#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21941	uniprotkb:P02459	intact:EBI-20828128|ensembl:ENSP00000362870|uniprotkb:B2R7E3|uniprotkb:Q5TBB9	intact:EBI-5281315|uniprotkb:Q28070|uniprotkb:Q9XT24|uniprotkb:Q9XT25|ensembl:ENSBTAP00000017505	psi-mi:matn1_human(display_long)|uniprotkb:MATN1(gene name)|psi-mi:MATN1(display_short)|uniprotkb:CMP(gene name synonym)|uniprotkb:CRTM(gene name synonym)|uniprotkb:Matrilin-1(gene name synonym)	psi-mi:co2a1_bovin(display_long)|uniprotkb:COL2A1(gene name)|psi-mi:COL2A1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Fresquet et al. (2010)	pubmed:20729554|imex:IM-26840	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828126|imex:IM-26840-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162510(gene)|ensembl:ENST00000373765(transcript)|go:"GO:0003429"(growth plate cartilage chondrocyte morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR019466|interpro:IPR030751|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|refseq:NP_002370.1	refseq:NP_001001135.2|ensembl:ENSBTAG00000013155(gene)|ensembl:ENSBTAT00000017505(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-1442490|reactome:R-BTA-1650814|reactome:R-BTA-2022090|reactome:R-BTA-3000171|reactome:R-BTA-3000178|reactome:R-BTA-8948216	-	-	-	figure legend:Fig.4|comment:"These studies demonstrated that whereas 1 mm Zn2+ supported strong binding of type II and IX collagens to the wild type M1A1 and M1A2 domains, in contrast, binding in the presence of 1 mm Mn2+ and Mg2+, or 1 mm EDTA (used as control) was negligible or completely abolished."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/12	2018/11/12	rogid:J2/5TMl0AHdwQAjaslkVNNpDgao9606	rogid:DbVTxYXx0hQRDcPXIPiPtwdIJiY9913	rigid:3g4TAiDZRudw8mKbScuT9oWzRlw	false	sufficient binding region:23-222(IPR002035)|sufficient binding region:264-453(IPR002035)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21941	uniprotkb:P20849	intact:EBI-20828128|ensembl:ENSP00000362870|uniprotkb:B2R7E3|uniprotkb:Q5TBB9	intact:EBI-2528238|uniprotkb:Q13699|uniprotkb:Q13700|uniprotkb:Q5TF52|uniprotkb:Q6P467|uniprotkb:Q96BM8|uniprotkb:Q99225|uniprotkb:Q9H151|uniprotkb:Q9H152|uniprotkb:Q9Y6P2|uniprotkb:Q9Y6P3|ensembl:ENSP00000349790	psi-mi:matn1_human(display_long)|uniprotkb:MATN1(gene name)|psi-mi:MATN1(display_short)|uniprotkb:CMP(gene name synonym)|uniprotkb:CRTM(gene name synonym)|uniprotkb:Matrilin-1(gene name synonym)	psi-mi:co9a1_human(display_long)|uniprotkb:COL9A1(gene name)|psi-mi:COL9A1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Fresquet et al. (2010)	pubmed:20729554|imex:IM-26840	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828169|imex:IM-26840-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162510(gene)|ensembl:ENST00000373765(transcript)|go:"GO:0003429"(growth plate cartilage chondrocyte morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR019466|interpro:IPR030751|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|refseq:NP_002370.1	refseq:NP_001842.3|refseq:NP_511040.2|ensembl:ENSG00000112280(gene)|ensembl:ENST00000357250(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005594"(collagen type IX trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:2UUR|rcsb pdb:5CTD|rcsb pdb:5CTI|rcsb pdb:5CVA|rcsb pdb:5CVB|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|go:"GO:0031012"(extracellular matrix)|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	figure legend:Fig.4|comment:"These studies demonstrated that whereas 1 mm Zn2+ supported strong binding of type II and IX collagens to the wild type M1A1 and M1A2 domains, in contrast, binding in the presence of 1 mm Mn2+ and Mg2+, or 1 mm EDTA (used as control) was negligible or completely abolished."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/12	2018/11/12	rogid:J2/5TMl0AHdwQAjaslkVNNpDgao9606	rogid:7hJT3j38iwgn8ITFp+fn0O4iNAA9606	rigid:DNLyuPngi1zXcz0D4+/BqjyP6Pg	false	sufficient binding region:23-222(IPR002035)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21941	uniprotkb:P02459	intact:EBI-20828128|ensembl:ENSP00000362870|uniprotkb:B2R7E3|uniprotkb:Q5TBB9	intact:EBI-5281315|uniprotkb:Q28070|uniprotkb:Q9XT24|uniprotkb:Q9XT25|ensembl:ENSBTAP00000017505	psi-mi:matn1_human(display_long)|uniprotkb:MATN1(gene name)|psi-mi:MATN1(display_short)|uniprotkb:CMP(gene name synonym)|uniprotkb:CRTM(gene name synonym)|uniprotkb:Matrilin-1(gene name synonym)	psi-mi:co2a1_bovin(display_long)|uniprotkb:COL2A1(gene name)|psi-mi:COL2A1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym)	psi-mi:"MI:2196"(quartz crystal microbalance)	Fresquet et al. (2010)	pubmed:20729554|imex:IM-26840	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828191|imex:IM-26840-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162510(gene)|ensembl:ENST00000373765(transcript)|go:"GO:0003429"(growth plate cartilage chondrocyte morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR019466|interpro:IPR030751|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|refseq:NP_002370.1	refseq:NP_001001135.2|ensembl:ENSBTAG00000013155(gene)|ensembl:ENSBTAT00000017505(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-1442490|reactome:R-BTA-1650814|reactome:R-BTA-2022090|reactome:R-BTA-3000171|reactome:R-BTA-3000178|reactome:R-BTA-8948216	-	-	-	figure legend:Fig.5|caution:the Kd provided in this interaction applies to the region [264-453] wt only, not to the full length protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:50.0x10^-9 ~7.7(molar)	2018/11/12	2018/11/12	rogid:J2/5TMl0AHdwQAjaslkVNNpDgao9606	rogid:DbVTxYXx0hQRDcPXIPiPtwdIJiY9913	rigid:3g4TAiDZRudw8mKbScuT9oWzRlw	false	mutation with no effect:344-344|sufficient binding region:264-453(IPR002035)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21941	uniprotkb:P02459	intact:EBI-20828128|ensembl:ENSP00000362870|uniprotkb:B2R7E3|uniprotkb:Q5TBB9	intact:EBI-5281315|uniprotkb:Q28070|uniprotkb:Q9XT24|uniprotkb:Q9XT25|ensembl:ENSBTAP00000017505	psi-mi:matn1_human(display_long)|uniprotkb:MATN1(gene name)|psi-mi:MATN1(display_short)|uniprotkb:CMP(gene name synonym)|uniprotkb:CRTM(gene name synonym)|uniprotkb:Matrilin-1(gene name synonym)	psi-mi:co2a1_bovin(display_long)|uniprotkb:COL2A1(gene name)|psi-mi:COL2A1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym)	psi-mi:"MI:2196"(quartz crystal microbalance)	Fresquet et al. (2010)	pubmed:20729554|imex:IM-26840	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828203|imex:IM-26840-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162510(gene)|ensembl:ENST00000373765(transcript)|go:"GO:0003429"(growth plate cartilage chondrocyte morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR019466|interpro:IPR030751|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|refseq:NP_002370.1	refseq:NP_001001135.2|ensembl:ENSBTAG00000013155(gene)|ensembl:ENSBTAT00000017505(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-1442490|reactome:R-BTA-1650814|reactome:R-BTA-2022090|reactome:R-BTA-3000171|reactome:R-BTA-3000178|reactome:R-BTA-8948216	-	-	-	figure legend:Fig.5|caution:the Kd provded in this interaction applies to the region [23-222] wt only, not to the full length protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:104.4x10^-9 ~6.6(molar)	2018/11/12	2018/11/12	rogid:J2/5TMl0AHdwQAjaslkVNNpDgao9606	rogid:DbVTxYXx0hQRDcPXIPiPtwdIJiY9913	rigid:3g4TAiDZRudw8mKbScuT9oWzRlw	false	mutation increasing interaction strength:76-76|sufficient binding region:23-222(IPR002035)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15232	uniprotkb:P02459	intact:EBI-6262458|ensembl:ENSP00000383894|uniprotkb:B2CPU0|uniprotkb:Q4ZG02	intact:EBI-5281315|uniprotkb:Q28070|uniprotkb:Q9XT24|uniprotkb:Q9XT25|ensembl:ENSBTAP00000017505	psi-mi:matn3_human(display_long)|uniprotkb:MATN3(gene name)|psi-mi:MATN3(display_short)	psi-mi:co2a1_bovin(display_long)|uniprotkb:COL2A1(gene name)|psi-mi:COL2A1(display_short)|uniprotkb:Alpha-1 type II collagen(gene name synonym)	psi-mi:"MI:2196"(quartz crystal microbalance)	Fresquet et al. (2010)	pubmed:20729554|imex:IM-26840	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828234|imex:IM-26840-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000407540(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0051216"(cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000132031(gene)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030765|interpro:IPR036337|interpro:IPR036465|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_002372.1	refseq:NP_001001135.2|ensembl:ENSBTAG00000013155(gene)|ensembl:ENSBTAT00000017505(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005585"(collagen type II trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030903"(notochord development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0097065"(anterior head development)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-1442490|reactome:R-BTA-1650814|reactome:R-BTA-2022090|reactome:R-BTA-3000171|reactome:R-BTA-3000178|reactome:R-BTA-8948216	-	-	-	figure legend:Fig.5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:91.0x10^-9(molar)	2018/11/12	2018/11/12	rogid:xaqtpmkOEndqB+T3wmDsDErSS8k9606	rogid:DbVTxYXx0hQRDcPXIPiPtwdIJiY9913	rigid:D1kwhggG8xYE+nW82txML9g863U	false	sufficient binding region:83-258(IPR002035)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)