#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13497	uniprotkb:Q15113	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20622918|imex:IM-26475-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:129.0x10^-9 ~19.0(molar)	2018/07/13	2018/07/16	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rigid:KKXh2tjhz6tp9Bf/FFr53HjEy18	false	-	sufficient binding region:273-433..437(IPR001134)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:P13497	intact:EBI-1379423	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20622927|imex:IM-26475-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.3x10^-6 ~0.7(molar)	2018/07/13	2018/07/16	-	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28304"	uniprotkb:Q15113	intact:EBI-1379423	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20622953|imex:IM-26475-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:70.0x10^-9 ~60.0(molar)	2018/07/13	2018/07/16	-	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-20622966	uniprotkb:P13497	-	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:peptide_yvadap(display_short)|psi-mi:EBI-20622966(display_long)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20622971|imex:IM-26475-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A2P9AAH7(see-also)	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	-	-	-	figure legend:Fig. S2|comment:We conclude that the NTR domain of PCPE-1 is not an inhibitor of BMP-1 or ADAMTS-2, -4, or -5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/13	2018/07/16	rogid:KY+FAwS6R3RMz0g94Oad8x0kVNM-1	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	rigid:+m7vheqencSP66g2giGJQFh/d3Y	false	fluorophore:c-c|fluorophore:n-n	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-20623017	uniprotkb:P08253	-	intact:EBI-1033518|uniprotkb:B2R6U1|uniprotkb:Q9UCJ8|ensembl:ENSP00000219070|uniprotkb:E9PE45|uniprotkb:B4DWH3	psi-mi:peptide_plgl(display_short)|psi-mi:EBI-20623017(display_long)	psi-mi:mmp2_human(display_long)|uniprotkb:MMP2(gene name)|psi-mi:MMP2(display_short)|uniprotkb:CLG4A(gene name synonym)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:TBE-1(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20623019|imex:IM-26475-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001289437.1|refseq:NP_001289438.1|refseq:NP_001289439.1|ensembl:ENSG00000087245(gene)|ensembl:ENST00000219070(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030017"(sarcomere)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|rcsb pdb:1CK7|rcsb pdb:1CXW|rcsb pdb:1EAK|rcsb pdb:1GEN|rcsb pdb:1GXD|rcsb pdb:1HOV|rcsb pdb:1J7M|rcsb pdb:1KS0|rcsb pdb:1QIB|rcsb pdb:1RTG|rcsb pdb:3AYU|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_001121363.1|refseq:NP_004521.1	-	-	-	figure legend:Fig. 3|comment:"We also tested the effects of both forms of NTR on MMP-2 cleavage of denatured collagen I but found no evidence of inhibition at a NTR concentration of 2 μm (supplemental Fig. S1).  We conclude that the NTR domain of PCPE-1 is not an inhibitor of MMP-2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/13	2018/07/16	rogid:7vJO1NwYfQEDgBmurmHzdD33suU-1	rogid:s0IHoSkzT9GNfkkLZsVsV7cIf1g9606	rigid:mwejxXoN7g+nyzUogi0qN69fbYY	false	fluorophore:c-c|fluorophore:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-20623042	uniprotkb:O75173	-	intact:EBI-3934482|uniprotkb:Q9UN83|uniprotkb:Q5VTW2|uniprotkb:Q6P4Q8|uniprotkb:Q6UWA8|uniprotkb:Q2HYD0|ensembl:ENSP00000356975	psi-mi:peptide_aelqgrpisiak(display_short)|psi-mi:EBI-20623042(display_long)	psi-mi:ats4_human(display_long)|uniprotkb:ADAMTS4(gene name)|psi-mi:ADAMTS4(display_short)|uniprotkb:KIAA0688(gene name synonym)|uniprotkb:ADMP-1(gene name synonym)|uniprotkb:Aggrecanase-1(gene name synonym)|uniprotkb:UNQ769/PRO1563(orf name)	psi-mi:"MI:0990"(cleavage assay)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20623031|imex:IM-26475-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001307265.1|ensembl:ENSG00000158859(gene)|ensembl:ENST00000367996(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002020"(protease binding)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2RJP|rcsb pdb:3B2Z|rcsb pdb:4WK7|rcsb pdb:4WKE|rcsb pdb:4WKI|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_005090.3	-	-	-	figure legend:Fig. S2|comment:We conclude that the NTR domain of PCPE-1 is not an inhibitor of BMP-1 or ADAMTS-2, -4, or -5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/13	2018/07/16	rogid:IGcsvBk01ErCDf1GKKVoFIcB1gU-1	rogid:1UE6ONvh3zdY9ZPdzKN3U3mYf3Q9606	rigid:LkhQYATm+SEelodgnu3srgNwcx4	false	fluorophore:c-c|fluorophore:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-20623042	uniprotkb:Q9UNA0	-	intact:EBI-2808663|ensembl:ENSP00000284987|uniprotkb:Q9UKP2|uniprotkb:Q52LV4	psi-mi:peptide_aelqgrpisiak(display_short)|psi-mi:EBI-20623042(display_long)	psi-mi:ats5_human(display_long)|uniprotkb:ADAMTS5(gene name)|psi-mi:ADAMTS5(display_short)|uniprotkb:ADAMTS11(gene name synonym)|uniprotkb:ADMP2(gene name synonym)|uniprotkb:A disintegrin and metalloproteinase with thrombospondin motifs 11(gene name synonym)|uniprotkb:ADMP-2(gene name synonym)|uniprotkb:Aggrecanase-2(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20623044|imex:IM-26475-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000154736(gene)|ensembl:ENST00000284987(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0044691"(tooth eruption)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR013276(Peptidase M12B, ADAM-TS5)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2RJQ|rcsb pdb:3B8Z|rcsb pdb:3HY7|rcsb pdb:3HY9|rcsb pdb:3HYG|rcsb pdb:3LJT|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|rcsb pdb:6YJM|refseq:NP_008969.2	-	-	-	figure legend:Fig. S2|comment:We conclude that the NTR domain of PCPE-1 is not an inhibitor of BMP-1 or ADAMTS-2, -4, or -5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/13	2018/07/16	rogid:IGcsvBk01ErCDf1GKKVoFIcB1gU-1	rogid:J+ZTdYjh2OrzLQM4ZUXxbyKaPHo9606	rigid:QItU2m62sl9hblVuvKhzG9mVhug	false	fluorophore:c-c|fluorophore:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15113	uniprotkb:P08253	intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061	intact:EBI-1033518|uniprotkb:B2R6U1|uniprotkb:Q9UCJ8|ensembl:ENSP00000219070|uniprotkb:E9PE45|uniprotkb:B4DWH3	psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym)	psi-mi:mmp2_human(display_long)|uniprotkb:MMP2(gene name)|psi-mi:MMP2(display_short)|uniprotkb:CLG4A(gene name synonym)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:TBE-1(gene name synonym)	psi-mi:"MI:0990"(cleavage assay)	Bekhouche et al. (2010)	pubmed:20207734|imex:IM-26475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20623054|imex:IM-26475-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919	refseq:NP_001289437.1|refseq:NP_001289438.1|refseq:NP_001289439.1|ensembl:ENSG00000087245(gene)|ensembl:ENST00000219070(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030017"(sarcomere)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|rcsb pdb:1CK7|rcsb pdb:1CXW|rcsb pdb:1EAK|rcsb pdb:1GEN|rcsb pdb:1GXD|rcsb pdb:1HOV|rcsb pdb:1J7M|rcsb pdb:1KS0|rcsb pdb:1QIB|rcsb pdb:1RTG|rcsb pdb:3AYU|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_001121363.1|refseq:NP_004521.1	-	-	-	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/13	2018/07/16	rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606	rogid:s0IHoSkzT9GNfkkLZsVsV7cIf1g9606	rigid:krWb8R5EMZFQolFgTzbdcJUN7ss	false	his tag:?-?|uncategorized protein modification:286-287	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)