#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750158|imex:IM-26271-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/02/05	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:E3FkxdJHZIflOIVK0denZMqsNmU	false	sufficient binding region:1-252	sufficient binding region:1-252	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750169|imex:IM-26271-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:"figure 1B (inset)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/02/05	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:E3FkxdJHZIflOIVK0denZMqsNmU	false	sufficient binding region:1-252	sufficient binding region:1-252	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750182|imex:IM-26271-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 1C|comment:monomeric ICOSL|comment:Both the oligomeric and monomeric forms of ICOSL-VC bound to soluble ICOS-Ig|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/02/05	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:21-139|fc-igg tag:c-c|tag:?-?	sufficient binding region:1-252	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752491|imex:IM-26271-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 1Ci|comment:oligomeric ICOSL|comment:Both the oligomeric and monomeric forms of ICOSL-VC bound to soluble ICOS-Ig.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/02/05	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:21-139|fc-igg tag:c-c|tag:?-?	sufficient binding region:1-252	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752491|imex:IM-26271-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 1Ci|comment:oligomeric ICOSL|comment:Both the oligomeric and monomeric forms of ICOSL-VC bound to soluble ICOS-Ig.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/02/05	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:21-139|fc-igg tag:c-c|tag:?-?	sufficient binding region:1-252	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750215|imex:IM-26271-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/30	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:ZsD2rnyZaN3+QrNq61mnrlIphEo	false	sufficient binding region:1-252	sufficient binding region:1-252	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750259|imex:IM-26271-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 2C|comment:Cross-linking shows presence of ICOSL oligomers of higher stoichiometry.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/31	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:ZsD2rnyZaN3+QrNq61mnrlIphEo	false	yellow fluorescent protein tag:c-c	yellow fluorescent protein tag:c-c	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750389|imex:IM-26271-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841|go:"GO:0005886"(plasma membrane)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841|go:"GO:0005886"(plasma membrane)	-	-	-	figure legend:figure 2Ci|comment:Cross-linking shows presence of ICOSL oligomers of higher stoichiometry.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/31	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:ZsD2rnyZaN3+QrNq61mnrlIphEo	false	yellow fluorescent protein tag:c-c	yellow fluorescent protein tag:c-c	3	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750396|imex:IM-26271-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 2Cii|comment:Cross-linking shows presence of ICOSL oligomers of higher stoichiometry.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/31	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:ZsD2rnyZaN3+QrNq61mnrlIphEo	false	yellow fluorescent protein tag:c-c	yellow fluorescent protein tag:c-c	4	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750231|imex:IM-26271-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 2A, 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/30	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:21-139|fc-igg tag:c-c|tag:?-?	yellow fluorescent protein tag:c-c|mutation disrupting interaction strength:53-53|mutation decreasing interaction strength:62-62|mutation disrupting interaction strength:51-51	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750403|imex:IM-26271-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 3 B/C, 4A|comment:The IgV domain of ICOSL alone could bind to ICOS, however ICOSL-V-Ig was found to bind at least 8- to 10-fold less well to ICOS compared with ICOSL-VC-Ig.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/31	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	yellow fluorescent protein tag:c-c	fc-igg tag:c-c|sufficient binding region:1-135(IPR013106)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y6W8	uniprotkb:O75144	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750422|imex:IM-26271-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 6A, table 1|comment:Disrupting mutations show equal or less than 5% binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/31	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:21-139|fc-igg tag:c-c|tag:?-?	yellow fluorescent protein tag:c-c|mutation disrupting interaction strength:53-53|mutation decreasing interaction strength:55-55|mutation with no effect:59-59|mutation with no effect:61-61|mutation decreasing interaction strength:62-62|mutation disrupting interaction strength:55-55,62-62|mutation with no effect:64-64|mutation decreasing interaction strength:66-66|mutation decreasing interaction strength:76-76|mutation with no effect:77-77|mutation disrupting interaction strength:80-80|mutation with no effect:87-87|mutation with no effect:47-47|mutation disrupting interaction strength:51-51|mutation disrupting interaction strength:53-53|mutation decreasing interaction strength:51-51|mutation with no effect:98-98|mutation decreasing interaction strength:114-114|mutation disrupting interaction rate:116-116|mutation decreasing interaction strength:120-120|mutation with no effect:121-121|mutation disrupting interaction strength:122-122|mutation with no effect:123-123|mutation decreasing interaction strength:124-124|mutation with no effect:138-138|mutation with no effect:141-141|mutation with no effect:143-143|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:70-70|mutation decreasing interaction strength:102-102|mutation with no effect:137-137|mutation with no effect:186-186|mutation with no effect:225-225	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75144	uniprotkb:O75144	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Chattopadhyay et al. (2006)	imex:IM-26271|pubmed:16951355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16750281|imex:IM-26271-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	-	-	-	figure legend:figure 2D-F,H.4 B/C|comment:The presence of ICOSL-YFP with a cysteine containing  linker did not change the average FRET efficiency values of ICOSL.|comment:Fret efficiency was increased using an ICOSL construct missing the IgC domain, suggesting a higher degree of homo-association.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/25	2018/01/30	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rigid:E3FkxdJHZIflOIVK0denZMqsNmU	false	sufficient binding region:1..1-135..135|cyan fluorescent protein tag:c-c	sufficient binding region:1..1-135..135|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)