#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BWV1	uniprotkb:Q62226	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	intact:EBI-15610166|ensembl:ENSMUSP00000002708	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:shh_mouse(display_long)|uniprotkb:HHG-1(gene name synonym)|uniprotkb:Shh(gene name)|psi-mi:Shh(display_short)|uniprotkb:Hhg1(gene name synonym)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561067|imex:IM-26431-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060438"(trachea development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060685"(regulation of prostatic bud formation)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0061189"(positive regulation of sclerotome development)|go:"GO:0061196"(fungiform papilla development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|ensembl:ENSMUST00000002708(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0001841"(neural tube formation)|go:"GO:0001942"(hair follicle development)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|ensembl:ENSMUSG00000002633(gene)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007502"(digestive tract mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0005576"(extracellular region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:1VHH|rcsb pdb:2WFX|rcsb pdb:2WG4|rcsb pdb:3D1M|rcsb pdb:3N1R|rcsb pdb:4C4M|rcsb pdb:4C4N|reactome:R-MMU-5358346|reactome:R-MMU-5362798|reactome:R-MMU-5632681|reactome:R-MMU-5635838|interpro:IPR000320(Hedgehog amino-terminal signaling region)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021924"(cell proliferation in external granule layer)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043586"(tongue development)|go:"GO:0043587"(tongue morphogenesis)|go:"GO:0043588"(skin development)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048678"(response to axon injury)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022006"(zona limitans intrathalamica formation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030323"(respiratory tube development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|refseq:NP_033196.1|dip:DIP-48537N	-	-	-	figure legend:Fig. 2A, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2018/05/15	2018/05/16	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rogid:IJHzAdnRoCfvYrFSCqkFzmZWOWE10090	rigid:6Kv76OGKgxqQhuQuQ8WNlkzCAVQ	false	sufficient binding region:710-817(IPR003961)	sufficient binding region:26-189(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BWV1	uniprotkb:Q14623	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	intact:EBI-3918622|ensembl:ENSP00000295731|uniprotkb:B9EGM5|uniprotkb:Q8N4B9|uniprotkb:O43322	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:ihh_human(display_long)|uniprotkb:IHH(gene name)|psi-mi:IHH(display_short)|uniprotkb:HHG-2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561085|imex:IM-26431-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	ensembl:ENST00000295731(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008233"(peptidase activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030704"(vitelline membrane formation)|ensembl:ENSG00000163501(gene)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048074"(negative regulation of eye pigmentation)|go:"GO:0048469"(cell maturation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060220"(camera-type eye photoreceptor cell fate commitment)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0072498"(embryonic skeletal joint development)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097421"(liver regeneration)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR033385|interpro:IPR036844|rcsb pdb:3K7G|rcsb pdb:3K7H|rcsb pdb:3K7I|rcsb pdb:3K7J|rcsb pdb:3N1F|rcsb pdb:3N1M|rcsb pdb:3N1O|rcsb pdb:3N1P|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-8941284|go:"GO:0048745"(smooth muscle tissue development)|refseq:NP_002172.2	-	-	-	figure legend:Fig. 2B, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.6x10^-6(molar)	2018/05/15	2018/05/16	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rogid:TabhDnEaZgjsUhv57AKpLUf7++c9606	rigid:xTCA6oqwvqVVQyP+RRoNzDy4HLc	false	sufficient binding region:710-817(IPR003961)	sufficient binding region:29-193(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BWV1	uniprotkb:O43323	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	intact:EBI-11667804|uniprotkb:Q15794|ensembl:ENSP00000497483	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:dhh_human(display_long)|uniprotkb:HHG-3(gene name synonym)|uniprotkb:DHH(gene name)|psi-mi:DHH(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561098|imex:IM-26431-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	refseq:NP_066382.1|ensembl:ENSG00000139549(gene)|ensembl:ENST00000649637(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007286"(spermatid development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030238"(male sex determination)|go:"GO:0032355"(response to estradiol)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043627"(response to estrogen)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:2WFQ|rcsb pdb:2WFR|rcsb pdb:2WG3|rcsb pdb:3N1G|rcsb pdb:3N1Q|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-9690406|dip:DIP-48538N	-	-	-	figure legend:Fig. 2C, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.2x10^-7(molar)	2018/05/15	2018/05/16	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rogid:np53v7gpwEphQ7mPKwzvTwjy0DU9606	rigid:PWL8veBO/+IylJrTU5yfqfZAVEE	false	sufficient binding region:710-817(IPR003961)	sufficient binding region:24-189(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4KMG0	uniprotkb:O43323	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-11667804|uniprotkb:Q15794|ensembl:ENSP00000497483	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:dhh_human(display_long)|uniprotkb:HHG-3(gene name synonym)|uniprotkb:DHH(gene name)|psi-mi:DHH(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561110|imex:IM-26431-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	refseq:NP_066382.1|ensembl:ENSG00000139549(gene)|ensembl:ENST00000649637(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007286"(spermatid development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030238"(male sex determination)|go:"GO:0032355"(response to estradiol)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043627"(response to estrogen)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:2WFQ|rcsb pdb:2WFR|rcsb pdb:2WG3|rcsb pdb:3N1G|rcsb pdb:3N1Q|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-9690406|dip:DIP-48538N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Fig. 2D, Supp Table 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.4x10^-7(molar)	2018/05/15	2018/05/16	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:np53v7gpwEphQ7mPKwzvTwjy0DU9606	rigid:rBjQmtUUr+b61FXelmSZFkKb30g	false	sufficient binding region:826-924(IPR003961)	sufficient binding region:24-189(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4KMG0	uniprotkb:O43323	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-11667804|uniprotkb:Q15794|ensembl:ENSP00000497483	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:dhh_human(display_long)|uniprotkb:HHG-3(gene name synonym)|uniprotkb:DHH(gene name)|psi-mi:DHH(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561166|imex:IM-26431-15|wwpdb:3n1q	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	refseq:NP_066382.1|ensembl:ENSG00000139549(gene)|ensembl:ENST00000649637(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007286"(spermatid development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030238"(male sex determination)|go:"GO:0032355"(response to estradiol)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043627"(response to estrogen)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:2WFQ|rcsb pdb:2WFR|rcsb pdb:2WG3|rcsb pdb:3N1G|rcsb pdb:3N1Q|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-9690406|dip:DIP-48538N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Table 1|3d-resolution:Rworking 0.237 Rfree 0.288|3d-resolution:2.89A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/15	2018/05/16	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:np53v7gpwEphQ7mPKwzvTwjy0DU9606	rigid:rBjQmtUUr+b61FXelmSZFkKb30g	false	sufficient binding region:826-924(IPR003961)	sufficient binding region:24-189(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BWV1	uniprotkb:O43323	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	intact:EBI-11667804|uniprotkb:Q15794|ensembl:ENSP00000497483	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:dhh_human(display_long)|uniprotkb:HHG-3(gene name synonym)|uniprotkb:DHH(gene name)|psi-mi:DHH(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561133|imex:IM-26431-9|wwpdb:3n1g	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	refseq:NP_066382.1|ensembl:ENSG00000139549(gene)|ensembl:ENST00000649637(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007286"(spermatid development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030238"(male sex determination)|go:"GO:0032355"(response to estradiol)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042552"(myelination)|go:"GO:0043627"(response to estrogen)|go:"GO:0050810"(regulation of steroid biosynthetic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:2WFQ|rcsb pdb:2WFR|rcsb pdb:2WG3|rcsb pdb:3N1G|rcsb pdb:3N1Q|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-9690406|dip:DIP-48538N	-	-	-	figure legend:Table 1|3d-r-factors:Rworking 0.182 Rfree 0.222|3d-resolution:1.9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/15	2018/05/16	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rogid:np53v7gpwEphQ7mPKwzvTwjy0DU9606	rigid:PWL8veBO/+IylJrTU5yfqfZAVEE	false	sufficient binding region:710-817(IPR003961)	sufficient binding region:24-189(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4KMG0	uniprotkb:Q14623	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-3918622|ensembl:ENSP00000295731|uniprotkb:B9EGM5|uniprotkb:Q8N4B9|uniprotkb:O43322	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:ihh_human(display_long)|uniprotkb:IHH(gene name)|psi-mi:IHH(display_short)|uniprotkb:HHG-2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561155|imex:IM-26431-13|wwpdb:3n1f	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	ensembl:ENST00000295731(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008233"(peptidase activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030704"(vitelline membrane formation)|ensembl:ENSG00000163501(gene)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048074"(negative regulation of eye pigmentation)|go:"GO:0048469"(cell maturation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060220"(camera-type eye photoreceptor cell fate commitment)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0072498"(embryonic skeletal joint development)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097421"(liver regeneration)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR033385|interpro:IPR036844|rcsb pdb:3K7G|rcsb pdb:3K7H|rcsb pdb:3K7I|rcsb pdb:3K7J|rcsb pdb:3N1F|rcsb pdb:3N1M|rcsb pdb:3N1O|rcsb pdb:3N1P|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-8941284|go:"GO:0048745"(smooth muscle tissue development)|refseq:NP_002172.2	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Table 1|3d-r-factors:Rworking 0.153 Rfree 0.189|3d-resolution:1.6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/15	2018/05/16	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:TabhDnEaZgjsUhv57AKpLUf7++c9606	rigid:bs8Ndk3ydnA7QHxes/98RVe2MuQ	false	sufficient binding region:826-924(IPR003961)	sufficient binding region:29-193(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BWV1	uniprotkb:Q14623	intact:EBI-718555|uniprotkb:A6NJ30|uniprotkb:Q6UXJ5|uniprotkb:Q8N2P7|uniprotkb:Q8NF26|uniprotkb:B2RMS8|uniprotkb:D3DN70|ensembl:ENSP00000347546|ensembl:ENSP00000418663	intact:EBI-3918622|ensembl:ENSP00000295731|uniprotkb:B9EGM5|uniprotkb:Q8N4B9|uniprotkb:O43322	psi-mi:boc_human(display_long)|uniprotkb:BOC(gene name)|psi-mi:BOC(display_short)|uniprotkb:UNQ604/PRO1190(orf name)	psi-mi:ihh_human(display_long)|uniprotkb:IHH(gene name)|psi-mi:IHH(display_short)|uniprotkb:HHG-2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561144|imex:IM-26431-11|wwpdb:3n1m|wwpdb:3n1p	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150279.1|refseq:XP_016862940.1|refseq:XP_011511607.1|refseq:NP_001288790.1|refseq:XP_005247948.1|refseq:XP_005247949.1|ensembl:ENSG00000144857(gene)|ensembl:ENST00000355385(transcript)|ensembl:ENST00000495514(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0045663"(positive regulation of myoblast differentiation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032982|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3N1G|rcsb pdb:3N1M|rcsb pdb:3N1P|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838|interpro:IPR003598(Immunoglobulin subtype 2)	ensembl:ENST00000295731(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008233"(peptidase activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030704"(vitelline membrane formation)|ensembl:ENSG00000163501(gene)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048074"(negative regulation of eye pigmentation)|go:"GO:0048469"(cell maturation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060220"(camera-type eye photoreceptor cell fate commitment)|go:"GO:0060323"(head morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0072498"(embryonic skeletal joint development)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097421"(liver regeneration)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR033385|interpro:IPR036844|rcsb pdb:3K7G|rcsb pdb:3K7H|rcsb pdb:3K7I|rcsb pdb:3K7J|rcsb pdb:3N1F|rcsb pdb:3N1M|rcsb pdb:3N1O|rcsb pdb:3N1P|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|reactome:R-HSA-8941284|go:"GO:0048745"(smooth muscle tissue development)|refseq:NP_002172.2	-	-	-	figure legend:Table 1|3d-r-factors:3N1M - working 0.164 free 0.201  3N1P - working 0.235 free 0.279|3d-resolution:3n1M - 1.69A  3N1P - 2.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/15	2018/05/16	rogid:SQPC0pqcAHVfuJCxq84BSi9k0IA9606	rogid:TabhDnEaZgjsUhv57AKpLUf7++c9606	rigid:xTCA6oqwvqVVQyP+RRoNzDy4HLc	false	sufficient binding region:710-817(IPR003961)	sufficient binding region:29-193(IPR000320)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4KMG0	uniprotkb:Q62226	intact:EBI-7016840|uniprotkb:O14631|intact:MINT-2795255|ensembl:ENSP00000376458|ensembl:ENSP00000507318	intact:EBI-15610166|ensembl:ENSMUSP00000002708	psi-mi:cdon_human(display_long)|uniprotkb:CDON(gene name)|psi-mi:CDON(display_short)|uniprotkb:CDO(gene name synonym)	psi-mi:shh_mouse(display_long)|uniprotkb:HHG-1(gene name synonym)|uniprotkb:Shh(gene name)|psi-mi:Shh(display_short)|uniprotkb:Hhg1(gene name synonym)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Kavran et al. (2010)	pubmed:20519495|imex:IM-26431	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20561394|imex:IM-26431-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541164.1|refseq:XP_011541165.1|refseq:XP_011541166.1|refseq:XP_011541167.1|refseq:XP_011541168.1|dip:DIP-57226N|refseq:XP_016873362.1|refseq:NP_001230526.1|refseq:NP_058648.4|ensembl:ENSG00000064309(gene)|ensembl:ENST00000392693(transcript)|ensembl:ENST00000684078(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048598"(embryonic morphogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032983|interpro:IPR036116|interpro:IPR036179|mint:Q4KMG0|rcsb pdb:3D1M|rcsb pdb:3N1F|rcsb pdb:3N1Q|reactome:R-HSA-525793|reactome:R-HSA-5632681|reactome:R-HSA-5635838	go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060174"(limb bud formation)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060438"(trachea development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060685"(regulation of prostatic bud formation)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0061189"(positive regulation of sclerotome development)|go:"GO:0061196"(fungiform papilla development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|ensembl:ENSMUST00000002708(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0001841"(neural tube formation)|go:"GO:0001942"(hair follicle development)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|ensembl:ENSMUSG00000002633(gene)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007502"(digestive tract mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0005576"(extracellular region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|rcsb pdb:1VHH|rcsb pdb:2WFX|rcsb pdb:2WG4|rcsb pdb:3D1M|rcsb pdb:3N1R|rcsb pdb:4C4M|rcsb pdb:4C4N|reactome:R-MMU-5358346|reactome:R-MMU-5362798|reactome:R-MMU-5632681|reactome:R-MMU-5635838|interpro:IPR000320(Hedgehog amino-terminal signaling region)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021924"(cell proliferation in external granule layer)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043586"(tongue development)|go:"GO:0043587"(tongue morphogenesis)|go:"GO:0043588"(skin development)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048678"(response to axon injury)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0022006"(zona limitans intrathalamica formation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030323"(respiratory tube development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|refseq:NP_033196.1|dip:DIP-48537N	-	comment:mint|function:Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells	-	figure legend:Fig. 3|comment:Interactions between SHH and CDOF are substantially reduced at pH 6.0 relative to pH 7.0 or 8.0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2018/05/15	2018/05/16	rogid:Yl+ZZK/y3xvR3KdtU0Tp0LfYDaU9606	rogid:IJHzAdnRoCfvYrFSCqkFzmZWOWE10090	rigid:HlnS/18gS+3Wug71tmV165vpblU	false	sufficient binding region:826-924(IPR003961)	sufficient binding region:26-189(IPR000320)	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)