#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:26667"	uniprotkb:O43699	intact:EBI-17173139	intact:EBI-2814604|uniprotkb:B2RTS8|uniprotkb:A8MV71|uniprotkb:O43700|uniprotkb:O15388|uniprotkb:C9JBE5|uniprotkb:F8WA78|ensembl:ENSP00000401502	psi-mi:sialic acid(display_short)|psi-mi:"CHEBI:26667"(display_long)|intact:acide sialique(synonym)|intact:acides sialique(synonym)|intact:sialic acids(synonym)|intact:Sialsaeure(synonym)|intact:Sialsaeuren(synonym)	psi-mi:sigl6_human(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Patel et al. (1999)	imex:IM-26382|pubmed:10428856	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17173137|imex:IM-26382-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171018.1|refseq:NP_001171019.1|refseq:NP_001171020.1|refseq:NP_001236.4|refseq:NP_942142.3|refseq:NP_942143.3|ensembl:ENSG00000105492(gene)|ensembl:ENST00000425629(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0005576"(extracellular region)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933	-	-	-	figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/23	2020/12/11	-	rogid:w9T3baYJE/Ki37MxnaQ+F7mKaq89606	-	false	carbohydrate chemical modification:?-?	fc-igg tag:c-c|flag tag:c-c|sufficient binding region:14..14-331..331	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43699	uniprotkb:P41159	intact:EBI-2814604|uniprotkb:B2RTS8|uniprotkb:A8MV71|uniprotkb:O43700|uniprotkb:O15388|uniprotkb:C9JBE5|uniprotkb:F8WA78|ensembl:ENSP00000401502	intact:EBI-12994693|ensembl:ENSP00000312652|uniprotkb:O15158|uniprotkb:Q56A88	psi-mi:sigl6_human(display_long)|uniprotkb:SIGLEC6(gene name)|psi-mi:SIGLEC6(display_short)|uniprotkb:CD33L(gene name synonym)|uniprotkb:CD33L1(gene name synonym)|uniprotkb:OBBP1(gene name synonym)|uniprotkb:CD33 antigen-like 1(gene name synonym)|uniprotkb:CDw327(gene name synonym)|uniprotkb:Obesity-binding protein 1(gene name synonym)	psi-mi:lep_human(display_long)|uniprotkb:LEP(gene name)|psi-mi:LEP(display_short)|uniprotkb:OB(gene name synonym)|uniprotkb:OBS(gene name synonym)|uniprotkb:Obese protein(gene name synonym)|uniprotkb:Obesity factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Patel et al. (1999)	imex:IM-26382|pubmed:10428856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17173179|imex:IM-26382-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171018.1|refseq:NP_001171019.1|refseq:NP_001171020.1|refseq:NP_001236.4|refseq:NP_942142.3|refseq:NP_942143.3|ensembl:ENSG00000105492(gene)|ensembl:ENST00000425629(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0005576"(extracellular region)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933	ensembl:ENSG00000174697(gene)|ensembl:ENST00000308868(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003677"(DNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007565"(female pregnancy)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032814"(regulation of natural killer cell activation)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035904"(aorta development)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0045471"(response to ethanol)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060587"(regulation of lipoprotein lipid oxidation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071298"(cellular response to L-ascorbic acid)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0019953"(sexual reproduction)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030073"(insulin secretion)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0030217"(T cell differentiation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:1904651"(positive regulation of fat cell apoptotic process)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990460"(leptin receptor binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000486"(negative regulation of glutamine transport)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000065(Obesity factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1AX8|reactome:R-HSA-2586552|reactome:R-HSA-381340|reactome:R-HSA-381771|reactome:R-HSA-422085|refseq:NP_000221.1|refseq:XP_005250397.1|dip:DIP-6116N	-	-	-	figure legend:Figure  8-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:91.0x10^-9(molar)	2018/03/23	2020/12/11	rogid:w9T3baYJE/Ki37MxnaQ+F7mKaq89606	rogid:9EbJ+u6ZLggQUr7jBDCWDUSDlHI9606	rigid:s2ygZZWSHsL8DTZYHeypWyoi4rs	false	his tag:?-?|flag tag:?-?|sufficient binding region:14..14-331..331	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15389	uniprotkb:P41159	intact:EBI-750381|ensembl:ENSP00000473238|ensembl:ENSP00000507738|ensembl:ENSP00000415200|ensembl:ENSP00000470259	intact:EBI-12994693|ensembl:ENSP00000312652|uniprotkb:O15158|uniprotkb:Q56A88	psi-mi:sigl5_human(display_long)|uniprotkb:Obesity-binding protein 2(gene name synonym)|uniprotkb:CD33 antigen-like 2(gene name synonym)|uniprotkb:SIGLEC5(gene name)|psi-mi:SIGLEC5(display_short)|uniprotkb:CD33L2(gene name synonym)|uniprotkb:OBBP2(gene name synonym)	psi-mi:lep_human(display_long)|uniprotkb:LEP(gene name)|psi-mi:LEP(display_short)|uniprotkb:OB(gene name synonym)|uniprotkb:OBS(gene name synonym)|uniprotkb:Obese protein(gene name synonym)|uniprotkb:Obesity factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Patel et al. (1999)	imex:IM-26382|pubmed:10428856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17173206|imex:IM-26382-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003821.1|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2ZG1|rcsb pdb:2ZG2|rcsb pdb:2ZG3|reactome:R-HSA-198933|reactome:R-HSA-6798695|ensembl:ENST00000429354(transcript)|ensembl:ENST00000534261(transcript)|ensembl:ENST00000599649(transcript)|ensembl:ENST00000683636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENSG00000105501(gene)|ensembl:ENSG00000268500(gene)	ensembl:ENSG00000174697(gene)|ensembl:ENST00000308868(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003677"(DNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007565"(female pregnancy)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032814"(regulation of natural killer cell activation)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035904"(aorta development)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0045471"(response to ethanol)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060587"(regulation of lipoprotein lipid oxidation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071298"(cellular response to L-ascorbic acid)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0019953"(sexual reproduction)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030073"(insulin secretion)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0030217"(T cell differentiation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:1904651"(positive regulation of fat cell apoptotic process)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990460"(leptin receptor binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000486"(negative regulation of glutamine transport)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000065(Obesity factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1AX8|reactome:R-HSA-2586552|reactome:R-HSA-381340|reactome:R-HSA-381771|reactome:R-HSA-422085|refseq:NP_000221.1|refseq:XP_005250397.1|dip:DIP-6116N	-	-	-	figure legend:Figure  8-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:880.0x10^-9(molar)	2018/03/23	2018/04/12	rogid:bwhrY7Zt2NHccOW9NOaiRf0hofY9606	rogid:9EbJ+u6ZLggQUr7jBDCWDUSDlHI9606	rigid:iJdE8A0L3aLyJES3i0ktmOrPu6g	false	his tag:?-?|flag tag:?-?|sufficient binding region:15..15-434..434	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20138-1	uniprotkb:P41159	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-12994693|ensembl:ENSP00000312652|uniprotkb:O15158|uniprotkb:Q56A88	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:lep_human(display_long)|uniprotkb:LEP(gene name)|psi-mi:LEP(display_short)|uniprotkb:OB(gene name synonym)|uniprotkb:OBS(gene name synonym)|uniprotkb:Obese protein(gene name synonym)|uniprotkb:Obesity factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Patel et al. (1999)	imex:IM-26382|pubmed:10428856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17173226|imex:IM-26382-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	ensembl:ENSG00000174697(gene)|ensembl:ENST00000308868(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003677"(DNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006909"(phagocytosis)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007565"(female pregnancy)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032814"(regulation of natural killer cell activation)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035904"(aorta development)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0045471"(response to ethanol)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060587"(regulation of lipoprotein lipid oxidation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0071298"(cellular response to L-ascorbic acid)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0098868"(bone growth)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0019953"(sexual reproduction)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030073"(insulin secretion)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0030217"(T cell differentiation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032310"(prostaglandin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:1904651"(positive regulation of fat cell apoptotic process)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990460"(leptin receptor binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000486"(negative regulation of glutamine transport)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000065(Obesity factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1AX8|reactome:R-HSA-2586552|reactome:R-HSA-381340|reactome:R-HSA-381771|reactome:R-HSA-422085|refseq:NP_000221.1|refseq:XP_005250397.1|dip:DIP-6116N	-	-	-	figure legend:Figure  8-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.9x10^-6(molar)	2018/03/23	2018/04/12	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rogid:9EbJ+u6ZLggQUr7jBDCWDUSDlHI9606	rigid:xZEX0pfSdoFVLfWyxklT7CB4kLo	false	flag tag:?-?|his tag:?-?|sufficient binding region:15..15-255..255	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)