#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IZT6	uniprotkb:O14545	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1396921|uniprotkb:B4DI89|uniprotkb:A8K5L6|intact:EBI-28969419|ensembl:ENSP00000257604|ensembl:ENSP00000396526	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:trad1_human(display_long)|uniprotkb:TRAFD1(gene name)|psi-mi:TRAFD1(display_short)|uniprotkb:FLN29(gene name synonym)|uniprotkb:Protein FLN29(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	ensembl:ENSP00000257604|ensembl:ENSP00000396526|ensembl:ENST00000552890|ensembl:ENSP00000447340|refseq:NP_001137378.1|refseq:NP_006691.1|ensembl:ENSG00000135148(gene)|ensembl:ENST00000257604(transcript)|ensembl:ENST00000412615(transcript)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2D9K	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:hDY19qxNvWdsjDOoUEpuYfe0cdA9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q6NZ67	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1052566|uniprotkb:Q96CG4|intact:EBI-2555069|ensembl:ENSP00000281871	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:mzt2b_human(display_long)|uniprotkb:MZT2B(gene name)|psi-mi:MZT2B(display_short)|uniprotkb:FAM128B(gene name synonym)|uniprotkb:MOZART2B(gene name synonym)|uniprotkb:Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_079305.2|ensembl:ENSG00000152082(gene)|ensembl:ENST00000281871(transcript)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|interpro:IPR024332|mint:Q6NZ67|reactome:R-HSA-380270|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:zjtQDl3ebeUtbVBixZvPf25VcxQ9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O75935	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-347442|uniprotkb:A6NII7|uniprotkb:Q5T1I5|uniprotkb:Q5T1I7|uniprotkb:Q5T8G3|uniprotkb:Q9BPU8|uniprotkb:B2RBM5|ensembl:ENSP00000259632	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:dctn3_human(display_long)|uniprotkb:DCTN22(gene name synonym)|uniprotkb:DCTN3(gene name)|psi-mi:DCTN3(display_short)|uniprotkb:Dynactin complex subunit 22 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_009165.1|refseq:NP_077324.1|ensembl:ENSG00000137100(gene)|ensembl:ENST00000259632(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|interpro:IPR009991(Dynactin subunit p22)|mint:O75935|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|refseq:NP_001268354.1|refseq:NP_001268355.1	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:KPLiGDMa0KR/H31QtEdl2YiwYzk9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q96L14	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-743488	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:c170l_human(display_long)|uniprotkb:KIAA0470L(gene name synonym)|uniprotkb:CEP170P1(gene name)|psi-mi:CEP170P1(display_short)|uniprotkb:CEP170L(gene name synonym)|uniprotkb:CEP170 pseudogene 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	interpro:IPR026644|interpro:IPR029300|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:Z/Rium0Kwj3ZUHa4WE5PPksPXdg9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O43379	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-714790|uniprotkb:Q63HP9|uniprotkb:Q659D7|uniprotkb:Q8NBF7|uniprotkb:Q96AD9|intact:EBI-2563293|ensembl:ENSP00000270301	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:wdr62_human(display_long)|uniprotkb:WDR62(gene name)|psi-mi:WDR62(display_short)|uniprotkb:C19orf14(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007099"(centriole replication)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0034451"(centriolar satellite)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR036322|mint:O43379|go:"GO:0005813"(centrosome)|ensembl:ENSG00000075702(gene)|ensembl:ENST00000270301(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|refseq:NP_001077430.1|refseq:NP_775907.4|refseq:XP_016882154.1|dip:DIP-56792N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:bKUivd80luQPFZHsU9mDdwyGwi89606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O14965	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q96RT8	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-2555061|uniprotkb:Q96PY8|uniprotkb:Q6IQ52|ensembl:ENSP00000480316|uniprotkb:E9PB12	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:gcp5_human(display_long)|uniprotkb:GCP5(gene name synonym)|uniprotkb:KIAA1899(gene name synonym)|uniprotkb:TUBGCP5(gene name)|psi-mi:TUBGCP5(display_short)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_001096080.1|refseq:NP_443135.3|ensembl:ENSG00000275835(gene)|ensembl:ENST00000615383(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|rcsb pdb:6L81|rcsb pdb:6V69|rcsb pdb:6V6S|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSP00000480316|ensembl:ENST00000620435|ensembl:ENSP00000481853	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:ERVu5LLd+VS+yKJoEk2tjh7z+n89606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q9BW19	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-2107279|uniprotkb:O60887|uniprotkb:Q14834|uniprotkb:Q4KMP0|uniprotkb:Q5SU09|uniprotkb:Q6GMS7|uniprotkb:Q6P4A5|uniprotkb:Q9UQP7|ensembl:ENSP00000363647|ensembl:ENSP00000393963|ensembl:ENSP00000407885	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:kifc1_human(display_long)|uniprotkb:KIFC1(gene name)|psi-mi:KIFC1(display_short)|uniprotkb:HSET(gene name synonym)|uniprotkb:KNSL2(gene name synonym)|uniprotkb:Kinesin-like protein 2(gene name synonym)|uniprotkb:Kinesin-related protein HSET(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_002254.2|ensembl:ENSG00000204197(gene)|ensembl:ENSG00000233450(gene)|ensembl:ENSG00000237649(gene)|ensembl:ENST00000374523(transcript)|ensembl:ENST00000428849(transcript)|ensembl:ENST00000448818(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q9BW19|rcsb pdb:5WDH|reactome:R-HSA-6811434|reactome:R-HSA-983189	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:2gWpNwZk9kWJGVvR8xLuDPJYP4M9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q96RT7	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-2555074|uniprotkb:Q9UGX3|uniprotkb:Q9UGX4|uniprotkb:Q5JZ80|uniprotkb:Q6PJ40|uniprotkb:Q9BY91|uniprotkb:Q86YE9|ensembl:ENSP00000248846	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:gcp6_human(display_long)|uniprotkb:GCP6(gene name synonym)|uniprotkb:KIAA1669(gene name synonym)|uniprotkb:TUBGCP6(gene name)|psi-mi:TUBGCP6(display_short)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_065194.2|ensembl:ENSG00000128159(gene)|ensembl:ENST00000248846(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|rcsb pdb:6M33|rcsb pdb:6V6C|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:H5Y8PvMXPZTmeJUq8yOQbPZ2jYY9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q9BVA0	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-11147603|uniprotkb:A6NCG6|uniprotkb:O60620|ensembl:ENSP00000368982	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ktnb1_human(display_long)|uniprotkb:KATNB1(gene name)|psi-mi:KATNB1(display_short)|uniprotkb:p80 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_005877.2|ensembl:ENSG00000140854(gene)|ensembl:ENST00000379661(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|refseq:XP_016878352.1|refseq:XP_016878353.1	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:llQT6GKslXidTcrFxJniQe6/gwc9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q96P70	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O75449	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1048692|uniprotkb:Q5TFA8|uniprotkb:Q5TFA9|uniprotkb:Q86VN2|uniprotkb:Q9NU52|uniprotkb:E1P5A3|ensembl:ENSP00000335106|ensembl:ENSP00000356381	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ktna1_human(display_long)|uniprotkb:p60 katanin(gene name synonym)|uniprotkb:KATNA1(gene name)|psi-mi:KATNA1(display_short)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_001191005.1|refseq:NP_008975.1|refseq:XP_016865696.1|refseq:XP_016865699.1|refseq:XP_005266861.1|ensembl:ENSG00000186625(gene)|ensembl:ENST00000335647(transcript)|ensembl:ENST00000367411(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016853"(isomerase activity)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR028596|interpro:IPR041569|rcsb pdb:5ZQL|rcsb pdb:5ZQM	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:pLCbxizZcPPDmfbqIugdN6G7azw9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P55072	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q9UGJ1	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1052544|uniprotkb:Q969X3|uniprotkb:Q9NVF0|uniprotkb:B3KNK6|ensembl:ENSP00000260383	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:gcp4_human(display_long)|uniprotkb:Gamma-ring complex protein 76 kDa(gene name synonym)|uniprotkb:TUBGCP4(gene name)|psi-mi:TUBGCP4(display_short)|uniprotkb:76P(gene name synonym)|uniprotkb:GCP4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_055259.2|refseq:NP_001273343.1|refseq:XP_011519757.1|ensembl:ENSG00000137822(gene)|ensembl:ENST00000260383(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|interpro:IPR042241|mint:Q9UGJ1|rcsb pdb:3RIP|rcsb pdb:6V69|rcsb pdb:6V6S|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|dip:DIP-50536N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:5pAlGB03qeX0CJ0etjcLInwgaZQ9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O00139	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-2692369|uniprotkb:A5YM42|uniprotkb:Q7Z5I3|uniprotkb:B4DY54|uniprotkb:A5YM54|uniprotkb:Q8N5Q7|uniprotkb:D3DW97|uniprotkb:E9PB70|ensembl:ENSP00000385622	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:kif2a_human(display_long)|uniprotkb:KIF2(gene name synonym)|uniprotkb:KNS2(gene name synonym)|uniprotkb:Kinesin-2(gene name synonym)|uniprotkb:KIF2A(gene name)|psi-mi:KIF2A(display_short)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_001091981.1|refseq:NP_004511.2|refseq:NP_001230881.1|ensembl:ENSG00000068796(gene)|ensembl:ENST00000401507(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0051301"(cell division)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:O00139|rcsb pdb:2GRY|rcsb pdb:6BBN|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-6811434|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983189|dip:DIP-56112N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:XuuV3xe7NwfZMTlyNE5I2mlgDVo9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q9UNE7	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:h4QyIM0TptgkQppPUgiKn68XjP49606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P30153	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-302388|uniprotkb:Q13773|uniprotkb:Q6ICQ3|uniprotkb:Q96DH3|ensembl:ENSP00000324804	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:2aaa_human(display_long)|uniprotkb:PPP2R1A(gene name)|psi-mi:PPP2R1A(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)|uniprotkb:Medium tumor antigen-associated 61 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	ensembl:ENSG00000105568(gene)|ensembl:ENST00000322088(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990405"(protein antigen binding)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:P30153|rcsb pdb:1B3U|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:2PKG|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3K7V|rcsb pdb:3K7W|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6IUR|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2995383|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-8854518|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_055040.2|dip:DIP-29394N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:73tR8yYYvViK8JdgIg18XWc3HRc9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:O95373	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q96CW5	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1046278|ensembl:ENSP00000261965|uniprotkb:O43631|uniprotkb:O60852|uniprotkb:O60853|uniprotkb:Q7Z4K1|uniprotkb:Q96I79|uniprotkb:Q5T8L2	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:gcp3_human(display_long)|uniprotkb:Spindle pole body protein Spc98 homolog(gene name synonym)|uniprotkb:TUBGCP3(gene name)|psi-mi:TUBGCP3(display_short)|uniprotkb:GCP3(gene name synonym)|uniprotkb:Gamma-ring complex protein 104 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007338"(single fertilization)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q96CW5|rcsb pdb:6V6B|go:"GO:0000930"(gamma-tubulin complex)|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSG00000126216(gene)|ensembl:ENST00000261965(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_006313.1|refseq:NP_001273207.1|refseq:NP_001273208.1|refseq:NP_001273206.1	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:xt+Ngo2s/4djh2PnyMEaxgDyLrs9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q9BSJ2	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-357881|uniprotkb:O43632|ensembl:ENSP00000252936|ensembl:ENSP00000506731|ensembl:ENSP00000507482|ensembl:ENSP00000507610|uniprotkb:Q5VWX7|uniprotkb:B4DM18|uniprotkb:F5H4E0|uniprotkb:B7ZKL8|uniprotkb:F5H4L0	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:gcp2_human(display_long)|uniprotkb:TUBGCP2(gene name)|psi-mi:TUBGCP2(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:Spindle pole body protein Spc97 homolog(gene name synonym)|uniprotkb:Gamma-ring complex protein 103 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_006650.1|ensembl:ENSG00000130640(gene)|ensembl:ENST00000252936(transcript)|ensembl:ENST00000682123(transcript)|ensembl:ENST00000682515(transcript)|ensembl:ENST00000683612(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001243547.1|refseq:NP_001243546.1|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q9BSJ2|rcsb pdb:6V6B|rcsb pdb:6V6S|rcsb pdb:6X0V|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:vhamYv9ZNsZkSBkGQCwVylqx9wE9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P62158	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P06899	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-6150252|uniprotkb:B2R4J4|uniprotkb:O60816|ensembl:ENSP00000342886|ensembl:ENSP00000476136	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:h2b1j_human(display_long)|uniprotkb:H2BC11(gene name)|psi-mi:H2BC11(display_short)|uniprotkb:H2BFR(gene name synonym)|uniprotkb:HIST1H2BJ(gene name synonym)|uniprotkb:Histone H2B.1(gene name synonym)|uniprotkb:Histone H2B.r(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_066402.2|dip:DIP-421N|ensembl:ENSG00000124635(gene)|ensembl:ENST00000339812(transcript)|ensembl:ENST00000607124(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003677"(DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:P06899|rcsb pdb:2RVQ|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WAA|rcsb pdb:3WTP|rcsb pdb:4CAY|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5FUG|rcsb pdb:5GSE|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JRG|rcsb pdb:5VEY|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:6A5P|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6BUZ|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6JXD|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6O1D|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6YOV|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7K5X|rcsb pdb:3WA9|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:74GQlSjGG1Ez6Uog74VXPLryKBc9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P23258	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-302589|ensembl:ENSP00000251413|uniprotkb:Q9BW59|uniprotkb:Q53X79	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:tbg1_human(display_long)|uniprotkb:TUBG1(gene name)|psi-mi:TUBG1(display_short)|uniprotkb:TUBG(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P23258|rcsb pdb:1Z5V|rcsb pdb:1Z5W|rcsb pdb:3CB2|rcsb pdb:6V5V|rcsb pdb:6V6S|rcsb pdb:7AS4|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|interpro:IPR017975|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000131462(gene)|ensembl:ENST00000251413(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|go:"GO:0005814"(centriole)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|refseq:NP_001061.2|dip:DIP-29890N	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:Y5WLH1ZKlS7FOa9ePmH3dpdE8Xk9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q99733	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-2255116|uniprotkb:B2R6J4|uniprotkb:F5HFY4|ensembl:ENSP00000369915|ensembl:ENSP00000483728	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:np1l4_human(display_long)|uniprotkb:NAP1L4(gene name)|psi-mi:NAP1L4(display_short)|uniprotkb:NAP2(gene name synonym)|uniprotkb:Nucleosome assembly protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_005960.1|ensembl:ENSG00000205531(gene)|ensembl:ENSG00000273562(gene)|ensembl:ENST00000380542(transcript)|ensembl:ENST00000619695(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q99733	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:tES8IJDlW4JONR/pdC8dq49I/7Y9606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:P55209	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8IZT6	uniprotkb:Q14257	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059515|imex:IM-25667-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1	-	-	-	figure legend:Fig. 1a, 1b, Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/09	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606	rigid:s+scwBip7hLoT9Uc0GXGfiUsLzM	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BVA0	uniprotkb:Q8IZT6	intact:EBI-11147603|uniprotkb:A6NCG6|uniprotkb:O60620|ensembl:ENSP00000368982	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	psi-mi:ktnb1_human(display_long)|uniprotkb:KATNB1(gene name)|psi-mi:KATNB1(display_short)|uniprotkb:p80 katanin(gene name synonym)	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059555|imex:IM-25667-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005877.2|ensembl:ENSG00000140854(gene)|ensembl:ENST00000379661(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|refseq:XP_016878352.1|refseq:XP_016878353.1	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	go:"GO:0097431"(mitotic spindle pole)	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2017/02/20	2017/05/09	rogid:llQT6GKslXidTcrFxJniQe6/gwc9606	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rigid:7T3Ox2uhqktDn91jxe8RbizQxfo	false	-	green fluorescent protein tag:n-n|strep tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059570|imex:IM-25667-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2017/02/20	2017/05/09	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:FckMFdAhfFCQgozJsXHNAMROQ2s	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n	sufficient binding region:1-78	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8BG40	uniprotkb:Q8CJ27	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059582|imex:IM-25667-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/08/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	green fluorescent protein tag:n-n|biotin tag:n-n	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059582|imex:IM-25667-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/08/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	green fluorescent protein tag:n-n|biotin tag:n-n	green fluorescent protein tag:n-n|biotin tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14060911|imex:IM-25667-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:FckMFdAhfFCQgozJsXHNAMROQ2s	false	mutation with no effect:538-538|green fluorescent protein tag:n-n|biotin tag:n-n|mutation with no effect:574-574|mutation with no effect:581-581|mutation with no effect:543-543	green fluorescent protein tag:n-n|mutation with no effect:18-18|mutation with no effect:19-19	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q8CJ27	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059662|imex:IM-25667-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	figure legend:Fig. 3D, 3F, 3G, 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n	green fluorescent protein tag:n-n|sufficient binding region:296-309|sufficient binding region:346-359|sufficient binding region:371-384|mutation disrupting interaction strength:302-302|mutation disrupting interaction strength:352-352|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:324-324	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059662|imex:IM-25667-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Fig. 3D, 3F, 3G, 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n	sufficient binding region:1-78	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q8CJ27	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059983|imex:IM-25667-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	figure legend:Fig.4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/08/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n	green fluorescent protein tag:n-n|mutation disrupting interaction strength:377-377,302-302	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059983|imex:IM-25667-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Fig.4G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/08/11	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n	sufficient binding region:1-78	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CJ27	uniprotkb:Q9WV86	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692898|intact:MINT-8307998	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059713|imex:IM-25667-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint	figure legend:Fig. 3H, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-6(molar)	2017/02/20	2017/05/09	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355|fluorescent dye label:?-?|mutation disrupting interaction strength:352-352	sufficient binding region:1-78|mutation disrupting interaction strength:18-18|mutation disrupting interaction strength:19-19	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CJ27	uniprotkb:Q8BG40	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059713|imex:IM-25667-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	figure legend:Fig. 3H, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-6(molar)	2017/02/20	2017/05/09	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355|fluorescent dye label:?-?|mutation disrupting interaction strength:352-352	sufficient binding region:481-658|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:538-538|mutation disrupting interaction strength:574-574	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8BG40	uniprotkb:Q9WV86	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	intact:EBI-7692898|intact:MINT-8307998	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059853|imex:IM-25667-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	comment:mint	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/09	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:FckMFdAhfFCQgozJsXHNAMROQ2s	false	sufficient binding region:481-658|glutathione s tranferase tag:n-n|mutation decreasing interaction strength:538-538|mutation with no effect:574-574|mutation with no effect:615-615	sufficient binding region:1-78|mutation with no effect:18-18|mutation with no effect:19-19	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CJ27	uniprotkb:Q9WV86	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692898|intact:MINT-8307998	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059777|wwpdb:5lb7|imex:IM-25667-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint	figure legend:Supp. Table 3|3d-resolution:1.5A|3d-r-factors:Rworking  0.183 Rfree 0.223|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/10	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355	sufficient binding region:1-78	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CJ27	uniprotkb:Q8BG40	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059777|wwpdb:5lb7|imex:IM-25667-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	figure legend:Supp. Table 3|3d-resolution:1.5A|3d-r-factors:Rworking  0.183 Rfree 0.223|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/10	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355	sufficient binding region:481-658|his tag:n-n	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CJ27	uniprotkb:Q9WV86	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692898|intact:MINT-8307998	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktna1_mouse(display_long)|uniprotkb:Katna1(gene name)|psi-mi:Katna1(display_short)|uniprotkb:Lipotransin(gene name synonym)|uniprotkb:p60 katanin(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059818|imex:IM-25667-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	interpro:IPR028596|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001764"(neuron migration)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008104"(protein localization)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016853"(isomerase activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097431"(mitotic spindle pole)|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:2RPA|interpro:IPR027417|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR036181|interpro:IPR041569|rcsb pdb:6GZC	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint	figure legend:Fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/09	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:NDsx6wb+8GW4j1BCk/kkwKUEVwc10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355|fluorescent dye label:?-?	sufficient binding region:1-78|mutation with no effect:18-18|mutation with no effect:19-19	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CJ27	uniprotkb:Q8BG40	intact:EBI-8384445|intact:MINT-4088484|uniprotkb:B1ARM7|uniprotkb:O88482|uniprotkb:Q8BJI8|uniprotkb:Q8BKT4|intact:EBI-14059618|uniprotkb:A0A0G2JES1|uniprotkb:Q4G1G9|ensembl:ENSMUSP00000059159	intact:EBI-7692933|ensembl:ENSMUSP00000034239|uniprotkb:Q8CD18|intact:UNK-5969950|uniprotkb:Q8R1J0|uniprotkb:Q9CWV2	psi-mi:aspm_mouse(display_long)|uniprotkb:Aspm(gene name)|psi-mi:Aspm(display_short)|uniprotkb:Calmbp1(gene name synonym)|uniprotkb:Sha1(gene name synonym)|uniprotkb:Calmodulin-binding protein Sha1(gene name synonym)|uniprotkb:Spindle and hydroxyurea checkpoint abnormal protein(gene name synonym)	psi-mi:ktnb1_mouse(display_long)|uniprotkb:p80 katanin(gene name synonym)|uniprotkb:Katnb1(gene name)|psi-mi:Katnb1(display_short)	psi-mi:"MI:0016"(circular dichroism)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14059818|imex:IM-25667-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033921.3|ensembl:ENSMUSG00000033952(gene)|ensembl:ENSMUST00000053364(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045769"(negative regulation of asymmetric cell division)|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|mint:Q8CJ27|rcsb pdb:5LB7	ensembl:ENSMUSG00000031787(gene)|ensembl:ENSMUST00000034239(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|rcsb pdb:5LB7|rcsb pdb:5NBT|rcsb pdb:5OW5|rcsb pdb:6GZC|refseq:NP_083081.2|refseq:XP_006531473.1|refseq:XP_006531474.1|refseq:XP_006531475.1	-	comment:mint|function:Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis	comment:mint|function:Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth	figure legend:Fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/02/20	2017/05/09	rogid:lrN7nnijUvVWmjI3/GyzZmDRYCo10090	rogid:ucjcfzxQveYTuxBO9P+HOgJaD3A10090	rigid:MVbEJt/8Lw9/lP3MKuOp4Hx7Xyc	false	sufficient binding region:347-355|fluorescent dye label:?-?	sufficient binding region:481-658|glutathione s tranferase tag:n-n|mutation decreasing interaction strength:538-538|mutation with no effect:574-574|mutation with no effect:615-615	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZT6	uniprotkb:Q9BVA0	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-11147603|uniprotkb:A6NCG6|uniprotkb:O60620|ensembl:ENSP00000368982	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ktnb1_human(display_long)|uniprotkb:KATNB1(gene name)|psi-mi:KATNB1(display_short)|uniprotkb:p80 katanin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14060948|imex:IM-25667-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_005877.2|ensembl:ENSG00000140854(gene)|ensembl:ENST00000379661(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0008017"(microtubule binding)|go:"GO:0008352"(katanin complex)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0060590"(ATPase regulator activity)|go:"GO:0070840"(dynein complex binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026962|interpro:IPR028021|interpro:IPR036322|refseq:XP_016878352.1|refseq:XP_016878353.1	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/11	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:llQT6GKslXidTcrFxJniQe6/gwc9606	rigid:+G+jYrTItuR3URPNVHNlE3LmfKU	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IZT6	uniprotkb:O75449	intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379	intact:EBI-1048692|uniprotkb:Q5TFA8|uniprotkb:Q5TFA9|uniprotkb:Q86VN2|uniprotkb:Q9NU52|uniprotkb:E1P5A3|ensembl:ENSP00000335106|ensembl:ENSP00000356381	psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym)	psi-mi:ktna1_human(display_long)|uniprotkb:p60 katanin(gene name synonym)|uniprotkb:KATNA1(gene name)|psi-mi:KATNA1(display_short)	psi-mi:"MI:0096"(pull down)	Kai et al. (2017)	pubmed:28436967|imex:IM-25667	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14060948|imex:IM-25667-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_001191005.1|refseq:NP_008975.1|refseq:XP_016865696.1|refseq:XP_016865699.1|refseq:XP_005266861.1|ensembl:ENSG00000186625(gene)|ensembl:ENST00000335647(transcript)|ensembl:ENST00000367411(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016853"(isomerase activity)|go:"GO:0030496"(midbody)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR028596|interpro:IPR041569|rcsb pdb:5ZQL|rcsb pdb:5ZQM	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/02/20	2017/05/11	rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606	rogid:pLCbxizZcPPDmfbqIugdN6G7azw9606	rigid:+G+jYrTItuR3URPNVHNlE3LmfKU	false	green fluorescent protein tag:n-n|strep tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)