#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75144	uniprotkb:Q9Y6W8	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wang et al. (2002)	pubmed:11956294|imex:IM-26262	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16721426|imex:IM-26262-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	-	-	-	figure legend:Figure 2B-D, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/11	2018/01/11	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:19..19-256..256|fc-igg tag:?-?	mutation disrupting interaction strength:51-51|mutation disrupting interaction strength:69-69|mutation disrupting interaction strength:115-115|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:119-119|mutation decreasing interaction strength:49-49|fc-igg tag:?-?|sufficient binding region:21..21-140..140|mutation increasing interaction strength:52-52|mutation increasing interaction strength:76-76|mutation disrupting interaction strength:114-114|mutation decreasing interaction strength:50-50|mutation disrupting interaction strength:67-67|mutation decreasing interaction strength:64-64	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75144	uniprotkb:Q9Y6W8	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Wang et al. (2002)	pubmed:11956294|imex:IM-26262	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16721478|imex:IM-26262-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	-	-	-	figure legend:Figure 2E, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/11	2018/01/16	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:19..19-256..256|fc-igg tag:?-?	mutation decreasing interaction strength:49-49|mutation disrupting interaction strength:117-117|fc-igg tag:?-?|sufficient binding region:21..21-140..140|mutation increasing interaction strength:52-52|mutation increasing interaction strength:76-76	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75144	uniprotkb:Q9Y6W8	intact:EBI-12923856|uniprotkb:A8MUZ1|uniprotkb:Q9HD18|uniprotkb:Q9NRQ1|ensembl:ENSP00000384432	intact:EBI-3922712|uniprotkb:Q8N6W8|ensembl:ENSP00000319476	psi-mi:icosl_human(display_long)|uniprotkb:ICOSLG(gene name)|psi-mi:ICOSLG(display_short)|uniprotkb:B7 homolog 2(gene name synonym)|uniprotkb:B7-like protein Gl50(gene name synonym)|uniprotkb:B7-related protein 1(gene name synonym)|uniprotkb:B7H2(gene name synonym)|uniprotkb:B7RP1(gene name synonym)|uniprotkb:ICOSL(gene name synonym)|uniprotkb:KIAA0653(gene name synonym)	psi-mi:icos_human(display_long)|uniprotkb:ICOS(gene name)|psi-mi:ICOS(display_short)|uniprotkb:AILIM(gene name synonym)|uniprotkb:Activation-inducible lymphocyte immunomediatory molecule(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2002)	pubmed:11956294|imex:IM-26262	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16721614|imex:IM-26262-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269979.1|refseq:NP_001269980.1|refseq:NP_056074.1|refseq:XP_006723963.1|ensembl:ENSG00000160223(gene)|ensembl:ENST00000407780(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6X4G|rcsb pdb:6X4T|reactome:R-HSA-388841	refseq:NP_036224.1|ensembl:ENSG00000163600(gene)|ensembl:ENST00000316386(transcript)|go:"GO:0002517"(T cell tolerance induction)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039943|rcsb pdb:6X4G|rcsb pdb:7JOO|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-6811558	-	-	-	figure legend:Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/11	2018/01/16	rogid:snSVC/Bkm9RU+dCMNlQek25Sgss9606	rogid:DglYRNszqEdwzyNShTUAjb1vomA9606	rigid:uhRMhIwoeLZljWO1Hm7dLU8CQvI	false	sufficient binding region:19..19-256..256|fc-igg tag:?-?	mutation disrupting interaction strength:117-117|fc-igg tag:?-?|sufficient binding region:21..21-140..140|mutation increasing interaction strength:76-76	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)