#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20138-1	matrixdb:MULT_82_human	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186028|imex:IM-25793-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:"1B (A/C)"|comment:The C1q collagen-like region of C1q did not bind CD33 isoform1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	-	-	false	biotin tag:c-c|his tag:c-c|sufficient binding region:18-259	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P02747	uniprotkb:P02746	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186291|imex:IM-25793-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V	-	-	-	figure legend:1 A-C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	sufficient binding region:117..117-245..245(IPR001073)	sufficient binding region:119..119-250..250(IPR001073)	6	6	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P02747	uniprotkb:P20138-1	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	intact:EBI-15186203|ensembl:ENSP00000262262	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186291|imex:IM-25793-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	-	-	-	figure legend:1 A-C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	sufficient binding region:117..117-245..245(IPR001073)	biotin tag:c-c|his tag:c-c|sufficient binding region:18-259	6	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P02747	uniprotkb:P02745	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186291|imex:IM-25793-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606	-	-	-	figure legend:1 A-C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	sufficient binding region:117..117-245..245(IPR001073)	sufficient binding region:112..112-244..244(IPR001073)	6	6	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20138-3	matrixdb:MULT_82_human	intact:EBI-15186348|ensembl:ENSP00000410126	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:p20138-3(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186337|imex:IM-25793-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000421133(transcript)|intact:EBI-3906571(isoform-parent)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	isoform-comment:Mostly detected on NKL and myeloid cell lines but poorly expressed on B-cell lines and T-lymphocytes.	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:1D, 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:vHidkNo6S5YckL18pjz3GdX/+WY9606	-	-	false	flag tag:c-c|myc tag:c-c	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20138-1	matrixdb:MULT_82_human	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186437|imex:IM-25793-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:2C, Supp fig 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	-	-	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:18-259	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q6GTX8	matrixdb:MULT_82_human	intact:EBI-965864|ensembl:ENSP00000301193|ensembl:ENSP00000375622|ensembl:ENSP00000418998|ensembl:ENSP00000479133|ensembl:ENSP00000479682|ensembl:ENSP00000479707	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:lair1_human(display_long)|uniprotkb:LAIR1(gene name)|psi-mi:LAIR1(display_short)|uniprotkb:CD305(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0049"(filter binding)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186478|imex:IM-25793-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_001275954.2|ensembl:ENSG00000167613(gene)|ensembl:ENSG00000274110(gene)|ensembl:ENSG00000276053(gene)|ensembl:ENSG00000278154(gene)|ensembl:ENST00000348231(transcript)|ensembl:ENST00000391742(transcript)|ensembl:ENST00000474878(transcript)|ensembl:ENST00000616612(transcript)|ensembl:ENST00000618434(transcript)|ensembl:ENST00000619717(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KGR|rcsb pdb:3RP1|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001275952.2|refseq:NP_002278.2|refseq:NP_068352.2	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:2Ci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:uwpvGL79EvmpZPhLt+8D+cq8x/c9606	-	-	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20138-3	matrixdb:MULT_82_human	intact:EBI-15186348|ensembl:ENSP00000410126	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:p20138-3(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186370|imex:IM-25793-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000421133(transcript)|intact:EBI-3906571(isoform-parent)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	isoform-comment:Mostly detected on NKL and myeloid cell lines but poorly expressed on B-cell lines and T-lymphocytes.	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:vHidkNo6S5YckL18pjz3GdX/+WY9606	-	-	false	flag tag:c-c|myc tag:c-c	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20138-1	matrixdb:MULT_82_human	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-6264901|reactome:R-HSA-173579|wwpdb:1PK6|wwpdb:2wnv|wwpdb:2jg8|wwpdb:2jg9|wwpdb:2wnu|reactome:R-HSA-173588	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1q_human(display_short)|psi-mi:MULT_82_human(display_long)|intact:Complement component C1q complex(complex recommended name)|intact:C1q(complex synonym)|intact:Complement 1q(complex synonym)|intact:C1QA-C1QB-C1QC complex(complex synonym)|intact:"6xC1QA:6xC1QB:6xC1QC"(complex systematic name)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186380|imex:IM-25793-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	go:"GO:0005509"(calcium ion binding)|go:"GO:0019865"(immunoglobulin binding)|efo:"MONDO:0013343"(see-also)|pubmed:28601358(see-also)|pubmed:22536204(see-also)|intact:EBI-6264878(exp-evidence)|evidence ontology:"ECO:0000353"|complex portal:CPX-1919(complex-primary)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0005576"(extracellular region)|pubmed:20548024(see-also)|pubmed:29449492(see-also)|pubmed:18250442(see-also)|go:"GO:0062167"(complement component C1q complex)|pubmed:31165008(see-also)|pubmed:27914690(see-also)|pubmed:26489954(see-also)	-	-	disease:"Complement component C1q deficiency (C1QD) [MONDO:0013343]: a disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis."|complex-properties:The complex comprises of six heterotrimeric collagen-like triple helices, formed from triplets of the A, B, and C chains, that associate in their N-terminal half to form a stalk, then diverge to form individual stems, each terminating in a C-terminal globular domain. Each of the six heterotrimeric globular heads or domains is made up of the globular domains from one A, one B, and one C chain, each of which in turn has its own ligand specificity. The six collagen-like stalks appear to be fibril-like and exist in the central region. The collagen-like region and the globular heads can independently interact with a multiplicity of biological structures including pathogen-associated and cell associated molecules, also each of the individual globular head domains is capable of independently interacting with specific ligands. Chains A and B are disulfide-linked whilst the C chain forms a disulfide bond with the C chain of the next strand.     Molecular weight 460 kDa.|curated-complex:"Recognition unit of the classical pathway of complement which associates with the Ca2+ - dependent C1r(2)-C1s(2) tetramer to form C1 (CPX-1920), the first component of the classical complement system. The complex's role in C1 is the recognition of immune complexes, or other molecules, which trigger the classical pathway of the complement system. Independent of complement activation C1q appears to have additional roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning."|complex-assembly:Heterooctadecamer	figure legend:2Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	-	-	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:18-259	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q6GTX8	uniprotkb:P20138	intact:EBI-965864|ensembl:ENSP00000301193|ensembl:ENSP00000375622|ensembl:ENSP00000418998|ensembl:ENSP00000479133|ensembl:ENSP00000479682|ensembl:ENSP00000479707	intact:EBI-3906571|uniprotkb:Q8TD24|uniprotkb:B4E3P8|uniprotkb:F8WAL2|uniprotkb:C9JEN7|ensembl:ENSP00000262262	psi-mi:lair1_human(display_long)|uniprotkb:LAIR1(gene name)|psi-mi:LAIR1(display_short)|uniprotkb:CD305(gene name synonym)	psi-mi:cd33_human(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186591|imex:IM-25793-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001275954.2|ensembl:ENSG00000167613(gene)|ensembl:ENSG00000274110(gene)|ensembl:ENSG00000276053(gene)|ensembl:ENSG00000278154(gene)|ensembl:ENST00000348231(transcript)|ensembl:ENST00000391742(transcript)|ensembl:ENST00000474878(transcript)|ensembl:ENST00000616612(transcript)|ensembl:ENST00000618434(transcript)|ensembl:ENST00000619717(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KGR|rcsb pdb:3RP1|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001275952.2|refseq:NP_002278.2|refseq:NP_068352.2	refseq:XP_011525834.1|refseq:NP_001763.3|refseq:NP_001076087.1|refseq:NP_001171079.1|ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5IHB|rcsb pdb:5J06|rcsb pdb:5J0B|rcsb pdb:6D48|rcsb pdb:6D49|rcsb pdb:6D4A|rcsb pdb:6TL8|rcsb pdb:7AW6|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:3E|agonist:whole C1q|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2017/05/16	2017/06/22	rogid:uwpvGL79EvmpZPhLt+8D+cq8x/c9606	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rigid:g9laOwdjN6nZcKWjhUJO6H9HV94	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08571	uniprotkb:P20138	intact:EBI-3905196|uniprotkb:Q96L99|uniprotkb:Q53XT5|uniprotkb:Q9UNS3|uniprotkb:Q96FR6|ensembl:ENSP00000304236|ensembl:ENSP00000385519	intact:EBI-3906571|uniprotkb:Q8TD24|uniprotkb:B4E3P8|uniprotkb:F8WAL2|uniprotkb:C9JEN7|ensembl:ENSP00000262262	psi-mi:cd14_human(display_long)|uniprotkb:CD14(gene name)|psi-mi:CD14(display_short)|uniprotkb:Myeloid cell-specific leucine-rich glycoprotein(gene name synonym)	psi-mi:cd33_human(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186740|imex:IM-25793-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000582.1|refseq:NP_001035110.1|refseq:NP_001167575.1|refseq:NP_001167576.1|dip:DIP-1030N|ensembl:ENSG00000170458(gene)|ensembl:ENST00000302014(transcript)|ensembl:ENST00000401743(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001847"(opsonin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR016337(Monocyte differentiation antigen CD14)|interpro:IPR032675|rcsb pdb:4GLP|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166020|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-168179|reactome:R-HSA-168188|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)	refseq:XP_011525834.1|refseq:NP_001763.3|refseq:NP_001076087.1|refseq:NP_001171079.1|ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5IHB|rcsb pdb:5J06|rcsb pdb:5J0B|rcsb pdb:6D48|rcsb pdb:6D49|rcsb pdb:6D4A|rcsb pdb:6TL8|rcsb pdb:7AW6|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 1F|antagonist:whole C1q|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2017/05/16	2017/06/22	rogid:MpfQfOF+t0EMlzBio2kyYeJU3hE9606	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rigid:6IZcgPRf+rb++66nq299dsilMWw	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P20138-1	uniprotkb:P02747	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186680|imex:IM-25793-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	-	-	-	figure legend:Supp 1B|comment:Direct binding of gC1q, but not C1qCLR to CD33M was  observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:18-259	sufficient binding region:117..117-245..245(IPR001073)	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20138-1	uniprotkb:P02746	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-2813376|uniprotkb:Q96H17|uniprotkb:Q5T959	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1qb_human(display_long)|uniprotkb:C1QB(gene name)|psi-mi:C1QB(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186680|imex:IM-25793-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	refseq:NP_000482.3|rcsb pdb:6FCZ|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|refseq:XP_011540361.1|interpro:IPR037573|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|rcsb pdb:5HKJ|rcsb pdb:5HZF|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:6Z6V	-	-	-	figure legend:Supp 1B|comment:Direct binding of gC1q, but not C1qCLR to CD33M was  observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rogid:K8MXRS5Vqyts/FhcmJMJce4t/109606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:18-259	sufficient binding region:119..119-250..250(IPR001073)	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20138-1	uniprotkb:P02745	intact:EBI-15186203|ensembl:ENSP00000262262	intact:EBI-1220209|uniprotkb:Q5T963|uniprotkb:B2R4X2|ensembl:ENSP00000363773|ensembl:ENSP00000385564	psi-mi:p20138-1(display_long)|uniprotkb:CD33(gene name)|psi-mi:CD33(display_short)|uniprotkb:SIGLEC3(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 3(gene name synonym)|uniprotkb:gp67(gene name synonym)	psi-mi:c1qa_human(display_long)|uniprotkb:C1QA(gene name)|psi-mi:C1QA(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Son et al. (2017)	imex:IM-25793|pubmed:28325905	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15186680|imex:IM-25793-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105383(gene)|ensembl:ENST00000262262(transcript)|intact:EBI-3906571(isoform-parent)	refseq:NP_057075.1|refseq:NP_001334394.1|refseq:NP_001334395.1|ensembl:ENSG00000173372(gene)|ensembl:ENST00000374642(transcript)|ensembl:ENST00000402322(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005602"(complement component C1 complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0010039"(response to iron ion)|go:"GO:0016322"(neuron remodeling)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050808"(synapse organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR037572|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|rcsb pdb:2WNU|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606	-	-	-	figure legend:Supp 1B|comment:Direct binding of gC1q, but not C1qCLR to CD33M was  observed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/16	2017/06/22	rogid:ieCNIo6r19WGIEbM4zdPtyPrmAA9606	rogid:JOnVJ11QPTmKEEGIr3BAlb2j6+s9606	rigid:N6bBGRYp1n5e5P0YxfvWyG/0a8E	false	fc-igg tag:c-c|his tag:c-c|sufficient binding region:18-259	sufficient binding region:112..112-244..244(IPR001073)	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)