#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26769	uniprotkb:P04896	intact:EBI-1027877	intact:EBI-1027885|uniprotkb:Q0II85|uniprotkb:Q3SZE7|ensembl:ENSBTAP00000072381	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:gnas2_bovin(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Tesmer et al. (1997)	pubmed:9417641|doi:10.1126/science.278.5345.1907|imex:IM-25236	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213489|imex:IM-25236-1|dip:DIP-64527E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787	ensembl:ENSBTAG00000052413(gene)|ensembl:ENSBTAT00000070189(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0050890"(cognition)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1AZS|rcsb pdb:1AZT|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|rcsb pdb:3SN6|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6R3Q|rcsb pdb:6R4O|rcsb pdb:6R4P|rcsb pdb:7D68|rcsb pdb:7JJO|refseq:NP_851364.1|refseq:NP_001258700.1|dip:DIP-588N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:rTD7fCRhOQ21mLZdPipFi9k9dEM9913	rigid:gp++KCaEKiPRBo2kanD1AieiKhc	false	sufficient binding region:870-1081	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26769	uniprotkb:P30803-1	intact:EBI-1027877	intact:EBI-16213478	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:p30803-1(display_long)|uniprotkb:ADCY5(gene name)|psi-mi:ADCY5(display_short)|uniprotkb:ATP pyrophosphate-lyase 5(gene name synonym)|uniprotkb:Adenylate cyclase type V(gene name synonym)|uniprotkb:Adenylyl cyclase 5(gene name synonym)|uniprotkb:"Ca(2+)-inhibitable adenylyl cyclase"(gene name synonym)|uniprotkb:V(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Tesmer et al. (1997)	pubmed:9417641|doi:10.1126/science.278.5345.1907|imex:IM-25236	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213489|imex:IM-25236-1|dip:DIP-64527E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787	intact:EBI-1027903(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:/JbcRESNO3Iro+ReDr6cy6jI3Jg9615	rigid:gp++KCaEKiPRBo2kanD1AieiKhc	false	sufficient binding region:870-1081	sufficient binding region:444-656	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26769	uniprotkb:P04896	intact:EBI-1027877	intact:EBI-1027885|uniprotkb:Q0II85|uniprotkb:Q3SZE7|ensembl:ENSBTAP00000072381	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:gnas2_bovin(display_long)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:GNAS1(gene name synonym)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Tesmer et al. (1997)	pubmed:9417641|doi:10.1126/science.278.5345.1907|imex:IM-25236	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213511|imex:IM-25236-2|dip:DIP-64527E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787	ensembl:ENSBTAG00000052413(gene)|ensembl:ENSBTAT00000070189(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048589"(developmental growth)|go:"GO:0050890"(cognition)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0060348"(bone development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:1AZS|rcsb pdb:1AZT|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|rcsb pdb:3SN6|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6R3Q|rcsb pdb:6R4O|rcsb pdb:6R4P|rcsb pdb:7D68|rcsb pdb:7JJO|refseq:NP_851364.1|refseq:NP_001258700.1|dip:DIP-588N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:rTD7fCRhOQ21mLZdPipFi9k9dEM9913	rigid:gp++KCaEKiPRBo2kanD1AieiKhc	false	sufficient binding region:870-1081	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26769	uniprotkb:P30803-1	intact:EBI-1027877	intact:EBI-16213478	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:p30803-1(display_long)|uniprotkb:ADCY5(gene name)|psi-mi:ADCY5(display_short)|uniprotkb:ATP pyrophosphate-lyase 5(gene name synonym)|uniprotkb:Adenylate cyclase type V(gene name synonym)|uniprotkb:Adenylyl cyclase 5(gene name synonym)|uniprotkb:"Ca(2+)-inhibitable adenylyl cyclase"(gene name synonym)|uniprotkb:V(isoform synonym)	psi-mi:"MI:0071"(molecular sieving)	Tesmer et al. (1997)	pubmed:9417641|doi:10.1126/science.278.5345.1907|imex:IM-25236	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213511|imex:IM-25236-2|dip:DIP-64527E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787	intact:EBI-1027903(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:/JbcRESNO3Iro+ReDr6cy6jI3Jg9615	rigid:gp++KCaEKiPRBo2kanD1AieiKhc	false	sufficient binding region:870-1081	sufficient binding region:444-656	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)