#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P06971 uniprotkb:P02929 intact:EBI-1116714|uniprotkb:P71280|uniprotkb:P75665|ensemblbacteria:AAC73261|ensemblbacteria:BAB96726 intact:EBI-6399993|ensemblbacteria:AAC74334|ensemblbacteria:BAA14784|uniprotkb:P76831|uniprotkb:P94719|uniprotkb:P94722|uniprotkb:P94726|uniprotkb:P94728|uniprotkb:P94732|uniprotkb:P94736|uniprotkb:P94739|uniprotkb:P97239 psi-mi:fhua_ecoli(display_long)|uniprotkb:JW0146(locus name)|uniprotkb:fhuA(gene name)|psi-mi:fhuA(display_short)|uniprotkb:tonA(gene name synonym)|uniprotkb:b0150(locus name)|uniprotkb:Ferric hydroxamate uptake(gene name synonym)|uniprotkb:Ferric hydroxamate receptor(gene name synonym)|uniprotkb:Ferrichrome-iron receptor(gene name synonym) psi-mi:tonb_ecoli(display_long)|uniprotkb:tonB(gene name)|psi-mi:tonB(display_short)|uniprotkb:exbA(gene name synonym)|uniprotkb:JW5195(locus name)|uniprotkb:b1252(locus name) psi-mi:"MI:0114"(x-ray crystallography) Pawelek et al. (2006) imex:IM-26484|pubmed:16741125 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20591892|wwpdb:2grx|imex:IM-26484-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_000124438.1|refseq:NP_414692.1|interpro:IPR012910(TonB-dependent receptor, plug)|interpro:IPR036942|interpro:IPR037066|interpro:IPR039423|rcsb pdb:1BY3|rcsb pdb:1BY5|rcsb pdb:1FCP|rcsb pdb:1FI1|rcsb pdb:1QFF|rcsb pdb:1QFG|rcsb pdb:1QJQ|rcsb pdb:1QKC|rcsb pdb:2FCP|rcsb pdb:2GRX|rcsb pdb:4CU4|ensemblbacteria:AAC73261(transcript)|ensemblbacteria:b0150(gene)|ensemblbacteria:BAB96726(gene)|ensemblbacteria:BAB96726(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015344"(siderophore uptake transmembrane transporter activity)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046790"(virion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR000531(TonB-dependent receptor, beta-barrel)|interpro:IPR010105(TonB-dependent siderophore receptor)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR010917(TonB-dependent receptor, conserved site)|dip:DIP-9602N refseq:WP_001360141.1|ensemblbacteria:AAC74334(transcript)|ensemblbacteria:b1252(gene)|ensemblbacteria:BAA14784(gene)|ensemblbacteria:BAA14784(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015343"(siderophore transmembrane transporter activity)|go:"GO:0015889"(cobalamin transport)|go:"GO:0015891"(siderophore transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030313"(cell envelope)|go:"GO:0031992"(energy transducer activity)|go:"GO:0042914"(colicin transport)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:0098002"(receptor-mediated bacteriophage irreversible attachment to host cell)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003538(Gram-negative bacterial tonB protein)|interpro:IPR006260(TonB, C-terminal)|interpro:IPR037682|rcsb pdb:1IHR|rcsb pdb:1QXX|rcsb pdb:1U07|rcsb pdb:1XX3|rcsb pdb:2GRX|rcsb pdb:2GSK|refseq:NP_415768.1|dip:DIP-48111N - - - figure legend:Supp. Table 1|3d-structure:3.3A|3d-r-factors:Rworking 0.284 Rfree 0.329|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/06/19 2018/06/19 rogid:YuhazS970KcEsyZqYsiK4AAwsqI83333 rogid:ia5lbqqvP+O4DJyZcLSRdxZV/tE83333 rigid:8NqHZK5tzwZypyXFKqatMTiRupo false sufficient binding region:34-747 sufficient binding region:29-239 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)