#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586693|imex:IM-26255-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:4D, lanes 9+10|agonist:IFN-gamma|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a375)|taxid:9606(Human malignant melanoma)	-	2017/10/12	2017/11/08	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586776|imex:IM-26255-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:4D, lanes 1+ 2|agonist:IFN-gamma|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a375)|taxid:9606(Human malignant melanoma)	-	2017/10/12	2017/11/08	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586783|imex:IM-26255-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:4D, lanes 7+8|agonist:IFN-gamma|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a375)|taxid:9606(Human malignant melanoma)	-	2017/10/12	2017/11/08	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZQ7	uniprotkb:Q9NX76	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586824|imex:IM-26255-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	-	-	-	figure legend:Extended data 7A, lanes 9+10|agonist:IFN-gamma|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a375)|taxid:9606(Human malignant melanoma)	-	2017/10/12	2017/11/08	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586810|imex:IM-26255-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7 B|agonist:IFN-gamma|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/08	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587100|imex:IM-26255-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZQ7	uniprotkb:Q9NX76	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587111|imex:IM-26255-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	-	-	-	figure legend:Extended Data 7D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZQ7	uniprotkb:Q8IZR5	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587111|imex:IM-26255-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	-	-	-	figure legend:Extended Data 7D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IZR5	uniprotkb:Q9NZQ7	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587116|imex:IM-26255-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7Di|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:GIxyRoI4WqCcqLKz7rTSzsWGsD8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q8IZR5	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587121|imex:IM-26255-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	-	-	-	figure legend:Extended Data 7Di|comment:only a weak band is seen for CMTM4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587121|imex:IM-26255-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7Di|comment:only a weak band is seen for CMTM4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IZR5	uniprotkb:Q9NX76	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587127|imex:IM-26255-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	-	-	-	figure legend:Extended Data 7Dii|comment:Only a weak band is seen for CMTM6. In the CMTM6 knockout cells there appears to be little or no interaction with PD-L1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IZR5	uniprotkb:Q9NZQ7	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587127|imex:IM-26255-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7Dii|comment:Only a weak band is seen for CMTM6. In the CMTM6 knockout cells there appears to be little or no interaction with PD-L1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8505C)|taxid:9606(human- 8505C undifferentiated thyroid carcinoma cell line)	-	2017/10/12	2017/11/09	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16586805|imex:IM-26255-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rko)|taxid:9606(Homo sapiens colorectal carcinoma cell line)	-	2017/10/12	2017/11/08	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:b99ilUflmon539j6LK7WReyslzo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q9NZQ7	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587104|imex:IM-26255-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	-	-	-	figure legend:Extended Data 7C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rko)|taxid:9606(Homo sapiens colorectal carcinoma cell line)	-	2017/10/12	2017/11/20	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX76	uniprotkb:Q8IZR5	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	intact:EBI-3925367|uniprotkb:Q52M40|uniprotkb:Q8IZV1|uniprotkb:Q8IZR4|ensembl:ENSP00000333833	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:cklf4_human(display_long)|uniprotkb:CMTM4(gene name)|psi-mi:CMTM4(display_short)|uniprotkb:CKLFSF4(gene name synonym)|uniprotkb:Chemokine-like factor superfamily member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587104|imex:IM-26255-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	refseq:XP_011521184.1|refseq:NP_848933.1|refseq:NP_852662.1|ensembl:ENSG00000183723(gene)|ensembl:ENST00000330687(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008253(Marvel)	-	-	-	figure legend:Extended Data 7C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rko)|taxid:9606(Homo sapiens colorectal carcinoma cell line)	-	2017/10/12	2017/11/20	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rogid:BKBUU+HrJpMDfEE5g0cgQtn4HBY9606	rigid:N3AjOMbdTmlIwl62kditBZ+foIs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZQ7	uniprotkb:Q9NX76	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-1054315|uniprotkb:Q6IAC4|ensembl:ENSP00000205636	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:cklf6_human(display_long)|uniprotkb:Chemokine-like factor superfamily member 6(gene name synonym)|uniprotkb:CMTM6(gene name)|psi-mi:CMTM6(display_short)|uniprotkb:CKLFSF6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587155|imex:IM-26255-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	refseq:NP_060271.1|ensembl:ENSG00000091317(gene)|ensembl:ENST00000205636(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR008253(Marvel)|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 8 F/G|comment:Only a faint band is seen for endogenous PD-L2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/10/12	2017/11/09	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:OrVBhhmdJZSWGfyJc/eYUYNtdYE9606	rigid:MDHgpLlQeamwsFSXnOpMEoC0vF0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZQ7	uniprotkb:Q9BQ51	intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989	intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9	psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym)	psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mezzadra et al. (2017)	pubmed:28813410|imex:IM-26255	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16587155|imex:IM-26255-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N	ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2	-	-	-	figure legend:Supp 8 F/G|comment:Only a faint band is seen for endogenous PD-L2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/10/12	2017/11/09	rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606	rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606	rigid:MDHgpLlQeamwsFSXnOpMEoC0vF0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)