#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99683	uniprotkb:Q9D1C8	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827746|imex:IM-26697-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/09	2018/12/13	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:YlYjb1UUDCYku0q/LJG6wbo9zH8	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:79-221|necessary binding region:175-221	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99683	uniprotkb:Q9D1C8	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827767|imex:IM-26697-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/09	2018/12/13	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:YlYjb1UUDCYku0q/LJG6wbo9zH8	false	sufficient binding region:1-656|35s radiolabel:?-?|necessary binding region:1-649	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827899|imex:IM-26697-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/09	2018/12/13	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-174|necessary binding region:1-79	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827911|imex:IM-26697-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/09	2018/12/13	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	sufficient binding region:1-162|35s radiolabel:?-?|necessary binding region:1-82	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O54786	uniprotkb:O54788	intact:EBI-1634519|uniprotkb:O54787|uniprotkb:Q8BQC7|uniprotkb:B2KFX0|ensembl:ENSMUSP00000030816	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	psi-mi:dffa_mouse(display_long)|uniprotkb:Dffa(gene name)|psi-mi:Dffa(display_short)|uniprotkb:Icad(gene name synonym)|uniprotkb:DNA fragmentation factor 45 kDa subunit(gene name synonym)|uniprotkb:Inhibitor of CAD(gene name synonym)	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827737|imex:IM-26697-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020467.1|ensembl:ENSMUSG00000028974(gene)|ensembl:ENSMUST00000030816(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032076"(negative regulation of deoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0060703"(deoxyribonuclease inhibitor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015121(DNA Fragmentation factor 45kDa, C terminal)|interpro:IPR017299(DNA fragmentation factor, alpha subunit)|interpro:IPR027296|rcsb pdb:1F2R|reactome:R-MMU-140342	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	-	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	figure legend:Fig. 2|comment:"Immunoblot analysis of the glycerol gradient fractions revealed that the majority of ASK1 and CIIA were present in the same fractions (Fig. 2, fractions 10–16). CIIA and CAD also resided in the same fractions (Fig. 2, fractions 10–17). These fractionation results suggest that CIIA is in close proximity to ASK1 and to CAD."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/11/09	2018/11/12	rogid:MVg3+6pxmmcKBjFz1apoG3Di0Ig10090	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rigid:eRLSuu+v6B5LUAXxKlsN6hrWsbI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54786	uniprotkb:O35099	intact:EBI-1634519|uniprotkb:O54787|uniprotkb:Q8BQC7|uniprotkb:B2KFX0|ensembl:ENSMUSP00000030816	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	psi-mi:dffa_mouse(display_long)|uniprotkb:Dffa(gene name)|psi-mi:Dffa(display_short)|uniprotkb:Icad(gene name synonym)|uniprotkb:DNA fragmentation factor 45 kDa subunit(gene name synonym)|uniprotkb:Inhibitor of CAD(gene name synonym)	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827737|imex:IM-26697-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020467.1|ensembl:ENSMUSG00000028974(gene)|ensembl:ENSMUST00000030816(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032076"(negative regulation of deoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0060703"(deoxyribonuclease inhibitor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015121(DNA Fragmentation factor 45kDa, C terminal)|interpro:IPR017299(DNA fragmentation factor, alpha subunit)|interpro:IPR027296|rcsb pdb:1F2R|reactome:R-MMU-140342	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	-	-	-	figure legend:Fig. 2|comment:"Immunoblot analysis of the glycerol gradient fractions revealed that the majority of ASK1 and CIIA were present in the same fractions (Fig. 2, fractions 10–16). CIIA and CAD also resided in the same fractions (Fig. 2, fractions 10–17). These fractionation results suggest that CIIA is in close proximity to ASK1 and to CAD."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/11/09	2018/11/12	rogid:MVg3+6pxmmcKBjFz1apoG3Di0Ig10090	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rigid:eRLSuu+v6B5LUAXxKlsN6hrWsbI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54786	uniprotkb:Q9D1C8	intact:EBI-1634519|uniprotkb:O54787|uniprotkb:Q8BQC7|uniprotkb:B2KFX0|ensembl:ENSMUSP00000030816	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffa_mouse(display_long)|uniprotkb:Dffa(gene name)|psi-mi:Dffa(display_short)|uniprotkb:Icad(gene name synonym)|uniprotkb:DNA fragmentation factor 45 kDa subunit(gene name synonym)|uniprotkb:Inhibitor of CAD(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827737|imex:IM-26697-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020467.1|ensembl:ENSMUSG00000028974(gene)|ensembl:ENSMUST00000030816(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032076"(negative regulation of deoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0060703"(deoxyribonuclease inhibitor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015121(DNA Fragmentation factor 45kDa, C terminal)|interpro:IPR017299(DNA fragmentation factor, alpha subunit)|interpro:IPR027296|rcsb pdb:1F2R|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig. 2|comment:"Immunoblot analysis of the glycerol gradient fractions revealed that the majority of ASK1 and CIIA were present in the same fractions (Fig. 2, fractions 10–16). CIIA and CAD also resided in the same fractions (Fig. 2, fractions 10–17). These fractionation results suggest that CIIA is in close proximity to ASK1 and to CAD."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/11/09	2018/11/12	rogid:MVg3+6pxmmcKBjFz1apoG3Di0Ig10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:eRLSuu+v6B5LUAXxKlsN6hrWsbI	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35099	uniprotkb:Q9D1C8	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827791|imex:IM-26697-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig.3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2018/11/09	2018/11/12	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:51V4PLWljlv9edYsgeVqeVFYgK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827965|imex:IM-26697-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig.4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2018/11/09	2018/11/12	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35099	uniprotkb:Q9D1C8	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827809|imex:IM-26697-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig.3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2018/11/09	2018/11/12	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:51V4PLWljlv9edYsgeVqeVFYgK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827954|imex:IM-26697-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig.4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2018/11/09	2018/11/12	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35099	uniprotkb:Q9D1C8	intact:EBI-777493|uniprotkb:Q14AY5|ensembl:ENSMUSP00000093485	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:Map3k5(gene name)|psi-mi:Map3k5(display_short)|uniprotkb:Ask1(gene name synonym)|uniprotkb:Mekk5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827861|imex:IM-26697-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032606.4|dip:DIP-38055N|ensembl:ENSMUSG00000071369(gene)|ensembl:ENSMUST00000095806(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902170"(cellular response to reactive nitrogen species)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:O35099|reactome:R-MMU-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	-	-	figure legend:Fig.3E|comment:"Subsequently, we examined a time course of the H2O2 action on the physical association of endogenous CIIA and ASK1 proteins in L929 cells (Fig. 3 E). Coimmunoprecipitation results indicated that H2O2-induced enhancement of the interaction between the two endogenous proteins was maximal at 1 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-l-929)|taxid:10090(Mus musculus L929 fibroblasts)	-	2018/11/09	2018/11/12	rogid:i1P8YtUNmpFauFUVVxzsMYoQYOw10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:51V4PLWljlv9edYsgeVqeVFYgK0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827969|imex:IM-26697-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	-	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig.3E|comment:"Physical interaction between CIIA and CAD was maximal after 30 min of an exposure of L929 cells to H2O2 (Fig. 4 F)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-l-929)|taxid:10090(Mus musculus L929 fibroblasts)	-	2018/11/09	2018/11/12	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9D1C8	uniprotkb:Q99683	intact:EBI-309205|ensembl:ENSMUSP00000077856	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827876|imex:IM-26697-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2018/11/09	2018/11/12	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rigid:YlYjb1UUDCYku0q/LJG6wbo9zH8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D1C8	uniprotkb:Q99683	intact:EBI-309205|ensembl:ENSMUSP00000077856	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827889|imex:IM-26697-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	-	-	-	figure legend:Fig. 3D|comment:"Physical association between CIIA and ASK1 was also confirmed by coimmunoprecipitation in 293T cells transfected with plasmids encoding HA-tagged CIIA and Flag-tagged ASK1 (ASK1-Flag; Fig. 3 D). Interestingly, the interaction between ectopic CIIA and ASK1 was increased by H2O2 treatment."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/11/09	2018/11/12	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rigid:YlYjb1UUDCYku0q/LJG6wbo9zH8	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99683	uniprotkb:Q9D1C8	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20827984|imex:IM-26697-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. S1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/11/09	2018/12/13	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:YlYjb1UUDCYku0q/LJG6wbo9zH8	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:O54788	uniprotkb:Q9D1C8	intact:EBI-7365197|intact:MINT-142143|ensembl:ENSMUSP00000030893	intact:EBI-309205|ensembl:ENSMUSP00000077856	psi-mi:dffb_mouse(display_long)|uniprotkb:Dffb(gene name)|psi-mi:Dffb(display_short)|uniprotkb:Cad(gene name synonym)|uniprotkb:DNA fragmentation factor 40 kDa subunit(gene name synonym)|uniprotkb:Caspase-activated deoxyribonuclease(gene name synonym)	psi-mi:vps28_mouse(display_long)|uniprotkb:Vps28(gene name)|psi-mi:Vps28(display_short)|uniprotkb:Caspase-activated DNase inhibitor that interacts with ASK1(gene name synonym)|uniprotkb:ESCRT-I complex subunit VPS28(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Cho et al. (2003)	imex:IM-26697|pubmed:14557248	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20828024|imex:IM-26697-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031885.3|ensembl:ENSMUSG00000029027(gene)|ensembl:ENSMUST00000030893(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006308"(DNA catabolic process)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015311(Apoptosis, DNA fragmentation factor 40 kDa)|interpro:IPR039729|mint:O54788|rcsb pdb:1C9F|rcsb pdb:1F2R|rcsb pdb:1V0D|reactome:R-MMU-140342	refseq:NP_080118.1|refseq:NP_001292597.1|ensembl:ENSMUSG00000115987(gene)|ensembl:ENSMUST00000078803(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR007143(Vacuolar protein sorting-associated, VPS28)|interpro:IPR017898|interpro:IPR017899|interpro:IPR037202|interpro:IPR037206|interpro:IPR038358|reactome:R-MMU-917729	go:"GO:0005634"(nucleus)	comment:mint|function:Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology|comment:homomint	-	figure legend:Fig. S1B|comment:Double-labeled immunostaining data revealed that ectopic CIIA was located in both the nucleus and the cytoplasm and that its distribution was overlapped with that of CAD or ASK1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2018/11/09	2018/12/13	rogid:6BiQzdEqkkJvzK4tj/xdBvpkWKY10090	rogid:taeCb221bgPQnpwI2/XdKkdkPeo10090	rigid:ihVszWe01qFDzaC1NskRCt9IHSw	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)