#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P80424 uniprotkb:P00761 intact:EBI-8611877|intact:MINT-1526663 intact:EBI-8103966|intact:MINT-1512991 psi-mi:ldti_hirme(display_long) psi-mi:tryp_pig(display_long) psi-mi:"MI:0114"(x-ray crystallography) Di et al. (1997) pubmed:9384562|doi:"10.1016/s0969-2126(97)00296-7"|imex:IM-23727 taxid:6421(medicinal leech)|taxid:6421(Hirudo medicinalis) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16213423|imex:IM-23727-1|dip:DIP-10966E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:1AN1|rcsb pdb:1LDT|rcsb pdb:2KMO|rcsb pdb:2KMP|rcsb pdb:2KMQ|rcsb pdb:2KMR|dip:DIP-6084N dip:DIP-6083N|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007586"(digestion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1AKS|rcsb pdb:1AN1|rcsb pdb:1AVW|rcsb pdb:1AVX|rcsb pdb:1C9P|rcsb pdb:1D3O|rcsb pdb:1DF2|rcsb pdb:1EJA|rcsb pdb:1EPT|rcsb pdb:1EWU|rcsb pdb:1FMG|rcsb pdb:1FN6|rcsb pdb:1FNI|rcsb pdb:1H9H|rcsb pdb:1H9I|rcsb pdb:1LDT|rcsb pdb:1LT2|rcsb pdb:1MCT|rcsb pdb:1QQU|rcsb pdb:1S5S|rcsb pdb:1S6F|rcsb pdb:1S6H|rcsb pdb:1S81|rcsb pdb:1S82|rcsb pdb:1S83|rcsb pdb:1S84|rcsb pdb:1S85|rcsb pdb:1TFX|rcsb pdb:1TX6|rcsb pdb:1UHB|rcsb pdb:1V6D|rcsb pdb:1YF4|rcsb pdb:1Z7K|rcsb pdb:2A31|rcsb pdb:2A32|rcsb pdb:3MYW|rcsb pdb:4AN7|rcsb pdb:4DOQ|rcsb pdb:5XWJ|rcsb pdb:5XWL psi-mi:"MI:0465"(dip) comment:mint|function:Acts as an inhibitor of human tryptase, trypsin and chymotrypsin. Probably acts to block host defense mechanisms comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:7hLTd4Ca6GPkdRJWs1bx2tNTKLc6421 rogid:ps55U1yXkewWxs1VL93BuAFWsa09823 rigid:rl48Y1V7aPYCojS3XLy4FU9mZN4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)