#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19073	uniprotkb:P29366	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20165892|imex:IM-26392-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:30BD644BA9836B2C	crc64:FB6C525AE9A19181	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/04/23	2018/04/24	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:Q2wQGNuwcdFs/cOSCWgH+q4wUzs	false	flag tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P29366	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20166405|imex:IM-26392-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:856BCAF4EB0A67D1	crc64:FB6C525AE9A19181	figure legend:Fig. 3C, 3F|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:3DWpBSdcUcxdkrnQitEqEpXyPO4	false	ha tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48562	uniprotkb:P11433	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20166628|imex:IM-26392-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	-	-	crc64:856BCAF4EB0A67D1	figure legend:Fig. 3D, 3F|comment:The amount of CDC24 associated with CLA4 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked Cdc42p was expressed in the cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/04/23	2018/04/24	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rigid:sG3LeDECKwEs1LozuiB+ilKGHr8	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P19073	uniprotkb:P11433	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20187640|imex:IM-26392-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	-	crc64:30BD644BA9836B2C	crc64:856BCAF4EB0A67D1	figure legend:Fig. 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/04/23	2018/04/25	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rigid:nb8DcaY//wsMX0mirwy18UrabCQ	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48562	uniprotkb:P29366	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20557948|imex:IM-26392-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	-	crc64:FB6C525AE9A19181	figure legend:Fig. 3B|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/04/23	2018/05/04	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:UHPKotdCnfoP74rLYaRr8mLC/fU	false	ha tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48562	uniprotkb:P29366	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20166261|imex:IM-26392-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	-	crc64:FB6C525AE9A19181	figure legend:Fig. 4D, Fig 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:UHPKotdCnfoP74rLYaRr8mLC/fU	false	myc tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P19073	uniprotkb:P29366	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20188037|imex:IM-26392-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:30BD644BA9836B2C	crc64:FB6C525AE9A19181	figure legend:Fig. 4A, 4E, 5A|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:Q2wQGNuwcdFs/cOSCWgH+q4wUzs	false	mutation with no effect:61-61|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:57-57	myc tag:c-c|necessary binding region:1-234,516-551	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P19073	uniprotkb:P29366	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20188125|imex:IM-26392-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:30BD644BA9836B2C	crc64:FB6C525AE9A19181	figure legend:Fig. 4B, 5D|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/05/04	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:Q2wQGNuwcdFs/cOSCWgH+q4wUzs	false	mutation disrupting interaction strength:57-57|mutation with no effect:61-61|myc tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P48562	uniprotkb:P29366	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190237|imex:IM-26392-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	-	crc64:FB6C525AE9A19181	figure legend:Fig. 4C, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:UHPKotdCnfoP74rLYaRr8mLC/fU	false	glutathione s tranferase tag:n-n	myc tag:c-c|necessary binding region:141-234(IPR035549)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P19073	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190813|imex:IM-26392-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	-	crc64:856BCAF4EB0A67D1	crc64:30BD644BA9836B2C	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rigid:AY9kSgP+7zZzHjekP2m7kTw97yE	false	glutathione s tranferase tag:?-?	mutation:61-61|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P11433	uniprotkb:P29366	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190813|imex:IM-26392-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:856BCAF4EB0A67D1	crc64:FB6C525AE9A19181	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:AY9kSgP+7zZzHjekP2m7kTw97yE	false	glutathione s tranferase tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P48562	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190860|imex:IM-26392-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	-	crc64:856BCAF4EB0A67D1	-	figure legend:Fig.  5A|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P29366	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190860|imex:IM-26392-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:856BCAF4EB0A67D1	crc64:FB6C525AE9A19181	figure legend:Fig.  5A|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P48562	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190935|imex:IM-26392-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	-	crc64:856BCAF4EB0A67D1	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P19073	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190935|imex:IM-26392-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	-	crc64:856BCAF4EB0A67D1	crc64:30BD644BA9836B2C	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:?-?	mutation:61-61|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P11433	uniprotkb:P29366	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20190935|imex:IM-26392-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:856BCAF4EB0A67D1	crc64:FB6C525AE9A19181	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P11433	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191127|imex:IM-26392-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	-	crc64:FB6C525AE9A19181	crc64:856BCAF4EB0A67D1	figure legend:Fig. 5C, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P48562	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191127|imex:IM-26392-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	-	crc64:FB6C525AE9A19181	-	figure legend:Fig. 5C, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P19073	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4274|uniprotkb:Q05978|uniprotkb:D6VYN1|ensemblfungi:YLR229C	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cdc42_yeast(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:SRO2(gene name synonym)|uniprotkb:YLR229C(locus name)|uniprotkb:L8083.13(orf name)|uniprotkb:Suppressor of RHO3 protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191854|imex:IM-26392-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	dip:DIP-862N|refseq:NP_013330.1|sgd:S000004219|mint:P19073|ensemblfungi:YLR229C(gene)|ensemblfungi:YLR229C_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005940"(septin ring)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007119"(budding cell isotropic bud growth)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031106"(septin ring organization)|go:"GO:0031384"(regulation of initiation of mating projection growth)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0043332"(mating projection tip)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060178"(regulation of exocyst localization)|go:"GO:0071944"(cell periphery)|go:"GO:2000222"(positive regulation of pseudohyphal growth)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5626467|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013148|reactome:R-SCE-9013406|reactome:R-SCE-9013409|reactome:R-SCE-983231	-	crc64:FB6C525AE9A19181	crc64:30BD644BA9836B2C	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:4FDrNURFjSZOYUFf/dADXTpoMTc559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P11433	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191854|imex:IM-26392-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	-	crc64:FB6C525AE9A19181	crc64:856BCAF4EB0A67D1	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P48562	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191854|imex:IM-26392-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	-	crc64:FB6C525AE9A19181	-	figure legend:Fig. 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/04/25	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rigid:QK9711Pl7icGD9+SzrGwZg63T70	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11433	uniprotkb:P29366	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:"MI:0096"(pull down)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20559255|imex:IM-26392-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	-	crc64:856BCAF4EB0A67D1	crc64:FB6C525AE9A19181	figure legend:Fig. 5D|comment:The amount of CDC24 associated with BEM1 was unaffected regardless of whether wild-type, GTP-locked, or GDP-locked CDC42 was expressed in the cells. The ohosphorylation state of CDC24 also did not affect BEM1 binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/05/09	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rigid:3DWpBSdcUcxdkrnQitEqEpXyPO4	false	myc tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29366	uniprotkb:P11433	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4220|uniprotkb:D6VPH5|ensemblfungi:YAL041W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cdc24_yeast(display_long)|uniprotkb:CLS4(gene name synonym)|uniprotkb:YAL041W(locus name)|uniprotkb:CDC24(gene name)|psi-mi:CDC24(display_short)|uniprotkb:Calcium regulatory protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191714|imex:IM-26392-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:1343"(enzyme regulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_009359.1|sgd:S000000039|dip:DIP-2228N|mint:P11433|ensemblfungi:YAL041W(gene)|ensemblfungi:YAL041W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000935"(division septum)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031106"(septin ring organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043332"(mating projection tip)|go:"GO:0043577"(chemotropism)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010481(CDC24 calponin)|interpro:IPR033511|interpro:IPR035899|interpro:IPR036872|rcsb pdb:1PQS|rcsb pdb:1Q1O|rcsb pdb:1TZ1|rcsb pdb:2KFJ|rcsb pdb:2KFK	go:"GO:0004672"(protein kinase activity)	crc64:FB6C525AE9A19181	crc64:856BCAF4EB0A67D1	figure legend:Fig. 5C, 5D|comment:Phosphorylation of CDC24 was unaffected by the presence or absence of CDC42|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/05/04	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:Q9eflcLn4oOOeRZ4tTjHrPguDUc559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P29366	uniprotkb:P48562	intact:EBI-3508|uniprotkb:D6VQJ6|ensemblfungi:YBR200W	intact:EBI-4750|uniprotkb:D6W0P6|ensemblfungi:YNL298W	psi-mi:bem1_yeast(display_long)|uniprotkb:Suppressor of RHO3 protein 1(gene name synonym)|uniprotkb:BEM1(gene name)|psi-mi:BEM1(display_short)|uniprotkb:SRO1(gene name synonym)|uniprotkb:YBR200W(locus name)|uniprotkb:YBR1412(orf name)	psi-mi:cla4_yeast(display_long)|uniprotkb:CLA4(gene name)|psi-mi:CLA4(display_short)|uniprotkb:N0450(orf name)|uniprotkb:YNL298W(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Bose et al. (2001)	imex:IM-26392|pubmed:11113154	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20191714|imex:IM-26392-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:1343"(enzyme regulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000404|refseq:NP_009759.3|dip:DIP-688N|mint:P29366|ensemblfungi:YBR200W(gene)|ensemblfungi:YBR200W_mRNA(transcript)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000747"(conjugation with cellular fusion)|go:"GO:0000753"(cell morphogenesis involved in conjugation with cellular fusion)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0005938"(cell cortex)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030427"(site of polarized growth)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR030507|interpro:IPR035548|interpro:IPR035549|interpro:IPR035550|interpro:IPR036028|interpro:IPR036871|rcsb pdb:1IP9|rcsb pdb:1IPG|rcsb pdb:2CZO|rcsb pdb:2KFK|rcsb pdb:2RQV|rcsb pdb:2RQW|rcsb pdb:2V6V|reactome:R-SCE-5668599	refseq:NP_014101.1|sgd:S000005242|dip:DIP-2276N|mint:P48562|ensemblfungi:YNL298W(gene)|ensemblfungi:YNL298W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005933"(cellular bud)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016301"(kinase activity)|go:"GO:0019236"(response to pheromone)|go:"GO:0019899"(enzyme binding)|go:"GO:0031106"(septin ring organization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033923|interpro:IPR036936|reactome:R-SCE-2029482|reactome:R-SCE-389359|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406	go:"GO:0004672"(protein kinase activity)	crc64:FB6C525AE9A19181	-	figure legend:Fig. 5C, 5D|comment:Phosphorylation of CDC24 was unaffected by the presence or absence of CDC42|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/04/23	2018/05/04	rogid:Fq7WxTviE31ivPWGJoZO5DsUcdg559292	rogid:dRa35JRDBbCIp/ocDOt0m9eb1AA559292	rigid:pz7vPmSvwnmJ0LaX8CbsvDDKFfU	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)