#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6V0K8 uniprotkb:P38432 intact:EBI-20771333 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q6v0k8_human(display_long) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20771301|imex:IM-26837-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1900383"(regulation of synaptic plasticity by receptor localization to synapse)|refseq:NP_001191009.1|interpro:IPR033636|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR006020(Phosphotyrosine interaction region)|refseq:AY356353(author identifier) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:na|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2018/10/11 2018/10/11 rogid:F6Qno7UYlZQtU68tqzDah/KiuVU9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:k1bCIUFYv0ypY/C8y5vVGk2Ftzw false - sufficient binding region:362-576 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7Z6G8-1 uniprotkb:P38432 intact:EBI-20771343|ensembl:ENSP00000449629 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-1(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1b(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20771295|imex:IM-26837-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000547776(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/10/11 2018/10/11 rogid:S/D2te61NTyW2f9ivzPFqIB1/NM9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:dhF1i08FAMlCRFuJ0/L8HAXKgEQ false - myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z6G8-1 uniprotkb:P38432 intact:EBI-20771343|ensembl:ENSP00000449629 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-1(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1b(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0096"(pull down) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20771365|imex:IM-26837-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000547776(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 3B, Fig.3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/10/11 2018/10/11 rogid:S/D2te61NTyW2f9ivzPFqIB1/NM9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:dhF1i08FAMlCRFuJ0/L8HAXKgEQ false - glutathione s tranferase tag:?-?|sufficient binding region:362-576 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z6G8-2 uniprotkb:P38432 intact:EBI-20771303|ensembl:ENSP00000448205 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-2(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1c(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0096"(pull down) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20771414|imex:IM-26837-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000546568(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 4B|comment:we conducted GST-pulldown assays using purified recombinant proteins. We found that soluble full-length coilin is recovered by AIDA-1c fused to GST. In support of our previous observations suggesting that the interaction between AIDA-1c and coilin is weak or transient, coilin binding is abolished when the assay was carried out in the presence of increasing salt concentrations|variable_condition:150mM NaCl|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/10/11 2018/10/11 rogid:r5Nf5IYD+8lTETlnH26htVE/tqA9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:KxwmUjP65thiLRr41OkDc6yd9Uc false glutathione s tranferase tag:?-? t7 tag:?-?|his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z6G8-2 uniprotkb:P38432 intact:EBI-20771303|ensembl:ENSP00000448205 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-2(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1c(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0096"(pull down) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20771424|imex:IM-26837-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000546568(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/10/11 2018/10/11 rogid:r5Nf5IYD+8lTETlnH26htVE/tqA9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:KxwmUjP65thiLRr41OkDc6yd9Uc false t7 tag:?-?|his tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:420-576 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z6G8-1 uniprotkb:P38432 intact:EBI-20771343|ensembl:ENSP00000449629 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-1(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1b(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0096"(pull down) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21004732|imex:IM-26837-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000547776(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/10/11 2018/12/11 rogid:S/D2te61NTyW2f9ivzPFqIB1/NM9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:dhF1i08FAMlCRFuJ0/L8HAXKgEQ false - glutathione s tranferase tag:?-?|sufficient binding region:362-576 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z6G8-2 uniprotkb:P38432 intact:EBI-20771303|ensembl:ENSP00000448205 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-2(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1c(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20771391|imex:IM-26837-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185046(gene)|ensembl:ENST00000546568(transcript)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/10/11 2018/10/11 rogid:r5Nf5IYD+8lTETlnH26htVE/tqA9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:KxwmUjP65thiLRr41OkDc6yd9Uc false green fluorescent protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z6G8-4 uniprotkb:P38432 intact:EBI-20771405|ensembl:ENSP00000447839 intact:EBI-945751|uniprotkb:B2R931|ensembl:ENSP00000240316 psi-mi:q7z6g8-4(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)|uniprotkb:AIDA-1a(isoform synonym) psi-mi:coil_human(display_long)|uniprotkb:COIL(gene name)|psi-mi:COIL(display_short)|uniprotkb:CLN80(gene name synonym)|uniprotkb:p80-coilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xu et al. (2004) pubmed:15862129|imex:IM-26837 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20771399|imex:IM-26837-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000546960(transcript)|ensembl:ENSG00000185046(gene)|intact:EBI-7876312(isoform-parent) refseq:NP_004636.1|dip:DIP-38503N|ensembl:ENSG00000121058(gene)|ensembl:ENST00000240316(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR024822|interpro:IPR031722|mint:P38432 - - - figure legend:Fig. 4A|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2018/10/11 2018/10/11 rogid:29aZS2WbfPq9lgEa99iVmJriKpw9606 rogid:hd5p6AbyA/GYNEeca99Mdb41qM09606 rigid:qQ5NW3ic1x2B79CSFcUPDCiyP3w false yellow fluorescent protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)