#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P07766 uniprotkb:O76036 intact:EBI-1211297|uniprotkb:A8K997|intact:EBI-28973315|ensembl:ENSP00000354566 intact:EBI-13915737|uniprotkb:B0V3L2|uniprotkb:B0V3L3|uniprotkb:B0V3L4|uniprotkb:B0V3L5|uniprotkb:B8JL03|uniprotkb:O76016|uniprotkb:O76017|uniprotkb:O76018|ensembl:ENSP00000478507|ensembl:ENSP00000481971|ensembl:ENSP00000482423|ensembl:ENSP00000483452|ensembl:ENSP00000484221|ensembl:ENSP00000484520 psi-mi:cd3e_human(display_long)|uniprotkb:CD3E(gene name)|psi-mi:CD3E(display_short)|uniprotkb:T3E(gene name synonym)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym) psi-mi:nctr1_human(display_long)|uniprotkb:NCR1(gene name)|psi-mi:NCR1(display_short)|uniprotkb:LY94(gene name synonym)|uniprotkb:Lymphocyte antigen 94 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p46-related protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Vitale et al. (1998) pubmed:9625766|imex:IM-25815 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13915735|imex:IM-25815-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000724.1|ensembl:ENSP00000354566|ensembl:ENSG00000198851(gene)|ensembl:ENST00000361763(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P07766|rcsb pdb:1A81|rcsb pdb:1SY6|rcsb pdb:1XIW|rcsb pdb:2ROL|rcsb pdb:5QU2|rcsb pdb:6JXR|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948 refseq:NP_001138929.2|refseq:NP_001138930.2|refseq:NP_001229285.1|refseq:NP_001229286.1|refseq:NP_004820.2|ensembl:ENSG00000273535(gene)|ensembl:ENSG00000275156(gene)|ensembl:ENSG00000278362(gene)|ensembl:ENST00000610621(transcript)|ensembl:ENST00000612896(transcript)|ensembl:ENST00000615622(transcript)|ensembl:ENST00000617154(transcript)|ensembl:ENST00000617784(transcript)|ensembl:ENST00000619077(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1OLL|rcsb pdb:1P6F|rcsb pdb:6IAP|reactome:R-HSA-198933 - - - figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells) - 2017/02/16 2017/02/16 rogid:9BgUsAHGr15di4bpGeW9UjdzWlE9606 rogid:FzfU+jTvlPUvjgqpbZjkL7NYZt09606 rigid:JFLazhNJSG9vRQbxIA7+aOagujs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)