#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P84022	uniprotkb:P23512	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	intact:EBI-20594253	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:foxa1_rat(display_long)|uniprotkb:Foxa1(gene name)|psi-mi:Foxa1(display_short)|uniprotkb:Hnf3a(gene name synonym)|uniprotkb:Tcf-3a(gene name synonym)|uniprotkb:Tcf3a(gene name synonym)|uniprotkb:Forkhead box protein A1(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20594237|imex:IM-26468-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061448"(connective tissue development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060425"(lung morphogenesis)|refseq:NP_036874.1|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018533|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rgd:2807|reactome:R-RNO-9018519	-	-	-	figure legend:Fig.6 Top|comment:"In contrast to the interactions with NKX2.1, significant interaction with FOXA1 occurred mainly with the SMAD3 MH2 domain (Figure 6)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2018/06/25	2018/06/25	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rogid:PEplomiLRvh0EmG1u14LITLHH+010116	rigid:bj8V2wGzOQh1Vcijl3V/icRWlWQ	false	gal4 dna binding domain:?-?|sufficient binding region:230-424(IPR017855)	vp16 activation domain:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43699	uniprotkb:P84022	intact:EBI-1391923|uniprotkb:O14954|uniprotkb:O14955|uniprotkb:Q9BRJ8|uniprotkb:Q7KZF6|uniprotkb:D3DSA3|ensembl:ENSP00000428341|ensembl:ENSP00000429607	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	psi-mi:nkx21_human(display_long)|uniprotkb:NKX2-1(gene name)|psi-mi:NKX2-1(display_short)|uniprotkb:TITF1(gene name synonym)|uniprotkb:NKX2A(gene name synonym)|uniprotkb:TTF1(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog A(gene name synonym)|uniprotkb:Thyroid transcription factor 1(gene name synonym)|uniprotkb:Thyroid nuclear factor 1(gene name synonym)|uniprotkb:Thyroid-specific enhancer-binding protein(gene name synonym)	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20594307|imex:IM-26468-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001073136.1|refseq:NP_003308.1|ensembl:ENSG00000136352(gene)|ensembl:ENST00000498187(transcript)|ensembl:ENST00000518149(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001161"(intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019899"(enzyme binding)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021877"(forebrain neuron fate commitment)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031128"(developmental induction)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	-	-	-	figure legend:Fig.5A|comment:"These constructs were then used in a mammalian A549 cell two-hybrid assay with either GAL4-fused-NKX2.1 (Figure 5, Panel A) or GAL4-fused-FOXA1 expression constructs (Figure 6 Panel A). The results showed significant interactions between full-length NKX2.1 and the MH1 domain of SMAD3 (Figure 5)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2018/06/25	2018/06/26	rogid:bl+uMAW9z5GF1R21A7VpncC1UR89606	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rigid:R0AQ41H9XL9UW0ylveJHhkQbnwU	false	vp16 activation domain:?-?	gal4 dna binding domain:?-?|sufficient binding region:1-130(IPR017855)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-9915276	uniprotkb:P50220	-	intact:EBI-9986706|ensembl:ENSMUSP00000001536|ensembl:ENSMUSP00000136103	psi-mi:spb_human_nkx2.1-site_dna-probe(display_short)|psi-mi:EBI-9915276(display_long)	psi-mi:nkx21_mouse(display_long)|uniprotkb:Nkx2-1(gene name)|psi-mi:Nkx2-1(display_short)|uniprotkb:Nkx-2.1(gene name synonym)|uniprotkb:Titf1(gene name synonym)|uniprotkb:Ttf1(gene name synonym)|uniprotkb:Thyroid nuclear factor 1(gene name synonym)|uniprotkb:Thyroid transcription factor 1(gene name synonym)|uniprotkb:Thyroid-specific enhancer-binding protein(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20594811|imex:IM-26468-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168878(see-also)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001161"(intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021877"(forebrain neuron fate commitment)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031128"(developmental induction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|go:"GO:0048663"(neuron fate commitment)|ensembl:ENSMUSG00000001496(gene)|ensembl:ENSMUST00000001536(transcript)|ensembl:ENSMUST00000178477(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_033411.3	-	-	-	figure legend:Fig. 5B, Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2018/06/25	2018/07/04	-	rogid:0Zwz5Ml8BYQvWD9b3yGKehXuaTw10090	-	false	33p radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-20597810	uniprotkb:P35582	-	intact:EBI-11515814|uniprotkb:Q4VA63|uniprotkb:Q61108|ensembl:ENSMUSP00000041118	psi-mi:spb_human_foxa1-site_dna-probe(display_short)|psi-mi:EBI-20597810(display_long)	psi-mi:foxa1_mouse(display_long)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Foxa1(gene name)|psi-mi:Foxa1(display_short)|uniprotkb:Hnf3a(gene name synonym)|uniprotkb:Tcf-3a(gene name synonym)|uniprotkb:Tcf3a(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20597804|imex:IM-26468-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168878(see-also)	refseq:NP_032285.2|refseq:XP_006515542.1|refseq:XP_006515544.1|refseq:XP_006515546.1|ensembl:ENSMUSG00000035451(gene)|ensembl:ENSMUST00000044380(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061448"(connective tissue development)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-9018519|refseq:XP_017170451.1	-	-	-	figure legend:Fig. 6 B, Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2018/06/25	2018/07/04	-	rogid:GScFT/iLixrzWVUXlf8ADqetLWE10090	-	false	33p radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P43699	uniprotkb:P55317	intact:EBI-1391923|uniprotkb:O14954|uniprotkb:O14955|uniprotkb:Q9BRJ8|uniprotkb:Q7KZF6|uniprotkb:D3DSA3|ensembl:ENSP00000428341|ensembl:ENSP00000429607	intact:EBI-3918034|uniprotkb:Q9H2A0|uniprotkb:B2R9H6|ensembl:ENSP00000250448|uniprotkb:B7ZAP5	psi-mi:nkx21_human(display_long)|uniprotkb:NKX2-1(gene name)|psi-mi:NKX2-1(display_short)|uniprotkb:TITF1(gene name synonym)|uniprotkb:NKX2A(gene name synonym)|uniprotkb:TTF1(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog A(gene name synonym)|uniprotkb:Thyroid transcription factor 1(gene name synonym)|uniprotkb:Thyroid nuclear factor 1(gene name synonym)|uniprotkb:Thyroid-specific enhancer-binding protein(gene name synonym)	psi-mi:foxa1_human(display_long)|uniprotkb:FOXA1(gene name)|psi-mi:FOXA1(display_short)|uniprotkb:HNF3A(gene name synonym)|uniprotkb:TCF3A(gene name synonym)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Transcription factor 3A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20597824|imex:IM-26468-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001073136.1|refseq:NP_003308.1|ensembl:ENSG00000136352(gene)|ensembl:ENST00000498187(transcript)|ensembl:ENST00000518149(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001161"(intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019899"(enzyme binding)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021877"(forebrain neuron fate commitment)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031128"(developmental induction)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479	refseq:NP_004487.2|ensembl:ENSG00000129514(gene)|ensembl:ENST00000250448(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:P55317|reactome:R-HSA-9018519|refseq:XP_016876735.1|dip:DIP-57138N	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nci_h441)|taxid:9606(Homo sapiens)	-	2018/06/25	2018/07/04	rogid:bl+uMAW9z5GF1R21A7VpncC1UR89606	rogid:RX9LFKwRrO2a2X9hXpHbZdcMpZE9606	rigid:PDcjuczlZQLHzQnvnbMF3Lncgdg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P50220	ensembl:ENSMUSG00000103879	intact:EBI-9986706|ensembl:ENSMUSP00000001536|ensembl:ENSMUSP00000136103	intact:EBI-20597844	psi-mi:nkx21_mouse(display_long)|uniprotkb:Nkx2-1(gene name)|psi-mi:Nkx2-1(display_short)|uniprotkb:Nkx-2.1(gene name synonym)|uniprotkb:Titf1(gene name synonym)|uniprotkb:Ttf1(gene name synonym)|uniprotkb:Thyroid nuclear factor 1(gene name synonym)|uniprotkb:Thyroid transcription factor 1(gene name synonym)|uniprotkb:Thyroid-specific enhancer-binding protein(gene name synonym)	psi-mi:spb_mouse_gene(display_short)|psi-mi:ENSMUSG00000103879(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20597842|imex:IM-26468-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001161"(intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0007492"(endoderm development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0009725"(response to hormone)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021759"(globus pallidus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021877"(forebrain neuron fate commitment)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031128"(developmental induction)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|go:"GO:0048663"(neuron fate commitment)|ensembl:ENSMUSG00000001496(gene)|ensembl:ENSMUST00000001536(transcript)|ensembl:ENSMUST00000178477(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|refseq:NP_033411.3	-	-	-	-	figure legend:Fig. 8A|agonist:TGFB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mle15)|taxid:10090(Mouse SV40 large T antigen immortalized mouse lung epithelial cells)	-	2018/06/25	2018/10/01	rogid:0Zwz5Ml8BYQvWD9b3yGKehXuaTw10090	-	-	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P35582	ensembl:ENSMUSG00000103879	intact:EBI-11515814|uniprotkb:Q4VA63|uniprotkb:Q61108|ensembl:ENSMUSP00000041118	intact:EBI-20597844	psi-mi:foxa1_mouse(display_long)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Foxa1(gene name)|psi-mi:Foxa1(display_short)|uniprotkb:Hnf3a(gene name synonym)|uniprotkb:Tcf-3a(gene name synonym)|uniprotkb:Tcf3a(gene name synonym)	psi-mi:spb_mouse_gene(display_short)|psi-mi:ENSMUSG00000103879(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20597848|imex:IM-26468-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_032285.2|refseq:XP_006515542.1|refseq:XP_006515544.1|refseq:XP_006515546.1|ensembl:ENSMUSG00000035451(gene)|ensembl:ENSMUST00000044380(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0061448"(connective tissue development)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-9018519|refseq:XP_017170451.1	-	-	-	-	figure legend:Fig. 8B|agonist:TGFB|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mle15)|taxid:10090(Mouse SV40 large T antigen immortalized mouse lung epithelial cells)	-	2018/06/25	2018/10/01	rogid:GScFT/iLixrzWVUXlf8ADqetLWE10090	-	-	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P84022	uniprotkb:P55317	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	intact:EBI-3918034|uniprotkb:Q9H2A0|uniprotkb:B2R9H6|ensembl:ENSP00000250448|uniprotkb:B7ZAP5	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:foxa1_human(display_long)|uniprotkb:FOXA1(gene name)|psi-mi:FOXA1(display_short)|uniprotkb:HNF3A(gene name synonym)|uniprotkb:TCF3A(gene name synonym)|uniprotkb:Forkhead box protein A1(gene name synonym)|uniprotkb:Transcription factor 3A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Minoo et al. (2008)	imex:IM-26468|pubmed:18003659	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20768435|imex:IM-26468-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	refseq:NP_004487.2|ensembl:ENSG00000129514(gene)|ensembl:ENST00000250448(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030154"(cell differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060741"(prostate gland stromal morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:1902691"(respiratory basal cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013638(Fork-head N-terminal)|interpro:IPR018122|interpro:IPR018533|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:P55317|reactome:R-HSA-9018519|refseq:XP_016876735.1|dip:DIP-57138N	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nci_h441)|taxid:9606(Homo sapiens)	-	2018/06/25	2018/10/01	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rogid:RX9LFKwRrO2a2X9hXpHbZdcMpZE9606	rigid:Gw0yzdlvyGwMTUflssYu+3et7GI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)