#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01909 uniprotkb:P01920 intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short) psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20561254|wwpdb:2nna|imex:IM-26404-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 - - - figure legend:Table S4|3d-resolution:2.1 A|3d-r-factors:RWork =0.217 RFree =0.248|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rigid:k3WJqgiwj41lXgYHJLKIZT4mH3I false variant:73-80|sufficient binding region:24-206|variant:49-49,57-57,63-63,70-70,129-129,178-178,183-183,185-185,197-197|variant:97-98 variant:58-58,77-77,45-45,89-89,199-199,217-217|sufficient binding region:33-224 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01909 uniprotkb:P18573 intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536 intact:EBI-20561561 psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short) psi-mi:gda9_wheat(display_long)|uniprotkb:Prolamin(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:4565(wheat)|taxid:4565("Triticum aestivum (Wheat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20561254|wwpdb:2nna|imex:IM-26404-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex) interpro:IPR044723|go:"GO:0045735"(nutrient reservoir activity)|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:4Z7U|rcsb pdb:4Z7V|rcsb pdb:4Z7W|rcsb pdb:5KS9|interpro:IPR036312|interpro:IPR016140(Bifunctional inhibitor/plant lipid transfer protein/seed storage)|interpro:IPR001954(Gliadin/LMW glutenin) - - - figure legend:Table S4|3d-resolution:2.1 A|3d-r-factors:RWork =0.217 RFree =0.248|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606 rogid:WM4mz8sIvk9fDcwt2jSLE8egcNs4565 rigid:k3WJqgiwj41lXgYHJLKIZT4mH3I false variant:73-80|sufficient binding region:24-206|variant:49-49,57-57,63-63,70-70,129-129,178-178,183-183,185-185,197-197|variant:97-98 mutation:249-249,257-257|sufficient binding region:243-260 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01920 uniprotkb:P01909 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536 psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short) psi-mi:"MI:0892"(solid phase assay) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20561988|imex:IM-26404-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex) - - - figure legend:Figure S1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606 rigid:XlVBFeP6L0rEy31++FbotqZ6pKU false variant:58-58,77-77,45-45,89-89,199-199,217-217|binding-associated region:?-? variant:73-80|binding-associated region:?-?|variant:49-49,57-57,63-63,70-70,129-129,178-178,183-183,185-185,197-197|variant:97-98 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01920 uniprotkb:P04233 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20561988|imex:IM-26404-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:Figure S1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:XlVBFeP6L0rEy31++FbotqZ6pKU false variant:58-58,77-77,45-45,89-89,199-199,217-217|binding-associated region:?-? sufficient binding region:97-116|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01920 uniprotkb:P18573 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 intact:EBI-20561561 psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:gda9_wheat(display_long)|uniprotkb:Prolamin(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:4565(wheat)|taxid:4565("Triticum aestivum (Wheat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20562095|imex:IM-26404-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 interpro:IPR044723|go:"GO:0045735"(nutrient reservoir activity)|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:4Z7U|rcsb pdb:4Z7V|rcsb pdb:4Z7W|rcsb pdb:5KS9|interpro:IPR036312|interpro:IPR016140(Bifunctional inhibitor/plant lipid transfer protein/seed storage)|interpro:IPR001954(Gliadin/LMW glutenin) - - - figure legend:Figure S1B|comment:"A peptide TPO 632–645(Y) of unknown origin and sequence also inhibited CLIP binding."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rogid:WM4mz8sIvk9fDcwt2jSLE8egcNs4565 rigid:QwaHmxX3hyyK2dftYnEhp72hVaE false variant:58-58,77-77,45-45,89-89,199-199,217-217|binding-associated region:?-? mutation causing an interaction:257-257,249-249|sufficient binding region:243-260 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01920 uniprotkb:P01909 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536 psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short) psi-mi:"MI:0892"(solid phase assay) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20562095|imex:IM-26404-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex) - - - figure legend:Figure S1B|comment:"A peptide TPO 632–645(Y) of unknown origin and sequence also inhibited CLIP binding."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606 rigid:QwaHmxX3hyyK2dftYnEhp72hVaE false variant:58-58,77-77,45-45,89-89,199-199,217-217|binding-associated region:?-? variant:73-80|binding-associated region:?-?|variant:49-49,57-57,63-63,70-70,129-129,178-178,183-183,185-185,197-197|variant:97-98 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01920 uniprotkb:P04233 intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Henderson et al. (2007) pubmed:17629515|imex:IM-26404 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20562095|imex:IM-26404-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300 refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:Figure S1B|comment:"A peptide TPO 632–645(Y) of unknown origin and sequence also inhibited CLIP binding."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/05/02 2018/05/17 rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:QwaHmxX3hyyK2dftYnEhp72hVaE false variant:58-58,77-77,45-45,89-89,199-199,217-217|binding-associated region:?-? sufficient binding region:97-116|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation)