#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16701966|imex:IM-26308-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 1B|comment:"CBC and ARS2 (147–871) only co-eluted in the presence of the cap analogue m7GTP"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16701966|imex:IM-26308-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 1B|comment:"CBC and ARS2 (147–871) only co-eluted in the presence of the cap analogue m7GTP"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/13	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:147-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702111|imex:IM-26308-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 2B|comment:"In the absence of m7GTP, CBC and NELF-E (1–380) partially co-eluted indicating a weak interaction of the two proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702111|imex:IM-26308-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 2B|comment:"In the absence of m7GTP, CBC and NELF-E (1–380) partially co-eluted indicating a weak interaction of the two proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/13	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9H814	reactome:R-HSA-162460	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702373|imex:IM-26308-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig Supplementary figure 1|comment:"The CBC–PHAX (1–394) complex can be co-purified using SEC in the absence of m7GTP.  As assayed by SEC, the minimal CBC binding region of PHAX could be narrowed down to residues 103–294."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/14	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	-	false	sufficient binding region:103-294	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710473|imex:IM-26308-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710473|imex:IM-26308-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Supplementary figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710481|imex:IM-26308-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary figure 2A/B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710481|imex:IM-26308-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Supplementary figure 2A/B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710481|imex:IM-26308-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Supplementary figure 2A/B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710489|imex:IM-26308-78	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary figure 2C|comment:A stable CBC–ARS2–PHAX complex can be separated using SEC, but no such complex containing CBC, NELF, and PHAX was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710489|imex:IM-26308-78	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Supplementary figure 2C|comment:A stable CBC–ARS2–PHAX complex can be separated using SEC, but no such complex containing CBC, NELF, and PHAX was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710489|imex:IM-26308-78	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Supplementary figure 2C|comment:A stable CBC–ARS2–PHAX complex can be separated using SEC, but no such complex containing CBC, NELF, and PHAX was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:147-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702046|imex:IM-26308-62	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-6(molar)	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702046|imex:IM-26308-62	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:845-871	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXP5-4	reactome:R-HSA-162460	intact:EBI-16701991|ensembl:ENSP00000483556	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702057|imex:IM-26308-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 1C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:12.2x10^-6(molar)	2017/11/14	2017/12/13	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	-	false	sufficient binding region:827-871	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702145|imex:IM-26308-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.05x10^-6(molar)	2017/11/14	2017/12/13	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702145|imex:IM-26308-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.05x10^-6(molar)	2017/11/14	2017/12/13	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18615-1	reactome:R-HSA-162460	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702176|imex:IM-26308-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 2C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.4x10^-6(molar)	2017/11/14	2017/12/13	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	-	false	sufficient binding region:244-380	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702364|imex:IM-26308-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 2C-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-6(molar)	2017/11/14	2017/12/14	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702364|imex:IM-26308-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 2C-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-6(molar)	2017/11/14	2017/12/14	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:360-380	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
reactome:R-HSA-162460	uniprotkb:Q9H814	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702383|imex:IM-26308-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	-	figure legend:Fig 3A, Table 1|kinetics:Full length PHAX molecule binds with a Kd of 300nM|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:300.0x10^-9(molar)	2017/11/14	2017/12/14	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	sufficient binding region:103-294|sufficient binding region:103-327|sufficient binding region:103-308	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702391|imex:IM-26308-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 3A-2, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:125.0x10^-9(molar)	2017/11/14	2017/12/14	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702391|imex:IM-26308-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Fig 3A-2, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:125.0x10^-9(molar)	2017/11/14	2017/12/14	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706505|imex:IM-26308-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 1C, 5C, Table 1|kinetics:"Kd values for the longer ARS2 constructs(aas 827-871 and 763-871) were 1uM"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-6(molar)	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706505|imex:IM-26308-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 1C, 5C, Table 1|kinetics:"Kd values for the longer ARS2 constructs(aas 827-871 and 763-871) were 1uM"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-6(molar)	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871|mutation decreasing interaction strength:871-871|mutation disrupting interaction strength:845-845,859-859|necessary binding region:845-871	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706600|imex:IM-26308-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:Fig  5C, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.6x10^-6(molar)	2017/11/14	2017/12/15	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation:461-461,610-610,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706600|imex:IM-26308-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Fig  5C, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.6x10^-6(molar)	2017/11/14	2017/12/15	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation:50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706600|imex:IM-26308-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig  5C, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:11.6x10^-6(molar)	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710402|imex:IM-26308-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:Fig 6D, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation disrupting interaction strength:651-651,461-461,610-610|sufficient binding region:1-790	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710402|imex:IM-26308-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Fig 6D, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	sufficient binding region:1-156|mutation disrupting interaction strength:50-50	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710402|imex:IM-26308-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 6D, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/18	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710629|imex:IM-26308-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary Figure 7, table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:125.0x10^-9(molar)	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710636|imex:IM-26308-54	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary Figure 7-2, table 1|comment:"CBC  saturated with  excess  of ARS2 (827-871)or  NELF-E(244-380)  was  titrated  by addition of  m7GTP.  ."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:18.0x10^-9(molar)	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710636|imex:IM-26308-54	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Supplementary Figure 7-2, table 1|comment:"CBC  saturated with  excess  of ARS2 (827-871)or  NELF-E(244-380)  was  titrated  by addition of  m7GTP.  ."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:18.0x10^-9(molar)	2017/11/14	2017/12/18	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710689|imex:IM-26308-56	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Supplementary Figure 7-3, table 1|comment:"CBC  saturated with  excess  of ARS2 (827-871)or  NELF-E(244-380)  was  titrated  by addition of  m7GTP.  ."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.044x10^-6(molar)	2017/11/14	2017/12/18	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710689|imex:IM-26308-56	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Supplementary Figure 7-3, table 1|comment:"CBC  saturated with  excess  of ARS2 (827-871)or  NELF-E(244-380)  was  titrated  by addition of  m7GTP.  ."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.044x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710781|imex:IM-26308-58	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Table 1-1(mut)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.095x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation:461-461,610-610,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710781|imex:IM-26308-58	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Table 1-1(mut)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.095x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation:50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710801|imex:IM-26308-60	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:Table 1-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.5x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation:610-610,461-461,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710801|imex:IM-26308-60	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Table 1-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.5x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation:50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710801|imex:IM-26308-60	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Table 1-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.5x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710819|imex:IM-26308-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Table 1-2 (6_mutations)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:70.0x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation:610-610,461-461,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710819|imex:IM-26308-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Table 1-2 (6_mutations)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:70.0x10^-6(molar)	2017/11/14	2017/12/18	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation:89-89,107-107,50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q09161	uniprotkb:P52298	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0030"(cross-linking study)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702444|imex:IM-26308-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Figure 3B, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/14	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	rigid:bhgVCwRihTZrpsw6zhqMTZR8hlA	false	cross linker:607-607|cross linker:654-654|cross linker:327-327|cross linker:607-607|cross linker:327-327	cross linker:120-120|cross linker:120-120|cross linker:67-67|cross linker:68-68|cross linker:120-120|cross linker:120-120|cross linker:34-34	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q09161	uniprotkb:Q9H814	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0030"(cross-linking study)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16702444|imex:IM-26308-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Figure 3B, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/14	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	rigid:bhgVCwRihTZrpsw6zhqMTZR8hlA	false	cross linker:607-607|cross linker:654-654|cross linker:327-327|cross linker:607-607|cross linker:327-327	cross linker:216-216|cross linker:162-162|cross linker:256-256|cross linker:173-173	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16703874|imex:IM-26308-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16703874|imex:IM-26308-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704234|imex:IM-26308-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4A-2|comment:ARS2 could displace NELF-E from the immobilised m7GTP–CBC–NELF–E complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704234|imex:IM-26308-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4A-2|comment:ARS2 could displace NELF-E from the immobilised m7GTP–CBC–NELF–E complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704234|imex:IM-26308-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4A-2|comment:ARS2 could displace NELF-E from the immobilised m7GTP–CBC–NELF–E complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704327|imex:IM-26308-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704327|imex:IM-26308-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P18615	intact:EBI-1788056	intact:EBI-348444|uniprotkb:B4DUN1|uniprotkb:B4DYX9|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879|ensembl:ENSP00000403623|uniprotkb:Q5JP74|uniprotkb:Q5JP75|uniprotkb:Q96F56|uniprotkb:Q9NPK2|uniprotkb:A2BE08	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:nelfe_human(display_long)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)|uniprotkb:RNA-binding protein RD(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704332|imex:IM-26308-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002895.3|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0032021"(NELF complex)|go:"GO:0005634"(nucleus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033102|interpro:IPR034637|interpro:IPR035979|mint:P18615|rcsb pdb:1X5P|rcsb pdb:2BZ2|rcsb pdb:2JX2|rcsb pdb:5OOB|rcsb pdb:6GML|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|dip:DIP-32669N	-	-	-	figure legend:Fig 4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704332|imex:IM-26308-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Fig 4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704332|imex:IM-26308-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710501|imex:IM-26308-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-1(WT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710501|imex:IM-26308-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:"Supplementary figure 6-1(WT)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	-	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710520|imex:IM-26308-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Supplementary figure 6-2(X6 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation disrupting interaction strength:461-461,610-610,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710520|imex:IM-26308-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-2(X6 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710520|imex:IM-26308-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Supplementary figure 6-2(X6 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation disrupting interaction strength:89-89,107-107,50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710542|imex:IM-26308-50	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Supplementary figure 6-3(cb80 mutant) Upper image"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	mutation decreasing interaction strength:461-461,610-610,651-651|sufficient binding region:1-790	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710542|imex:IM-26308-50	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-3(cb80 mutant) Upper image"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710542|imex:IM-26308-50	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Supplementary figure 6-3(cb80 mutant) Upper image"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	sufficient binding region:1-156	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710563|imex:IM-26308-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Supplementary figure 6-4(cb20 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	sufficient binding region:1-790	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710563|imex:IM-26308-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-4(cb20 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710563|imex:IM-26308-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Supplementary figure 6-4(cb20 mutant)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	sufficient binding region:1-156|mutation decreasing interaction strength:50-50,89-89,107-107	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710585|imex:IM-26308-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Supplementary figure 6-6(bottom-2)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	sufficient binding region:1-790|mutation decreasing interaction strength:461-461,610-610,651-651	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710585|imex:IM-26308-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-6(bottom-2)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710585|imex:IM-26308-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Supplementary figure 6-6(bottom-2)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation decreasing interaction strength:50-50,89-89|sufficient binding region:1-156	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710607|imex:IM-26308-80	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:"Supplementary figure 6-5(cb80mut)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	sufficient binding region:1-790|mutation decreasing interaction strength:461-461,610-610,651-651	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710607|imex:IM-26308-80	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:"Supplementary figure 6-5(cb80mut)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0004"(affinity chromatography technology)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16710607|imex:IM-26308-80	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:"Supplementary figure 6-5(cb80mut)"|comment:"Using the CBC mut ( Y50A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80) and the CBP double mutant (Y50A/Y89A mutation in CBP20 + Y461A/R610E/H651A mutations in CBP80)  a faint band is visible."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/20	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	mutation decreasing interaction strength:50-50|sufficient binding region:1-156	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704644|imex:IM-26308-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704644|imex:IM-26308-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	fluorescein label:n-n|sufficient binding region:845-871	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704650|imex:IM-26308-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4D|comment:The decrease in polarisation indicates the competitive dissociation of the FAM-labelled ARS2 peptide from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704650|imex:IM-26308-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4D|comment:The decrease in polarisation indicates the competitive dissociation of the FAM-labelled ARS2 peptide from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16704650|imex:IM-26308-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4D|comment:The decrease in polarisation indicates the competitive dissociation of the FAM-labelled ARS2 peptide from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:845-871|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706297|imex:IM-26308-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4E, Supplementary Figure 3C|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706297|imex:IM-26308-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4E, Supplementary Figure 3C|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9H814	intact:EBI-1788056	intact:EBI-5667190|uniprotkb:Q9H8W1|ensembl:ENSP00000297540	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:phax_human(display_long)|uniprotkb:RNA U small nuclear RNA export adapter protein(gene name synonym)|uniprotkb:RNUXA(gene name synonym)|uniprotkb:PHAX(gene name)|psi-mi:PHAX(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706297|imex:IM-26308-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_115553.2|rcsb pdb:2XC7|reactome:R-HSA-191859|reactome:R-HSA-6807505|ensembl:ENSG00000164902(gene)|ensembl:ENST00000297540(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0015031"(protein transport)|go:"GO:0015643"(toxic substance binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043489"(RNA stabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019385|interpro:IPR038092|interpro:IPR039047|mint:Q9H814	-	-	-	figure legend:Fig 4E, Supplementary Figure 3C|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:5cyoxIMxtl/gBViCRP3lTsoH/RU9606	-	false	-	sufficient binding region:103-327	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706297|imex:IM-26308-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4E, Supplementary Figure 3C|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:845-871|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706344|imex:IM-26308-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4F, Supplementary figure 3B|comment:"Figure 4H: titration of PHAX (103–327) to m7GTP-CBC-NELF-E (354–380+FAM) did not change the polarisation."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706344|imex:IM-26308-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4F, Supplementary figure 3B|comment:"Figure 4H: titration of PHAX (103–327) to m7GTP-CBC-NELF-E (354–380+FAM) did not change the polarisation."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:354-380|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706354|imex:IM-26308-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4G, Supplementary Fig 2A|comment:The decrease in polarisation indicates the competitive dissociation of  FAM-labelled NELF-E   from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706354|imex:IM-26308-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4G, Supplementary Fig 2A|comment:The decrease in polarisation indicates the competitive dissociation of  FAM-labelled NELF-E   from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:354-380|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706354|imex:IM-26308-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4G, Supplementary Fig 2A|comment:The decrease in polarisation indicates the competitive dissociation of  FAM-labelled NELF-E   from m7GTP-CBC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	reactome:R-HSA-162460	intact:EBI-1788056	intact:EBI-16686827|wwpdb:1h2u|wwpdb:1h2v|wwpdb:1h2t|wwpdb:1n52|wwpdb:1n54|wwpdb:1h6k	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:cbc_human(display_short)|psi-mi:R-HSA-162460(display_long)|intact:Nuclear cap-binding complex(complex recommended name)|intact:CBP20-CBP80 complex(complex synonym)|intact:CBC(complex synonym)|intact:"NCBP1:NCBP2"(complex systematic name)|intact:Cap complex(complex synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20592158|imex:IM-26308-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	go:"GO:0002191"(cap-dependent translational initiation)|intact:EBI-1034907(exp-evidence)|go:"GO:0005845"(mRNA cap binding complex)|pubmed:15547136(see-also)|pubmed:11158589(see-also)|pubmed:24270878(see-also)|complex portal:CPX-1427(complex-primary)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0005737"(cytoplasm)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0005634"(nucleus)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0017069"(snRNA binding)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0031053"(primary miRNA processing)|go:"GO:1901409"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0031124"(mRNA 3'-end processing)|pubmed:24354960(see-also)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|evidence ontology:"ECO:0000353"	-	-	curated-complex:"Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (pre-mRNAs and pre-miRNAs). Required for processes such as transcription elongation, pre-mRNA splicing through commitment and NELF complexes and spliceosome formation, classic mRNA 3-prime end processing, suppression of poly-A tail formation in histone 3-prime end pre-mRNA processing in complex with serrate (SRRT/ARS2, Q9BXP5) and NELF complex, nuclear export of mRNAs and U snRNAs in complex with importin-alpha and either ALYREF (Q86V81) and TREX complex (mRNAs) or PHAX-XPO1/CRM1-RAN.GTP complex (U snRNAs), degradation of nuclear mRNAs via nonsense-mediated decay (NMD), primary miRNA processing in complex with serrate (SRRT/ARS2), miRNA-mediated RNA interference and the pioneer round of translation. During the pioneer round of translation it interacts with CTIF (O43310) which facilitates the eventual release of CBC from the transcript and its replacement by the cytoplasmic cap-binding complex eIF4F. In the cytosol, importin-beta interacts with CBC-bound importin-alpha and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse. NCBP1 phosphorylation correlate with increased cap-dependent splicing activity. Histone pre-mRNA processing and the pioneer round of translation may be restricted to mammalian CBC."|complex-assembly:Heterodimer|complex-properties:NCBP2 directly binds the capped RNAs and NCBP1 is required to stabilize the movement of the N-terminal loop of NCBP2 and lock the CBC into a high affinity cap-binding state with the cap structure.	figure legend:Fig 4E|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/19	-	-	-	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20592158|imex:IM-26308-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Fig 4E|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/19	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:244-380	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20592158|imex:IM-26308-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Fig 4E|comment:"in the presence of ARS2 (827–871+FAM) PHAX (103–327)  was able to displace NELF-E (244–380)  from m7GTP-CBC allowing CBC to rebind ARS2 (827–871+ FAM)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2018/06/19	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:845-871|fluorescein label:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706368|wwpdb:5oob|imex:IM-26308-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:Table 2|3d-resolution:2.79A|3d-r-factors:R free = 0.229  R work= 0.202|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	sufficient binding region:20-790	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706368|wwpdb:5oob|imex:IM-26308-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Table 2|3d-resolution:2.79A|3d-r-factors:R free = 0.229  R work= 0.202|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	sufficient binding region:1-156	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P18615-1	intact:EBI-1788056	intact:EBI-16702122|ensembl:ENSP00000403623|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:p18615-1(display_long)|uniprotkb:RNA-binding protein RD(gene name synonym)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706368|wwpdb:5oob|imex:IM-26308-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|intact:EBI-348444(isoform-parent)	-	-	-	figure legend:Table 2|3d-resolution:2.79A|3d-r-factors:R free = 0.229  R work= 0.202|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606	-	false	-	sufficient binding region:360-380	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q09161	intact:EBI-1788056	intact:EBI-464743|uniprotkb:Q59G76|uniprotkb:Q5T1V0|ensembl:ENSP00000364289|uniprotkb:B2R718|uniprotkb:Q5T7X2	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp1_human(display_long)|uniprotkb:NCBP1(gene name)|psi-mi:NCBP1(display_short)|uniprotkb:CBP80(gene name synonym)|uniprotkb:NCBP(gene name synonym)|uniprotkb:80 kDa nuclear cap-binding protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706477|wwpdb:5oo6|imex:IM-26308-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1905216"(positive regulation of RNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR015172(MIF4G-like, type 1)|interpro:IPR015174(MIF4G-like, type 2)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027159|mint:Q09161|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-167158|ensembl:ENSG00000136937(gene)|ensembl:ENST00000375147(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006406"(mRNA export from nucleus)|refseq:NP_002477.1|dip:DIP-33244N	-	-	-	figure legend:Table 2-2|3d-resolution:2.8A|3d-r-factors:R free = 0.268  R work= 0.231|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:VpCpiIQQZAXyOpu4J7G2k6ilhxY9606	-	false	-	sufficient binding region:20-790	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:P52298	intact:EBI-1788056	intact:EBI-464729|ensembl:ENSP00000326806|uniprotkb:Q14924|uniprotkb:Q2TS50|uniprotkb:B2RE91|uniprotkb:B4DMK7|uniprotkb:E9PAR5	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:ncbp2_human(display_long)|uniprotkb:20 kDa nuclear cap-binding protein(gene name synonym)|uniprotkb:NCBP 20 kDa subunit(gene name synonym)|uniprotkb:NCBP-interacting protein 1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 55 protein(gene name synonym)|uniprotkb:NCBP2(gene name)|psi-mi:NCBP2(display_short)|uniprotkb:CBP20(gene name synonym)|uniprotkb:PIG55(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706477|wwpdb:5oo6|imex:IM-26308-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000114503(gene)|ensembl:ENST00000321256(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005846"(nuclear cap binding complex)|go:"GO:0006408"(snRNA export from nucleus)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008380"(RNA splicing)|go:"GO:0017069"(snRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0034518"(RNA cap binding complex)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P52298|rcsb pdb:1H2T|rcsb pdb:1H2U|rcsb pdb:1H2V|rcsb pdb:1H6K|rcsb pdb:1N52|rcsb pdb:1N54|rcsb pdb:3FEX|rcsb pdb:3FEY|rcsb pdb:5OO6|rcsb pdb:5OOB|rcsb pdb:6D0Y|rcsb pdb:7ABG|reactome:R-HSA-111367|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167242|reactome:R-HSA-191859|interpro:IPR034148|reactome:R-HSA-674695|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-72203|reactome:R-HSA-73856|reactome:R-HSA-77588|reactome:R-HSA-77595|reactome:R-HSA-8851708|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|interpro:IPR027157|refseq:NP_001036005.1|refseq:NP_031388.2|refseq:NP_001294965.1|dip:DIP-33246N	-	-	-	figure legend:Table 2-2|3d-resolution:2.8A|3d-r-factors:R free = 0.268  R work= 0.231|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:o6RiNMygBsTpGq5WzXytRBcC+us9606	-	false	-	sufficient binding region:1-156	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50210"	uniprotkb:Q9BXP5-4	intact:EBI-1788056	intact:EBI-16701991|ensembl:ENSP00000483556	psi-mi:7-methyl-gtp(display_short)|psi-mi:"CHEBI:50210"(display_long)	psi-mi:q9bxp5-4(display_long)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ARS2(gene name synonym)|uniprotkb:ASR2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schulze et al. (2017)	imex:IM-26308|pubmed:29101316	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16706477|wwpdb:5oo6|imex:IM-26308-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000087087(gene)|ensembl:ENST00000618411(transcript)|intact:EBI-712721(isoform-parent)|uniprotkb:Q9BXP5-4(isoform-parent)	-	-	-	figure legend:Table 2-2|3d-resolution:2.8A|3d-r-factors:R free = 0.268  R work= 0.231|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/14	2017/12/15	-	rogid:FjTHOsCifvo/LkeoyfUyU8P+kpk9606	-	false	-	sufficient binding region:827-871	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)