#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16428578|imex:IM-26150-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Fig. 2, 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:70.5x10^-9 ~22.5(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	glutathione s tranferase tag:n-n|sufficient binding region:75-155	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P27615	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519136|imex:IM-26150-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/18	2017/10/30	-	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	-	glutathione s tranferase tag:n-n|125i radiolabel:?-?|sufficient binding region:75-155	1	1	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	uniprotkb:P16671	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519219|imex:IM-26150-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	-	-	-	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:45.0x10^-9 ~5.0(molar)|ic50:55.0x10^-9 ~5.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	sufficient binding region:93-120,67-157	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519219|imex:IM-26150-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:45.0x10^-9 ~5.0(molar)|ic50:55.0x10^-9 ~5.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P16671	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519252|imex:IM-26150-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)|ic50:80.0x10^-9(molar)	2017/10/18	2017/10/30	-	rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606	-	false	-	sufficient binding region:93-120,67-157	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P27615	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519252|imex:IM-26150-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:40.0x10^-9(molar)|ic50:80.0x10^-9(molar)	2017/10/18	2017/10/30	-	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	-	sufficient binding region:75-155|125i radiolabel:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	uniprotkb:P07996	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530274|uniprotkb:A8K6H4|uniprotkb:B9EGH6|uniprotkb:Q15667|ensembl:ENSP00000260356|uniprotkb:B4E3J7|uniprotkb:Q59E99	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:tsp1_human(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519270|imex:IM-26150-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	ensembl:ENSG00000137801(gene)|ensembl:ENST00000260356(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002581"(negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0010754"(negative regulation of cGMP-mediated signaling)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030141"(secretory granule)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032570"(response to progesterone)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0008201"(heparin binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070052"(collagen V binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003367(Thrombospondin type 3 repeat)|interpro:IPR008859(Thrombospondin, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017897|interpro:IPR028499|interpro:IPR028974|interpro:IPR036383|mint:P07996|rcsb pdb:1LSL|rcsb pdb:1UX6|rcsb pdb:1Z78|rcsb pdb:1ZA4|rcsb pdb:2ERF|rcsb pdb:2ES3|rcsb pdb:2OUH|rcsb pdb:2OUJ|rcsb pdb:3R6B|rcsb pdb:5FOE|reactome:R-HSA-114608|reactome:R-HSA-186797|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-5083635|reactome:R-HSA-5173214|reactome:R-HSA-8936459|refseq:NP_003237.2|dip:DIP-1037N	-	-	-	figure legend:Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	rogid:wqgWk4yWvhfEjrD+H6BdJrJgVgg9606	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	sufficient binding region:504-509	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519270|imex:IM-26150-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519287|imex:IM-26150-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:55.0x-9^-9 ~15.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519287|imex:IM-26150-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:55.0x-9^-9 ~15.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	sufficient binding region:75-155|glutathione s tranferase tag:n-n	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	matrixdb:MULT_57_human	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519299|imex:IM-26150-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:1302"(stable complex)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:49.0x-9^-9 ~15.0(molar)	2017/10/18	2017/10/30	-	-	-	false	-	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P27615	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519299|imex:IM-26150-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:49.0x-9^-9 ~15.0(molar)	2017/10/18	2017/10/30	-	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	-	125i radiolabel:?-?|sufficient binding region:75-155|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	uniprotkb:P27615	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519313|imex:IM-26150-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	-	-	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:58.0x10^-9 ~10.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	glutathione s tranferase tag:n-n|sufficient binding region:75-155	sufficient binding region:75-155|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P27615	matrixdb:MULT_57_human	intact:EBI-917015|ensembl:ENSRNOP00000003052	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519313|imex:IM-26150-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	-	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:58.0x10^-9 ~10.0(molar)	2017/10/18	2017/10/30	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	-	false	glutathione s tranferase tag:n-n|sufficient binding region:75-155	125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P27615	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519332|imex:IM-26150-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:58.0x10^-9 ~10.0(molar)	2017/10/18	2017/10/30	-	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	-	sufficient binding region:75-155|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
matrixdb:MULT_57_human	uniprotkb:P27615	intact:EBI-2530370|reactome:R-HSA-265405|reactome:R-HSA-549142	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:thbs1_human(display_short)|psi-mi:MULT_57_human(display_long)|intact:Thrombospondin 1 complex(complex recommended name)|intact:THBS1 trimer(complex systematic name)|intact:TSP1 trimer(complex synonym)|intact:TSP-1 trimer(complex synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Crombie et al. (1998)	pubmed:9478926|imex:IM-26150	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-16519332|imex:IM-26150-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0008201"(heparin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0043236"(laminin binding)|go:"GO:0043394"(proteoglycan binding)|pubmed:15094115(see-also)|go:"GO:1990341"(thrombospondin complex)|complex portal:CPX-1785(complex-primary)|evidence ontology:"ECO:0005547"	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	curated-complex:Secreted glycoprotein that functions during the tissue remodeling that is associated with development, wound healing, synaptogenesis, angiogenesis, and cancer. Through its interactions with proteins and proteoglycans, such as glycosaminoglycans, low density lipoprotein receptor-related protein-1, various integrins, calreticulin, and fibrinogen, TSP-1 functions at the interface of the cell membrane and the extracellular matrix to regulate matrix structure and cellular behaviour.|complex-assembly:Homotrimer	-	figure legend:Figure 3, Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:58.0x10^-9 ~10.0(molar)	2017/10/18	2017/10/30	-	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	-	false	-	125i radiolabel:?-?|glutathione s tranferase tag:n-n|sufficient binding region:75-155	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)