#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O89049	uniprotkb:O89049	intact:EBI-20724661|uniprotkb:Q5U344|uniprotkb:Q9JKZ3|uniprotkb:Q9JKZ4|uniprotkb:Q9R1I3	intact:EBI-20724661|uniprotkb:Q5U344|uniprotkb:Q9JKZ3|uniprotkb:Q9JKZ4|uniprotkb:Q9R1I3	psi-mi:trxr1_rat(display_long)|uniprotkb:NADPH-dependent thioredoxin reductase(gene name synonym)|uniprotkb:Thioredoxin reductase TR1(gene name synonym)|uniprotkb:Txnrd1(gene name)|psi-mi:Txnrd1(display_short)|uniprotkb:Trxr1(gene name synonym)	psi-mi:trxr1_rat(display_long)|uniprotkb:NADPH-dependent thioredoxin reductase(gene name synonym)|uniprotkb:Thioredoxin reductase TR1(gene name synonym)|uniprotkb:Txnrd1(gene name)|psi-mi:Txnrd1(display_short)|uniprotkb:Trxr1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sandalova et al. (2001)	pubmed:11481439|imex:IM-26725	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20724659|wwpdb:1H6V|imex:IM-26725-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-5263617|reactome:R-RNO-5628897|reactome:R-RNO-3299685|reactome:R-RNO-499943|go:"GO:0001707"(mesoderm formation)|go:"GO:0001890"(placenta development)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007369"(gastrulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016259"(selenocysteine metabolic process)|go:"GO:0033797"(selenate reductase activity)|go:"GO:0042493"|go:"GO:0042537"(benzene-containing compound metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070276"(halogen metabolic process)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0043025"(neuronal cell body)|rcsb pdb:1H6V|rcsb pdb:3EAN|rcsb pdb:3EAO|rcsb pdb:4KPR|interpro:IPR036188|interpro:IPR023753|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR006338(Thioredoxin and glutathione reductase selenoprotein)|rgd:61959	reactome:R-RNO-5263617|reactome:R-RNO-5628897|reactome:R-RNO-3299685|reactome:R-RNO-499943|go:"GO:0001707"(mesoderm formation)|go:"GO:0001890"(placenta development)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007369"(gastrulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016259"(selenocysteine metabolic process)|go:"GO:0033797"(selenate reductase activity)|go:"GO:0042493"|go:"GO:0042537"(benzene-containing compound metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070276"(halogen metabolic process)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0043025"(neuronal cell body)|rcsb pdb:1H6V|rcsb pdb:3EAN|rcsb pdb:3EAO|rcsb pdb:4KPR|interpro:IPR036188|interpro:IPR023753|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR006338(Thioredoxin and glutathione reductase selenoprotein)|rgd:61959	-	-	-	figure legend:Fig 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2018/08/28	2018/08/28	rogid:QdImA8cc2I5Zq3spceqK0BhOFg010116	rogid:QdImA8cc2I5Zq3spceqK0BhOFg010116	rigid:1hUYqIhp/Q5iQV+R0W0z6betuuU	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)