#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28304"	uniprotkb:Q9BXS0-3	intact:EBI-1379423	intact:EBI-11682418	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993666|imex:IM-26973-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-2529321(isoform-parent)	-	-	-	figure legend:Fig 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/01	-	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	-	false	-	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:28304"	matrixdb:MULT_53_VAR3_human	intact:EBI-1379423	intact:EBI-11682400	psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long)	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993679|imex:IM-26973-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	-	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	figure legend:Fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	-	-	false	-	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_53_VAR3_human	intact:EBI-14348029	intact:EBI-11682400	-	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993954|imex:IM-26973-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	-	-	false	myc tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_53_VAR3_human	intact:EBI-15485299	intact:EBI-11682400	-	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:abeta-40-oligomer_human(display_short)|psi-mi:EBI-15485299(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 40 homooligomer(complex synonym)|intact:beta-amyloid protein 40 complex(complex synonym)|intact:beta-amyloid-40 complex(complex synonym)|intact:beta amyloid protein 40 complex(complex synonym)|intact:amyloid-beta-40 complex(complex synonym)|intact:amyloid beta protein 40 complex(complex synonym)|intact:amyloid-beta protein 40 homooligomer(complex synonym)|intact:amyloid-beta-40 homooligomer(complex synonym)|intact:amyloid beta protein 40 homooligomer(complex synonym)|intact:beta-amyloid-40 heterooligomer(complex synonym)|intact:beta amyloid protein 40 homooligomer(complex synonym)|intact:Abeta protein 40 complex(complex synonym)|intact:Amyloid-beta protein 40 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993967|imex:IM-26973-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	evidence ontology:"ECO:0005546"|efo:"EFO:0000249"(see-also)|complex portal:CPX-1070(inferred-from)|pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|pubmed:15190117(see-also)|pubmed:22179788(see-also)|complex portal:CPX-1180(complex-primary)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1069) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Homooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig 6A, 6B, 6C, 8A, 8F|comment:Collagen type XXV trimer, variant 3 binding to the Amyloid-beta protein 40 oligomeric complex was inversely related to NaCl concentration|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	-	-	false	myc tag:c-c|his tag:c-c|necessary binding region:175-182|sufficient binding region:1-126,135-654|mutation with no effect:127-134	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
matrixdb:MULT_53_VAR3_human	uniprotkb:P37840	intact:EBI-11682400	intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993977|imex:IM-26973-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	-	figure legend:Fig6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606	-	false	myc tag:c-c|his tag:c-c	sufficient binding region:61..61-95..95	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-15485299	uniprotkb:Q9BXS0-3	-	intact:EBI-11682418	psi-mi:abeta-40-oligomer_human(display_short)|psi-mi:EBI-15485299(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 40 homooligomer(complex synonym)|intact:beta-amyloid protein 40 complex(complex synonym)|intact:beta-amyloid-40 complex(complex synonym)|intact:beta amyloid protein 40 complex(complex synonym)|intact:amyloid-beta-40 complex(complex synonym)|intact:amyloid beta protein 40 complex(complex synonym)|intact:amyloid-beta protein 40 homooligomer(complex synonym)|intact:amyloid-beta-40 homooligomer(complex synonym)|intact:amyloid beta protein 40 homooligomer(complex synonym)|intact:beta-amyloid-40 heterooligomer(complex synonym)|intact:beta amyloid protein 40 homooligomer(complex synonym)|intact:Abeta protein 40 complex(complex synonym)|intact:Amyloid-beta protein 40 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20994071|imex:IM-26973-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	evidence ontology:"ECO:0005546"|efo:"EFO:0000249"(see-also)|complex portal:CPX-1070(inferred-from)|pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|pubmed:15190117(see-also)|pubmed:22179788(see-also)|complex portal:CPX-1180(complex-primary)	intact:EBI-2529321(isoform-parent)	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1069) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Homooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	-	figure legend:Fig 8C|comment:Collagen type XXV trimer, variant 3 binding to the Amyloid-beta protein 40 oligomeric complex was inversely related to NaCl concentration|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	-	false	-	sufficient binding region:173-184	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15485299	matrixdb:MULT_53_VAR3_human	-	intact:EBI-11682400	psi-mi:abeta-40-oligomer_human(display_short)|psi-mi:EBI-15485299(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 40 homooligomer(complex synonym)|intact:beta-amyloid protein 40 complex(complex synonym)|intact:beta-amyloid-40 complex(complex synonym)|intact:beta amyloid protein 40 complex(complex synonym)|intact:amyloid-beta-40 complex(complex synonym)|intact:amyloid beta protein 40 complex(complex synonym)|intact:amyloid-beta protein 40 homooligomer(complex synonym)|intact:amyloid-beta-40 homooligomer(complex synonym)|intact:amyloid beta protein 40 homooligomer(complex synonym)|intact:beta-amyloid-40 heterooligomer(complex synonym)|intact:beta amyloid protein 40 homooligomer(complex synonym)|intact:Abeta protein 40 complex(complex synonym)|intact:Amyloid-beta protein 40 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20994071|imex:IM-26973-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	evidence ontology:"ECO:0005546"|efo:"EFO:0000249"(see-also)|complex portal:CPX-1070(inferred-from)|pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|pubmed:15190117(see-also)|pubmed:22179788(see-also)|complex portal:CPX-1180(complex-primary)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1069) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Homooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	figure legend:Fig 8C|comment:Collagen type XXV trimer, variant 3 binding to the Amyloid-beta protein 40 oligomeric complex was inversely related to NaCl concentration|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	-	-	-	false	-	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9BXS0-3	uniprotkb:Q9BXS0-3	intact:EBI-11682418	intact:EBI-11682418	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0605"(enzymatic footprinting)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993693|imex:IM-26973-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2529321(isoform-parent)	intact:EBI-2529321(isoform-parent)	-	-	-	figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/01	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rigid:AYM7bgaE3atBtbbLzIfiL4jPWGs	false	myc tag:c-c|his tag:c-c|sufficient binding region:176->185	his tag:c-c|myc tag:c-c|sufficient binding region:424->431	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:Q9BXS0-3	uniprotkb:Q9BXS0-3	intact:EBI-11682418	intact:EBI-11682418	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993720|imex:IM-26973-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2529321(isoform-parent)	intact:EBI-2529321(isoform-parent)	-	-	-	figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/01	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rigid:TvAQvNYCZuxfn+5mvX8ylCSsJ9E	false	myc tag:c-c|his tag:c-c	myc tag:c-c|his tag:c-c	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS0-3	uniprotkb:Q9BXS0-3	intact:EBI-11682418	intact:EBI-11682418	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0807"(comigration in gel electrophoresis)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993729|imex:IM-26973-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2529321(isoform-parent)	intact:EBI-2529321(isoform-parent)	-	-	-	figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/01	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rigid:TvAQvNYCZuxfn+5mvX8ylCSsJ9E	false	myc tag:c-c|his tag:c-c	myc tag:c-c|his tag:c-c	3	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BXS0-3	uniprotkb:Q9BXS0-3	intact:EBI-11682418	intact:EBI-11682418	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993743|imex:IM-26973-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2529321(isoform-parent)	intact:EBI-2529321(isoform-parent)	-	-	-	figure legend:Fig 5B, 8D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/01	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	rigid:TvAQvNYCZuxfn+5mvX8ylCSsJ9E	false	myc tag:c-c|his tag:c-c|sufficient binding region:1-174,183-581	myc tag:c-c|his tag:c-c|sufficient binding region:1-174,183-581	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXS0-3	intact:EBI-15485299	intact:EBI-11682418	-	psi-mi:q9bxs0-3(display_long)|uniprotkb:COL25A1(gene name)|psi-mi:COL25A1(display_short)|uniprotkb:Alzheimer disease amyloid-associated protein(gene name synonym)|uniprotkb:CLAC-P(gene name synonym)	psi-mi:abeta-40-oligomer_human(display_short)|psi-mi:EBI-15485299(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 40 homooligomer(complex synonym)|intact:beta-amyloid protein 40 complex(complex synonym)|intact:beta-amyloid-40 complex(complex synonym)|intact:beta amyloid protein 40 complex(complex synonym)|intact:amyloid-beta-40 complex(complex synonym)|intact:amyloid beta protein 40 complex(complex synonym)|intact:amyloid-beta protein 40 homooligomer(complex synonym)|intact:amyloid-beta-40 homooligomer(complex synonym)|intact:amyloid beta protein 40 homooligomer(complex synonym)|intact:beta-amyloid-40 heterooligomer(complex synonym)|intact:beta amyloid protein 40 homooligomer(complex synonym)|intact:Abeta protein 40 complex(complex synonym)|intact:Amyloid-beta protein 40 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0049"(filter binding)	Söderberg et al. (2005)	imex:IM-26973|pubmed:15522881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20993995|imex:IM-26973-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	intact:EBI-2529321(isoform-parent)	evidence ontology:"ECO:0005546"|efo:"EFO:0000249"(see-also)|complex portal:CPX-1070(inferred-from)|pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|pubmed:15190117(see-also)|pubmed:22179788(see-also)|complex portal:CPX-1180(complex-primary)	-	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1069) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Homooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/30	2018/12/03	rogid:KI/HzEOrfFcZ6vB82qYjUpEaEeI9606	-	-	false	sufficient binding region:175-182	125i radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)