#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-18719996|wwpdb:3d24|imex:IM-26388-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Table 1|3d-resolution:2.11 A|3d-r-factors:RWork = 0.212 RFree = 0.255|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/23 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false sufficient binding region:198-219 his tag:n-n|sufficient binding region:189-423(IPR000536) 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-18720021|imex:IM-26388-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 2, 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/23 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false sufficient binding region:135-221|mutation decreasing interaction strength:144-144|mutation decreasing interaction strength:210-210|mutation disrupting interaction strength:144-144,210-210|binding-associated region:189-221|binding-associated region:135-180 sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-18720045|imex:IM-26388-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 2-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/23 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false mutation disrupting interaction strength:144-144|sufficient binding region:135-180 sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-18720069|imex:IM-26388-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 2-3, figure 3A|comment:"These results revealed that amino acids at positions -6 to -3 (Arg-204/Arg-205 and Cys-207) determine high affinity binding of the PGC-1a box3 region to the ERRa LBD."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/23 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false mutation decreasing interaction strength:211-211|mutation disrupting interaction strength:213-213|mutation disrupting interaction strength:207-207|mutation disrupting interaction strength:207-207|mutation disrupting interaction strength:210-210|sufficient binding region:189-221 sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P11474 uniprotkb:Q9UBK2 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-18720104|imex:IM-26388-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 - - - figure legend:figure 3A-2|comment:"These results revealed that amino acids at positions -6 to -3 (Arg-204/Arg-205 and Cys-207) determine high affinity binding of the PGC-1a box3 region to the ERRa LBD."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/23 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false sufficient binding region:189-423(IPR000536) mutation with no effect:202-203|mutation disrupting interaction strength:204-205|necessary binding region:202-205|binding-associated region:202-214 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20085575|imex:IM-26388-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/24 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false sufficient binding region:135-221|binding-associated region:189-221 mutation disrupting interaction strength:258-258,262-262|mutation decreasing interaction strength:341-341|mutation decreasing interaction strength:423-423|mutation decreasing interaction strength:421-423|sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20182589|imex:IM-26388-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 4Ai|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false binding-associated region:135-180 mutation disrupting interaction strength:258-258,262-262|mutation decreasing interaction strength:341-341|mutation with no effect:423-423|mutation decreasing interaction strength:421-423|sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20183222|imex:IM-26388-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 4C1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false binding-associated region:135-180|sufficient binding region:135-221|binding-associated region:189-221 mutation disrupting interaction strength:338-341|mutation disrupting interaction strength:338-338|mutation disrupting interaction strength:315-315|sufficient binding region:189-423(IPR000536)|mutation decreasing interaction strength:259-259 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20183447|imex:IM-26388-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false mutation decreasing interaction strength:212-212|binding-associated region:189-221|mutation:211-211 sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20183715|imex:IM-26388-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 4C-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false sufficient binding region:135-221 mutation decreasing interaction strength:343-343|sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P11474 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20183756|imex:IM-26388-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 4C-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY false binding-associated region:135-180|binding-associated region:189-221 mutation with no effect:343-343|sufficient binding region:189-423(IPR000536) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBK2 uniprotkb:P03372 intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20184210|imex:IM-26388-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB - - - figure legend:Figure 5D|comment:"The wild-type ERa LBD interacted in an estradiol (E2)-dependent manner, detectable only with the PGC-1a ID and box2 but not with box3."|agonist:"E2- estradiol CHEBI:23965"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2018/03/21 2018/04/25 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606 rigid:18aRFaR1BUjnF3i0AtEsH8emVt0 false sufficient binding region:135-221|binding-associated region:135-180 sufficient binding region:307-548(IPR000536)|mutation increasing interaction strength:376-376,380-380 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-20184588 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20184538|imex:IM-26388-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6 A/B, supp fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation decreasing interaction strength:315-315|mutation decreasing interaction strength:338-338|mutation with no effect:343-343|mutation decreasing interaction strength:338-341 - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 intact:EBI-20184588 - - psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20184629|imex:IM-26388-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) - - - - - figure legend:Figure 6A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - - - false 32p radiolabel:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20184629|imex:IM-26388-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? - - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20184664|imex:IM-26388-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6 A/B, supp fig 2B|comment:"Only a weak band is seen here for the DR0-E343A ERRa mutant (monomer)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation causing an interaction:315-315|mutation causing an interaction:338-338|mutation causing an interaction:343-343|mutation causing an interaction:338-341 - 1 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20185384 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20185317|imex:IM-26388-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6 A/C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation with no effect:315-315|mutation with no effect:338-338|mutation with no effect:343-343|mutation disrupting interaction strength:338-341 - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20185384 intact:EBI-20185384 - - psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20185627|imex:IM-26388-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) - - - - - figure legend:Figure 6A-ii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - - - false 32p radiolabel:?-? - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20185384 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20185627|imex:IM-26388-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6A-ii|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? - - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:Q9UBK2 - intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20186814|imex:IM-26388-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 - - - figure legend:Figure 6B-1, supp fig 2B|comment:"The addition of small amounts of E. coli-expressed, partially purified GST-PGC-1a ID fusion protein resulted in an upshift of DNA-bound ERRa (Fig. 6, B and C). This upshift was not observed when GST-PGC-1a ID(L144A/L210A) was added. Compared with the wild-type receptor, all DNA-bound mutants were less efficiently shifted by GST-PGC-1a ID."|comment:Mutations in the H8–H9 loop such as R315A or D338A influence not only homodimerization but also Coactivator binding of DNA-bound, full-length ERRa.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 - false 32p radiolabel:?-? sufficient binding region:135-221|mutation disrupting interaction strength:144-144,210-210|glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20186814|imex:IM-26388-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6B-1, supp fig 2B|comment:"The addition of small amounts of E. coli-expressed, partially purified GST-PGC-1a ID fusion protein resulted in an upshift of DNA-bound ERRa (Fig. 6, B and C). This upshift was not observed when GST-PGC-1a ID(L144A/L210A) was added. Compared with the wild-type receptor, all DNA-bound mutants were less efficiently shifted by GST-PGC-1a ID."|comment:Mutations in the H8–H9 loop such as R315A or D338A influence not only homodimerization but also Coactivator binding of DNA-bound, full-length ERRa.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation decreasing interaction strength:315-315|mutation decreasing interaction strength:338-338|mutation decreasing interaction strength:343-343|mutation disrupting interaction strength:338-341 - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:Q9UBK2 - intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20187102|imex:IM-26388-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 - - - figure legend:Figure 6B, supp fig 2B|comment:"Only a very weak band is seen here for the DR0-E343A ERRa mutant (monomer)."|comment:"DNA-bound ERRa(SwapH8–H9) did not interact with GST-PGC-1a ID."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 - false 32p radiolabel:?-? sufficient binding region:135-221 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20184588 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:dr0_probe(display_short)|psi-mi:EBI-20184588(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20187102|imex:IM-26388-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6B, supp fig 2B|comment:"Only a very weak band is seen here for the DR0-E343A ERRa mutant (monomer)."|comment:"DNA-bound ERRa(SwapH8–H9) did not interact with GST-PGC-1a ID."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation causing an interaction:315-315|mutation causing an interaction:338-338|mutation causing an interaction:343-343 - 1 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20185384 uniprotkb:Q9UBK2 - intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867 psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20187559|imex:IM-26388-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616 - - - figure legend:Figure 6C|comment:"The addition of small amounts of E. coli-expressed, partially purified GST-PGC-1a ID fusion protein resulted in an upshift of DNA-bound ERRa (Fig. 6, B and C). This upshift was not observed when GST-PGC-1a ID(L144A/L210A) was added. Compared with the wild-type receptor, all DNA-bound mutants were less efficiently shifted by GST-PGC-1a ID."|comment:Mutations in the H8–H9 loop such as R315A or D338A influence not only homodimerization but also Coactivator binding of DNA-bound, full-length ERRa.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 - false 32p radiolabel:?-? sufficient binding region:135-221|mutation disrupting interaction strength:144-144,210-210|glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) intact:EBI-20185384 uniprotkb:P11474 - intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851 psi-mi:ere_probe(display_short)|psi-mi:EBI-20185384(display_long) psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Greschik et al. (2008) pubmed:18441008|imex:IM-26388 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20187559|imex:IM-26388-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902 - - - figure legend:Figure 6C|comment:"The addition of small amounts of E. coli-expressed, partially purified GST-PGC-1a ID fusion protein resulted in an upshift of DNA-bound ERRa (Fig. 6, B and C). This upshift was not observed when GST-PGC-1a ID(L144A/L210A) was added. Compared with the wild-type receptor, all DNA-bound mutants were less efficiently shifted by GST-PGC-1a ID."|comment:Mutations in the H8–H9 loop such as R315A or D338A influence not only homodimerization but also Coactivator binding of DNA-bound, full-length ERRa.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/03/21 2018/04/25 - rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606 - false 32p radiolabel:?-? mutation decreasing interaction strength:315-315|mutation decreasing interaction strength:338-338|mutation decreasing interaction strength:343-343|mutation disrupting interaction strength:338-341 - 2 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)