding region:1-613	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16820	uniprotkb:P05067-1	intact:EBI-968418|ensembl:ENSP00000269202|uniprotkb:Q670J1|uniprotkb:B7ZM35|uniprotkb:B9EGL6	intact:EBI-20766660|ensembl:ENSP00000284981	psi-mi:mep1b_human(display_long)|uniprotkb:MEP1B(gene name)|psi-mi:MEP1B(display_short)|uniprotkb:Endopeptidase-2(gene name synonym)|uniprotkb:N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta(gene name synonym)|uniprotkb:PABA peptide hydrolase(gene name synonym)|uniprotkb:PPH beta(gene name synonym)|uniprotkb:Meprin B(gene name synonym)	psi-mi:p05067-1(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:PreA4 770(isoform synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Jefferson et al. (2011)	pubmed:21646356|imex:IM-26685	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20766669|imex:IM-26685-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141434(gene)|ensembl:ENST00000269202(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017090"(meprin A complex)|go:"GO:0042802"(identical protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000998(MAM)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR002083(MATH)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR008294(Peptidase M12A, meprin alpha subunit)|interpro:IPR008974(TRAF-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024079|interpro:IPR034038|interpro:IPR034302|rcsb pdb:4GWM|rcsb pdb:4GWN|rcsb pdb:7AQ1|rcsb pdb:7AUW|refseq:NP_005916.2|refseq:NP_001295100.1|dip:DIP-34900N	ensembl:ENSG00000142192(gene)|ensembl:ENST00000346798(transcript)|intact:EBI-77613(isoform-parent)	go:"GO:0004222"(metalloendopeptidase activity)	-	isoform-comment:A major isoform.	figure legend:Fig. 2, Supp Fig 2|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/09/26	2018/09/26	rogid:nDkbvnrqRM45H231bQ8XUntenNM9606	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rigid:4x8lcJN0MGkfpyo3V4Np++4s/C0	false	his tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)