#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32917	uniprotkb:P23561	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	intact:EBI-18259|uniprotkb:D6VZ00|ensemblfungi:YLR362W	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:ste11_yeast(display_long)|uniprotkb:STE11(gene name)|psi-mi:STE11(display_short)|uniprotkb:L8039.10(orf name)|uniprotkb:YLR362W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inouye et al. (1997)	pubmed:9311911|doi:10.1126/science.278.5335.103|imex:IM-25234	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213302|imex:IM-25234-1|dip:DIP-1015E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	refseq:NP_013466.1|sgd:S000004354|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035405"(histone-threonine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029458|rcsb pdb:1OW5|rcsb pdb:1X9X|reactome:R-SCE-2559580|ensemblfungi:YLR362W(gene)|ensemblfungi:YLR362W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|dip:DIP-861N|mint:P23561	psi-mi:"MI:0465"(dip)	crc64:0435BDA0196B2D6F	crc64:E9E0DF27114EEEEF	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	rogid:KhdnSv61wKSQuH5bBkQS9yVxLns559292	rigid:E0KvwRakNEg7hYiAWsrICIO1gdo	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06784	uniprotkb:P32917	intact:EBI-18389|uniprotkb:D6VRJ2|ensemblfungi:YDL159W	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	psi-mi:ste7_yeast(display_long)|uniprotkb:STE7(gene name)|psi-mi:STE7(display_short)|uniprotkb:D1525(orf name)|uniprotkb:YDL159W(locus name)	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inouye et al. (1997)	pubmed:9311911|doi:10.1126/science.278.5335.103|imex:IM-25234	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213344|imex:IM-25234-3|dip:DIP-1016E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010122.1|sgd:S000002318|reactome:R-SCE-112411|reactome:R-SCE-445144|reactome:R-SCE-5674135|reactome:R-SCE-5674499|ensemblfungi:YDL159W(gene)|ensemblfungi:YDL159W_mRNA(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0043332"(mating projection tip)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-110056|dip:DIP-9N|mint:P06784	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	psi-mi:"MI:0465"(dip)	crc64:C8A75899CFBE8BDE	crc64:0435BDA0196B2D6F	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:dyC78MRkFAByOXZMkYmZ8nul+dU559292	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	rigid:gtEoqcBVpwl+M5VAwVak6f5qAyU	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18851	uniprotkb:P32917	intact:EBI-7390|uniprotkb:D6W2R8|ensemblfungi:YOR212W	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	psi-mi:gbb_yeast(display_long)|uniprotkb:YOR50-2(orf name)|uniprotkb:YOR212W(locus name)|uniprotkb:STE4(gene name)|psi-mi:STE4(display_short)	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inouye et al. (1997)	pubmed:9311911|doi:10.1126/science.278.5335.103|imex:IM-25234	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213321|imex:IM-25234-2|dip:DIP-1067E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005738|refseq:NP_014855.3|mint:P18851|dip:DIP-954N|ensemblfungi:YOR212W(gene)|ensemblfungi:YOR212W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005937"(mating projection)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043577"(chemotropism)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120171"(Cdc24p-Far1p-Gbetagamma complex)|go:"GO:1903260"(protein localization to mating projection tip)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1SCG|reactome:R-SCE-6814122	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	psi-mi:"MI:0465"(dip)	crc64:4B0E26040AAA83E5	crc64:0435BDA0196B2D6F	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:nDgadSWQPcmSvQlIEjpNHPl3Hjc559292	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	rigid:UCR03YFGyq6xGOlieNkwhdGZTCk	false	-	myc tag:n-n|mutation disrupting interaction:180-180,177-177	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16892	uniprotkb:P32917	intact:EBI-7193|uniprotkb:D6VPY4|ensemblfungi:YBL016W	intact:EBI-18373|uniprotkb:D6VS89|ensemblfungi:YDR103W	psi-mi:fus3_yeast(display_long)|uniprotkb:FUS3(gene name)|psi-mi:FUS3(display_short)|uniprotkb:DAC2(gene name synonym)|uniprotkb:YBL016W(locus name)|uniprotkb:YBL0303(orf name)|uniprotkb:YBL03.21(orf name)	psi-mi:ste5_yeast(display_long)|uniprotkb:STE5(gene name)|psi-mi:STE5(display_short)|uniprotkb:NUL3(gene name synonym)|uniprotkb:YDR103W(locus name)|uniprotkb:YD8557.12(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Inouye et al. (1997)	pubmed:9311911|doi:10.1126/science.278.5335.103|imex:IM-25234	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16213363|imex:IM-25234-4|dip:DIP-1017E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009537.1|sgd:S000000112|dip:DIP-714N|mint:P16892|ensemblfungi:YBL016W(gene)|ensemblfungi:YBL016W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010526"(negative regulation of transposition, RNA-mediated)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042597"(periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051301"(cell division)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2B9F|rcsb pdb:2B9H|rcsb pdb:2B9I|rcsb pdb:2B9J|rcsb pdb:2F49|rcsb pdb:2F9G|rcsb pdb:2FA2|reactome:R-SCE-110056|reactome:R-SCE-111995|reactome:R-SCE-112409|reactome:R-SCE-112411|reactome:R-SCE-170968|reactome:R-SCE-198753|reactome:R-SCE-202670|reactome:R-SCE-2559582|reactome:R-SCE-3371453|reactome:R-SCE-375165|reactome:R-SCE-437239|reactome:R-SCE-445144|reactome:R-SCE-450341|reactome:R-SCE-5673001|reactome:R-SCE-5674135|reactome:R-SCE-5674499|reactome:R-SCE-5687128|reactome:R-SCE-6798695|reactome:R-SCE-881907|reactome:R-SCE-9634635	refseq:NP_010388.1|sgd:S000002510|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0019900"(kinase binding)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0070867"(mating projection tip membrane)|interpro:IPR021106|interpro:IPR021651|interpro:IPR038382|rcsb pdb:2KGN|rcsb pdb:2L4U|rcsb pdb:3FZE|rcsb pdb:4F2H|go:"GO:0005886"(plasma membrane)|ensemblfungi:YDR103W(gene)|ensemblfungi:YDR103W_mRNA(transcript)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|dip:DIP-858N|mint:P32917	psi-mi:"MI:0465"(dip)	crc64:5117980D20A1E7E2	crc64:0435BDA0196B2D6F	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:FaPNQ+7PYnYCFIVspwEcRFOgv0w559292	rogid:4AGoihw1xiRnhpu4/VuycJzCLaE559292	rigid:z8bRRQgHqqK7UzwqDKBKeV8YYTo	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)