#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96IZ0	uniprotkb:Q01094	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620472|imex:IM-26779-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	go:"GO:0005634"(nucleus)	-	-	figure legend:f6|comment:As shown in Figure 3, Par-4 co-immunoprecipitated with E2F1 protein in nuclear extracts from the glutamate-treated hBMSCs, indicating the direct interaction between Par-4 and E2F1. By contrast, in nuclear extracts from the hBMSCs without the treatment of glutamate, Par-4 failed to associate with E2F1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bmsc)|taxid:9606(human)	-	2018/07/10	2018/07/10	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	rigid:ZdTWq0NqslUkzP7OrnoMnz+s9cw	false	myc tag:?-?|necessary binding region:271-340	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01094	ensembl:ENSG00000184047	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	intact:EBI-20620404	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)|ensembl:dbloh_human_gene(shortlabel)|psi-mi:ENSG00000184047(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620398|imex:IM-26779-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_063940.1|refseq:NP_620308.1|ensembl:ENSG00000284934	go:"GO:0005634"(nucleus)	-	-	figure legend:f5|comment:"Chromatin immunoprecipitated with anti-Par-4 antibody or anti-E2F1 antibody was subjected to PCR using primers representing BS2 (−542 to −535 bp relative to ATG) site, another previously reported E2F1-binding site. No DNA could be amplified from the chromatins, (data not shown), demonstrating that Par-4 and E2F1 specifically bind to the BS3 (−200 to −193 bp relative to ATG) site on the Smac promoter."|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bmsc)|taxid:9606(human)	-	2018/07/10	2018/07/10	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q96IZ0	ensembl:ENSG00000184047	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-20620404	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)|ensembl:dbloh_human_gene(shortlabel)|psi-mi:ENSG00000184047(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620501|imex:IM-26779-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_063940.1|refseq:NP_620308.1|ensembl:ENSG00000284934	go:"GO:0005634"(nucleus)	-	-	figure legend:f5|comment:"Chromatin immunoprecipitated with anti-Par-4 antibody or anti-E2F1 antibody was subjected to PCR using primers representing BS2 (−542 to −535 bp relative to ATG) site, another previously reported E2F1-binding site. No DNA could be amplified from the chromatins, (data not shown), demonstrating that Par-4 and E2F1 specifically bind to the BS3 (−200 to −193 bp relative to ATG) site on the Smac promoter."|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bmsc)|taxid:9606(human)	-	2018/07/10	2018/07/10	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
intact:EBI-20620429	uniprotkb:Q01094	-	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:diablo_human_e2f1-site_dna-probe(display_short)|psi-mi:EBI-20620429(display_long)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620427|imex:IM-26779-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184047(see-also)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	-	-	-	figure legend:f4b|comment:"Indeed, we found that Par-4 and E2F1 existed in nuclear extracts from glutamate-treated cells (Figure 4A, lane 1; Figure 4B, lane 1)."|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/10	2018/07/10	-	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-20620429	uniprotkb:Q96IZ0	-	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	psi-mi:diablo_human_e2f1-site_dna-probe(display_short)|psi-mi:EBI-20620429(display_long)	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620440|imex:IM-26779-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184047(see-also)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	-	-	-	figure legend:f4a|comment:"Indeed, we found that Par-4 and E2F1 existed in nuclear extracts from glutamate-treated cells (Figure 4A, lane 1; Figure 4B, lane 1)."|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/10	2018/07/10	-	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01094	intact:EBI-20620429	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	-	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:diablo_human_e2f1-site_dna-probe(display_short)|psi-mi:EBI-20620429(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620451|imex:IM-26779-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	ensembl:ENSG00000184047(see-also)	go:"GO:0005634"(nucleus)	-	-	figure legend:f4c|comment:"The neutralizing antibody against E2F1 caused disappearance of both the faster and the slower migrating complex, thus indicating the presence of E2F1 in both the complexes (Figure 4C, lane 5). These results supported that it was E2F1, not Par-4, in Par-4-E2F1 proteins complex that directly bound to Smac promoter, and that Par-4 might indirectly exert its transcriptional control on Smac gene though interacting with E2F1. The BS3 E2F1-binding site was also used as a probe to perform EMSA with nuclear extracts from the hBMSCs without treatment of glutamate. However, no DNA–protein complex was found (Figure 4C, lane 7)."|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/10	2018/07/10	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	-	-	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96IZ0	uniprotkb:Q01094	intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088	intact:EBI-448924|uniprotkb:Q13143|uniprotkb:Q92768|ensembl:ENSP00000345571	psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym)	psi-mi:e2f1_human(display_long)|uniprotkb:Retinoblastoma-associated protein 1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 3(gene name synonym)|uniprotkb:PBR3(gene name synonym)|uniprotkb:E2F1(gene name)|psi-mi:E2F1(display_short)|uniprotkb:RBBP3(gene name synonym)|uniprotkb:pRB-binding protein E2F-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lu et al. (2008)	pubmed:18660514|imex:IM-26779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20620458|imex:IM-26779-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9	refseq:NP_005216.1|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048255"(mRNA stabilization)|ensembl:ENSG00000101412(gene)|ensembl:ENST00000343380(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-6804116|reactome:R-HSA-68689|reactome:R-HSA-68911|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:Q01094|rcsb pdb:1H24|rcsb pdb:1O9K|rcsb pdb:2AZE|rcsb pdb:5M9N|rcsb pdb:5M9O|rcsb pdb:6G0P|rcsb pdb:6ULS|reactome:R-HSA-111448|reactome:R-HSA-113501|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-69656|reactome:R-HSA-8953750|reactome:R-HSA-9616222|reactome:R-HSA-9661069|dip:DIP-24227N	-	-	-	figure legend:f3|comment:As shown in Figure 3, Par-4 co-immunoprecipitated with E2F1 protein in nuclear extracts from the glutamate-treated hBMSCs, indicating the direct interaction between Par-4 and E2F1. By contrast, in nuclear extracts from the hBMSCs without the treatment of glutamate, Par-4 failed to associate with E2F1.|agonist:Glutamate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bmsc)|taxid:9606(human)	-	2018/07/10	2018/07/10	rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606	rogid:vPNenpmxyXpHjMzUID54cwMFk+Y9606	rigid:ZdTWq0NqslUkzP7OrnoMnz+s9cw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)