#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16288	uniprotkb:Q6PKX4	intact:EBI-3936704|uniprotkb:Q16289|uniprotkb:Q12827|uniprotkb:O75682|intact:EBI-28971821|ensembl:ENSP00000354207|ensembl:ENSP00000485864|uniprotkb:B7Z4C5|uniprotkb:E9PG56|uniprotkb:H0YND1	intact:EBI-2880244|ensembl:ENSP00000372160|uniprotkb:Q4V9S3|uniprotkb:Q96LU2|uniprotkb:A6NNG3|uniprotkb:Q96HI2|uniprotkb:Q8WUZ8	psi-mi:ntrk3_human(display_long)|uniprotkb:NTRK3(gene name)|psi-mi:NTRK3(display_short)|uniprotkb:TRKC(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:dok6_human(display_long)|uniprotkb:DOK6(gene name)|psi-mi:DOK6(display_short)|uniprotkb:DOK5L(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585313|imex:IM-26442-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000317501|ensembl:ENSP00000318328|ensembl:ENST00000355254|ensembl:ENSP00000347397|ensembl:ENST00000357724|ensembl:ENSP00000350356|ensembl:ENSP00000354207|ensembl:ENST00000394480|ensembl:ENSP00000377990|ensembl:ENST00000540489|ensembl:ENSP00000444673|ensembl:ENST00000557856|ensembl:ENSP00000453959|ensembl:ENSP00000485864|refseq:NP_001307063.1|refseq:NP_001307064.1|ensembl:ENSG00000140538(gene)|ensembl:ENST00000360948(transcript)|ensembl:ENST00000629765(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q16288|rcsb pdb:1WWC|rcsb pdb:3V5Q|rcsb pdb:4YMJ|rcsb pdb:6KZC|rcsb pdb:6KZD|reactome:R-HSA-388844|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|reactome:R-HSA-9603505|refseq:NP_001012338.1|refseq:NP_002521.2|refseq:XP_016877742.1|dip:DIP-5723N	ensembl:ENSG00000206052(gene)|ensembl:ENST00000382713(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_689934.2	-	-	-	figure legend:Fig. 1C, Fig. 1D, Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2018/06/05	2018/06/05	rogid:PiKp8Av9Q20Xxv00akwE0dazVY09606	rogid:hMHjc6pZ74mtPXhTetfA9SvFdf49606	rigid:vUXc3AO1ZdGtE70SB4o7HxHAqAM	false	sufficient binding region:454..454-839..839|mutation disrupting interaction strength:572-572|mutation disrupting interaction strength:516-516|mutation decreasing interaction strength:821-821|mutation with no effect:710-710|mutation with no effect:709-709|mutation with no effect:705-705	sufficient binding region:130-232(IPR002404)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PKX4	uniprotkb:P20783	intact:EBI-2880244|ensembl:ENSP00000372160|uniprotkb:Q4V9S3|uniprotkb:Q96LU2|uniprotkb:A6NNG3|uniprotkb:Q96HI2|uniprotkb:Q8WUZ8	intact:EBI-1025994|uniprotkb:Q6FH50|ensembl:ENSP00000328738|uniprotkb:B7Z1T5	psi-mi:dok6_human(display_long)|uniprotkb:DOK6(gene name)|psi-mi:DOK6(display_short)|uniprotkb:DOK5L(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)	psi-mi:ntf3_human(display_long)|uniprotkb:Neurotrophic factor(gene name synonym)|uniprotkb:HDNF(gene name synonym)|uniprotkb:Nerve growth factor 2(gene name synonym)|uniprotkb:NTF3(gene name)|psi-mi:NTF3(display_short)	psi-mi:"MI:0096"(pull down)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585345|imex:IM-26442-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206052(gene)|ensembl:ENST00000382713(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_689934.2	refseq:NP_001096124.1|refseq:NP_002518.1|refseq:XP_011519265.1|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR002072(Nerve growth factor)|interpro:IPR015578(Neurotrophin-3)|interpro:IPR019846|interpro:IPR020408|interpro:IPR029034|rcsb pdb:1B8K|rcsb pdb:1BND|rcsb pdb:1NT3|rcsb pdb:3BUK|reactome:R-HSA-9025046|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|ensembl:ENSG00000185652(gene)|ensembl:ENST00000331010(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0021675"(nerve development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|dip:DIP-346N	-	-	-	figure legend:Fig. 2A, Fig. 3C|comment:"Consistent with results from the yeast two-hybrid assay findings, the precipitation results proved that the Dok6 PTB domain binds to the activated TrkC receptor strongly in vitro, while no remarkable binding was found between Dok6 and TrkA or TrkB with activation or no activation (Figure (Figure2a,2a, panel 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/05	2018/06/14	rogid:hMHjc6pZ74mtPXhTetfA9SvFdf49606	rogid:E2ZTORtat5r2YRbDmEB3Qt+ojMQ9606	rigid:FAWHkME+YE76xhp1/bLfYqDGo6I	false	glutathione s tranferase tag:n-n|sufficient binding region:130-232(IPR002404)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PKX4	uniprotkb:Q16288	intact:EBI-2880244|ensembl:ENSP00000372160|uniprotkb:Q4V9S3|uniprotkb:Q96LU2|uniprotkb:A6NNG3|uniprotkb:Q96HI2|uniprotkb:Q8WUZ8	intact:EBI-3936704|uniprotkb:Q16289|uniprotkb:Q12827|uniprotkb:O75682|intact:EBI-28971821|ensembl:ENSP00000354207|ensembl:ENSP00000485864|uniprotkb:B7Z4C5|uniprotkb:E9PG56|uniprotkb:H0YND1	psi-mi:dok6_human(display_long)|uniprotkb:DOK6(gene name)|psi-mi:DOK6(display_short)|uniprotkb:DOK5L(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)	psi-mi:ntrk3_human(display_long)|uniprotkb:NTRK3(gene name)|psi-mi:NTRK3(display_short)|uniprotkb:TRKC(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585345|imex:IM-26442-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206052(gene)|ensembl:ENST00000382713(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_689934.2	ensembl:ENST00000317501|ensembl:ENSP00000318328|ensembl:ENST00000355254|ensembl:ENSP00000347397|ensembl:ENST00000357724|ensembl:ENSP00000350356|ensembl:ENSP00000354207|ensembl:ENST00000394480|ensembl:ENSP00000377990|ensembl:ENST00000540489|ensembl:ENSP00000444673|ensembl:ENST00000557856|ensembl:ENSP00000453959|ensembl:ENSP00000485864|refseq:NP_001307063.1|refseq:NP_001307064.1|ensembl:ENSG00000140538(gene)|ensembl:ENST00000360948(transcript)|ensembl:ENST00000629765(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q16288|rcsb pdb:1WWC|rcsb pdb:3V5Q|rcsb pdb:4YMJ|rcsb pdb:6KZC|rcsb pdb:6KZD|reactome:R-HSA-388844|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|reactome:R-HSA-9603505|refseq:NP_001012338.1|refseq:NP_002521.2|refseq:XP_016877742.1|dip:DIP-5723N	-	-	-	figure legend:Fig. 2A, Fig. 3C|comment:"Consistent with results from the yeast two-hybrid assay findings, the precipitation results proved that the Dok6 PTB domain binds to the activated TrkC receptor strongly in vitro, while no remarkable binding was found between Dok6 and TrkA or TrkB with activation or no activation (Figure (Figure2a,2a, panel 1)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/05	2018/06/14	rogid:hMHjc6pZ74mtPXhTetfA9SvFdf49606	rogid:PiKp8Av9Q20Xxv00akwE0dazVY09606	rigid:FAWHkME+YE76xhp1/bLfYqDGo6I	false	glutathione s tranferase tag:n-n|sufficient binding region:130-232(IPR002404)	mutation disrupting interaction strength:572-572|mutation disrupting interaction strength:516-516|mutation with no effect:821-821|v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PKX4	uniprotkb:P20783	intact:EBI-2880244|ensembl:ENSP00000372160|uniprotkb:Q4V9S3|uniprotkb:Q96LU2|uniprotkb:A6NNG3|uniprotkb:Q96HI2|uniprotkb:Q8WUZ8	intact:EBI-1025994|uniprotkb:Q6FH50|ensembl:ENSP00000328738|uniprotkb:B7Z1T5	psi-mi:dok6_human(display_long)|uniprotkb:DOK6(gene name)|psi-mi:DOK6(display_short)|uniprotkb:DOK5L(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)	psi-mi:ntf3_human(display_long)|uniprotkb:Neurotrophic factor(gene name synonym)|uniprotkb:HDNF(gene name synonym)|uniprotkb:Nerve growth factor 2(gene name synonym)|uniprotkb:NTF3(gene name)|psi-mi:NTF3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585388|imex:IM-26442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206052(gene)|ensembl:ENST00000382713(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_689934.2	refseq:NP_001096124.1|refseq:NP_002518.1|refseq:XP_011519265.1|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR002072(Nerve growth factor)|interpro:IPR015578(Neurotrophin-3)|interpro:IPR019846|interpro:IPR020408|interpro:IPR029034|rcsb pdb:1B8K|rcsb pdb:1BND|rcsb pdb:1NT3|rcsb pdb:3BUK|reactome:R-HSA-9025046|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|ensembl:ENSG00000185652(gene)|ensembl:ENST00000331010(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0021675"(nerve development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|dip:DIP-346N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/06/05	2018/06/14	rogid:hMHjc6pZ74mtPXhTetfA9SvFdf49606	rogid:E2ZTORtat5r2YRbDmEB3Qt+ojMQ9606	rigid:FAWHkME+YE76xhp1/bLfYqDGo6I	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PKX4	uniprotkb:Q16288	intact:EBI-2880244|ensembl:ENSP00000372160|uniprotkb:Q4V9S3|uniprotkb:Q96LU2|uniprotkb:A6NNG3|uniprotkb:Q96HI2|uniprotkb:Q8WUZ8	intact:EBI-3936704|uniprotkb:Q16289|uniprotkb:Q12827|uniprotkb:O75682|intact:EBI-28971821|ensembl:ENSP00000354207|ensembl:ENSP00000485864|uniprotkb:B7Z4C5|uniprotkb:E9PG56|uniprotkb:H0YND1	psi-mi:dok6_human(display_long)|uniprotkb:DOK6(gene name)|psi-mi:DOK6(display_short)|uniprotkb:DOK5L(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)	psi-mi:ntrk3_human(display_long)|uniprotkb:NTRK3(gene name)|psi-mi:NTRK3(display_short)|uniprotkb:TRKC(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585388|imex:IM-26442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206052(gene)|ensembl:ENST00000382713(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-HSA-8853659|refseq:NP_689934.2	ensembl:ENST00000317501|ensembl:ENSP00000318328|ensembl:ENST00000355254|ensembl:ENSP00000347397|ensembl:ENST00000357724|ensembl:ENSP00000350356|ensembl:ENSP00000354207|ensembl:ENST00000394480|ensembl:ENSP00000377990|ensembl:ENST00000540489|ensembl:ENSP00000444673|ensembl:ENST00000557856|ensembl:ENSP00000453959|ensembl:ENSP00000485864|refseq:NP_001307063.1|refseq:NP_001307064.1|ensembl:ENSG00000140538(gene)|ensembl:ENST00000360948(transcript)|ensembl:ENST00000629765(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q16288|rcsb pdb:1WWC|rcsb pdb:3V5Q|rcsb pdb:4YMJ|rcsb pdb:6KZC|rcsb pdb:6KZD|reactome:R-HSA-388844|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|reactome:R-HSA-9603505|refseq:NP_001012338.1|refseq:NP_002521.2|refseq:XP_016877742.1|dip:DIP-5723N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/06/05	2018/06/14	rogid:hMHjc6pZ74mtPXhTetfA9SvFdf49606	rogid:PiKp8Av9Q20Xxv00akwE0dazVY09606	rigid:FAWHkME+YE76xhp1/bLfYqDGo6I	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6VNS1	uniprotkb:Q2MHE5	intact:EBI-16744951|ensembl:ENSMUSP00000037909|uniprotkb:A4QPD0|uniprotkb:Q9Z2P9|uniprotkb:Q9Z2Q0	intact:EBI-20585476|uniprotkb:B2RSP9|ensembl:ENSMUSP00000095103	psi-mi:ntrk3_mouse(display_long)|uniprotkb:Ntrk3(gene name)|psi-mi:Ntrk3(display_short)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:dok6_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)|uniprotkb:Dok6(gene name)|psi-mi:Dok6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585474|imex:IM-26442-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059146(gene)|ensembl:ENSMUST00000039431(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|reactome:R-MMU-388844|reactome:R-MMU-9034013|reactome:R-MMU-9034793|reactome:R-MMU-9603381|refseq:NP_032772.3|refseq:NP_877961.1	refseq:NP_001034262.1|ensembl:ENSMUSG00000073514(gene)|ensembl:ENSMUST00000097495(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-MMU-8853659	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2018/06/05	2018/06/06	rogid:awHq4B+I8bd3A6XndEgDYNbRS5Y10090	rogid:n4qeLCmIVpFfcGxdBwUcwE6pHW410090	rigid:m76EjTLDPcgVh535mDKf3F5inxY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VNS1	uniprotkb:Q2MHE5	intact:EBI-16744951|ensembl:ENSMUSP00000037909|uniprotkb:A4QPD0|uniprotkb:Q9Z2P9|uniprotkb:Q9Z2Q0	intact:EBI-20585476|uniprotkb:B2RSP9|ensembl:ENSMUSP00000095103	psi-mi:ntrk3_mouse(display_long)|uniprotkb:Ntrk3(gene name)|psi-mi:Ntrk3(display_short)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:dok6_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)|uniprotkb:Dok6(gene name)|psi-mi:Dok6(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585498|imex:IM-26442-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000059146(gene)|ensembl:ENSMUST00000039431(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|reactome:R-MMU-388844|reactome:R-MMU-9034013|reactome:R-MMU-9034793|reactome:R-MMU-9603381|refseq:NP_032772.3|refseq:NP_877961.1	refseq:NP_001034262.1|ensembl:ENSMUSG00000073514(gene)|ensembl:ENSMUST00000097495(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-MMU-8853659	go:"GO:0005886"(plasma membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 4B|comment:"Immunostaining showed that TrkC and Dok6 colocalise at the membrane, cytoplasm and neurites in primary cultured cortex neurons (Figure 4b)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex)	-	2018/06/05	2018/06/06	rogid:awHq4B+I8bd3A6XndEgDYNbRS5Y10090	rogid:n4qeLCmIVpFfcGxdBwUcwE6pHW410090	rigid:m76EjTLDPcgVh535mDKf3F5inxY	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q2MHE5	uniprotkb:P20783	intact:EBI-20585476|uniprotkb:B2RSP9|ensembl:ENSMUSP00000095103	intact:EBI-1025994|uniprotkb:Q6FH50|ensembl:ENSP00000328738|uniprotkb:B7Z1T5	psi-mi:dok6_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)|uniprotkb:Dok6(gene name)|psi-mi:Dok6(display_short)	psi-mi:ntf3_human(display_long)|uniprotkb:Neurotrophic factor(gene name synonym)|uniprotkb:HDNF(gene name synonym)|uniprotkb:Nerve growth factor 2(gene name synonym)|uniprotkb:NTF3(gene name)|psi-mi:NTF3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585508|imex:IM-26442-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034262.1|ensembl:ENSMUSG00000073514(gene)|ensembl:ENSMUST00000097495(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-MMU-8853659	refseq:NP_001096124.1|refseq:NP_002518.1|refseq:XP_011519265.1|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR002072(Nerve growth factor)|interpro:IPR015578(Neurotrophin-3)|interpro:IPR019846|interpro:IPR020408|interpro:IPR029034|rcsb pdb:1B8K|rcsb pdb:1BND|rcsb pdb:1NT3|rcsb pdb:3BUK|reactome:R-HSA-9025046|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|ensembl:ENSG00000185652(gene)|ensembl:ENST00000331010(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0021675"(nerve development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|dip:DIP-346N	-	-	-	figure legend:Fig. 6A|comment:"Consistent with previous results, Dok6 binds to the TrkC receptor in cortex neurons upon NT-3 stimulation, while without NT-3 stimulation no obvious interactions exist (Figure (Figure6a).6a)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2018/06/05	2018/06/14	rogid:n4qeLCmIVpFfcGxdBwUcwE6pHW410090	rogid:E2ZTORtat5r2YRbDmEB3Qt+ojMQ9606	rigid:tPTcTYeF1bOno1PJfy4a5UiruSg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2MHE5	uniprotkb:Q6VNS1	intact:EBI-20585476|uniprotkb:B2RSP9|ensembl:ENSMUSP00000095103	intact:EBI-16744951|ensembl:ENSMUSP00000037909|uniprotkb:A4QPD0|uniprotkb:Q9Z2P9|uniprotkb:Q9Z2Q0	psi-mi:dok6_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 6(gene name synonym)|uniprotkb:Dok6(gene name)|psi-mi:Dok6(display_short)	psi-mi:ntrk3_mouse(display_long)|uniprotkb:Ntrk3(gene name)|psi-mi:Ntrk3(display_short)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2009)	pubmed:20565848|imex:IM-26442	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20585508|imex:IM-26442-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034262.1|ensembl:ENSMUSG00000073514(gene)|ensembl:ENSMUST00000097495(transcript)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037816|reactome:R-MMU-8853659	ensembl:ENSMUSG00000059146(gene)|ensembl:ENSMUST00000039431(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|reactome:R-MMU-388844|reactome:R-MMU-9034013|reactome:R-MMU-9034793|reactome:R-MMU-9603381|refseq:NP_032772.3|refseq:NP_877961.1	-	-	-	figure legend:Fig. 6A|comment:"Consistent with previous results, Dok6 binds to the TrkC receptor in cortex neurons upon NT-3 stimulation, while without NT-3 stimulation no obvious interactions exist (Figure (Figure6a).6a)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2018/06/05	2018/06/14	rogid:n4qeLCmIVpFfcGxdBwUcwE6pHW410090	rogid:awHq4B+I8bd3A6XndEgDYNbRS5Y10090	rigid:tPTcTYeF1bOno1PJfy4a5UiruSg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)