#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:77563"	uniprotkb:P00519	intact:EBI-13635573	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9UHD2	intact:EBI-13635573	intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9H2G2	intact:EBI-13635573	intact:EBI-1022272|uniprotkb:O00211|uniprotkb:Q6P1Z4|uniprotkb:Q86WU7|uniprotkb:Q86WW1|uniprotkb:Q92603|uniprotkb:Q9NQL0|uniprotkb:Q9NQL1|uniprotkb:D3DRA0|uniprotkb:D3DRA1|ensembl:ENSP00000358770	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:slk_human(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 2(gene name synonym)|uniprotkb:CTCL tumor antigen se20-9(gene name synonym)|uniprotkb:SLK(gene name)|psi-mi:SLK(display_short)|uniprotkb:KIAA0204(gene name synonym)|uniprotkb:STK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_055535.2|refseq:NP_001291672.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|mint:Q9H2G2|rcsb pdb:2J51|rcsb pdb:2JFL|rcsb pdb:2JFM|rcsb pdb:2UV2|rcsb pdb:4USF|rcsb pdb:6HVD|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000065613(gene)|ensembl:ENST00000369755(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:T9Ej6CkWUmqEmPLcptvF2/f1Q+09606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q14289	intact:EBI-13635573	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q05397-1	intact:EBI-13635573	intact:EBI-13635519|ensembl:ENSP00000429474|ensembl:ENSP00000429911	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:q05397-1(display_long)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:p125FAK(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-702142(isoform-parent)|ensembl:ENSG00000169398(gene)|ensembl:ENST00000521059(transcript)|ensembl:ENST00000522684(transcript)	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:P36639	intact:EBI-13635573	intact:EBI-1048967|uniprotkb:Q6P0Y6|uniprotkb:Q9UBM0|uniprotkb:Q9UBM9|ensembl:ENSP00000343439|uniprotkb:Q8IV95|ensembl:ENSP00000380239|ensembl:ENSP00000349148|uniprotkb:A4D205|ensembl:ENSP00000380242|uniprotkb:Q6LES7|uniprotkb:Q7Z7N6	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:8odp_human(display_long)|uniprotkb:8-oxo-dGTPase(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 1(gene name synonym)|uniprotkb:NUDT1(gene name)|psi-mi:NUDT1(display_short)|uniprotkb:MTH1(gene name synonym)|uniprotkb:2-hydroxy-dATP diphosphatase(gene name synonym)|uniprotkb:7,8-dihydro-8-oxoguanine triphosphatase(gene name synonym)|uniprotkb:Methylated purine nucleoside triphosphate hydrolase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000106268(gene)|refseq:NP_002443.3|refseq:NP_945186.1|refseq:NP_945187.1|refseq:NP_945188.1|refseq:NP_945190.1|refseq:NP_945191.1|refseq:NP_945192.1|ensembl:ENST00000339737(transcript)|ensembl:ENST00000397046(transcript)|ensembl:ENST00000356714(transcript)|ensembl:ENST00000397049(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006152"(purine nucleoside catabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008413"(8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008828"(dATP pyrophosphohydrolase activity)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035539"(8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity)|go:"GO:0042262"(DNA protection)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047693"(ATP diphosphatase activity)|go:"GO:0106377"(2-hydroxy-ATP hydrolase activity)|go:"GO:0106378"(2-hydroxy-dATP hydrolase activity)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003563(7,8-dihydro-8-oxoguanine triphosphatase)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR020476|rcsb pdb:1IRY|rcsb pdb:3Q93|rcsb pdb:3WHW|rcsb pdb:3ZR0|rcsb pdb:3ZR1|rcsb pdb:4C9W|rcsb pdb:4C9X|rcsb pdb:4N1T|rcsb pdb:4N1U|rcsb pdb:5ANS|rcsb pdb:5ANT|rcsb pdb:5ANU|rcsb pdb:5ANV|rcsb pdb:5ANW|rcsb pdb:5FSI|rcsb pdb:5FSK|rcsb pdb:5FSL|rcsb pdb:5FSM|rcsb pdb:5FSN|rcsb pdb:5FSO|rcsb pdb:5GHI|rcsb pdb:5GHJ|rcsb pdb:5GHM|rcsb pdb:5GHN|rcsb pdb:5GHO|rcsb pdb:5GHP|rcsb pdb:5GHQ|rcsb pdb:5NGR|rcsb pdb:5NGS|rcsb pdb:5NGT|rcsb pdb:5NHY|rcsb pdb:5OTM|rcsb pdb:5WS7|rcsb pdb:6AA3|rcsb pdb:6AA4|rcsb pdb:6AA5|rcsb pdb:6EQ2|rcsb pdb:6EQ3|rcsb pdb:6EQ4|rcsb pdb:6EQ5|rcsb pdb:6EQ6|rcsb pdb:6EQ7|rcsb pdb:6F1X|rcsb pdb:6F20|rcsb pdb:6F22|rcsb pdb:6F23|rcsb pdb:6GLE|rcsb pdb:6GLF|rcsb pdb:6GLG|rcsb pdb:6GLH|rcsb pdb:6GLI|rcsb pdb:6GLJ|rcsb pdb:6GLK|rcsb pdb:6GLL|rcsb pdb:6GLM|rcsb pdb:6GLN|rcsb pdb:6GLO|rcsb pdb:6GLP|rcsb pdb:6GLQ|rcsb pdb:6GLR|rcsb pdb:6GLS|rcsb pdb:6GLT|rcsb pdb:6GLU|rcsb pdb:6GLV|rcsb pdb:6IJY|rcsb pdb:6ILI|rcsb pdb:6IMZ|rcsb pdb:6JVF|rcsb pdb:6JVG|rcsb pdb:6JVH|rcsb pdb:6JVI|rcsb pdb:6JVJ|rcsb pdb:6JVK|rcsb pdb:6JVL|rcsb pdb:6JVM|rcsb pdb:6JVN|rcsb pdb:6JVO|rcsb pdb:6JVP|rcsb pdb:6JVQ|rcsb pdb:6JVR|rcsb pdb:6JVS|rcsb pdb:6JVT|rcsb pdb:6QVO|rcsb pdb:6US2|rcsb pdb:6US3|rcsb pdb:6US4|rcsb pdb:7ESF|reactome:R-HSA-2393930	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:erF2lD2RVURwEzFcyHqrIpWkO8U9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q04912	intact:EBI-13635573	intact:EBI-2637518|uniprotkb:B5A944|uniprotkb:B5A945|uniprotkb:B5A946|uniprotkb:B5A947|ensembl:ENSP00000296474|uniprotkb:A0A087WZG2	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:ron_human(display_long)|uniprotkb:MST1R(gene name)|psi-mi:MST1R(display_short)|uniprotkb:PTK8(gene name synonym)|uniprotkb:RON(gene name synonym)|uniprotkb:p185-Ron(gene name synonym)|uniprotkb:Protein-tyrosine kinase 8(gene name synonym)|uniprotkb:CDw136(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001231866.1|refseq:NP_002438.2|ensembl:ENSG00000164078(gene)|ensembl:ENST00000296474(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036352|interpro:IPR039413|mint:Q04912|rcsb pdb:3PLS|rcsb pdb:4FWW|rcsb pdb:4QT8|reactome:R-HSA-8852405|dip:DIP-6029N	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:qwF0CoIEkkzk0ETJxoUnwwKDHho9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q8N1N4	intact:EBI-13635573	intact:EBI-1056564|uniprotkb:Q7RTT2|uniprotkb:Q5HYM7|uniprotkb:A8K4D6|ensembl:ENSP00000306261	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:k2c78_human(display_long)|uniprotkb:KRT78(gene name)|psi-mi:KRT78(display_short)|uniprotkb:K5B(gene name synonym)|uniprotkb:KB40(gene name synonym)|uniprotkb:Cytokeratin-78(gene name synonym)|uniprotkb:Type-II keratin Kb40(gene name synonym)|uniprotkb:Keratin-5b(gene name synonym)|uniprotkb:Keratin-78(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001287743.1|refseq:NP_775487.2|ensembl:ENSG00000170423(gene)|ensembl:ENST00000304620(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:7DFQlPKPQ4Bu1Q5+nxLQufA7ghU9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9Y616	intact:EBI-13635573	intact:EBI-447690|uniprotkb:B4DQ57|ensembl:ENSP00000261233	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:irak3_human(display_long)|uniprotkb:IL-1 receptor-associated kinase M(gene name synonym)|uniprotkb:IRAK3(gene name)|psi-mi:IRAK3(display_short)|uniprotkb:Inactive IL-1 receptor-associated kinase 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001135995.1|refseq:NP_009130.2|ensembl:ENSG00000090376(gene)|ensembl:ENST00000261233(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009615"(response to virus)|go:"GO:0010933"(positive regulation of macrophage tolerance induction)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043244"(regulation of protein-containing complex disassembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043407"(negative regulation of MAP kinase activity)|rcsb pdb:5UKE|rcsb pdb:6RUU|rcsb pdb:6ZIW|reactome:R-HSA-166058|reactome:R-HSA-9020702|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR033610|interpro:IPR042698|interpro:IPR042747	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:dAA3oQDTONBbjFJJubCJyY1Jnog9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:P51617	intact:EBI-13635573	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:P29317	intact:EBI-13635573	intact:EBI-702104|uniprotkb:Q8N3Z2|uniprotkb:B5A968|intact:EBI-28989000|ensembl:ENSP00000351209	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:epha2_human(display_long)|uniprotkb:Tyrosine-protein kinase receptor ECK(gene name synonym)|uniprotkb:Epithelial cell kinase(gene name synonym)|uniprotkb:EPHA2(gene name)|psi-mi:EPHA2(display_short)|uniprotkb:ECK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004422.2|ensembl:ENSP00000351209|dip:DIP-96N|ensembl:ENSG00000142627(gene)|ensembl:ENST00000358432(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007411"(axon guidance)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019838"(growth factor binding)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046058"(cAMP metabolic process)|go:"GO:0046849"(bone remodeling)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048870"(cell motility)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060035"(notochord cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0070160"(tight junction)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904238"(pericyte cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034263|interpro:IPR036116|mint:P29317|rcsb pdb:1MQB|rcsb pdb:2E8N|rcsb pdb:2K9Y|rcsb pdb:2KSO|rcsb pdb:2X10|rcsb pdb:2X11|rcsb pdb:3C8X|rcsb pdb:3CZU|rcsb pdb:3FL7|rcsb pdb:3HEI|rcsb pdb:3HPN|rcsb pdb:3KKA|rcsb pdb:3MBW|rcsb pdb:3MX0|rcsb pdb:3SKJ|rcsb pdb:4P2K|rcsb pdb:4PDO|rcsb pdb:4TRL|rcsb pdb:5EK7|rcsb pdb:5I9U|rcsb pdb:5I9V|rcsb pdb:5I9W|rcsb pdb:5I9X|rcsb pdb:5I9Y|rcsb pdb:5I9Z|rcsb pdb:5IA0|rcsb pdb:5IA1|rcsb pdb:5IA2|rcsb pdb:5IA3|rcsb pdb:5IA4|rcsb pdb:5IA5|rcsb pdb:5NJZ|rcsb pdb:5NK0|rcsb pdb:5NK1|rcsb pdb:5NK2|rcsb pdb:5NK3|rcsb pdb:5NK4|rcsb pdb:5NK5|rcsb pdb:5NK6|rcsb pdb:5NK7|rcsb pdb:5NK8|rcsb pdb:5NK9|rcsb pdb:5NKA|rcsb pdb:5NKB|rcsb pdb:5NKC|rcsb pdb:5NKD|rcsb pdb:5NKE|rcsb pdb:5NKF|rcsb pdb:5NKG|rcsb pdb:5NKH|rcsb pdb:5NKI|rcsb pdb:5NZ9|rcsb pdb:6B9L|rcsb pdb:6F7M|rcsb pdb:6F7N|rcsb pdb:6FNF|rcsb pdb:6FNG|rcsb pdb:6FNH|rcsb pdb:6HES|rcsb pdb:6HET|rcsb pdb:6HEU|rcsb pdb:6HEV|rcsb pdb:6HEW|rcsb pdb:6HEX|rcsb pdb:6HEY|rcsb pdb:6NJZ|rcsb pdb:6NK0|rcsb pdb:6NK1|rcsb pdb:6NK2|rcsb pdb:6NKP|rcsb pdb:6Q7B|rcsb pdb:6Q7C|rcsb pdb:6Q7D|rcsb pdb:6Q7E|rcsb pdb:6Q7F|rcsb pdb:6Q7G|rcsb pdb:6RW2|rcsb pdb:7B7N|rcsb pdb:7CZE|rcsb pdb:7CZF|rcsb pdb:7KJA|rcsb pdb:7KJB|rcsb pdb:7KJC|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:9VFikLd4ftRmEyBpY0JHdpHINT09606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9HC35	intact:EBI-13635573	intact:EBI-717876|uniprotkb:Q3SWW0|uniprotkb:Q53R29|uniprotkb:Q53TW8|uniprotkb:Q6PJ45|uniprotkb:Q9NV40|uniprotkb:B2RTW7|uniprotkb:B2RBK3|uniprotkb:A6H8Y6|uniprotkb:B5MCW9|intact:EBI-28969987|ensembl:ENSP00000320663	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:emal4_human(display_long)|uniprotkb:Restrictedly overexpressed proliferation-associated protein(gene name synonym)|uniprotkb:Ropp 120(gene name synonym)|uniprotkb:EML4(gene name)|psi-mi:EML4(display_short)|uniprotkb:C2orf2(gene name synonym)|uniprotkb:EMAPL4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_061936.2|ensembl:ENSP00000320663|ensembl:ENST00000402711|ensembl:ENSP00000385059|refseq:NP_001138548.1|ensembl:ENSG00000143924(gene)|ensembl:ENST00000318522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:4CGC|reactome:R-HSA-9648025	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:Uil30Xzo4QqT/8hfUP7TJbuCG3o9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9H6S1-1	intact:EBI-13635573	intact:EBI-13635537|ensembl:ENSP00000419371	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:q9h6s1-1(display_long)|uniprotkb:NF-kappa-B-activating kinase-associated protein 1(gene name synonym)|uniprotkb:TILP(gene name synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:AZI2(gene name)|psi-mi:AZI2(display_short)|uniprotkb:NAP1(gene name synonym)|uniprotkb:TBKBP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000163512(gene)|ensembl:ENST00000479665(transcript)|intact:EBI-359973(isoform-parent)	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:lfjd4cD2rm6NOjdh3XTTuFxnK9A9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q9UM73	intact:EBI-13635573	intact:EBI-357361|ensembl:ENSP00000373700|uniprotkb:Q4ZFX9|uniprotkb:Q53QQ6|uniprotkb:Q53RZ4|uniprotkb:Q59FI3|uniprotkb:Q9Y4K6	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:alk_human(display_long)|uniprotkb:ALK(gene name)|psi-mi:ALK(display_short)|uniprotkb:Anaplastic lymphoma kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000171094(gene)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016310"(phosphorylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030534"(adult behavior)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036269"(swimming behavior)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENST00000389048(transcript)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090648"(response to environmental enrichment)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000998(MAM)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR026830|interpro:IPR036055|mint:Q9UM73|rcsb pdb:2KUP|rcsb pdb:2KUQ|rcsb pdb:2XB7|rcsb pdb:2XBA|rcsb pdb:2XP2|rcsb pdb:2YFX|rcsb pdb:2YHV|rcsb pdb:2YJR|rcsb pdb:2YJS|rcsb pdb:2YS5|rcsb pdb:2YT2|rcsb pdb:3L9P|rcsb pdb:3LCS|rcsb pdb:3LCT|rcsb pdb:4ANL|rcsb pdb:4ANQ|rcsb pdb:4ANS|rcsb pdb:4CCB|rcsb pdb:4CCU|rcsb pdb:4CD0|rcsb pdb:3AOX|rcsb pdb:4CLI|rcsb pdb:4CLJ|rcsb pdb:4CMO|rcsb pdb:4CMT|rcsb pdb:4CMU|rcsb pdb:4CNH|rcsb pdb:4CTB|rcsb pdb:4CTC|rcsb pdb:4DCE|rcsb pdb:4FNW|rcsb pdb:4FNX|rcsb pdb:4FNY|rcsb pdb:4FNZ|rcsb pdb:4FOB|rcsb pdb:4FOC|rcsb pdb:4FOD|rcsb pdb:4JOA|rcsb pdb:4MKC|rcsb pdb:4TT7|rcsb pdb:4Z55|rcsb pdb:5A9U|rcsb pdb:5AA9|rcsb pdb:5AAA|rcsb pdb:5AAB|rcsb pdb:5AAC|rcsb pdb:5FTO|rcsb pdb:5FTQ|rcsb pdb:5IMX|rcsb pdb:5IUG|rcsb pdb:5IUH|rcsb pdb:5IUI|rcsb pdb:5KZ0|rcsb pdb:5VZ5|rcsb pdb:6AT9|rcsb pdb:6CDT|rcsb pdb:6E0R|rcsb pdb:6EBW|rcsb pdb:6EDL|rcsb pdb:6MX8|rcsb pdb:7BTT|rcsb pdb:7JY4|rcsb pdb:7JYR|rcsb pdb:7JYS|rcsb pdb:7JYT|rcsb pdb:5AA8|refseq:NP_004295.2|dip:DIP-5954N	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:AVut3q3smPUsklP/IahGM8qzDM49606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:Q04771	intact:EBI-13635573	intact:EBI-1383616|ensembl:ENSP00000263640|ensembl:ENSP00000387127|ensembl:ENSP00000387273|ensembl:ENSP00000400767|ensembl:ENSP00000405004|ensembl:ENSP00000440091|ensembl:ENSP00000500109|ensembl:ENSP00000500605|ensembl:ENSP00000507086|ensembl:ENSP00000507102|ensembl:ENSP00000507113|ensembl:ENSP00000507727|ensembl:ENSP00000507730|ensembl:ENSP00000508136|ensembl:ENSP00000508189	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:acvr1_human(display_long)|uniprotkb:Activin receptor-like kinase 2(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)|uniprotkb:ACVRLK2(gene name synonym)|uniprotkb:Activin receptor type I(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R1(gene name synonym)|uniprotkb:ACVR1(gene name)|psi-mi:ACVR1(display_short)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:XP_006712888.1|refseq:NP_001096.1|refseq:NP_001104537.1|refseq:NP_001334592.1|refseq:NP_001334593.1|refseq:NP_001334594.1|refseq:NP_001334595.1|refseq:NP_001334596.1|refseq:XP_011510410.1|dip:DIP-212N|ensembl:ENSG00000115170(gene)|ensembl:ENST00000263640(transcript)|ensembl:ENST00000409283(transcript)|ensembl:ENST00000410057(transcript)|ensembl:ENST00000424669(transcript)|ensembl:ENST00000434821(transcript)|ensembl:ENST00000539637(transcript)|ensembl:ENST00000672582(transcript)|ensembl:ENST00000673324(transcript)|ensembl:ENST00000682025(transcript)|ensembl:ENST00000682300(transcript)|ensembl:ENST00000683441(transcript)|ensembl:ENST00000683487(transcript)|ensembl:ENST00000683820(transcript)|ensembl:ENST00000684348(transcript)|ensembl:ENST00000684595(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061445"(endocardial cushion cell fate commitment)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3H9R|rcsb pdb:3MTF|rcsb pdb:3OOM|rcsb pdb:3Q4U|rcsb pdb:4BGG|rcsb pdb:4C02|rcsb pdb:4DYM|rcsb pdb:5OXG|rcsb pdb:5OY6|rcsb pdb:5S75|rcsb pdb:5S76|rcsb pdb:5S77|rcsb pdb:5S78|rcsb pdb:5S79|rcsb pdb:5S7A|rcsb pdb:5S7B|rcsb pdb:5S7C|rcsb pdb:5S7D|rcsb pdb:5S7E|rcsb pdb:5S7F|rcsb pdb:5S7G|rcsb pdb:5S7H|rcsb pdb:5S7I|rcsb pdb:5S7K|rcsb pdb:5S7L|rcsb pdb:5S7M|rcsb pdb:5S7N|rcsb pdb:5S7O|rcsb pdb:5S7P|rcsb pdb:5S7Q|rcsb pdb:5S7R|rcsb pdb:5S7S|rcsb pdb:5S7T|rcsb pdb:5S7U|rcsb pdb:5S7V|rcsb pdb:5S7W|rcsb pdb:5S7X|rcsb pdb:5S7Y|rcsb pdb:5S7Z|rcsb pdb:5S80|rcsb pdb:5S81|rcsb pdb:5S82|rcsb pdb:5S83|rcsb pdb:5S84|rcsb pdb:5S7J|rcsb pdb:5S86|rcsb pdb:5S87|rcsb pdb:5S88|rcsb pdb:5S89|rcsb pdb:5S8A|rcsb pdb:5S8B|rcsb pdb:5S9K|rcsb pdb:6ACR|rcsb pdb:6EIX|rcsb pdb:6GI6|rcsb pdb:6GIN|rcsb pdb:6GIP|rcsb pdb:6I1S|rcsb pdb:6JUX|rcsb pdb:6SRH|rcsb pdb:6SZM|rcsb pdb:6T6D|rcsb pdb:6T8N|rcsb pdb:6TN8|rcsb pdb:6Z36|rcsb pdb:6ZGC|rcsb pdb:7A21|rcsb pdb:7C3G|rcsb pdb:7NNS|rcsb pdb:5S85	-	-	-	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:NzjgauTNWRsw1ItUdgycs1LAQ2s9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:77563"	uniprotkb:P42684-4	intact:EBI-13635573	intact:EBI-13635528|ensembl:ENSP00000426831	psi-mi:rac-crizotinib(display_short)|psi-mi:"CHEBI:77563"(display_long)|intact:"(+-)-crizotinib"(synonym)|intact:"(RS)-crizotinib"(synonym)|intact:racemic crizotinib(synonym)|intact:"rac-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine"(iupac name)	psi-mi:p42684-4(display_long)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:1ASCTS(isoform synonym)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vladimer et al. (2017)	pubmed:28437395|imex:IM-25603	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13635545|imex:IM-25603-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143322(gene)|ensembl:ENST00000504405(transcript)|intact:EBI-1102694(isoform-parent)	-	-	isoform-comment:"Variant in position: 12:S->T (in dbSNP:rs1318056). Contains a phosphotyrosine at position 647."	figure legend:Supplementary table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/16	2021/11/30	-	rogid:/oBPZiGiqQrC2idW7sKaKuFSe5o9606	-	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)