#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40073	uniprotkb:P08018	intact:EBI-18140|uniprotkb:D3DM24|ensemblfungi:YER118C	intact:EBI-12972|uniprotkb:D6VW57|ensemblfungi:YJL128C	psi-mi:sho1_yeast(display_long)|uniprotkb:YER118C(locus name)|uniprotkb:SHO1(gene name)|psi-mi:SHO1(display_short)|uniprotkb:SSU81(gene name synonym)|uniprotkb:Osmosensor SHO1(gene name synonym)|uniprotkb:Suppressor of SUA8-1 mutation(gene name synonym)|uniprotkb:Synthetic high osmolarity-sensitive protein 1(gene name synonym)	psi-mi:pbs2_yeast(display_long)|uniprotkb:PBS2(gene name)|psi-mi:PBS2(display_short)|uniprotkb:HOG4(gene name synonym)|uniprotkb:SFS4(gene name synonym)|uniprotkb:SSK4(gene name synonym)|uniprotkb:YJL128C(locus name)|uniprotkb:J0699(orf name)|uniprotkb:Polymyxin B resistance protein 2(gene name synonym)|uniprotkb:Suppressor of fluoride sensitivity 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posas et al. (1997)	pubmed:9180081|doi:10.1126/science.276.5319.1702|imex:IM-25230	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16212736|imex:IM-25230-1|dip:DIP-3124E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011043.1|sgd:S000000920|go:"GO:0005886"(plasma membrane)|go:"GO:0005933"(cellular bud)|go:"GO:0005935"(cellular bud neck)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0043332"(mating projection tip)|go:"GO:0044697"(HICS complex)|go:"GO:0071944"(cell periphery)|interpro:IPR001452(Src homology-3)|interpro:IPR035522|interpro:IPR036028|ensemblfungi:YER118C(gene)|interpro:IPR039644|rcsb pdb:2VKN|ensemblfungi:YER118C_mRNA(transcript)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005783"(endoplasmic reticulum)|dip:DIP-2472N|mint:P40073	refseq:NP_012407.2|sgd:S000003664|go:"GO:0031416"(NatB complex)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2VKN|reactome:R-SCE-168638|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-450302|reactome:R-SCE-450321|reactome:R-SCE-6811555|go:"GO:0010494"(cytoplasmic stress granule)|ensemblfungi:YJL128C(gene)|ensemblfungi:YJL128C_mRNA(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004596"(peptide alpha-N-acetyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007231"(osmosensory signaling pathway)|mint:P08018|dip:DIP-2368N	psi-mi:"MI:0465"(dip)	crc64:E467A4D50AA3EDB6	crc64:9BC3435BDAFE8019	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:DPpJB36kZxbFXugXajgs899epuY559292	rogid:8kVv+9++58zg4knrpUYi+uGfLK8559292	rigid:Ggx8tZbYSAt8MzKGTpAbD3XBwzw	false	sufficient binding region:170-367|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32485	uniprotkb:P08018	intact:EBI-8437|uniprotkb:Q06232|uniprotkb:Q12294|uniprotkb:D6VYB1|ensemblfungi:YLR113W	intact:EBI-12972|uniprotkb:D6VW57|ensemblfungi:YJL128C	psi-mi:hog1_yeast(display_long)|uniprotkb:HOG1(gene name)|psi-mi:HOG1(display_short)|uniprotkb:SSK3(gene name synonym)|uniprotkb:YLR113W(locus name)|uniprotkb:L2931(orf name)|uniprotkb:L9354.2(orf name)|uniprotkb:High osmolarity glycerol response protein 1(gene name synonym)	psi-mi:pbs2_yeast(display_long)|uniprotkb:PBS2(gene name)|psi-mi:PBS2(display_short)|uniprotkb:HOG4(gene name synonym)|uniprotkb:SFS4(gene name synonym)|uniprotkb:SSK4(gene name synonym)|uniprotkb:YJL128C(locus name)|uniprotkb:J0699(orf name)|uniprotkb:Polymyxin B resistance protein 2(gene name synonym)|uniprotkb:Suppressor of fluoride sensitivity 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posas et al. (1997)	pubmed:9180081|doi:10.1126/science.276.5319.1702|imex:IM-25230	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16212759|imex:IM-25230-2|dip:DIP-2784E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013214.1|sgd:S000004103|dip:DIP-1558N|mint:P32485|ensemblfungi:YLR113W_mRNA(transcript)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038783|reactome:R-SCE-168638|reactome:R-SCE-193648|reactome:R-SCE-198753|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-418592|reactome:R-SCE-432142|reactome:R-SCE-450321|reactome:R-SCE-450341|reactome:R-SCE-525793|reactome:R-SCE-6798695|reactome:R-SCE-9007892|ensemblfungi:YLR113W(gene)	refseq:NP_012407.2|sgd:S000003664|go:"GO:0031416"(NatB complex)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2VKN|reactome:R-SCE-168638|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-450302|reactome:R-SCE-450321|reactome:R-SCE-6811555|go:"GO:0010494"(cytoplasmic stress granule)|ensemblfungi:YJL128C(gene)|ensemblfungi:YJL128C_mRNA(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004596"(peptide alpha-N-acetyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007231"(osmosensory signaling pathway)|mint:P08018|dip:DIP-2368N	psi-mi:"MI:0465"(dip)	crc64:D95A20242587CE06	crc64:9BC3435BDAFE8019	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:Re8xLAJEvP2Fjr0lOGtLB6ANybM559292	rogid:8kVv+9++58zg4knrpUYi+uGfLK8559292	rigid:eFJJYL5SCm70w/C1FEGDv47UQyI	false	ha tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P23561	uniprotkb:P08018	intact:EBI-18259|uniprotkb:D6VZ00|ensemblfungi:YLR362W	intact:EBI-12972|uniprotkb:D6VW57|ensemblfungi:YJL128C	psi-mi:ste11_yeast(display_long)|uniprotkb:STE11(gene name)|psi-mi:STE11(display_short)|uniprotkb:L8039.10(orf name)|uniprotkb:YLR362W(locus name)	psi-mi:pbs2_yeast(display_long)|uniprotkb:PBS2(gene name)|psi-mi:PBS2(display_short)|uniprotkb:HOG4(gene name synonym)|uniprotkb:SFS4(gene name synonym)|uniprotkb:SSK4(gene name synonym)|uniprotkb:YJL128C(locus name)|uniprotkb:J0699(orf name)|uniprotkb:Polymyxin B resistance protein 2(gene name synonym)|uniprotkb:Suppressor of fluoride sensitivity 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Posas et al. (1997)	pubmed:9180081|doi:10.1126/science.276.5319.1702|imex:IM-25230	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16212780|imex:IM-25230-3|dip:DIP-3123E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013466.1|sgd:S000004354|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010525"(regulation of transposition, RNA-mediated)|go:"GO:0032093"(SAM domain binding)|go:"GO:0035405"(histone-threonine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0071507"(pheromone response MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029458|rcsb pdb:1OW5|rcsb pdb:1X9X|reactome:R-SCE-2559580|ensemblfungi:YLR362W(gene)|ensemblfungi:YLR362W_mRNA(transcript)|go:"GO:0000161"(osmosensory signaling MAPK cascade)|go:"GO:0000196"(cell wall integrity MAPK cascade)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|dip:DIP-861N|mint:P23561	refseq:NP_012407.2|sgd:S000003664|go:"GO:0031416"(NatB complex)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2VKN|reactome:R-SCE-168638|reactome:R-SCE-2559580|reactome:R-SCE-2871796|reactome:R-SCE-450302|reactome:R-SCE-450321|reactome:R-SCE-6811555|go:"GO:0010494"(cytoplasmic stress granule)|ensemblfungi:YJL128C(gene)|ensemblfungi:YJL128C_mRNA(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004596"(peptide alpha-N-acetyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007231"(osmosensory signaling pathway)|mint:P08018|dip:DIP-2368N	psi-mi:"MI:0465"(dip)	crc64:E9E0DF27114EEEEF	crc64:9BC3435BDAFE8019	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:KhdnSv61wKSQuH5bBkQS9yVxLns559292	rogid:8kVv+9++58zg4knrpUYi+uGfLK8559292	rigid:ctEIypVKFMSiUL6eX5QRRcJG5Eo	false	ha tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)