#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:X5D6G5 uniprotkb:P00761 intact:EBI-16584505 intact:EBI-8103966|intact:MINT-1512991 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:tryp_pig(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 dip:DIP-6083N|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007586"(digestion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1AKS|rcsb pdb:1AN1|rcsb pdb:1AVW|rcsb pdb:1AVX|rcsb pdb:1C9P|rcsb pdb:1D3O|rcsb pdb:1DF2|rcsb pdb:1EJA|rcsb pdb:1EPT|rcsb pdb:1EWU|rcsb pdb:1FMG|rcsb pdb:1FN6|rcsb pdb:1FNI|rcsb pdb:1H9H|rcsb pdb:1H9I|rcsb pdb:1LDT|rcsb pdb:1LT2|rcsb pdb:1MCT|rcsb pdb:1QQU|rcsb pdb:1S5S|rcsb pdb:1S6F|rcsb pdb:1S6H|rcsb pdb:1S81|rcsb pdb:1S82|rcsb pdb:1S83|rcsb pdb:1S84|rcsb pdb:1S85|rcsb pdb:1TFX|rcsb pdb:1TX6|rcsb pdb:1UHB|rcsb pdb:1V6D|rcsb pdb:1YF4|rcsb pdb:1Z7K|rcsb pdb:2A31|rcsb pdb:2A32|rcsb pdb:3MYW|rcsb pdb:4AN7|rcsb pdb:4DOQ|rcsb pdb:5XWJ|rcsb pdb:5XWL - - comment:mint figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:ps55U1yXkewWxs1VL93BuAFWsa09823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 sufficient binding region:1-82 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q9TUY2 intact:EBI-16584505 intact:EBI-16414302 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:q9tuy2_pig(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0016620"(oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)|go:"GO:0051287"(NAD binding)|interpro:IPR020831|interpro:IPR020830|interpro:IPR020829|interpro:IPR020828|interpro:IPR036291 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:X19QPkBUPOwl09AxzGKK9O6jR5E9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q7YS84 intact:EBI-16584505 intact:EBI-16414295 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:q7ys84_pig(display_long)|uniprotkb:ADD1(gene name)|psi-mi:ADD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0046983"(protein dimerization activity)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:eZ40ODZQVb9a001RbaiNMWsJNxg9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q6QRN9 intact:EBI-16584505 intact:EBI-16414270 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:adt3_pig(display_long)|uniprotkb:AAC3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|refseq:NP_999583.1|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:2kkZZaw6sF+K26aYnPKXI9y6tTA9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q6QAQ7 intact:EBI-16584505 intact:EBI-16414529 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:q6qaq7_pig(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0003676"(nucleic acid binding)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:tAcAzQlwkBshfqY6iSI8I5eQovQ9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:I3LA20 intact:EBI-16584505 intact:EBI-16414621|ensembl:ENSSSCP00000020886 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:i3la20_pig(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000027075(gene)|ensembl:ENSSSCT00000030274(transcript)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:GvL2kkfKairLQCJBUDLtX/L5TG49823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SKS0 intact:EBI-16584505 intact:EBI-16414369|ensembl:ENSSSCP00000017965 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1sks0_pig(display_long)|uniprotkb:MAST4(gene name)|psi-mi:MAST4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCT00000018465(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015022(Region of unknown function DUF1908)|interpro:IPR023142|interpro:IPR036034|interpro:IPR037711|interpro:IPR041489|ensembl:ENSSSCG00000016956(gene) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:vb/qgWrLnVjWN9k5V79diMAupo49823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1S586 intact:EBI-16584505 intact:EBI-16414549|ensembl:ENSSSCP00000014491 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1s586_pig(display_long)|uniprotkb:Guanine insertion enzyme(gene name synonym)|uniprotkb:tRNA-guanine transglycosylase(gene name synonym)|uniprotkb:QTRT1(gene name)|psi-mi:QTRT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000013637(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006400"(tRNA modification)|go:"GO:0008479"(queuine tRNA-ribosyltransferase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0101030"(tRNA-guanine transglycosylation)|interpro:IPR002616(Queuine/other tRNA-ribosyltransferase)|interpro:IPR004803(Queuine tRNA-ribosyltransferase)|interpro:IPR036511|ensembl:ENSSSCT00000014892(transcript)|refseq:XP_003123257.3 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:hygOsbkrGV6ihmmFCa+qKGUuhmM9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1S0W0 intact:EBI-16584505 intact:EBI-16414131|ensembl:ENSSSCP00000006127 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1s0w0_pig(display_long)|uniprotkb:RAPGEF1(gene name)|psi-mi:RAPGEF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000005719(gene)|ensembl:ENSSSCT00000006289(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964|reactome:R-SSC-170968|reactome:R-SSC-186763|reactome:R-SSC-8875555|reactome:R-SSC-9013423|reactome:R-SSC-9027284|reactome:R-SSC-912631 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:uu+jeDUlZtYT+ek7avDag2XFPQs9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RWB6 intact:EBI-16584505 intact:EBI-16414089|ensembl:ENSSSCP00000011769 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rwb6_pig(display_long)|uniprotkb:ST8SIA6(gene name)|psi-mi:ST8SIA6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000011034(gene)|ensembl:ENSSSCT00000012077(transcript)|go:"GO:0001574"(ganglioside biosynthetic process)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003828"(alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006491"(N-glycan processing)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016051"(carbohydrate biosynthetic process)|interpro:IPR001675(Glycosyl transferase, family 29)|interpro:IPR012163(Sialyltransferase)|interpro:IPR038578|reactome:R-SSC-4085001|reactome:R-SSC-975577 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:1XgWkEWOHNx9QjluTVuSinRAWWc9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RKG1 intact:EBI-16584505 intact:EBI-16414404|ensembl:ENSSSCP00000010519 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rkg1_pig(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000009855(gene)|ensembl:ENSSSCT00000010802(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|reactome:R-SSC-5674135 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:lpk5i1zjcJYkm2NIuQQlZ7LMxMU9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q6T4P4 intact:EBI-16584505 intact:EBI-16414286 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:q6t4p4_pig(display_long)|uniprotkb:PGK2(gene name)|psi-mi:PGK2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006096"(glycolytic process)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR036043 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:g6iZj0OklLpnS6Nw5xfTlh79K/Q9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SCV9 intact:EBI-16584505 intact:EBI-16584087|ensembl:ENSSSCP00000009166 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1scv9_pig(display_long)|uniprotkb:APOB(gene name)|psi-mi:APOB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000008595(gene)|ensembl:ENSSSCT00000009406(transcript)|go:"GO:0005319"(lipid transporter activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR009454(Lipid transport, open beta-sheet)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015255(Vitellinogen, open beta-sheet)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:1ShYXYSaTd4YNnTTkmo/v1Ir1Ao9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1S4M8 intact:EBI-16584505 intact:EBI-16414231|ensembl:ENSSSCP00000026389|uniprotkb:I3LQK9 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1s4m8_pig(display_long)|uniprotkb:STIM2(gene name)|psi-mi:STIM2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000008762(gene)|ensembl:ENSSSCT00000023243(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032393|interpro:IPR037608|interpro:IPR037610 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:oMsHYsczcstrJfK2m4+cRDgEcSk9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:I3LC25 intact:EBI-16584505 intact:EBI-16414216|ensembl:ENSSSCP00000021598 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:i3lc25_pig(display_long)|uniprotkb:LMNB2(gene name)|psi-mi:LMNB2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000026784(gene)|ensembl:ENSSSCT00000027018(transcript)|go:"GO:0005882"(intermediate filament)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:TVnQSab3U7D1M6srhm6R4Z5qbas9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:I3L7W7 intact:EBI-16584505 intact:EBI-16414204|ensembl:ENSSSCP00000020125 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:i3l7w7_pig(display_long)|uniprotkb:TTC21A(gene name)|psi-mi:TTC21A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000011263(gene)|ensembl:ENSSSCT00000022750(transcript)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR040364 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:lmF3fDxqFcEWxSqB7RYsVPgKq+49823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SIK8 intact:EBI-16584505 intact:EBI-16414426|ensembl:ENSSSCP00000017651 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1sik8_pig(display_long)|uniprotkb:TBX20(gene name)|psi-mi:TBX20(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000016662(gene)|ensembl:ENSSSCT00000018141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001764"(neuron migration)|go:"GO:0001947"(heart looping)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003175"(tricuspid valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003193"(pulmonary valve formation)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008015"(blood circulation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035922"(foramen ovale closure)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0036306"(embryonic heart tube elongation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060577"(pulmonary vein morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0006936"(muscle contraction)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|interpro:IPR001699(Transcription factor, T-box)|refseq:XP_003134842.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:wBEMHAhRGMpmc+m/pnG6PKkKql09823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SFV3 intact:EBI-16584505 intact:EBI-16414176|ensembl:ENSSSCP00000007017 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1sfv3_pig(display_long)|uniprotkb:S100A14(gene name)|psi-mi:S100A14(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000006582(gene)|ensembl:ENSSSCT00000007211(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071624"(positive regulation of granulocyte chemotaxis)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028493|refseq:NP_001177097.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:4aZl0AqBU3c5dKdt+115onvZ8SA9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1S8L8 intact:EBI-16584505 intact:EBI-16414165|ensembl:ENSSSCP00000011597 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1s8l8_pig(display_long)|uniprotkb:EFCAB2(gene name)|psi-mi:EFCAB2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000010878(gene)|ensembl:ENSSSCT00000011901(transcript)|go:"GO:0005509"(calcium ion binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:+83tCCanxgHbix4DOKq9dIc1i5Q9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1S031 intact:EBI-16584505 intact:EBI-16414107|ensembl:ENSSSCP00000018131 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1s031_pig(display_long)|uniprotkb:NDUFS6(gene name)|psi-mi:NDUFS6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000017114(gene)|ensembl:ENSSSCT00000018632(transcript)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|interpro:IPR016668("NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria")|interpro:IPR019401|rcsb pdb:5GPN|rcsb pdb:5GUP|reactome:R-SSC-611105|reactome:R-SSC-6799198|refseq:XP_003134215.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:4Vi1s36AX8Wo9foq4zKCZGzluoc9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RGD9 intact:EBI-16584505 intact:EBI-16414599|ensembl:ENSSSCP00000015292 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rgd9_pig(display_long)|uniprotkb:HARS1(gene name)|psi-mi:HARS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCT00000015705(transcript)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000738(WHEP-TRS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|ensembl:ENSSSCG00000014375(gene)|refseq:XP_003124081.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:qZyZDmREnKBwWFvMzolur76pD209823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RFE3 intact:EBI-16584505 intact:EBI-16414656|ensembl:ENSSSCP00000008354 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rfe3_pig(display_long)|uniprotkb:LCMT1(gene name)|psi-mi:LCMT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000007826(gene)|ensembl:ENSSSCT00000008575(transcript)|interpro:IPR007213(Leucine carboxyl methyltransferase)|go:"GO:0005829"(cytosol)|go:"GO:0006481"(C-terminal protein methylation)|interpro:IPR016651(Leucine carboxyl methyltransferase, LCTM1 1)|go:"GO:0018423"(protein C-terminal leucine carboxyl O-methyltransferase activity)|interpro:IPR029063|refseq:XP_003124581.3 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:BnE4HGBITo4PRVtsn0MbECg+USs9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q764N2 intact:EBI-16584505 intact:EBI-16414568|ensembl:ENSSSCP00000028968|ensembl:ENSSSCP00015004916|ensembl:ENSSSCP00025004656|ensembl:ENSSSCP00035018253|ensembl:ENSSSCP00045018630|ensembl:ENSSSCP00055030370|ensembl:ENSSSCP00060003275|ensembl:ENSSSCP00070005535 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:cd3d_pig(display_long)|uniprotkb:T-cell receptor T3 delta chain(gene name synonym)|uniprotkb:CD3D(gene name)|psi-mi:CD3D(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000015093(gene)|ensembl:ENSSSCG00015009364(gene)|ensembl:ENSSSCG00025008789(gene)|ensembl:ENSSSCG00035034468(gene)|ensembl:ENSSSCG00045015841(gene)|ensembl:ENSSSCG00055019519(gene)|ensembl:ENSSSCG00060007000(gene)|ensembl:ENSSSCG00070003612(gene)|ensembl:ENSSSCT00000034310(transcript)|ensembl:ENSSSCT00015012707(transcript)|ensembl:ENSSSCT00025011684(transcript)|ensembl:ENSSSCT00035045679(transcript)|ensembl:ENSSSCT00045026960(transcript)|ensembl:ENSSSCT00055038230(transcript)|ensembl:ENSSSCT00060008949(transcript)|ensembl:ENSSSCT00070006786(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045059"(positive thymic T cell selection)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR015485(CD3 signaling complex delta subunit)|interpro:IPR032052|interpro:IPR036179|reactome:R-SSC-198933|reactome:R-SSC-202424|reactome:R-SSC-202427|reactome:R-SSC-202430|reactome:R-SSC-202433|reactome:R-SSC-389948|reactome:R-SSC-8856825|reactome:R-SSC-8856828|refseq:NP_998940.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:Uf8dViGgjDGKgIJ7JjjagY9bbk49823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q52QT8 intact:EBI-16584505 intact:EBI-16414631|ensembl:ENSSSCP00005042706|ensembl:ENSSSCP00015005194|ensembl:ENSSSCP00025017891|ensembl:ENSSSCP00030039054|ensembl:ENSSSCP00035025894|ensembl:ENSSSCP00040037440|ensembl:ENSSSCP00045032372|ensembl:ENSSSCP00050021805|ensembl:ENSSSCP00055007924|ensembl:ENSSSCP00060024620|ensembl:ENSSSCP00065046879|ensembl:ENSSSCP00070022463|ensembl:ENSSSCP00070022472 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:ccng1_pig(display_long)|uniprotkb:CCNG1(gene name)|psi-mi:CCNG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00005042723(gene)|ensembl:ENSSSCG00015010126(gene)|ensembl:ENSSSCG00025030659(gene)|ensembl:ENSSSCG00030060617(gene)|ensembl:ENSSSCG00035047997(gene)|ensembl:ENSSSCG00040062448(gene)|ensembl:ENSSSCG00045027306(gene)|ensembl:ENSSSCG00050038477(gene)|ensembl:ENSSSCG00055005093(gene)|ensembl:ENSSSCG00060042428(gene)|ensembl:ENSSSCG00065076429(gene)|ensembl:ENSSSCG00070013834(gene)|ensembl:ENSSSCT00005068631(transcript)|ensembl:ENSSSCT00015013429(transcript)|ensembl:ENSSSCT00025042033(transcript)|ensembl:ENSSSCT00030084818(transcript)|ensembl:ENSSSCT00035063959(transcript)|ensembl:ENSSSCT00040085558(transcript)|ensembl:ENSSSCT00045046642(transcript)|ensembl:ENSSSCT00050051912(transcript)|ensembl:ENSSSCT00055010025(transcript)|ensembl:ENSSSCT00060057552(transcript)|ensembl:ENSSSCT00065105619(transcript)|ensembl:ENSSSCT00070027020(transcript)|ensembl:ENSSSCT00070027029(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028860|interpro:IPR036915|interpro:IPR039361|refseq:NP_001026951.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:wh9CpzsqwRnioyARjb9KM9fxpl49823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:K7GS49 intact:EBI-16584505 intact:EBI-16367109|ensembl:ENSSSCP00000030729 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:A0A286ZS41 intact:EBI-16584505 intact:EBI-16584127|ensembl:ENSSSCP00000034392 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:a0a286zs41_pig(display_long)|uniprotkb:LRRC75A(gene name)|psi-mi:LRRC75A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000036776(gene)|ensembl:ENSSSCT00000063598(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR032675 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:ntLtIjXrBL/AwEai6DsIi0xb2MM9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SBK5 intact:EBI-16584505 intact:EBI-16414392|ensembl:ENSSSCP00000007526 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1sbk5_pig(display_long)|uniprotkb:ANKEF1(gene name)|psi-mi:ANKEF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000007063(gene)|ensembl:ENSSSCT00000007734(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR020683|interpro:IPR036770|refseq:XP_005672754.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:y0xXC8mq7vWx1XKErklJ3U6DrZI9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RS52 intact:EBI-16584505 intact:EBI-16414074|ensembl:ENSSSCP00000009644 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rs52_pig(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000009039(gene)|ensembl:ENSSSCT00000009899(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|reactome:R-SSC-196741|reactome:R-SSC-71032|refseq:XP_013853584.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:1qPHqACSs/WzqG6wWzLHTkKJ8ik9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RS11 intact:EBI-16584505 intact:EBI-16414039|ensembl:ENSSSCP00000006018 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rs11_pig(display_long)|uniprotkb:STXBP1(gene name)|psi-mi:STXBP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000005617(gene)|ensembl:ENSSSCT00000006177(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|refseq:XP_005660500.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:JEoimwWdD8A/A/Kshiif7AKqNoM9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:D0G785 intact:EBI-16584505 intact:EBI-16414648 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:d0g785_pig(display_long)|uniprotkb:PDK3(gene name)|psi-mi:PDK3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR039028|interpro:IPR036890 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:tTJk4K3ZRfrZV6i7tJVx3LC+tOM9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:A7UAT8 intact:EBI-16584505 intact:EBI-16414028 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:a7uat8_pig(display_long)|uniprotkb:SLA-DRB1(gene name)|psi-mi:SLA-DRB1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0006955"(immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:36/O1PySaCcEvoCJWepUvpbaQAg9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:A6N8P5 intact:EBI-16584505 intact:EBI-16414006|uniprotkb:F1RW00 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:a6n8p5_pig(display_long)|uniprotkb:MBF1(gene name)|psi-mi:MBF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|refseq:XP_003480683.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013729(Multiprotein bridging factor 1, N-terminal) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:y1wb876wA2tLnFXDEffKuOuyZJk9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:A5A751 intact:EBI-16584505 intact:EBI-16414487 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:a5a751_pig(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|interpro:IPR011364(BRCA1)|interpro:IPR031099|interpro:IPR025994|interpro:IPR001357(BRCT)|interpro:IPR018957|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036420 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:vhkwKVRuqmOIbwWBYwiPdr5zKlU9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:A0A287AS36 intact:EBI-16584505 intact:EBI-16687511|ensembl:ENSSSCP00000046878 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:a0a287as36_pig(display_long)|uniprotkb:VPS37D(gene name)|psi-mi:VPS37D(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000033358(gene)|ensembl:ENSSSCT00000065981(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009851(Modifier of rudimentary, Modr)|reactome:R-SSC-917729|refseq:XP_003124451(identity) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:Bu+EmXu5bMvHf5z294Om7a+dQdI9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1SDJ8 intact:EBI-16584505 intact:EBI-16413966|ensembl:ENSSSCP00000011469 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1sdj8_pig(display_long)|uniprotkb:GLRX3(gene name)|psi-mi:GLRX3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249|ensembl:ENSSSCG00000010759(gene)|ensembl:ENSSSCT00000011771(transcript)|go:"GO:0005634"(nucleus) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:CB1UwW8//bVMJdImKeOJofYvMTQ9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F1RTC2 intact:EBI-16584505 intact:EBI-16413950|ensembl:ENSSSCP00000019475 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f1rtc2_pig(display_long)|uniprotkb:MMGT1(gene name)|psi-mi:MMGT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000025854(gene)|ensembl:ENSSSCT00000029855(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0022890"(inorganic cation transmembrane transporter activity)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR018937|refseq:NP_001230137.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:7BbiieAAD1aGAXmQL1XKZluYQBg9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:Q6RI85 intact:EBI-16584505 intact:EBI-16413935|ensembl:ENSSSCP00055009207|ensembl:ENSSSCP00060028173|ensembl:ENSSSCP00065003084|ensembl:ENSSSCP00070034394|ensembl:ENSSSCP00050001635|ensembl:ENSSSCP00000045543|ensembl:ENSSSCP00005005203|ensembl:ENSSSCP00030018351|ensembl:ENSSSCP00040015448|uniprotkb:Q6RFZ5 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:pgk2_pig(display_long)|uniprotkb:Phosphoglycerate kinase, testis specific(gene name synonym)|uniprotkb:PGK2(gene name)|psi-mi:PGK2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCT00000001943(transcript)|ensembl:ENSSSCT00005008811(transcript)|ensembl:ENSSSCT00030039845(transcript)|ensembl:ENSSSCT00040037149(transcript)|ensembl:ENSSSCT00050004221(transcript)|ensembl:ENSSSCT00055011631(transcript)|ensembl:ENSSSCT00060065813(transcript)|ensembl:ENSSSCT00065007143(transcript)|ensembl:ENSSSCT00070040987(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043531"(ADP binding)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|ensembl:ENSSSCG00000001738(gene)|ensembl:ENSSSCG00005005823(gene)|ensembl:ENSSSCG00030028466(gene)|ensembl:ENSSSCG00040027666(gene)|ensembl:ENSSSCG00050003199(gene)|ensembl:ENSSSCG00055005986(gene)|ensembl:ENSSSCG00060048462(gene)|ensembl:ENSSSCG00065005263(gene)|ensembl:ENSSSCG00070020628(gene)|refseq:NP_998947.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:kl6TA7h/YxZdtiSVebpgZ8UM82E9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:I3LTP0 intact:EBI-16584505 intact:EBI-16413911|ensembl:ENSSSCP00000027488 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:i3ltp0_pig(display_long)|uniprotkb:TOP1MT(gene name)|psi-mi:TOP1MT(display_short)|uniprotkb:DNA topoisomerase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000006958(gene)|ensembl:ENSSSCT00000029650(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005694"(chromosome)|go:"GO:0006265"(DNA topological change)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR036202|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type) - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:6mlypwejO/IWFe1c3S602qC8WLU9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:B5SNZ6 intact:EBI-16584505 intact:EBI-16413896|ensembl:ENSSSCP00005012715|ensembl:ENSSSCP00015019244|ensembl:ENSSSCP00025039006|ensembl:ENSSSCP00030008252|ensembl:ENSSSCP00035035006|ensembl:ENSSSCP00045028372|ensembl:ENSSSCP00060018809|ensembl:ENSSSCP00070014531 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:abra_pig(display_long)|uniprotkb:Striated muscle activator of Rho-dependent signaling(gene name synonym)|uniprotkb:ABRA(gene name)|psi-mi:ABRA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00005013617(gene)|ensembl:ENSSSCG00015036376(gene)|ensembl:ENSSSCG00025064982(gene)|ensembl:ENSSSCG00030013589(gene)|ensembl:ENSSSCG00035062655(gene)|ensembl:ENSSSCG00045023911(gene)|ensembl:ENSSSCG00060032554(gene)|ensembl:ENSSSCG00070009047(gene)|ensembl:ENSSSCT00005021245(transcript)|ensembl:ENSSSCT00015048398(transcript)|ensembl:ENSSSCT00025089178(transcript)|ensembl:ENSSSCT00030018633(transcript)|ensembl:ENSSSCT00035084200(transcript)|ensembl:ENSSSCT00045040820(transcript)|ensembl:ENSSSCT00060044091(transcript)|ensembl:ENSSSCT00070017535(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015031"(protein transport)|go:"GO:0030017"(sarcomere)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|interpro:IPR026111|interpro:IPR027817|interpro:IPR038095|refseq:NP_001129432.1 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:ZbLfyVODlovMHr6HKMpfs4mXMyw9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:I3LPL4 intact:EBI-16584505 intact:EBI-16413870|ensembl:ENSSSCP00000026041 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:i3lpl4_pig(display_long)|uniprotkb:RRP8(gene name)|psi-mi:RRP8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 ensembl:ENSSSCG00000023880(gene)|ensembl:ENSSSCT00000022514(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006364"(rRNA processing)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0046015"(regulation of transcription by glucose)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR007823(Methyltransferase-related)|interpro:IPR023576|interpro:IPR029063|interpro:IPR042036|reactome:R-SSC-427359 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:Gzxl7BIB3cvbJgLOiUUk11uRFCU9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 uniprotkb:F8TEL5 intact:EBI-16584505 intact:EBI-16584039 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:f8tel5_pig(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|interpro:IPR016021(MIF4-like, type 1/2/3)|refseq:NP_001233182.1|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR037584 - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:llZISjmde38IOC84MGqFa0RJ75s9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:X5D6G5 intact:EBI-16584376 intact:EBI-16584505 ddbj/embl/genbank:AAM55417 psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:tcr-delta chain cdr3 region_pig(display_short)|psi-mi:EBI-16584376(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16407211|imex:IM-26220-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 - - - - figure legend:1 and additional file 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-3d4/21)|taxid:9823(pig lung macrophage) - 2017/08/30 2020/01/08 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rogid:4jHBxnOodyCf7K0NNyAH0KK144w9823 rigid:3Aq68wn5FJhzLqjaKxDwU9Y4XQg false green fluorescent protein tag:?-?|sufficient binding region:4-643 - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:K7GS49 uniprotkb:X5D6G5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584505 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414670|imex:IM-26220-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 - - - figure legend:2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rigid:I+JUePjdwvi94rYJKZA/kk/bDwA false ha tag:n-n sufficient binding region:4-463|myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:K7GS49 uniprotkb:X5D6G5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584505 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414678|imex:IM-26220-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 - - - figure legend:2A, 4B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/08/30 2017/11/01 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rigid:I+JUePjdwvi94rYJKZA/kk/bDwA false myc tag:n-n sufficient binding region:4-643|ha tag:n-n|necessary binding region:389-643 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:K7GS49 uniprotkb:A6YQT5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584543 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414789|imex:IM-26220-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504 - - - figure legend:3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 rigid:LRcgy41aqiCSqkdfvWYHaZ3cNXw false myc tag:n-n sufficient binding region:384-1549|ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:K7GS49 uniprotkb:A6YQT5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584543 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414797|imex:IM-26220-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504 - - - figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 rigid:LRcgy41aqiCSqkdfvWYHaZ3cNXw false myc tag:n-n sufficient binding region:384-1549|ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:K7GS49 uniprotkb:A6YQT5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584543 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414822|imex:IM-26220-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1 go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504 - - - figure legend:4D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293ft)|taxid:9606(Homo sapiens HEK293FT cell line) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 rigid:LRcgy41aqiCSqkdfvWYHaZ3cNXw false myc tag:n-n sufficient binding region:384-1549|green fluorescent protein tag:?-?|sufficient binding region:384-789|sufficient binding region:706-1197 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-16414699 uniprotkb:X5D6G5 intact:EBI-16427092 intact:EBI-16584505 psi-mi:ilf2_chlae(display_short)|psi-mi:EBI-16414699(display_long) psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414694|imex:IM-26220-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502 - - - figure legend:2C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-marc145)|taxid:9534(chlae MARC- 145 cells) - 2017/08/30 2017/11/02 - rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 - false - sufficient binding region:4-643|green fluorescent protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6YQT5 intact:EBI-16414699 intact:EBI-16584543 intact:EBI-16427092 psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:ilf2_chlae(display_short)|psi-mi:EBI-16414699(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414812|imex:IM-26220-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504 - - - - figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-marc145)|taxid:9534(chlae MARC- 145 cells) - 2017/08/30 2017/12/06 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 - - false sufficient binding region:384-1549 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A6YQT5 intact:EBI-16414699 intact:EBI-16584543 intact:EBI-16427092 psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:ilf2_chlae(display_short)|psi-mi:EBI-16414699(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414812|imex:IM-26220-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504 - - - - figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-marc145)|taxid:9534(chlae MARC- 145 cells) - 2017/08/30 2017/12/06 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 - - false sufficient binding region:384-1549 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-16414699 uniprotkb:X5D6G5 intact:EBI-16427092 intact:EBI-16584505 psi-mi:ilf2_chlae(display_short)|psi-mi:EBI-16414699(display_long) psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414841|imex:IM-26220-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502|go:"GO:0030430"(host cell cytoplasm) go:"GO:0030430"(host cell cytoplasm) - - figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-marc145)|taxid:9534(chlae MARC- 145 cells) - 2017/08/30 2017/11/02 - rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 - false - sufficient binding region:4-643 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) intact:EBI-16414699 uniprotkb:A6YQT5 intact:EBI-16427092 intact:EBI-16584543 psi-mi:ilf2_chlae(display_short)|psi-mi:EBI-16414699(display_long) psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414849|imex:IM-26220-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus) go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|go:"GO:0030430"(host cell cytoplasm) go:"GO:0030430"(host cell cytoplasm) - - figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-marc145)|taxid:9534(chlae MARC- 145 cells) - 2017/08/30 2017/11/02 - rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 - false - sufficient binding region:384-1549 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:K7GS49 uniprotkb:X5D6G5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584505 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:x5d6g5_prrsv(display_long)|uniprotkb:ORF1b(gene name)|psi-mi:ORF1b(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414861|imex:IM-26220-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1|go:"GO:0005634"(nucleus) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR044314|interpro:IPR044320|interpro:IPR044348|interpro:IPR027351|interpro:IPR027355|interpro:IPR037227|interpro:IPR027417|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR043609|interpro:IPR043502|go:"GO:0030430"(host cell cytoplasm) go:"GO:0030430"(host cell cytoplasm) - - figure legend:5B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-pam)|taxid:9823(pig pulmonary alveolar macrophages) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:kV4ml42SwnCXhDdbbK62DzvBmEU28344 rigid:I+JUePjdwvi94rYJKZA/kk/bDwA false - sufficient binding region:4-643 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:K7GS49 uniprotkb:A6YQT5 intact:EBI-16367109|ensembl:ENSSSCP00000030729 intact:EBI-16584543 psi-mi:k7gs49_pig(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:a6yqt5_prrsv(display_long)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Nsp1(gene name synonym)|uniprotkb:Nsp1-alpha papain-like cysteine proteinase(gene name synonym)|uniprotkb:Nsp1-beta papain-like cysteine proteinase(gene name synonym)|uniprotkb:PCP1-alpha(gene name synonym)|uniprotkb:PCP1-beta(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Wen et al. (2017) imex:IM-26220|pubmed:28693575 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:28344(prrsv)|taxid:28344(Porcine reproductive and respiratory syndrome virus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-16414866|imex:IM-26220-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSSSCG00000028553(gene)|ensembl:ENSSSCT00000034724(transcript)|interpro:IPR006561(DZF)|interpro:IPR043519|refseq:XP_005663466.1|go:"GO:0005634"(nucleus) go:"GO:0003724"(RNA helicase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033644"(host cell membrane)|go:"GO:0039503"(suppression by virus of host innate immune response)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038154|interpro:IPR038155|interpro:IPR038451|interpro:IPR023183|interpro:IPR031932|interpro:IPR008743(Peptidase C33, arteritis virus equine ORF1A)|interpro:IPR023338|interpro:IPR008741(Peptidase C31, arterivirus porcine ORF1A)|interpro:IPR025773|interpro:IPR008760(Peptidase S32, arteritis virus equine ORF1A)|interpro:IPR032855|interpro:IPR032785|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|go:"GO:0030430"(host cell cytoplasm) go:"GO:0030430"(host cell cytoplasm) - - figure legend:5B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-pam)|taxid:9823(pig pulmonary alveolar macrophages) - 2017/08/30 2017/11/02 rogid:6CXH9nUIeCbyCYVL6P4QX5Zqvbk9823 rogid:G0rV9h7dJHKNQpbNLhOF5fg2rEY28344 rigid:LRcgy41aqiCSqkdfvWYHaZ3cNXw false - sufficient binding region:384-1549 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)