#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56817-1	uniprotkb:Q14974	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992725|imex:IM-26971-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	-	-	figure legend:Fig. 2|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	rigid:UyvrDBR6UhvQTaF5G2LuVDxysvk	false	rho tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P56817-1	uniprotkb:Q9H270	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-373380|uniprotkb:Q8WY89|uniprotkb:Q96EP8|uniprotkb:Q9H6D9|uniprotkb:Q9HCS6|ensembl:ENSP00000479680	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:vps11_human(display_long)|uniprotkb:VPS11(gene name)|psi-mi:VPS11(display_short)|uniprotkb:PP3476(orf name)|uniprotkb:RING finger protein 108(gene name synonym)|uniprotkb:RNF108(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992725|imex:IM-26971-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	refseq:NP_068375.3|refseq:NP_001277114.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016528(Vacuolar protein sorting-associated protein 11)|interpro:IPR024763|interpro:IPR036322|mint:Q9H270|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|ensembl:ENSG00000160695(gene)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|ensembl:ENST00000620429(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005764"(lysosome)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0030897"(HOPS complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007032"(endosome organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0007033"(vacuole organization)|go:"GO:0048284"(organelle fusion)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)	-	-	-	figure legend:Fig. 2|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:jHCrh6Lc0dS37Fumbf/lTE8Y1Og9606	rigid:UyvrDBR6UhvQTaF5G2LuVDxysvk	false	rho tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P56817-1	uniprotkb:Q9NQC3-2	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-10296096|ensembl:ENSP00000322147	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:q9nqc3-2(display_long)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:Foocen(gene name synonym)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name)|uniprotkb:ASY(isoform synonym)|uniprotkb:Foocen-M(isoform synonym)|uniprotkb:Nogo-B(isoform synonym)|uniprotkb:RTN-xS(isoform synonym)|uniprotkb:Nogo-B1(isoform synonym)|uniprotkb:RTN4B(isoform synonym)|uniprotkb:RTN4B1(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992725|imex:IM-26971-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	intact:EBI-715945(isoform-parent)|ensembl:ENSG00000115310(gene)|ensembl:ENST00000317610(transcript)|uniprotkb:Q9NQC3-2(isoform-parent)	-	-	-	figure legend:Fig. 2|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:2r64W1jh2yaSciLBRcCthaCHWWA9606	rigid:UyvrDBR6UhvQTaF5G2LuVDxysvk	false	rho tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NQC3-2	uniprotkb:P56817-1	intact:EBI-10296096|ensembl:ENSP00000322147	intact:EBI-2433297|ensembl:ENSP00000318585	psi-mi:q9nqc3-2(display_long)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:Foocen(gene name synonym)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name)|uniprotkb:ASY(isoform synonym)|uniprotkb:Foocen-M(isoform synonym)|uniprotkb:Nogo-B(isoform synonym)|uniprotkb:RTN-xS(isoform synonym)|uniprotkb:Nogo-B1(isoform synonym)|uniprotkb:RTN4B(isoform synonym)|uniprotkb:RTN4B1(isoform synonym)	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992745|imex:IM-26971-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-715945(isoform-parent)|ensembl:ENSG00000115310(gene)|ensembl:ENST00000317610(transcript)|uniprotkb:Q9NQC3-2(isoform-parent)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	-	-	-	figure legend:Fig. 3A, 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/30	2018/11/30	rogid:2r64W1jh2yaSciLBRcCthaCHWWA9606	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rigid:YPRsHp0Ni6XPgomN/4K5dfknIts	false	-	sufficient binding region:443-501|rho tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NQC3-3	uniprotkb:P56817-1	intact:EBI-11526335|ensembl:ENSP00000378107	intact:EBI-2433297|ensembl:ENSP00000318585	psi-mi:q9nqc3-3(display_long)|uniprotkb:Foocen(gene name synonym)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name)|uniprotkb:Foocen-S(isoform synonym)|uniprotkb:Nogo-C(isoform synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:RTN4C(isoform synonym)	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992755|imex:IM-26971-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-715945(isoform-parent)|ensembl:ENSG00000115310(gene)|ensembl:ENST00000394609(transcript)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	-	-	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/30	2018/11/30	rogid:Iq/LlFtXjFyIIfxZ1l3NTKURpyA9606	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rigid:MpIzunlZ6AmiaRenQah+ip9JSYI	false	-	rho tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95197-3	uniprotkb:P56817-1	intact:EBI-11525735|ensembl:ENSP00000440874	intact:EBI-2433297|ensembl:ENSP00000318585	psi-mi:o95197-3(display_long)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:A1(isoform synonym)|uniprotkb:B1(isoform synonym)	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992762|imex:IM-26971-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000133318(gene)|ensembl:ENST00000537981(transcript)|intact:EBI-740467(isoform-parent)|uniprotkb:O95197-3(isoform-parent)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	-	-	-	figure legend:Fig. 3C, 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/30	2019/04/29	rogid:+TJnANu85CM52dRZ6s+hYMlUABE9606	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rigid:EIF92qKlrSo2AuS7ypLa5AJJ79g	false	myc tag:c-c	rho tag:c-c|sufficient binding region:443-501	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817-1	uniprotkb:O95197-3	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-11525735|ensembl:ENSP00000440874	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:o95197-3(display_long)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:A1(isoform synonym)|uniprotkb:B1(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992777|imex:IM-26971-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	ensembl:ENSG00000133318(gene)|ensembl:ENST00000537981(transcript)|intact:EBI-740467(isoform-parent)|uniprotkb:O95197-3(isoform-parent)	-	-	-	figure legend:Fig. 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/30	2019/04/29	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:+TJnANu85CM52dRZ6s+hYMlUABE9606	rigid:EIF92qKlrSo2AuS7ypLa5AJJ79g	false	rho tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95197-3	uniprotkb:Q9Y5Z0-1	intact:EBI-11525735|ensembl:ENSP00000440874	intact:EBI-20992838|ensembl:ENSP00000332979	psi-mi:o95197-3(display_long)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:A1(isoform synonym)|uniprotkb:B1(isoform synonym)	psi-mi:q9y5z0-1(display_long)|uniprotkb:Aspartic-like protease 56 kDa(gene name synonym)|uniprotkb:Aspartyl protease 1(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 2(gene name synonym)|uniprotkb:Down region aspartic protease(gene name synonym)|uniprotkb:Memapsin-1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 1(gene name synonym)|uniprotkb:Theta-secretase(gene name synonym)|uniprotkb:CDA13(orf name)|uniprotkb:UNQ418/PRO852(orf name)|uniprotkb:Isoform A(isoform synonym)|uniprotkb:BACE2(gene name)|psi-mi:BACE2(display_short)|uniprotkb:AEPLC(gene name synonym)|uniprotkb:ALP56(gene name synonym)|uniprotkb:ASP21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992830|imex:IM-26971-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000133318(gene)|ensembl:ENST00000537981(transcript)|intact:EBI-740467(isoform-parent)|uniprotkb:O95197-3(isoform-parent)	ensembl:ENSG00000182240(gene)|ensembl:ENST00000330333(transcript)|intact:EBI-11282723(isoform-parent)	-	-	-	figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/30	2019/04/29	rogid:+TJnANu85CM52dRZ6s+hYMlUABE9606	rogid:t3aaeDzIiH1u/vKvOVHLGqVru7s9606	rigid:UJUWGiw+UPg2GLx9WkybpR8JfTo	false	myc tag:c-c	rho tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817-1	uniprotkb:O95197	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992816|imex:IM-26971-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1	-	-	-	figure legend:Fig. 3E|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606	rigid:/nI+J5D7rQTGZ8r3LrCeoOJQmBs	false	rho tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P56817-1	uniprotkb:Q9NQC3-2	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-10296096|ensembl:ENSP00000322147	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:q9nqc3-2(display_long)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:Foocen(gene name synonym)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name)|uniprotkb:ASY(isoform synonym)|uniprotkb:Foocen-M(isoform synonym)|uniprotkb:Nogo-B(isoform synonym)|uniprotkb:RTN-xS(isoform synonym)|uniprotkb:Nogo-B1(isoform synonym)|uniprotkb:RTN4B(isoform synonym)|uniprotkb:RTN4B1(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992816|imex:IM-26971-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	intact:EBI-715945(isoform-parent)|ensembl:ENSG00000115310(gene)|ensembl:ENST00000317610(transcript)|uniprotkb:Q9NQC3-2(isoform-parent)	-	-	-	figure legend:Fig. 3E|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:2r64W1jh2yaSciLBRcCthaCHWWA9606	rigid:/nI+J5D7rQTGZ8r3LrCeoOJQmBs	false	rho tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)|psi-mi:"MI:0113"(western blot)
uniprotkb:P56817-1	uniprotkb:Q9NQC3-3	intact:EBI-2433297|ensembl:ENSP00000318585	intact:EBI-11526335|ensembl:ENSP00000378107	psi-mi:p56817-1(display_long)|uniprotkb:BACE-1A(isoform synonym)|uniprotkb:BAC-501(isoform synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)	psi-mi:q9nqc3-3(display_long)|uniprotkb:Foocen(gene name synonym)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name)|uniprotkb:Foocen-S(isoform synonym)|uniprotkb:Nogo-C(isoform synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:RTN4C(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Murayama et al. (2006)	pubmed:16965550|imex:IM-26971	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20992816|imex:IM-26971-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2433139(isoform-parent)|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)	intact:EBI-715945(isoform-parent)|ensembl:ENSG00000115310(gene)|ensembl:ENST00000394609(transcript)	-	-	-	figure legend:Fig. 3E|comment:HSP70 proteins were also identified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2018/11/30	2018/11/30	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:Iq/LlFtXjFyIIfxZ1l3NTKURpyA9606	rigid:/nI+J5D7rQTGZ8r3LrCeoOJQmBs	false	rho tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)|psi-mi:"MI:0113"(western blot)