#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6U7R4 uniprotkb:Q5QNS5-2 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217763 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:q5qns5-2(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-16764479|imex:IM-26338-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 intact:EBI-20217708(isoform-parent) - - - figure legend:Figure 3a second row far right|comment:"The authors state that:-\"There was staining of TIM-4 transfectants with TIM-1–Ig fusion protein whether full-length TIM-1–Ig, containing the TIM-1 IgV and mucin domains, or a TIM-1–Ig containing only the IgV domain was used\"."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:lc8WBUKY238uhk5ZGuXs0e7eIw410090 rigid:AHdunIGCGdE20aUB9drSvMvwXvw false ha tag:n-n|sufficient binding region:30-343|myc tag:c-c|tag:c-c sufficient binding region:22-212|fc-igg1:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6U7R4 uniprotkb:Q5QNS5 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217708|uniprotkb:Q7TPU2|uniprotkb:Q8VIM1|uniprotkb:Q8VIM2 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:havr1_mouse(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-16764636|imex:IM-26338-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005903"(brush border)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033005"(positive regulation of mast cell activation)|refseq:NP_001160103.1|refseq:NP_001160104.1|refseq:NP_599009.2|rcsb pdb:2OR8|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) - - - figure legend:Figure 3a fourth row far left|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:5uYXNe7cQkZWxaXSQcSPuuoyUFQ10090 rigid:xv8Tx+v80sw2+aeod4Ifho2+RdU false fc-igg1:c-c|sufficient binding region:22-279 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6U7R4 uniprotkb:Q5QNS5-2 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217763 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:q5qns5-2(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-20217820|imex:IM-26338-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 intact:EBI-20217708(isoform-parent) - - - figure legend:Figure 3b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:lc8WBUKY238uhk5ZGuXs0e7eIw410090 rigid:AHdunIGCGdE20aUB9drSvMvwXvw false ha tag:n-n|sufficient binding region:30-343|myc tag:c-c|tag:c-c sufficient binding region:22-212|fc-igg1:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6U7R4 uniprotkb:Q5QNS5 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217708|uniprotkb:Q7TPU2|uniprotkb:Q8VIM1|uniprotkb:Q8VIM2 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:havr1_mouse(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-20217841|imex:IM-26338-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005903"(brush border)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033005"(positive regulation of mast cell activation)|refseq:NP_001160103.1|refseq:NP_001160104.1|refseq:NP_599009.2|rcsb pdb:2OR8|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) - - - figure legend:Figure 3b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:5uYXNe7cQkZWxaXSQcSPuuoyUFQ10090 rigid:xv8Tx+v80sw2+aeod4Ifho2+RdU false fc-igg1:c-c|sufficient binding region:22-279 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6U7R4 uniprotkb:Q5QNS5 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217708|uniprotkb:Q7TPU2|uniprotkb:Q8VIM1|uniprotkb:Q8VIM2 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:havr1_mouse(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-20217880|imex:IM-26338-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005903"(brush border)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033005"(positive regulation of mast cell activation)|refseq:NP_001160103.1|refseq:NP_001160104.1|refseq:NP_599009.2|rcsb pdb:2OR8|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) - - - figure legend:Figure 4A|comment:TIM-4–Ig stained T cells activated with anti-CD3 and anti-CD28, but did not stain unactivated T cells.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:5uYXNe7cQkZWxaXSQcSPuuoyUFQ10090 rigid:xv8Tx+v80sw2+aeod4Ifho2+RdU false fc-igg1:c-c|sufficient binding region:22-279 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q6U7R4 uniprotkb:Q5QNS5 intact:EBI-16764486|ensembl:ENSMUSP00000069456|uniprotkb:Q6U7R3|uniprotkb:Q8CIC7 intact:EBI-20217708|uniprotkb:Q7TPU2|uniprotkb:Q8VIM1|uniprotkb:Q8VIM2 psi-mi:timd4_mouse(display_long)|uniprotkb:Timd4(gene name)|psi-mi:Timd4(display_short)|uniprotkb:Tim4(gene name synonym)|uniprotkb:Spleen, mucin-containing, knockout of lymphotoxin protein(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 4(gene name synonym)|uniprotkb:T-cell membrane protein 4(gene name synonym) psi-mi:havr1_mouse(display_long)|uniprotkb:Kidney injury molecule 1(gene name synonym)|uniprotkb:T cell immunoglobulin and mucin domain-containing protein 1(gene name synonym)|uniprotkb:T cell membrane protein 1(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 1(gene name synonym)|uniprotkb:Havcr1(gene name)|psi-mi:Havcr1(display_short)|uniprotkb:Kim1(gene name synonym)|uniprotkb:Tim1(gene name synonym)|uniprotkb:Timd1(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Meyers et al. (2005) imex:IM-26338|pubmed:15793576 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-20217896|imex:IM-26338-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000055546(gene)|ensembl:ENSMUST00000068877(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043277"(apoptotic cell clearance)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3BI9|rcsb pdb:3BIA|rcsb pdb:3BIB|refseq:NP_848874.3 go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005903"(brush border)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033005"(positive regulation of mast cell activation)|refseq:NP_001160103.1|refseq:NP_001160104.1|refseq:NP_599009.2|rcsb pdb:2OR8|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) - - - figure legend:Figure 4B|comment:splenocytes were stimulated with concanavalin A.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/02/13 2018/04/30 rogid:+f0sbjppixHzUiAkrlgSWuOU7g810090 rogid:5uYXNe7cQkZWxaXSQcSPuuoyUFQ10090 rigid:xv8Tx+v80sw2+aeod4Ifho2+RdU false fc-igg1:c-c|sufficient binding region:22-279 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)