#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q07955 intact:EBI-20563711 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 ensembl:ENSMUST00000172812.2 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:lncrn_malat1 mouse(display_short)|psi-mi:EBI-20563711(display_long) psi-mi:"MI:0416"(fluorescence microscopy) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20568020|imex:IM-26604-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - go:"GO:0016607"(nuclear speck) - - figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/06/07 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - - false enhanced yellow fluorescent protein tag:n-n binding-associated region:5185-6982|binding-associated region:1677-3600 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) intact:EBI-17172839 uniprotkb:Q07955 rnacentral:URS0000A77400_9606 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20585766|imex:IM-26604-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A go:"GO:0016607"(nuclear speck) - - figure legend:Fig 3B, D; Suppl Fig3C,E|comment:Silencing Prp6 or Son genes diminishes the colocalization|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/06/07 - rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - false - enhanced yellow fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q01130 intact:EBI-17172839 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 rnacentral:URS0000A77400_9606 psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:0416"(fluorescence microscopy) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20585773|imex:IM-26604-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N - go:"GO:0016607"(nuclear speck) - - figure legend:Fig 3A|comment:Silencing srsf1 genes does not influence the colocalization|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/07/13 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 - - false red fluorescent protein tag:?-? - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q07955 intact:EBI-17172839 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 rnacentral:URS0000A77400_9606 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20563803|imex:IM-26604-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - - figure legend:Fig 1 C, D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - - false sufficient binding region:121-195|sufficient binding region:16-91|t7 tag:n-n|mutation decreasing interaction:58-58,56-56 - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:Q01130 intact:EBI-17172839 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 rnacentral:URS0000A77400_9606 psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20563806|imex:IM-26604-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N - - - - figure legend:Fig 1 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/22 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 - - false t7 tag:n-n - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) intact:EBI-17172839 uniprotkb:Q13243 rnacentral:URS0000A77400_9606 intact:EBI-720503|uniprotkb:O14797|uniprotkb:Q16662|uniprotkb:Q49AD6|uniprotkb:Q6FGE0|ensembl:ENSP00000377892|ensembl:ENSP00000451088|ensembl:ENSP00000452123 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:srsf5_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP40(gene name synonym)|uniprotkb:Delayed-early protein HRS(gene name synonym)|uniprotkb:SRSF5(gene name)|psi-mi:SRSF5(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:SRP40(gene name synonym)|uniprotkb:SFRS5(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 5(gene name synonym) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20563809|imex:IM-26604-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - go:"GO:0003729"(mRNA binding)|refseq:NP_001034554.1|refseq:NP_008856.2|refseq:NP_001307143.1|dip:DIP-46894N|ensembl:ENSG00000100650(gene)|ensembl:ENST00000394366(transcript)|ensembl:ENST00000553521(transcript)|ensembl:ENST00000557154(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979|mint:Q13243|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|go:"GO:0005654"(nucleoplasm)|reactome:R-HSA-73856 - - - figure legend:Fg 1 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 - rogid:q+kwVNXjDcA8o9hJ+BDF0S5ZSlY9606 - false - - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:Q8WXF1 intact:EBI-20564368 intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916 rnacentral:URS000075DAEC_9606 psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym) psi-mi:lncrn_neat1 human short(display_short)|psi-mi:EBI-20564368(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564513|imex:IM-26604-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA - - - - figure legend:Fig 1 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606 - - false t7 tag:n-n - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:Q07955 intact:EBI-17172839 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 rnacentral:URS0000A77400_9606 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20567681|imex:IM-26604-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - - figure legend:Fig 1Bc|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/30 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - - false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:1195"(quantitative pcr) intact:EBI-20563711 uniprotkb:Q6PDM2 ensembl:ENSMUST00000172812.2 intact:EBI-2550360|ensembl:ENSMUSP00000120595|uniprotkb:B2KGJ5|uniprotkb:Q3UCH2|uniprotkb:Q5SXC5|uniprotkb:Q8BJV3|uniprotkb:Q8C1H9 psi-mi:lncrn_malat1 mouse(display_short)|psi-mi:EBI-20563711(display_long) psi-mi:srsf1_mouse(display_long)|uniprotkb:Sfrs1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)|uniprotkb:Srsf1(gene name)|psi-mi:Srsf1(display_short)|uniprotkb:ASF/SF2(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30a(gene name synonym) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20568257|imex:IM-26604-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSMUSG00000018379(gene)|ensembl:ENSMUST00000139129(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0050733"(RS domain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q6PDM2|rcsb pdb:1X4C|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-72165|refseq:NP_001071635.1|refseq:NP_775550.2|dip:DIP-48723N - - - figure legend:Suppl fig 2 A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/31 - rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y10090 - false sufficient binding region:3476-5331|sufficient binding region:1677-3600|sufficient binding region:1-1892 - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:O94906 intact:EBI-17172839 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 rnacentral:URS0000A77400_9606 psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20585788|imex:IM-26604-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N - - - - figure legend:Suppl Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/06/07 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 - - false t7 tag:n-n - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) intact:EBI-20563711 uniprotkb:O94906 ensembl:ENSMUST00000172812.2 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 psi-mi:lncrn_malat1 mouse(display_short)|psi-mi:EBI-20563711(display_long) psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20585792|imex:IM-26604-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N - - - figure legend:Suppl Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/06/07 - rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 - false - t7 tag:n-n - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:Q07955 intact:EBI-17172839 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 rnacentral:URS0000A77400_9606 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564502|imex:IM-26604-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - - figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - - false - - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:1194"(reverse transcription pcr) uniprotkb:Q07955 intact:EBI-17172839 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 rnacentral:URS0000A77400_9606 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564539|imex:IM-26604-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A - - - - figure legend:Suppl Fig 1B, C; Fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - - false t7 tag:n-n - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:1194"(reverse transcription pcr) uniprotkb:Q01130 intact:EBI-17172839 intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49 rnacentral:URS0000A77400_9606 psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564545|imex:IM-26604-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N - - - - figure legend:Suppl Fig 1B, C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 - - false t7 tag:n-n - - - psi-mi:"MI:1194"(reverse transcription pcr) psi-mi:"MI:1194"(reverse transcription pcr) intact:EBI-17172839 uniprotkb:Q13243 rnacentral:URS0000A77400_9606 intact:EBI-720503|uniprotkb:O14797|uniprotkb:Q16662|uniprotkb:Q49AD6|uniprotkb:Q6FGE0|ensembl:ENSP00000377892|ensembl:ENSP00000451088|ensembl:ENSP00000452123 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:srsf5_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP40(gene name synonym)|uniprotkb:Delayed-early protein HRS(gene name synonym)|uniprotkb:SRSF5(gene name)|psi-mi:SRSF5(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:SRP40(gene name synonym)|uniprotkb:SFRS5(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 5(gene name synonym) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564551|imex:IM-26604-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - go:"GO:0003729"(mRNA binding)|refseq:NP_001034554.1|refseq:NP_008856.2|refseq:NP_001307143.1|dip:DIP-46894N|ensembl:ENSG00000100650(gene)|ensembl:ENST00000394366(transcript)|ensembl:ENST00000553521(transcript)|ensembl:ENST00000557154(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979|mint:Q13243|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|go:"GO:0005654"(nucleoplasm)|reactome:R-HSA-73856 - - - figure legend:Suppl Fig 1B, C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/25 - rogid:q+kwVNXjDcA8o9hJ+BDF0S5ZSlY9606 - false - - - - psi-mi:"MI:1194"(reverse transcription pcr) psi-mi:"MI:1194"(reverse transcription pcr) uniprotkb:P84103 intact:EBI-17172839 intact:EBI-372557|uniprotkb:P23152|uniprotkb:O08831|uniprotkb:B4E241|intact:EBI-11020748|uniprotkb:Q5R3K0|ensembl:ENSP00000362820|ensembl:ENSP00000482833 rnacentral:URS0000A77400_9606 psi-mi:srsf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP20(gene name synonym)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)|uniprotkb:SRP20(gene name synonym)|uniprotkb:SFRS3(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 3(gene name synonym) psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20564555|imex:IM-26604-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:2190"(long non-coding ribonucleic acid) refseq:NP_003008.1|ensembl:ENSG00000112081(gene)|ensembl:ENST00000373715(transcript)|ensembl:ENST00000620941(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0043274"(phospholipase binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P84103|rcsb pdb:2I2Y|rcsb pdb:2I38|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-32961N - - - - figure legend:Suppl Fig 1B, C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/30 rogid:BcfyCj2cNNTH1igANKpvh4IHDVU9606 - - false t7 tag:n-n - - - psi-mi:"MI:1194"(reverse transcription pcr) psi-mi:"MI:1194"(reverse transcription pcr) intact:EBI-17172839 uniprotkb:O94906 rnacentral:URS0000A77400_9606 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:"MI:1017"(rna immunoprecipitation) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20568254|imex:IM-26604-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N - - - figure legend:Fig 3 C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/06/07 - rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 - false - t7 tag:n-n - - psi-mi:"MI:1194"(reverse transcription pcr) psi-mi:"MI:1194"(reverse transcription pcr) intact:EBI-17172839 intact:EBI-16224158 rnacentral:URS0000A77400_9606 rnacentral:URS00003EE995_9606 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:snrna u2-1(display_short)|psi-mi:EBI-16224158(display_long) psi-mi:"MI:0416"(fluorescence microscopy) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20563625|imex:IM-26604-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0607"(small nuclear rna) - hgnc:"HGNC:10142"(see-also) go:"GO:0016607"(nuclear speck) - - figure legend:Fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/22 - - - false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) intact:EBI-17172839 uniprotkb:Q07955 rnacentral:URS0000A77400_9606 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962 psi-mi:lncrn_malat1 human(display_short)|psi-mi:EBI-17172839(display_long) psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Tripathi et al. (2010) pubmed:20797886|imex:IM-26604 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20563625|imex:IM-26604-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:2190"(long non-coding ribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A go:"GO:0016607"(nuclear speck) - - figure legend:Fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/05/21 2018/05/22 - rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 - false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:0421"(identification by antibody)